Dr Mark KotterUniversity positionClinical Lecturer Dr Mark Kotter is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Clinical Neurosciences Home pagehttp://www.lrm.medschl.cam.ac.uk/researc... (personal home page) Research ThemesInterestsMy group is interested in the biology of adult CNS stem and precursor cells in the context of disease. A particular focus lies on mechanisms of CNS remyelination, a stem/precursor cell-mediated process in which new myelin sheaths are restored to demyelinated nerve fibres (axons). To understand how the differentiation of multipotent oligodendrocyte precursor cells (OPCs) is regulated we use a combination of in vitro and in vivo models. Furthermore, we integrate findings of post mortem studies and aim at translating our findings into clinical studies. Research Focus
EquipmentCell culture Confocal microscopy Enzyme assays Fluorescence microscopy FPLC/HPLC Immunohistochemistry Microscopy Protein purification Recombinant protein expression Collaborators
Associated News Items
Key publicationsBaer AS, Syed YA, Kang SU, Mitteregger D, Vig R, Ffrench-Constant C, Franklin RJ, Altmann F, Lubec G, Kotter MR (2009), “Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.” Brain 132(Pt 2):465-81 Details Neumann H, Kotter MR, Franklin RJ (2009), “Debris clearance by microglia: an essential link between degeneration and regeneration.” Brain 132(Pt 2):288-95 Details Kotter MR, Li WW, Zhao C, Franklin RJ (2006), “Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation.” J Neurosci 26(1):328-32 Details Kotter MR, Setzu A, Sim FJ, Van Rooijen N, Franklin RJ (2001), “Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination.” Glia 35(3):204-12 Details |