Maura Malpetti


University position

Research Associate

Maura Malpetti is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Neurology Unit

Email

mm2243@cam.ac.uk

Home page

https://ftd.neurology.cam.ac.uk/

Research Themes

Clinical and Veterinary Neuroscience

Cognitive and Behavioural Neuroscience

Interests

I am interested in the study of neuropathology, biomarkers and clinical features of neurodegenerative diseases, with special interest in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD).

My work focuses on the application of neuroimaging techniques (multi-tracer PET and MRI) to investigate the pathophysiology of neurodegenerative diseases, in order to identify early diagnostic and prognostic markers.

To this end, I apply longitudinal statistical models and multimodal imaging analyses, with an interdisciplinary approach that integrates imaging and clinical data with fluid markers and post-mortem pathology.

My main projects focus on

i) characterising the predictive value of in vivo PET imaging for molecular pathology and inflammation in tauopathies;

ii) identifying novel clinically viable PET and fluid biomarkers in dementias;

iii) investigating the role of behavioural and brain changes in pre-symptomatic genetic frontotemporal dementia.

Research Focus

Keywords

Dementia

Neuroimaging

Neurodegenerative diseases

Longitudinal modeling

Clinical conditions

Alzheimer's disease

Dementia

Dementia with Lewy bodies

Frontotemporal dementia

Progressive Supranuclear Palsy

Equipment

Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)

Collaborators

Cambridge

Rogier Kievit

John O'Brien

James Rowe

Associated News Items


Key publications

Malpetti M, Kievit RA, Passamonti L, Jones PS, Tsvetanov KA, Rittman T, Mak E, Nicastro N, Bevan-Jones WR, Su L, Hong YT, Fryer TD, Aigbirhio FI, O'Brien JT, Rowe JB (2020), “Microglial activation and tau burden predict cognitive decline in Alzheimer's disease” Brain 143(5):1588-1602