Olivier Cahn

University position

MPhil student
Supervised by Dr Simone Mazzaferro


Department of Physiology, Development and Neuroscience


Institute of Metabolic Science



Research Theme

Cellular and Molecular Neuroscience


Endogenous GLP-1 plays an important biological role in regulating metabolism and agonists that target the GLP-1 receptor have been recently approved as treatment of obesity.

Studies in mice have shown that activation of hypothalamic pro-opiomelanocortin (POMC) neurons by GLP-1 receptor agonists promote weight loss by reducing food intake. POMC neurons are known to mediate weight loss by releasing melanocyte-stimulating hormone (MSH) upon excitation,. However, the molecular mechanisms on how the GLP-1 R agonists excite POMC neurons, and whereas this excitation enhance the release of MSH hormone is unknown.

This MPhil research will provide essential mechanistic insight on the role of GLP-1 receptor in human POMC neurons, which may reveal new molecular targets for further enhancing the appetite-reducing action of GLP-1 receptor agonists.

Research Focus


Calcium Imaging

Eating Disorders

Cellular Neuroscience

Clinical conditions

Eating disorders


Calcium imaging


No collaborators listed

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