Dr Nicole Horst


I am interested in investigating the role of cortico-striatal circuits in flexible behaviour in order to understand how disruption of these circuits and their modulation by various neurotransmitters may underpin the inflexible behaviours observed in conditions like Obsessive-Compulsive Disorder.

Research Focus




Prefrontal cortex



Clinical conditions

Obsessive compulsive disorder


Behavioural analysis


No collaborators listed

Associated News Items



    Clarke HF, Horst NK, Roberts AC (2015), “Regional inactivations of primate ventral prefrontal cortex reveal two distinct mechanisms underlying negative bias in decision making.” Proc Natl Acad Sci U S A 112(13):4176-81 Details


    Horst NK, Laubach M (2013), “Reward-related activity in the medial prefrontal cortex is driven by consumption.” Front Neurosci 7:56 Details


    Caetano MS, Horst NK, Harenberg L, Liu B, Arnsten AF, Laubach M (2012), “Lost in transition: aging-related changes in executive control by the medial prefrontal cortex.” J Neurosci 32(11):3765-77 Details

    Horst NK, Heath CJ, Neugebauer NM, Kimchi EY, Laubach M, Picciotto MR (2012), “Impaired auditory discrimination learning following perinatal nicotine exposure or ?2 nicotinic acetylcholine receptor subunit deletion.” Behav Brain Res 231(1):170-80 Details

    Horst NK, Laubach M (2012), “Working with memory: evidence for a role for the medial prefrontal cortex in performance monitoring during spatial delayed alternation.” J Neurophysiol 108(12):3276-88 Details


    Heath CJ, Horst NK, Picciotto MR (2010), “Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence.” Physiol Behav 101(5):764-9 Details

    Smith NJ, Horst NK, Liu B, Caetano MS, Laubach M (2010), “Reversible Inactivation of Rat Premotor Cortex Impairs Temporal Preparation, but not Inhibitory Control, During Simple Reaction-Time Performance.” Front Integr Neurosci 4:124 Details


    Horst NK, Laubach M (2009), “The role of rat dorsomedial prefrontal cortex in spatial working memory.” Neuroscience 164(2):444-56 Details


    Narayanan NS, Horst NK, Laubach M (2006), “Reversible inactivations of rat medial prefrontal cortex impair the ability to wait for a stimulus.” Neuroscience 139(3):865-76 Details


    Lambe EK, Olausson P, Horst NK, Taylor JR, Aghajanian GK (2005), “Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat.” J Neurosci 25(21):5225-9 Details


    Zenisek D, Horst NK, Merrifield C, Sterling P, Matthews G (2004), “Visualizing synaptic ribbons in the living cell.” J Neurosci 24(44):9752-9 Details