Dr Megan Oliva


University position

Research Associate

Departments

Department of Genetics

Email

mo412@cam.ac.uk

Home page

https://www.gen.cam.ac.uk/researc...

Research Theme

Cellular and Molecular Neuroscience

Interests

Axonal endoplasmic reticulum (ER) forms an intracellular tubular network,

continuous throughout neurons; its long-range continuity could carry signals

independently of action potentials, like a “neuron within a neuron”. An important

role for it is implied by many mutations for the motor axon disease, hereditary

spastic paraplegia (HSP), affecting proteins that model tubular ER. My host lab

has shown that loss of HSP genes can disrupt ER organisation in Drosophila

axons, allowing study of the roles of the ER network there. I am testing the roles

of ER continuity in localised and long range calcium signaling in axons. I have generated flies carrying calcium sensors in and around axon ER, to monitor calcium flux. I am testing whether mutations that disrupt the axon

ER network affect such fluxes.

This work should reveal the role of axon ER in processes central to cellular

coordination and degeneration in neurons.

Research Focus

Keywords

calcium imaging

neurodegeneration

drosophila

endoplasmic reticulum

hereditary spastic paraplegia

Clinical conditions

Hereditary Spastic Paraplegia

Motor Neuron Disease

Equipment

Calcium imaging

Fluorescence microscopy

Collaborators

Cambridge

Trevor Wardill

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