Dr Mary McLean University positionSenior Research Associate DepartmentsInstitutesCancer Research UK, Cambridge Research Institute Home pageResearch ThemeInterestsI perform magnetic resonance imaging and spectroscopy studies on patients with brain tumours (as well as tumours of other parts of the body). The aim is to improve non-invasive diagnosis and the prediction and monitoring of response to treatment. Prior to 2007 I spent nine years performing similar studies in a wide gamut of neurological and psychological disorders at the Institute of Neurology, London.  magnetic resonance spectra from an astrocytoma Click image to view full-size Research Focus
EquipmentMagnetic resonance imaging (MRI) CollaboratorsNo collaborators listed Associated News ItemsKey publicationsMcLean MA, Barker GJ (2006), “Concentrations and magnetization transfer ratios of metabolites in gray and white matter” Magn Reson Med 56:1365-1370 Details McLean MA, Simister RJ, Barker GJ, Duncan JS (2005), “Magnetization transfer effect on human brain metaboites and macromolecules” Magn Reson Med 54:1281-1285 Details McLean MA, Simister RJ, Barker GJ, Duncan JS (2004), “Discrimination between neurochemical and macromolecular signals in human frontal lobes using short echo time proton magnetic resonance spectroscopy” Faraday Discuss 126:93-102 Details Publications2013Taviani V, Nagala S, Priest AN, McLean MA, Jani P, Graves MJ (2013), “3T diffusion-weighted MRI of the thyroid gland with reduced distortion: preliminary results.” Br J Radiol 86(1028):20130022 Details 2012Barrett T, Gill AB, Kataoka MY, Priest AN, Joubert I, McLean MA, Graves MJ, Stearn S, Lomas DJ, Griffiths JR, Neal D, Gnanapragasam VJ, Sala E (2012), “DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: a feasibility study.” Magn Reson Med 67(3):778-85 Details McLean MA, Sun A, Bradstreet TE, Schaeffer AK, Liu H, Iannone R, Herman G, Railkar RA, Joubert I, Gillard JH, Price SJ, Griffiths JR (2012), “Repeatability of edited lactate and other metabolites in astrocytoma at 3T.” J Magn Reson Imaging 36(2):468-75 Details Sala E, Kataoka MY, Priest AN, Gill AB, McLean MA, Joubert I, Graves MJ, Crawford RA, Jimenez-Linan M, Earl HM, Hodgkin C, Griffiths JR, Lomas DJ, Brenton JD (2012), “Advanced ovarian cancer: multiparametric MR imaging demonstrates response- and metastasis-specific effects.” Radiology 263(1):149-59 Details 2011Fusar-Poli P, Stone JM, Broome MR, Valli I, Mechelli A, McLean MA, Lythgoe DJ, O'Gorman RL, Barker GJ, McGuire PK (2011), “Thalamic Glutamate Levels as a Predictor of Cortical Response During Executive Functioning in Subjects at High Risk for Psychosis.” Arch Gen Psychiatry Details McLean MA, Barrett T, Gnanapragasam VJ, Priest AN, Joubert I, Lomas DJ, Neal DE, Griffiths JR, Sala E (2011), “Prostate cancer metabolite quantification relative to water in 1H-MRSI in vivo at 3 Tesla.” Magn Reson Med 65(4):914-9 Details 2010Ciccarelli O, Altmann DR, McLean MA, Wheeler-Kingshott CA, Wimpey K, Miller DH, Thompson AJ (2010), “Spinal cord repair in MS: does mitochondrial metabolism play a role?” Neurology 74(9):721-7 Details Priest AN, Gill AB, Kataoka M, McLean MA, Joubert I, Graves MJ, Griffiths JR, Crawford RA, Earl H, Brenton JD, Lomas DJ, Sala E (2010), “Dynamic contrast-enhanced MRI in ovarian cancer: Initial experience at 3 tesla in primary and metastatic disease.” Magn Reson Med 63(4):1044-9 Details Sala E, Priest AN, Kataoka M, Graves MJ, McLean MA, Joubert I, Griffiths JR, Crawford RA, Jimenez-Linan M, Earl HM, Brenton JD, Lomas DJ (2010), “Apparent diffusion coefficient and vascular signal fraction measurements with magnetic resonance imaging: feasibility in metastatic ovarian cancer at 3 Tesla: technical development.” Eur Radiol 20(2):491-6 Details Stone JM, Howes OD, Egerton A, Kambeitz J, Allen P, Lythgoe DJ, O'Gorman RL, McLean MA, Barker GJ, McGuire P (2010), “Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosis.” Biol Psychiatry 68(7):599-602 Details 2009McLean MA, Cross JJ (2009), “Magnetic resonance spectroscopy: principles and applications in neurosurgery.” Br J Neurosurg 23(1):5-13 Details McLean MA, Priest AN, Joubert I, Lomas DJ, Kataoka MY, Earl H, Crawford R, Brenton JD, Griffiths JR, Sala E (2009), “Metabolic characterization of primary and metastatic ovarian cancer by 1H-MRS in vivo at 3T.” Magn Reson Med 62(4):855-61 Details Simister RJ, McLean MA, Barker GJ, Duncan JS (2009), “Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection.” Epilepsy Res 83(2-3):168-76 Details Stone JM, Day F, Tsagaraki H, Valli I, McLean MA, Lythgoe DJ, O'Gorman RL, Barker GJ, McGuire PK, OASIS (2009), “Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume.” Biol Psychiatry 66(6):533-9 Details 2008Simister RJ, McLean MA, Salmenpera TM, Barker GJ, Duncan JS (2008), “The effect of epileptic seizures on proton MRS visible neurochemical concentrations.” Epilepsy Res 81(1):36-43 Details 2007Ciccarelli O, Wheeler-Kingshott CA, McLean MA, Cercignani M, Wimpey K, Miller DH, Thompson AJ (2007), “Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis.” Brain 130(Pt 8):2220-31 Details Simister RJ, McLean MA, Barker GJ, Duncan JS (2007), “The effect of sodium valproate on proton MRS visible neurochemical concentrations.” Epilepsy Res 74(2-3):215-9 Details Simister RJ, McLean MA, Barker GJ, Duncan JS (2007), “Proton magnetic resonance spectroscopy of malformations of cortical development causing epilepsy.” Epilepsy Res 74(2-3):107-15 Details 2006Samson RS, Thornton JS, McLean MA, Williams SC, Tofts PS (2006), “1H-MRS internal thermometry in test-objects (phantoms) to within 0.1 K for quality assurance in long-term quantitative MR studies.” NMR Biomed 19(5):560-5 Details Tiberio M, Chard DT, Altmann DR, Davies G, Griffin CM, McLean MA, Rashid W, Sastre-Garriga J, Thompson AJ, Miller DH (2006), “Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up study.” J Neurol 253(2):224-30 Details 2005Sastre-Garriga J, Ingle GT, Chard DT, Ramió-Torrentą L, McLean MA, Miller DH, Thompson AJ (2005), “Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis.” Arch Neurol 62(4):569-73 Details 2004Fernando KT, McLean MA, Chard DT, MacManus DG, Dalton CM, Miszkiel KA, Gordon RM, Plant GT, Thompson AJ, Miller DH (2004), “Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis.” Brain 127(Pt 6):1361-9 Details 2003Howe FA, Barton SJ, Cudlip SA, Stubbs M, Saunders DE, Murphy M, Wilkins P, Opstad KS, Doyle VL, McLean MA, Bell BA, Griffiths JR (2003), “Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.” Magn Reson Med 49(2):223-32 Details Simister RJ, McLean MA, Barker GJ, Duncan JS (2003), “A proton magnetic resonance spectroscopy study of metabolites in the occipital lobes in epilepsy.” Epilepsia 44(4):550-8 Details 2002Chard DT, Griffin CM, McLean MA, Kapeller P, Kapoor R, Thompson AJ, Miller DH (2002), “Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis.” Brain 125(Pt 10):2342-52 Details Chard DT, McLean MA, Parker GJ, MacManus DG, Miller DH (2002), “Reproducibility of in vivo metabolite quantification with proton magnetic resonance spectroscopic imaging.” J Magn Reson Imaging 15(2):219-25 Details Kapeller P, Brex PA, Chard D, Dalton C, Griffin CM, McLean MA, Parker GJ, Thompson AJ, Miller DH (2002), “Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis.” Mult Scler 8(3):207-10 Details Simister RJ, Woermann FG, McLean MA, Bartlett PA, Barker GJ, Duncan JS (2002), “A short-echo-time proton magnetic resonance spectroscopic imaging study of temporal lobe epilepsy.” Epilepsia 43(9):1021-31 Details 2001Kapeller P, McLean MA, Griffin CM, Chard D, Parker GJ, Barker GJ, Thompson AJ, Miller DH (2001), “Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: a quantitative MR spectroscopic imaging study.” J Neurol 248(2):131-8 Details McLean MA, Woermann FG, Simister RJ, Barker GJ, Duncan JS (2001), “In vivo short echo time 1H-magnetic resonance spectroscopic imaging (MRSI) of the temporal lobes.” Neuroimage 14(2):501-9 Details Woermann FG, McLean MA, Bartlett PA, Barker GJ, Duncan JS (2001), “Quantitative short echo time proton magnetic resonance spectroscopic imaging study of malformations of cortical development causing epilepsy.” Brain 124(Pt 2):427-36 Details 1999Krakow K, Wieshmann UC, Woermann FG, Symms MR, McLean MA, Lemieux L, Allen PJ, Barker GJ, Fish DR, Duncan JS (1999), “Multimodal MR imaging: functional, diffusion tensor, and chemical shift imaging in a patient with localization-related epilepsy.” Epilepsia 40(10):1459-62 Details Woermann FG, McLean MA, Bartlett PA, Parker GJ, Barker GJ, Duncan JS (1999), “Short echo time single-voxel 1H magnetic resonance spectroscopy in magnetic resonance imaging-negative temporal lobe epilepsy: different biochemical profile compared with hippocampal sclerosis.” Ann Neurol 45(3):369-76 Details 1995Saunders DE, Howe FA, van den Boogaart A, McLean MA, Griffiths JR, Brown MM (1995), “Continuing ischemic damage after acute middle cerebral artery infarction in humans demonstrated by short-echo proton spectroscopy.” Stroke 26(6):1007-13 Details 1994Howe FA, Saunders DE, Filler AG, McLean MA, Heron C, Brown MM, Griffiths JR (1994), “Magnetic resonance neurography of the median nerve.” Br J Radiol 67(804):1169-72 Details |