Dr Matthias Landgraf

Matthias Landgraf

University position


Dr Matthias Landgraf is pleased to consider applications from prospective PhD students.


Department of Zoology



Home page

https://www.zoo.cam.ac.uk/researc... (personal home page)

Research Themes

Developmental Neuroscience

Cellular and Molecular Neuroscience


We seek to understand how neural networks are specified and how they assemble during development. The locomotor network of the Drosophila embryo and larva serves as a powerful experimental model. Composed of identified neurons whose connections have been reconstructed, we use genetics, imaging and electrophysiology to study fundamental questions about synapse development, dendritic growth and the regulation of plasticity.

Current research topics include:

Charting the developmental logic of neurotransmitters specification

Determining how patterned growth during development leads to patterns of synaptic connections

Activity dependent structural homeostasis and the maturation of network properties

Reactive oxygen species seen in a different light, as newly identified regulators of synaptic growth

Connectomics of memory circuits

Research Focus





reactive oxygen species


Clinical conditions

Alzheimer's disease

Mental Retardation

Parkinson's disease

Prion diseases

Prion diseases


Cell labelling

Confocal microscopy

Electrophysiological recording techniques

Fluorescence microscopy

Fluorescence microscopy

Genetic intersectional strategies


Live imaging



Michael Bate

Raymond Bujdoso

Gregory Jefferis

Kevin O'Holleran

Matthew Wayland

United Kingdom

Richard Baines Web: http://www.ls.manchester.ac.uk/people/...

Sangeeta Chawla Web: https://www.york.ac.uk/biology...

Richard Ribchester Web: http://www.ed.ac.uk/integra...

Sean Sweeney Web: http://www.york.ac.uk/biology...


Albert Cardona Web: http://www.hhmi.org/scienti...

Haluk Lacin Web: https://www.janelia.org/people/...

Gerd Technau Web: http://www.uni-mainz.de/FB/Biol...

Jim Truman Web: https://www.janelia.org/lab/tru...

Don van Meyel Web: http://www.mcgill.ca/crn/inv...

Benjamin White Web: http://neuroscience.nih.gov/Lab.asp...

Marta Zlatic Web: https://www.janelia.org/lab/zla...

Associated News Items

Key publications

Oswald MCW, Brooks PS, Zwart MF, Mukherjee A, West RJH, Morarach K, Sweeney ST and Landgraf M. (2018), “Reactive Oxygen Species Regulate Activity-Dependent Neuronal Structural Plasticity. ” eLife DOI: 10.7554/eLife.39393

Zwart MF, Pulver SR, Truman JW, Fushiki A, Fetter, RD, Cardona A, Landgraf M. (2016), “Selective Inhibition Mediates the Sequential Recruitment of Motor Pools. ” Neuron 91(3):615-628

Couton L, Mauss AS, Yunusov T, Diegelmann S, Evers JF, Landgraf M. (2015), “Development of connectivity in a motoneuronal network in Drosophila larvae. ” Current Biology 25(5): 568–576

Diao F, Ironfield H, Luan H, Diao F, Shropshire WC, Ewer J, Marr E, Potter CJ, Landgraf M, White BH. (2015), “Plug-and-Play Genetic Access to Drosophila Cell Types using Exchangeable Exon Cassettes. ” Cell Reports 10(8): 1410–1421

Zwart MF, Randlett O, Evers JF, Landgraf M (2013), “Dendritic growth gated by a steroid hormone receptor underlies increases in activity in the developing Drosophila locomotor system.” Proc Natl Acad Sci U S A 110(40):E3878-87 Details



Oswald, M. C. W., Garnham, N., Sweeney, S. T., & Landgraf, M. (2018), “Regulation of neuronal development and function by ROS.” FEBS Letters doi.org/10.1002/1873-3468.12972


Singh AP, Das RN, Rao G, Aggarwal A, Diegelmann S, Evers JF, Karandikar H, Landgraf M, Rodrigues V, Vijayraghavan K (2013), “Sensory neuron-derived eph regulates glomerular arbors and modulatory function of a central serotonergic neuron.” PLoS Genet 9(4):e1003452 Details


Thackray AM, Muhammad F, Zhang C, Di Y, Jahn TR, Landgraf M, Crowther DC, Evers JF, Bujdoso R (2012), “Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival.” Biochem J 444(3):487-95 Details


Nicolaď LJ, Ramaekers A, Raemaekers T, Drozdzecki A, Mauss AS, Yan J, Landgraf M, Annaert W, Hassan BA (2010), “Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila.” Proc Natl Acad Sci U S A 107(47):20553-8 Details


Mauss A, Tripodi M, Evers JF, Landgraf M (2009), “Midline signalling systems direct the formation of a neural map by dendritic targeting in the Drosophila motor system.” PLoS Biol 7(9):e1000200 Details


Diegelmann S, Bate M, Landgraf M (2008), “Gateway cloning vectors for the LexA-based binary expression system in Drosophila.” Fly (Austin) 2(4):236-9 Details

Ou Y, Chwalla B, Landgraf M, van Meyel DJ (2008), “Identification of genes influencing dendrite morphogenesis in developing peripheral sensory and central motor neurons.” Neural Dev 3:16 Details

Tripodi M, Evers JF, Mauss A, Bate M, Landgraf M (2008), “Structural homeostasis: compensatory adjustments of dendritic arbor geometry in response to variations of synaptic input.” PLoS Biol 6(10):e260 Details


Landgraf M, Thor S (2006), “Development and structure of motoneurons.” Int Rev Neurobiol 75:33-53 Details

Landgraf M, Thor S (2006), “Development of Drosophila motoneurons: specification and morphology.” Semin Cell Dev Biol 17(1):3-11 Details


Landgraf M, Evers JF (2005), “Control of dendritic diversity.” Curr Opin Cell Biol 17(6):690-6 Details


Landgraf M, Jeffrey V, Fujioka M, Jaynes JB, Bate M (2003), “Embryonic origins of a motor system: motor dendrites form a myotopic map in Drosophila.” PLoS Biol 1(2):E41 Details

Landgraf M, Sánchez-Soriano N, Technau GM, Urban J, Prokop A (2003), “Charting the Drosophila neuropile: a strategy for the standardised characterisation of genetically amenable neurites.” Dev Biol 260(1):207-25 Details

Zlatic M, Landgraf M, Bate M (2003), “Genetic specification of axonal arbors: atonal regulates robo3 to position terminal branches in the Drosophila nervous system.” Neuron 37(1):41-51 Details