Professor Ole Paulsen University positionProfessor Professor Ole Paulsen is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Physiology, Development and Neuroscience InstitutesBehavioural and Clinical Neuroscience Institute Home pagehttp://noggin.pdn.cam.ac.uk/?Group.... (personal home page) Research ThemesInterestsThe primary interest of my group is the relationship between network oscillations and synaptic plasticity. Network oscillations naturally organise spike timing conducive to spike timing-dependent plasticity (STDP), a strong candidate for a mechanism involved in neural development as well as learning and memory processes. We aim to gain insight into how information can be stored and retrieved as changes of synaptic weights in neural networks displaying oscillatory activity. To this end, we use a combination of techniques, including whole-cell patch-clamp and planar multi-electrode recording, calcium imaging and light-activated channels (channelrhodopsins). Research Focus
EquipmentCalcium imaging Cell culture Computational modelling Confocal microscopy Electrophysiological recording techniques Field potential recording Fluorescence microscopy Immunohistochemistry Intracellular recording Microscopy Whole cell patch clamp Collaborators
Associated News Items
Publications2014Banerjee A, González-Rueda A, Sampaio-Baptista C, Paulsen O, Rodríguez-Moreno A (2014), “Distinct mechanisms of spike timing-dependent LTD at vertical and horizontal inputs onto L2/3 pyramidal neurons in mouse barrel cortex.” Physiol Rep 2(3):e00271 Details Groen MR, Paulsen O, Pérez-Garci E, Nevian T, Wortel J, Dekker MP, Mansvelder HD, van Ooyen A, Meredith RM (2014), “Development of dendritic tonic GABAergic inhibition regulates excitability and plasticity in CA1 pyramidal neurons.” J Neurophysiol 112(2):287-99 Details Palmer LM, Shai AS, Reeve JE, Anderson HL, Paulsen O, Larkum ME (2014), “NMDA spikes enhance action potential generation during sensory input.” Nat Neurosci Details Shipton OA, Paulsen O (2014), “GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity.” Philos Trans R Soc Lond B Biol Sci 369(1633):20130163 Details 2013Borel M, Guadagna S, Jang HJ, Kwag J, Paulsen O (2013), “Frequency dependence of CA3 spike phase response arising from h-current properties.” Front Cell Neurosci 7:263 Details Craig MT, Mayne EW, Bettler B, Paulsen O, McBain CJ (2013), “Distinct roles of GABAB1a- and GABAB1b-containing GABAB receptors in spontaneous and evoked termination of persistent cortical activity.” J Physiol 591(Pt 4):835-43 Details Mayne EW, Craig MT, McBain CJ, Paulsen O (2013), “Dopamine suppresses persistent network activity via D(1) -like dopamine receptors in rat medial entorhinal cortex.” Eur J Neurosci Details Rodríguez-Moreno A, González-Rueda A, Banerjee A, Upton AL, Craig MT, Paulsen O (2013), “Presynaptic self-depression at developing neocortical synapses.” Neuron 77(1):35-42 Details Tailor J, Kittappa R, Leto K, Gates M, Borel M, Paulsen O, Spitzer S, Karadottir RT, Rossi F, Falk A, Smith A (2013), “Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency.” J Neurosci 33(30):12407-22 Details 2012Botcherby EJ, Smith CW, Kohl MM, Débarre D, Booth MJ, Jukaitis R, Paulsen O, Wilson T (2012), “Aberration-free three-dimensional multiphoton imaging of neuronal activity at kHz rates.” Proc Natl Acad Sci U S A 109(8):2919-24 Details Catterall WA, Raman IM, Robinson HP, Sejnowski TJ, Paulsen O (2012), “The Hodgkin-Huxley heritage: from channels to circuits.” J Neurosci 32(41):14064-73 Details Kwag J, Paulsen O (2012), “Gating of NMDA receptor-mediated hippocampal spike timing-dependent potentiation by mGluR5.” Neuropharmacology 63(4):701-9 Details Reeve JE, Kohl MM, Rodríguez-Moreno A, Paulsen O, Anderson HL (2012), “Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function.” Commun Integr Biol 5(3):240-2 Details 2011Deakin IH, Nissen W, Law AJ, Lane T, Kanso R, Schwab MH, Nave KA, Lamsa KP, Paulsen O, Bannerman DM, Harrison PJ (2011), “Transgenic Overexpression of the Type I Isoform of Neuregulin 1 Affects Working Memory and Hippocampal Oscillations but not Long-term Potentiation.” Cereb Cortex Details Kohl MM, Shipton OA, Deacon RM, Rawlins JN, Deisseroth K, Paulsen O (2011), “Hemisphere-specific optogenetic stimulation reveals left-right asymmetry of hippocampal plasticity.” Nat Neurosci 14(11):1413-5 Details Kwag J, McLelland D, Paulsen O (2011), “Phase of firing as a local window for efficient neuronal computation: tonic and phasic mechanisms in the control of theta spike phase.” Front Hum Neurosci 5:3 Details Lyon L, Borel M, Carrión M, Kew JN, Corti C, Harrison PJ, Burnet PW, Paulsen O, Rodríguez-Moreno A (2011), “Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice.” Synapse 65(9):945-54 Details Rodríguez-Moreno A, Kohl MM, Reeve JE, Eaton TR, Collins HA, Anderson HL, Paulsen O (2011), “Presynaptic induction and expression of timing-dependent long-term depression demonstrated by compartment-specific photorelease of a use-dependent NMDA receptor antagonist.” J Neurosci 31(23):8564-9 Details Shipton OA, Leitz JR, Dworzak J, Acton CE, Tunbridge EM, Denk F, Dawson HN, Vitek MP, Wade-Martins R, Paulsen O, Vargas-Caballero M (2011), “Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.” J Neurosci 31(5):1688-92 Details 2010Ellender TJ, Nissen W, Colgin LL, Mann EO, Paulsen O (2010), “Priming of hippocampal population bursts by individual perisomatic-targeting interneurons.” J Neurosci 30(17):5979-91 Details Ellender TJ, Paulsen O (2010), “The many tunes of perisomatic targeting interneurons in the hippocampal network.” Front Cell Neurosci 4 Details Kohl MM, Paulsen O (2010), “The roles of GABAB receptors in cortical network activity.” Adv Pharmacol 58:205-29 Details Mann EO, Paulsen O (2010), “Local field potential oscillations as a cortical soliloquy.” Neuron 67(1):3-5 Details Oren I, Hájos N, Paulsen O (2010), “Identification of the current generator underlying cholinergically induced gamma frequency field potential oscillations in the hippocampal CA3 region.” J Physiol 588(Pt 5):785-97 Details Oren I, Paulsen O (2010), “Currents in space: understanding inhibitory field potentials.” J Physiol 588(Pt 12):2015-6 Details Rodríguez-Moreno A, Banerjee A, Paulsen O (2010), “Presynaptic NMDA Receptors and Spike Timing-Dependent Depression at Cortical Synapses.” Front Synaptic Neurosci 2:18 Details Zemankovics R, Káli S, Paulsen O, Freund TF, Hájos N (2010), “Differences in subthreshold resonance of hippocampal pyramidal cells and interneurons: the role of h-current and passive membrane characteristics.” J Physiol 588(Pt 12):2109-32 Details 2009Banerjee A, Meredith RM, Rodríguez-Moreno A, Mierau SB, Auberson YP, Paulsen O (2009), “Double dissociation of spike timing-dependent potentiation and depression by subunit-preferring NMDA receptor antagonists in mouse barrel cortex.” Cereb Cortex 19(12):2959-69 Details Hájos N, Ellender TJ, Zemankovics R, Mann EO, Exley R, Cragg SJ, Freund TF, Paulsen O (2009), “Maintaining network activity in submerged hippocampal slices: importance of oxygen supply.” Eur J Neurosci 29(2):319-27 Details Hájos N, Paulsen O (2009), “Network mechanisms of gamma oscillations in the CA3 region of the hippocampus.” Neural Netw 22(8):1113-9 Details Hoerder-Suabedissen A, Wang WZ, Lee S, Davies KE, Goffinet AM, Raki? S, Parnavelas J, Reim K, Nicoli? M, Paulsen O, Molnár Z (2009), “Novel markers reveal subpopulations of subplate neurons in the murine cerebral cortex.” Cereb Cortex 19(8):1738-50 Details Kwag J, Paulsen O (2009), “The timing of external input controls the sign of plasticity at local synapses.” Nat Neurosci 12(10):1219-21 Details Kwag J, Paulsen O (2009), “Bidirectional control of spike timing by GABA(A) receptor-mediated inhibition during theta oscillation in CA1 pyramidal neurons.” Neuroreport 20(13):1209-13 Details Mann EO, Kohl MM, Paulsen O (2009), “Distinct roles of GABA(A) and GABA(B) receptors in balancing and terminating persistent cortical activity.” J Neurosci 29(23):7513-8 Details McLelland D, Paulsen O (2009), “Neuronal oscillations and the rate-to-phase transform: mechanism, model and mutual information.” J Physiol 587(Pt 4):769-85 Details Reeve JE, Collins HA, Mey KD, Kohl MM, Thorley KJ, Paulsen O, Clays K, Anderson HL (2009), “Amphiphilic Porphyrins for Second Harmonic Generation Imaging.” J Am Chem Soc Details Romberg C, Raffel J, Martin L, Sprengel R, Seeburg PH, Rawlins JN, Bannerman DM, Paulsen O (2009), “Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus.” Eur J Neurosci 29(6):1141-52 Details van Aerde KI, Mann EO, Canto CB, Heistek TS, Linkenkaer-Hansen K, Mulder AB, van der Roest M, Paulsen O, Brussaard AB, Mansvelder HD (2009), “Flexible spike timing of layer 5 neurons during dynamic beta oscillation shifts in rat prefrontal cortex.” J Physiol 587(Pt 21):5177-96 Details Vargas-Caballero M, Martin LJ, Salter MW, Orser BA, Paulsen O (2009), “alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation.” Neuropharmacology Details 2008Hoerder-Suabedissen A, Paulsen O, Molnár Z (2008), “Thalamocortical maturation in mice is influenced by body weight.” J Comp Neurol 511(3):415-20 Details Rodríguez-Moreno A, Paulsen O (2008), “Spike timing-dependent long-term depression requires presynaptic NMDA receptors.” Nat Neurosci 11(7):744-5 Details 2007Mann EO, Paulsen O (2007), “Role of GABAergic inhibition in hippocampal network oscillations.” Trends Neurosci 30(7):343-9 Details McLelland D, Paulsen O (2007), “Cortical songs revisited: a lesson in statistics.” Neuron 53(3):319-21 Details Molnár Z, Hoerder-Suabedissen A, Wang WZ, DeProto J, Davies K, Lee S, Jacobs EC, Campagnoni AT, Paulsen O, Pińon MC, Cheung AF (2007), “Genes involved in the formation of the earliest cortical circuits.” Novartis Found Symp 288:212-24; discussion 224-9, 276-81 Details 2006Mann EO, Paulsen O (2006), “Keeping inhibition timely.” Neuron 49(1):8-9 Details Oren I, Mann EO, Paulsen O, Hájos N (2006), “Synaptic currents in anatomically identified CA3 neurons during hippocampal gamma oscillations in vitro.” J Neurosci 26(39):9923-34 Details Paulsen O, Sejnowski TJ (2006), “From invertebrate olfaction to human cognition: emerging computational functions of synchronized oscillatory activity.” J Neurosci 26(6):1661-2 Details Sejnowski TJ, Paulsen O (2006), “Network oscillations: emerging computational principles.” J Neurosci 26(6):1673-6 Details 2005Lengyel M, Kwag J, Paulsen O, Dayan P (2005), “Matching storage and recall: hippocampal spike timing-dependent plasticity and phase response curves.” Nat Neurosci 8(12):1677-83 Details Mann EO, Paulsen O (2005), “Mechanisms underlying gamma ('40 Hz') network oscillations in the hippocampus--a mini-review.” Prog Biophys Mol Biol 87(1):67-76 Details Mann EO, Radcliffe CA, Paulsen O (2005), “Hippocampal gamma-frequency oscillations: from interneurones to pyramidal cells, and back.” J Physiol 562(Pt 1):55-63 Details Mann EO, Suckling JM, Hajos N, Greenfield SA, Paulsen O (2005), “Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro.” Neuron 45(1):105-17 Details 2004Ganter P, Szücs P, Paulsen O, Somogyi P (2004), “Properties of horizontal axo-axonic cells in stratum oriens of the hippocampal CA1 area of rats in vitro.” Hippocampus 14(2):232-43 Details Hájos N, Pálhalmi J, Mann EO, Németh B, Paulsen O, Freund TF (2004), “Spike timing of distinct types of GABAergic interneuron during hippocampal gamma oscillations in vitro.” J Neurosci 24(41):9127-37 Details López-Bendito G, Sturgess K, Erdélyi F, Szabó G, Molnár Z, Paulsen O (2004), “Preferential origin and layer destination of GAD65-GFP cortical interneurons.” Cereb Cortex 14(10):1122-33 Details Mierau SB, Meredith RM, Upton AL, Paulsen O (2004), “Dissociation of experience-dependent and -independent changes in excitatory synaptic transmission during development of barrel cortex.” Proc Natl Acad Sci U S A 101(43):15518-23 Details Pálhalmi J, Paulsen O, Freund TF, Hájos N (2004), “Distinct properties of carbachol- and DHPG-induced network oscillations in hippocampal slices.” Neuropharmacology 47(3):381-9 Details 2003López-Bendito G, Luján R, Shigemoto R, Ganter P, Paulsen O, Molnár Z (2003), “Blockade of GABA(B) receptors alters the tangential migration of cortical neurons.” Cereb Cortex 13(9):932-42 Details Meredith RM, Floyer-Lea AM, Paulsen O (2003), “Maturation of long-term potentiation induction rules in rodent hippocampus: role of GABAergic inhibition.” J Neurosci 23(35):11142-6 Details 2002López-Bendito G, Shigemoto R, Kulik A, Paulsen O, Fairén A, Luján R (2002), “Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development.” Eur J Neurosci 15(11):1766-78 Details Paulsen O, Morris RG (2002), “Flies put the buzz back into long-term-potentiation.” Nat Neurosci 5(4):289-90 Details 2001Moser EI, Paulsen O (2001), “New excitement in cognitive space: between place cells and spatial memory.” Curr Opin Neurobiol 11(6):745-51 Details 2000Paulsen O, Sejnowski TJ (2000), “Natural patterns of activity and long-term synaptic plasticity.” Curr Opin Neurobiol 10(2):172-9 Details Pike FG, Goddard RS, Suckling JM, Ganter P, Kasthuri N, Paulsen O (2000), “Distinct frequency preferences of different types of rat hippocampal neurones in response to oscillatory input currents.” J Physiol 529 Pt 1:205-13 Details 1999Pike FG, Meredith RM, Olding AW, Paulsen O (1999), “Rapid report: postsynaptic bursting is essential for 'Hebbian' induction of associative long-term potentiation at excitatory synapses in rat hippocampus.” J Physiol 518 ( Pt 2):571-6 Details 1998Bon CL, Paulsen O, Greenfield SA (1998), “Association between the low threshold calcium spike and activation of NMDA receptors in guinea-pig substantia nigra pars compacta neurons.” Eur J Neurosci 10(6):2009-15 Details Fisahn A, Pike FG, Buhl EH, Paulsen O (1998), “Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro.” Nature 394(6689):186-9 Details Paulsen O, Moser EI (1998), “A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity.” Trends Neurosci 21(7):273-8 Details Sprengel R, Suchanek B, Amico C, Brusa R, Burnashev N, Rozov A, Hvalby O, Jensen V, Paulsen O, Andersen P, Kim JJ, Thompson RF, Sun W, Webster LC, Grant SG, Eilers J, Konnerth A, Li J, McNamara JO, Seeburg PH (1998), “Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo.” Cell 92(2):279-89 Details 1997Buhl EH, Tamás G, Szilágyi T, Stricker C, Paulsen O, Somogyi P (1997), “Effect, number and location of synapses made by single pyramidal cells onto aspiny interneurones of cat visual cortex.” J Physiol 500 ( Pt 3):689-713 Details 1996Paulsen O, Heggelund P (1996), “Quantal properties of spontaneous EPSCs in neurones of the guinea-pig dorsal lateral geniculate nucleus.” J Physiol 496 ( Pt 3):759-72 Details 1995Cobb SR, Buhl EH, Halasy K, Paulsen O, Somogyi P (1995), “Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons.” Nature 378(6552):75-8 Details 1994Hvalby O, Hemmings HC Jr, Paulsen O, Czernik AJ, Nairn AC, Godfraind JM, Jensen V, Raastad M, Storm JF, Andersen P (1994), “Specificity of protein kinase inhibitor peptides and induction of long-term potentiation.” Proc Natl Acad Sci U S A 91(11):4761-5 Details Paulsen O, Heggelund P (1994), “The quantal size at retinogeniculate synapses determined from spontaneous and evoked EPSCs in guinea-pig thalamic slices.” J Physiol 480 ( Pt 3):505-11 Details 1993Paulsen O, Li YG, Hvalby O, Anderson P, Bliss TV (1993), “Failure to induce long-term depression by an anti-correlation procedure in area CA1 of the rat hippocampal slice.” Eur J Neurosci 5(10):1241-6 Details 1992Oye I, Paulsen O, Maurset A (1992), “Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.” J Pharmacol Exp Ther 260(3):1209-13 Details |