I am currently a junior doctor and a visiting fellow at Professor James Rowe's laboratory.
My research interests lie in understanding the changes in the motor system that occur across the lifespan and in cases of disease. I use behavioural tasks that tap into principles from computational neuroscience, for example the integration of different sources of information for performing an action. I combine these tasks with brain imaging methods, such as functional magnetic resonance imaging, which allow me to examine the activity and connectivity of brain networks.
My current research at Cambridge looks at the effect of age on the brain's motor system. Ageing is typically associated with increased variability in performance across individuals. My endeavour, therefore, is to find the behavioural and neural markers that not only predict healthy ageing, but also those that identify the brain changes that put people at risk for falls and deteriorating motor systems.
Magnetic resonance imaging (MRI)
Associated News Items
Wolpe N, Ingram JN, Tsvetanov KA, Geerligs L, Kievit RA, Henson RN, Wolpert DM, Cam-CAN, Rowe JB (2016), “Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits” Nature Communications 7
Wolpe N, Zhang J, Nombela C, Ingram JN, Wolpert DM; Cam-CAN, Rowe JB (2018), “Sensory attenuation in Parkinson's disease is related to disease severity and dopamine dose” Scientific Reports 8(1): 15643
Tsvetanov KA, Ye Z, Hughes L, Samu D, Treder MS, Wolpe N, Tyler LK, Rowe JB, Cambridge Centre for Ageing and Neuroscience (2018), “Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span” Journal of Neuroscience 38(36): 7887-7900
Zhang J, Nombela C, Wolpe N, Barker RA, Rowe JB (2016), “Time on timing: Dissociating premature responding from interval sensitivity in Parkinson's” Movement Disorders 31(8)
Wolpe N, Nombela C, Rowe JB (2015), “Dopaminergic modulation of positive expectations for goal-directed action: evidence from Parkinson’s disease” Frontiers in psychology 6
Wolpe N, Rowe JB (2014), “Beyond the "urge to move": objective measures for the study of agency in the post-Libet era.” Front Hum Neurosci 8:450 Details
Wolpe N, Wolpert DM, Rowe JB (2014), “Seeing what you want to see: priors for one's own actions represent exaggerated expectations of success.” Front Behav Neurosci 8:232 Details
Wolpe N, Haggard P, Siebner HR, Rowe JB (2013), “Cue integration and the perception of action in intentional binding.” Exp Brain Res Details
Wolpe N, Moore JW, Rae CL, Rittman T, Altena E, Haggard P, Rowe JB (2013), “The medial frontal-prefrontal network for altered awareness and control of action in corticobasal syndrome.” Brain Details
Galli G, Wolpe N, Otten LJ (2011), “Sex differences in the use of anticipatory brain activity to encode emotional events.” J Neurosci 31(34):12364-70 Details