Mikail Rubinov

Mikail Rubinov

University position

Visiting Scientist


HHMI Janelia Research Campus and Department of Psychiatry


Brain Mapping Unit and Behavioural and Clinical Neuroscience Institute



Home page

http://www.mikail-rubinov.net (personal home page)

Research Themes

Systems and Computational Neuroscience

Cognitive and Behavioural Neuroscience


Complex-network mapping of structural and functional connectomes; constraints and principles of whole-brain network organization; information transfer in large-scale brain dynamics; neuropsychiatric connectivity phenotypes.

Illustrative anatomical, functional, and effective connectivity networks of the macaque cortex. These networks include the ventral and dorsal streams of visual cortex, as well as groups of somatosensory and somatomotor regions. Network modules representing these groups form largely contiguous (color-coded) anatomical regions. Figure from: Rubinov M, Sporns O (2010) NeuroImage 52:1059-69.
Click image to view full-size

Research Focus







Clinical conditions


Huntington's disease



Calcium imaging

Computational modelling

Light-sheet microscopy

Magnetic resonance imaging (MRI)



Ed Bullmore

Linda Geerligs

Rik Henson

Tim Rittman

John Suckling

Rolf Ypma


Misha Ahrens

Michael Breakspear

Jeremy Freeman

Joseph Lizier

Stephen Rao

Olaf Sporns

Associated News Items



Crossley NA, Mechelli A, Ginestet C, Rubinov M, Bullmore ET, McGuire P (2016), “Altered Hub Functioning and Compensatory Activations in the Connectome: A Meta-Analysis of Functional Neuroimaging Studies in Schizophrenia” Schizophr Bull 42:434-42

Lowe MJ, Sakaie KE, Beall EB, Calhoun VD, Bridwell DA, Rubinov M, Rao SM (2016), “Modern Methods for Interrogating the Human Connectome” J Int Neuropsychol Soc 22:105-19

Rittman T, Rubinov M, Vértes PE, Patel AX, Ginestet CE, Ghosh BC, Barker RA, Spillantini MG, Bullmore ET, Rowe JB (2016), “Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy.” Neurobiol Aging 9;48:153-160

Rubinov M (2016), “Constraints and spandrels of interareal connectomes” Nat Commun 7:13812

Ypma RJ, Moseley RL, Holt RJ, Rughooputh N, Floris DL, Chura LR, Spencer MD, Baron-Cohen S, Suckling J, Bullmore ET, Rubinov M (2016), “Default Mode Hypoconnectivity Underlies a Sex-Related Autism Spectrum” Biol Psychiatry Cogn Neurosci Neuroimaging 1:364-371


Geerligs L, Rubinov M, Cam-Can, Henson RN (2015), “State and Trait Components of Functional Connectivity: Individual Differences Vary with Mental State” J Neurosci 35(41):13949-61

Harrington DL, Rubinov M, Durgerian S, Mourany L, Reece C, Koenig K, Bullmore E, Long JD, Paulsen JS, PREDICT-HD investigators of the Huntington Study Group, Rao SM (2015), “Network topology and functional connectivity disturbances precede the onset of Huntington's disease.” Brain Details

Kruschwitz JD, List D, Waller L, Rubinov M, Walter H (2015), “GraphVar: A user-friendly toolbox for comprehensive graph analyses of functional brain connectivity.” J Neurosci Methods 245:107-115 Details

Moseley RL, Ypma RJ, Holt RJ, Floris D, Chura LR, Spencer MD, Baron-Cohen S, Suckling J, Bullmore E, Rubinov M (2015), “Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents.” Neuroimage Clin 9:140-52

Rubinov M (2015), “Neural networks in the future of neuroscience research (commentary)” Nat Rev Neurosci doi: 10.1038/nrn4042

Rubinov M, Ypma RJ, Watson C, Bullmore ET (2015), “Wiring cost and topological participation of the mouse brain connectome.” Proc Natl Acad Sci U S A Details


Alstott J, Panzarasa P, Rubinov M, Bullmore ET, Vértes PE (2014), “A unifying framework for measuring weighted rich clubs.” Sci Rep 4:7258 Details

Patel AX, Kundu P, Rubinov M, Simon Jones P, Vértes PE, Ersche KD, Suckling J, Bullmore ET (2014), “A wavelet method for modeling and despiking motion artifacts from resting-state fMRI time series.” Neuroimage Details


Monti MM, Lutkenhoff ES, Rubinov M, Boveroux P, Vanhaudenhuyse A, Gosseries O, Bruno MA, Noirhomme Q, Boly M, Laureys S (2013), “Dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness.” PLoS Comput Biol 9(10):e1003271 Details

Rubinov M (2013), “Review of 'Psychiatry and Clinical Neuroscience: A Primer'” Psychol Med 43(03): 667-668 PDF

Rubinov M, Bullmore E (2013), “Schizophrenia and abnormal brain network hubs.” Dialogues Clin Neurosci 15(3):339-49 PDF Details

Rubinov M, Bullmore E (2013), “Fledgling pathoconnectomics of psychiatric disorders.” Trends Cogn Sci 17(12):641-7 PDF Details


Rubinov M, Bassett DS (2011), “Emerging evidence of connectomic abnormalities in schizophrenia.” J Neurosci 31(17):6263-5 PDF Details

Rubinov M, Sporns O (2011), “Weight-conserving characterization of complex functional brain networks.” Neuroimage 56(4):2068-79 PDF Details

Rubinov M, Sporns O, Thivierge JP, Breakspear M (2011), “Neurobiologically realistic determinants of self-organized criticality in networks of spiking neurons.” PLoS Comput Biol 7(6):e1002038 PDF Details


Rubinov M, Sporns O (2010), “Complex network measures of brain connectivity: uses and interpretations.” Neuroimage 52(3):1059-69 PDF Details


Rubinov M, Knock SA, Stam CJ, Micheloyannis S, Harris AW, Williams LM, Breakspear M (2009), “Small-world properties of nonlinear brain activity in schizophrenia.” Hum Brain Mapp 30(2):403-16 PDF Details

Rubinov M, McIntosh AR, Valenzuela MJ, Breakspear M (2009), “Simulation of neuronal death and network recovery in a computational model of distributed cortical activity.” Am J Geriatr Psychiatry 17(3):210-7 PDF Details

Rubinov M, Sporns O, van Leeuwen C, Breakspear M (2009), “Symbiotic relationship between brain structure and dynamics.” BMC Neurosci 10:55 PDF Details