Professor Mike Edwardson

Mike Edwardson

University position

Professor

Departments

Department of Pharmacology

Email

jme1000@cam.ac.uk

Home page

http://www.phar.cam.ac.uk/researc... (personal home page)

Research Theme

Cellular and Molecular Neuroscience

Interests

My research involves imaging of biomolecules using atomic force microscopy (AFM). AFM permits the visualization of single molecules under near-physiological conditions. I am currently studying the effects of activation on the behaviour of ionotropic glutamate receptors.

The AFM image shows neurotransmitter-containing vesicles docked at the plasma membrane of a PC12 cell.
The AFM image shows neurotransmitter-containing vesicles docked at the plasma membrane of a PC12 cell.
Click image to view full-size

Research Focus

Keywords

ionotropic receptors

receptor structure

atomic force microscopy

neurotransmitter release

Clinical conditions

No direct clinical relevance

Equipment

Atomic force microscopy (AFM)

Cell culture

Confocal microscopy

Protein purification

Recombinant protein expression

Collaborators

International

Derek Bowie Web: http://www.medicine.mcgill.ca/pharma/...

Edwin Chapman Web: http://neuro.wisc.edu/faculty...

Associated News Items


    Key publications

    Dawe GB, Kadir MF, VenskutonytÄ— R, Perozzo AM, Yan Y, Alexander RPD, Navarrete C., Santander EA, Arsenault M, Fuentes C, Aurousseau MRP, Frydenvang K, Barrera NP, Kastrup JS, Edwardson JM and Bowie D (2019), “Nanoscale mobility of the apo state and TARP stoichiometry dictate the gating behavior of alternatively-spliced AMPA receptors” Neuron 102: 976-992

    Bao H, Goldschen-Ohm M, Jeggle P, Chanda B, Edwardson JM and Chapman ER (2016), “Exocytotic fusion pores are composed of both lipids and proteins” Nat Struct Mol Biol 23: 67-73

    Srivats S, Balasuriya D, Pasche M, Vistal G, Edwardson JM, Taylor CW and Murrell-Lagnado RD (2016), “Sigma1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1” J Cell Biol 213: 65-79

    Liu H, Bai H, Xue R, Takahashi H, Edwardson JM and Chapman ER (2014), “Linker mutations dissociate the function of synaptotagmin I during evoked and spontaneous release and reveal membrane penetration as a step during excitation-secretion coupling” Nat Neurosci 17: 670-677