Professor Mike Edwardson

Mike Edwardson

University position

Head of Department

Professor Mike Edwardson is pleased to consider applications from prospective PhD students.


Department of Pharmacology


Home page (personal home page)

Research Theme

Cellular and Molecular Neuroscience


My research involves imaging of biomolecules using atomic force microscopy (AFM). AFM permits the visualization of single molecules under near-physiological conditions. Current projects include studies of:

1. The subunit arrangement in ionotropic receptors.

2. The structural changes occurring during receptor activation.

3. The association of sigma-1 receptors with ion channels.

4. The behaviour of proteins involved in membrane fusion during neurotransmitter release.

The AFM image shows neurotransmitter-containing vesicles docked at the plasma membrane of a PC12 cell.
The AFM image shows neurotransmitter-containing vesicles docked at the plasma membrane of a PC12 cell.
Click image to view full-size

Research Focus


ionotropic receptors

receptor structure

atomic force microscopy

neurotransmitter release

Clinical conditions

No direct clinical relevance


Atomic force microscopy (AFM)

Cell culture

Confocal microscopy

Protein purification

Recombinant protein expression



Ruth Murrell-Lagnado


Jon Audhya Web:

Edwin Chapman Web:

Associated News Items



    Jeggle P, Smith ES, Stewart AP, Haerteis S, Korbmacher C, Edwardson JM (2015), “Atomic force microscopy imaging reveals the formation of ASIC/ENaC cross-clade ion channels.” Biochem Biophys Res Commun 464(1):38-44 Details

    Stewart AP, Sandford RN, Karet Frankl FE, Edwardson JM (2015), “Pathogenic uromodulin mutations result in premature intracellular polymerization.” FEBS Lett 589(1):89-93 Details

    Takahashi H, Mayers JR, Wang L, Edwardson JM, Audhya A (2015), “Hrs and STAM function synergistically to bind ubiquitin-modified cargoes in vitro.” Biophys J 108(1):76-84 Details

    Talukder MM, Sim MF, O'Rahilly S, Edwardson JM, Rochford JJ (2015), “Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis.” Mol Metab 4(3):199-209 Details

    Unwin RR, Cabanas RA, Yanagishima T, Blower TR, Takahashi H, Salmond GP, Edwardson JM, Fraden S, Eiser E (2015), “DNA driven self-assembly of micron-sized rods using DNA-grafted bacteriophage fd virions.” Phys Chem Chem Phys 17(12):8194-202 Details


    Antonio LS, Stewart AP, Varanda WA, Edwardson JM (2014), “Identification of P2X2/P2X4/P2X6 heterotrimeric receptors using atomic force microscopy (AFM) imaging.” FEBS Lett 588(12):2125-8 Details

    Balasuriya D, D'Sa L, Talker R, Dupuis E, Maurin F, Martin P, Borgese F, Soriani O, Edwardson JM (2014), “A direct interaction between the sigma-1 receptor and the hERG voltage-gated K+ channel revealed by atomic force microscopy and homogeneous time-resolved fluorescence (HTRF®).” J Biol Chem 289(46):32353-63 Details

    Balasuriya D, Srivats S, Murrell-Lagnado RD, Edwardson JM (2014), “Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry.” FEBS Lett Details

    Balasuriya D, Takahashi H, Srivats S, Edwardson JM (2014), “Activation-induced structural change in the GluN1/GluN3A excitatory glycine receptor.” Biochem Biophys Res Commun Details

    Fischer MJ, Balasuriya D, Jeggle P, Goetze TA, McNaughton PA, Reeh PW, Edwardson JM (2014), “Direct evidence for functional TRPV1/TRPA1 heteromers.” Pflugers Arch Details

    Liu H, Bai H, Xue R, Takahashi H, Edwardson JM, Chapman ER (2014), “Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission.” Nat Neurosci 17(5):670-7 Details

    Namadurai S, Balasuriya D, Rajappa R, Wiemhöfer M, Stott K, Klingauf J, Edwardson JM, Chirgadze DY, Jackson AP (2014), “Crystal structure and molecular imaging of the Nav channel β3 subunit indicates a trimeric assembly.” J Biol Chem 289(15):10797-811 Details

    Sim MF, Talukder MU, Dennis RJ, Edwardson JM, Rochford JJ (2014), “Analyzing the functions and structure of the human lipodystrophy protein seipin.” Methods Enzymol 537:161-75 Details


    Balasuriya D, Goetze TA, Barrera NP, Stewart AP, Suzuki Y, Edwardson JM (2013), “α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors adopt different subunit arrangements.” J Biol Chem 288(30):21987-98 Details

    Balasuriya D, Stewart AP, Edwardson JM (2013), “The σ-1 receptor interacts directly with GluN1 but not GluN2A in the GluN1/GluN2A NMDA receptor.” J Neurosci 33(46):18219-24 Details

    Ferrari E, Gu C, Niranjan D, Restani L, Rasetti-Escargueil C, Obara I, Geranton SM, Arsenault J, Goetze TA, Harper CB, Nguyen TH, Maywood E, O'Brien J, Schiavo G, Wheeler DW, Meunier FA, Hastings M, Edwardson JM, Sesardic D, Caleo M, Hunt SP, Davletov B (2013), “Synthetic self-assembling clostridial chimera for modulation of sensory functions.” Bioconjug Chem 24(10):1750-9 Details

    Ma L, Chen K, Clarke DJ, Nortcliffe CP, Wilson GG, Edwardson JM, Morton AJ, Jones AC, Dryden DT (2013), “Restriction endonuclease TseI cleaves A:A and T:T mismatches in CAG and CTG repeats.” Nucleic Acids Res 41(9):4999-5009 Details

    Oatley P, Talukder MM, Stewart AP, Sandford R, Edwardson JM (2013), “Polycystin-2 induces a conformational change in polycystin-1.” Biochemistry 52(31):5280-7 Details

    Sim MF, Talukder MM, Dennis RJ, O'Rahilly S, Edwardson JM, Rochford JJ (2013), “Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms.” Diabetologia 56(11):2498-506 Details

    Suzuki Y, Goetze TA, Stroebel D, Balasuriya D, Yoshimura SH, Henderson RM, Paoletti P, Takeyasu K, Edwardson JM (2013), “Visualization of structural changes accompanying activation of N-methyl-D-aspartate (NMDA) receptors using fast-scan atomic force microscopy imaging.” J Biol Chem 288(2):778-84 Details


    Balasuriya D, Stewart AP, Crottès D, Borgese F, Soriani O, Edwardson JM (2012), “The sigma-1 receptor binds to the Nav1.5 voltage-gated Na+ channel with 4-fold symmetry.” J Biol Chem 287(44):37021-9 Details

    Mela I, Kranaster R, Henderson RM, Balasubramanian S, Edwardson JM (2012), “Demonstration of ligand decoration, and ligand-induced perturbation, of G-quadruplexes in a plasmid using atomic force microscopy.” Biochemistry 51(2):578-85 Details

    Oatley P, Stewart AP, Sandford R, Edwardson JM (2012), “Atomic force microscopy imaging reveals the domain structure of polycystin-1.” Biochemistry 51(13):2879-88 Details

    Riou M, Stroebel D, Edwardson JM, Paoletti P (2012), “An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors.” PLoS One 7(4):e35134 Details

    Stewart AP, Gómez-Posada JC, McGeorge J, Rouhani MJ, Villarroel A, Murrell-Lagnado RD, Edwardson JM (2012), “The Kv7.2/Kv7.3 heterotetramer assembles with a random subunit arrangement.” J Biol Chem 287(15):11870-7 Details


    Antonio LS, Stewart AP, Xu XJ, Varanda WA, Murrell-Lagnado RD, Edwardson JM (2011), “P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers.” Br J Pharmacol 163(5):1069-77 Details

    Carnally SM, Edwardson JM, Barrera NP (2011), “Imaging the spatial orientation of subunits within membrane receptors by atomic force microscopy.” Methods Mol Biol 736:47-60 Details

    Dryden DT, Edwardson JM, Henderson RM (2011), “DNA translocation by type III restriction enzymes: a comparison of current models of their operation derived from ensemble and single-molecule measurements.” Nucleic Acids Res 39(11):4525-31 Details

    Duzdevich D, Li J, Whang J, Takahashi H, Takeyasu K, Dryden DT, Morton AJ, Edwardson JM (2011), “Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats.” PLoS One 6(2):e17119 Details

    Fyfe I, Schuh AL, Edwardson JM, Audhya A (2011), “Association of the endosomal sorting complex ESCRT-II with the Vps20 subunit of ESCRT-III generates a curvature-sensitive complex capable of nucleating ESCRT-III filaments.” J Biol Chem 286(39):34262-70 Details

    Mayers JR, Fyfe I, Schuh AL, Chapman ER, Edwardson JM, Audhya A (2011), “ESCRT-0 assembles as a heterotetrameric complex on membranes and binds multiple ubiquitinylated cargoes simultaneously.” J Biol Chem 286(11):9636-45 Details

    Stewart AP, Haerteis S, Diakov A, Korbmacher C, Edwardson JM (2011), “Atomic force microscopy reveals the architecture of the epithelial sodium channel (ENaC).” J Biol Chem 286(37):31944-52 Details

    Sun S, Suresh S, Liu H, Tepp WH, Johnson EA, Edwardson JM, Chapman ER (2011), “Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly.” Cell Host Microbe 10(3):237-47 Details


    Carnally SM, Johannessen M, Henderson RM, Jackson MB, Edwardson JM (2010), “Demonstration of a direct interaction between sigma-1 receptors and acid-sensing ion channels.” Biophys J 98(7):1182-91 Details

    Stewart AP, Egressy K, Lim A, Edwardson JM (2010), “AFM imaging reveals the tetrameric structure of the TRPM8 channel.” Biochem Biophys Res Commun 394(2):383-6 Details

    Stewart AP, Smith GD, Sandford RN, Edwardson JM (2010), “Atomic force microscopy reveals the alternating subunit arrangement of the TRPP2-TRPV4 heterotetramer.” Biophys J 99(3):790-7 Details

    Suresh S, Edwardson JM (2010), “The endophilin N-BAR domain perturbs the structure of lipid bilayers.” Biochemistry 49(27):5766-71 Details

    Suresh S, Edwardson JM (2010), “Phase separation in lipid bilayers triggered by low pH.” Biochem Biophys Res Commun 399(4):571-4 Details

    Suresh S, Wang C, Nanekar R, Kursula P, Edwardson JM (2010), “Myelin basic protein and myelin protein 2 act synergistically to cause stacking of lipid bilayers.” Biochemistry 49(16):3456-63 Details

    Takahashi H, Shahin V, Henderson RM, Takeyasu K, Edwardson JM (2010), “Interaction of synaptotagmin with lipid bilayers, analyzed by single-molecule force spectroscopy.” Biophys J 99(8):2550-8 Details

    Yokokawa M, Carnally SM, Henderson RM, Takeyasu K, Edwardson JM (2010), “Acid-sensing ion channel (ASIC) 1a undergoes a height transition in response to acidification.” FEBS Lett 584(14):3107-10 Details


    Boumechache M, Masin M, Edwardson JM, Górecki DC, Murrell-Lagnado R (2009), “Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cells.” J Biol Chem 284(20):13446-54 Details

    Creutz CE, Edwardson JM (2009), “Organization and synergistic binding of copine I and annexin A1 on supported lipid bilayers observed by atomic force microscopy.” Biochim Biophys Acta 1788(9):1950-61 Details

    Kobori T, Smith GD, Sandford R, Edwardson JM (2009), “The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement.” J Biol Chem 284(51):35507-13 Details

    Neaves KJ, Cooper LP, White JH, Carnally SM, Dryden DT, Edwardson JM, Henderson RM (2009), “Atomic force microscopy of the EcoKI Type I DNA restriction enzyme bound to DNA shows enzyme dimerization and DNA looping.” Nucleic Acids Res 37(6):2053-63 Details

    Neaves KJ, Huppert JL, Henderson RM, Edwardson JM (2009), “Direct visualization of G-quadruplexes in DNA using atomic force microscopy.” Nucleic Acids Res 37(18):6269-75 Details


    Barrera NP, Betts J, You H, Henderson RM, Martin IL, Dunn SM, Edwardson JM (2008), “Atomic force microscopy reveals the stoichiometry and subunit arrangement of the alpha4beta3delta GABA(A) receptor.” Mol Pharmacol 73(3):960-7 Details

    Barrera NP, Edwardson JM (2008), “The subunit arrangement and assembly of ionotropic receptors.” Trends Neurosci 31(11):569-76 Details

    Barrera NP, Ge H, Henderson RM, Fitzgerald WJ, Edwardson JM (2008), “Automated analysis of the architecture of receptors, imaged by atomic force microscopy.” Micron 39(2):101-10 Details

    Barrera NP, Henderson RM, Edwardson JM (2008), “Determination of the architecture of ionotropic receptors using AFM imaging.” Pflugers Arch 456(1):199-209 Details

    Carnally SM, Dev HS, Stewart AP, Barrera NP, Van Bemmelen MX, Schild L, Henderson RM, Edwardson JM (2008), “Direct visualization of the trimeric structure of the ASIC1a channel, using AFM imaging.” Biochem Biophys Res Commun 372(4):752-5 Details

    Shahin V, Datta D, Hui E, Henderson RM, Chapman ER, Edwardson JM (2008), “Synaptotagmin perturbs the structure of phospholipid bilayers.” Biochemistry 47(7):2143-52 Details


    Barrera NP, Henderson RM, Murrell-Lagnado RD, Edwardson JM (2007), “The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels.” Biophys J 93(2):505-12 Details

    Barrera NP, Shaifta Y, McFadzean I, Ward JP, Henderson RM, Edwardson JM (2007), “AFM imaging reveals the tetrameric structure of the TRPC1 channel.” Biochem Biophys Res Commun 358(4):1086-90 Details

    Crampton N, Roes S, Dryden DT, Rao DN, Edwardson JM, Henderson RM (2007), “DNA looping and translocation provide an optimal cleavage mechanism for the type III restriction enzymes.” EMBO J 26(16):3815-25 Details

    Crampton N, Yokokawa M, Dryden DT, Edwardson JM, Rao DN, Takeyasu K, Yoshimura SH, Henderson RM (2007), “Fast-scan atomic force microscopy reveals that the type III restriction enzyme EcoP15I is capable of DNA translocation and looping.” Proc Natl Acad Sci U S A 104(31):12755-60 Details

    Larina O, Bhat P, Pickett JA, Launikonis BS, Shah A, Kruger WA, Edwardson JM, Thorn P (2007), “Dynamic regulation of the large exocytotic fusion pore in pancreatic acinar cells.” Mol Biol Cell 18(9):3502-11 Details

    Pickett JA, Campos-Toimil M, Thomas P, Edwardson JM (2007), “Identification of SNAREs that mediate zymogen granule exocytosis.” Biochem Biophys Res Commun 359(3):599-603 Details


    Ormond SJ, Barrera NP, Qureshi OS, Henderson RM, Edwardson JM, Murrell-Lagnado RD (2006), “An uncharged region within the N terminus of the P2X6 receptor inhibits its assembly and exit from the endoplasmic reticulum.” Mol Pharmacol 69(5):1692-700 Details

    Pickett JA, Edwardson JM (2006), “Compound exocytosis: mechanisms and functional significance.” Traffic 7(2):109-16 Details

    Thomas P, Bagrij T, Campos-Toimil M, Edwardson JM (2006), “Mitochondria play a critical role in shaping the exocytotic response of rat pancreatic acinar cells.” Cell Calcium 39(1):57-63 Details


    Barrera NP, Herbert P, Henderson RM, Martin IL, Edwardson JM (2005), “Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors.” Proc Natl Acad Sci U S A 102(35):12595-600 Details

    Barrera NP, Ormond SJ, Henderson RM, Murrell-Lagnado RD, Edwardson JM (2005), “Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize.” J Biol Chem 280(11):10759-65 Details

    Hays LB, Wicksteed B, Wang Y, McCuaig JF, Philipson LH, Edwardson JM, Rhodes CJ (2005), “Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.” J Endocrinol 185(1):57-67 Details

    Madziva MT, Bai J, Bhalla A, Chapman ER, Edwardson JM (2005), “Effects of synaptotagmin reveal two distinct mechanisms of agonist-stimulated internalization of the M4 muscarinic acetylcholine receptor.” Br J Pharmacol 144(6):761-71 Details

    Pickett JA, Thorn P, Edwardson JM (2005), “The plasma membrane Q-SNARE syntaxin 2 enters the zymogen granule membrane during exocytosis in the pancreatic acinar cell.” J Biol Chem 280(2):1506-11 Details

    Tseng YD, Ge H, Wang X, Edwardson JM, Waring MJ, Fitzgerald WJ, Henderson RM (2005), “Atomic force microscopy study of the structural effects induced by echinomycin binding to DNA.” J Mol Biol 345(4):745-58 Details

    Wäsle B, Turvey M, Larina O, Thorn P, Skepper J, Morton AJ, Edwardson JM (2005), “Syncollin is required for efficient zymogen granule exocytosis.” Biochem J 385(Pt 3):721-7 Details


    Edwardson JM, Henderson RM (2004), “Atomic force microscopy and drug discovery.” Drug Discov Today 9(2):64-71 Details

    Geisse NA, Cover TL, Henderson RM, Edwardson JM (2004), “Targeting of Helicobacter pylori vacuolating toxin to lipid raft membrane domains analysed by atomic force microscopy.” Biochem J 381(Pt 3):911-7 Details

    Henderson RM, Edwardson JM, Geisse NA, Saslowsky DE (2004), “Lipid rafts: feeling is believing.” News Physiol Sci 19:39-43 Details

    Ma L, Bindokas VP, Kuznetsov A, Rhodes C, Hays L, Edwardson JM, Ueda K, Steiner DF, Philipson LH (2004), “Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.” Proc Natl Acad Sci U S A 101(25):9266-71 Details

    Wäsle B, Hays LB, Rhodes CJ, Edwardson JM (2004), “Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population.” Biochem J 380(Pt 3):897-905 Details


    Edwardson JM, Wang CT, Gong B, Wyttenbach A, Bai J, Jackson MB, Chapman ER, Morton AJ (2003), “Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II.” J Biol Chem 278(33):30849-53 Details

    Lawrence JC, Saslowsky DE, Edwardson JM, Henderson RM (2003), “Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy.” Biophys J 84(3):1827-32 Details

    Saslowsky DE, Lawrence JC, Henderson RM, Edwardson JM (2003), “Syntaxin is efficiently excluded from sphingomyelin-enriched domains in supported lipid bilayers containing cholesterol.” J Membr Biol 194(3):153-64 Details

    Tucker WC, Edwardson JM, Bai J, Kim HJ, Martin TF, Chapman ER (2003), “Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells.” J Cell Biol 162(2):199-209 Details


    Berge T, Jenkins NS, Hopkirk RB, Waring MJ, Edwardson JM, Henderson RM (2002), “Structural perturbations in DNA caused by bis-intercalation of ditercalinium visualised by atomic force microscopy.” Nucleic Acids Res 30(13):2980-6 Details

    Burton TJ, Edwardson JM, Ingham J, Tempest HV, Ferguson DR (2002), “Regulation of Na+ channel density at the apical surface of rabbit urinary bladder epithelium.” Eur J Pharmacol 448(2-3):215-23 Details

    Campos-Toimil M, Bagrij T, Edwardson JM, Thomas P (2002), “Two modes of secretion in pancreatic acinar cells: involvement of phosphatidylinositol 3-kinase and regulation by capacitative Ca(2+) entry.” Curr Biol 12(3):211-5 Details

    Campos-Toimil M, Edwardson JM, Thomas P (2002), “Acetylcholine-induced zymogen granule exocytosis: comparison between acini and single pancreatic acinar cells.” Pancreas 24(2):179-83 Details

    Ellis DJ, Shadan S, James PS, Henderson RM, Edwardson JM, Hutchings A, Jones R (2002), “Post-testicular development of a novel membrane substructure within the equatorial segment of ram, bull, boar, and goat spermatozoa as viewed by atomic force microscopy.” J Struct Biol 138(3):187-98 Details

    Geisse NA, Wäsle B, Saslowsky DE, Henderson RM, Edwardson JM (2002), “Syncollin homo-oligomers associate with lipid bilayers in the form of doughnut-shaped structures.” J Membr Biol 189(2):83-92 Details

    Kalus I, Hodel A, Koch A, Kleene R, Edwardson JM, Schrader M (2002), “Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains.” Biochem J 362(Pt 2):433-42 Details

    Neish CS, Martin IL, Henderson RM, Edwardson JM (2002), “Direct visualization of ligand-protein interactions using atomic force microscopy.” Br J Pharmacol 135(8):1943-50 Details

    Saslowsky DE, Lawrence J, Ren X, Brown DA, Henderson RM, Edwardson JM (2002), “Placental alkaline phosphatase is efficiently targeted to rafts in supported lipid bilayers.” J Biol Chem 277(30):26966-70 Details

    Walkinshaw MD, Taylor P, Sturrock SS, Atanasiu C, Berge T, Henderson RM, Edwardson JM, Dryden DT (2002), “Structure of Ocr from bacteriophage T7, a protein that mimics B-form DNA.” Mol Cell 9(1):187-94 Details

    Wäsle B, Edwardson JM (2002), “The regulation of exocytosis in the pancreatic acinar cell.” Cell Signal 14(3):191-7 Details


    Hodel A, An SJ, Hansen NJ, Lawrence J, Wäsle B, Schrader M, Edwardson JM (2001), “Cholesterol-dependent interaction of syncollin with the membrane of the pancreatic zymogen granule.” Biochem J 356(Pt 3):843-50 Details

    Madziva MT, Edwardson JM (2001), “Trafficking of green fluorescent protein-tagged muscarinic M4 receptors in NG108-15 cells.” Eur J Pharmacol 428(1):9-18 Details

    Morton AJ, Edwardson JM (2001), “Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease.” J Neurochem 76(1):166-72 Details

    Morton AJ, Faull RL, Edwardson JM (2001), “Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease.” Brain Res Bull 56(2):111-7 Details


    An SJ, Hansen NJ, Hodel A, Jahn R, Edwardson JM (2000), “Analysis of the association of syncollin with the membrane of the pancreatic zymogen granule.” J Biol Chem 275(15):11306-11 Details

    Avery J, Ellis DJ, Lang T, Holroyd P, Riedel D, Henderson RM, Edwardson JM, Jahn R (2000), “A cell-free system for regulated exocytosis in PC12 cells.” J Cell Biol 148(2):317-24 Details

    Berge T, Ellis DJ, Dryden DT, Edwardson JM, Henderson RM (2000), “Translocation-independent dimerization of the EcoKI endonuclease visualized by atomic force microscopy.” Biophys J 79(1):479-84 Details

    Campos-Toimil M, Edwardson JM, Thomas P (2000), “Real-time studies of zymogen granule exocytosis in intact rat pancreatic acinar cells.” J Physiol 528 Pt 2:317-26 Details

    Hodel A, Edwardson JM (2000), “Targeting of the zymogen-granule protein syncollin in AR42J and AtT-20 cells.” Biochem J 350 Pt 3:637-43 Details


    Avery J, Jahn R, Edwardson JM (1999), “Reconstitution of regulated exocytosis in cell-free systems: a critical appraisal.” Annu Rev Physiol 61:777-807 Details

    Dryden DT, Davies GD, Martin I, Powell LM, Murray NE, Ellis DJ, Berge T, Edwardson JM, Henderson RM (1999), “The assembly of the EcoKI type I DNA restriction/modification enzyme and its interaction with DNA.” Biochem Soc Trans 27(4):691-6 Details

    Edwardson JM, Szekeres PG (1999), “Endocytosis and recycling of muscarinic receptors.” Life Sci 64(6-7):487-94 Details

    Ellis DJ, Berge T, Edwardson JM, Henderson RM (1999), “Investigation of protein partnerships using atomic force microscopy.” Microsc Res Tech 44(5):368-77 Details

    Ellis DJ, Dryden DT, Berge T, Edwardson JM, Henderson RM (1999), “Direct observation of DNA translocation and cleavage by the EcoKI endonuclease using atomic force microscopy.” Nat Struct Biol 6(1):15-7 Details

    Hansen NJ, Antonin W, Edwardson JM (1999), “Identification of SNAREs involved in regulated exocytosis in the pancreatic acinar cell.” J Biol Chem 274(32):22871-6 Details

    Holroyd EW, Szekeres PG, Whittaker RD, Kelly E, Edwardson JM (1999), “Effect of G protein-coupled receptor kinase 2 on the sensitivity of M4 muscarinic acetylcholine receptors to agonist-induced internalization and desensitization in NG108-15 cells.” J Neurochem 73(3):1236-45 Details


    Edwardson JM (1998), “A cell-free system for Ca2+-regulated exocytosis.” Methods 16(2):209-14 Details

    Edwardson JM (1998), “Membrane fusion: all done with SNAREpins?” Curr Biol 8(11):R390-3 Details

    Koenig JA, Kaur R, Dodgeon I, Edwardson JM, Humphrey PP (1998), “Fates of endocytosed somatostatin sst2 receptors and associated agonists.” Biochem J 336 ( Pt 2):291-8 Details

    Szekeres PG, Koenig JA, Edwardson JM (1998), “The relationship between agonist intrinsic activity and the rate of endocytosis of muscarinic receptors in a human neuroblastoma cell line.” Mol Pharmacol 53(4):759-65 Details

    Szekeres PG, Koenig JA, Edwardson JM (1998), “Involvement of receptor cycling and receptor reserve in resensitization of muscarinic responses in SH-SY5Y human neuroblastoma cells.” J Neurochem 70(4):1694-703 Details


    Edwardson JM, An S, Jahn R (1997), “The secretory granule protein syncollin binds to syntaxin in a Ca2(+)-sensitive manner.” Cell 90(2):325-33 Details

    Koenig JA, Edwardson JM (1997), “Endocytosis and recycling of G protein-coupled receptors.” Trends Pharmacol Sci 18(8):276-87 Details

    Koenig JA, Edwardson JM, Humphrey PP (1997), “Somatostatin receptors in Neuro2A neuroblastoma cells: ligand internalization.” Br J Pharmacol 120(1):52-9 Details

    Koenig JA, Edwardson JM, Humphrey PP (1997), “Somatostatin receptors in Neuro2A neuroblastoma cells: operational characteristics.” Br J Pharmacol 120(1):45-51 Details

    Steel GJ, Buchheim G, Edwardson JM, Woodman PG (1997), “Evidence for interaction of the fusion protein alpha-SNAP with membrane lipid.” Biochem J 325 ( Pt 2):511-8 Details


    Chapman ER, An S, Edwardson JM, Jahn R (1996), “A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerization.” J Biol Chem 271(10):5844-9 Details

    Koenig JA, Edwardson JM (1996), “Intracellular trafficking of the muscarinic acetylcholine receptor: importance of subtype and cell type.” Mol Pharmacol 49(2):351-9 Details

    Marciniak SJ, Edwardson JM (1996), “Association of nucleoside diphosphate kinase with pancreatic zymogen granules: effects of local GTP generation on granule membrane characteristics.” Biochem J 316 ( Pt 1):99-106 Details


    Edwardson JM, Marciniak SJ (1995), “Molecular mechanisms in exocytosis.” J Membr Biol 146(2):113-22 Details


    Koenig JA, Edwardson JM (1994), “Kinetic analysis of the trafficking of muscarinic acetylcholine receptors between the plasma membrane and intracellular compartments.” J Biol Chem 269(25):17174-82 Details

    Koenig JA, Edwardson JM (1994), “Routes of delivery of muscarinic acetylcholine receptors to the plasma membrane in NG108-15 cells.” Br J Pharmacol 111(4):1023-8 Details

    Lee EG, Marciniak SJ, MacLean CM, Edwardson JM (1994), “Pancreatic plasma membranes: promiscuous partners in membrane fusion.” Biochem J 298 Pt 3:599-604 Details


    Edwardson JM, MacLean CM, Law GJ (1993), “Synthetic peptides of the rab3 effector domain stimulate a membrane fusion event involved in regulated exocytosis.” FEBS Lett 320(1):52-6 Details

    MacLean CM, Law GJ, Edwardson JM (1993), “Stimulation of exocytotic membrane fusion by modified peptides of the rab3 effector domain: re-evaluation of the role of rab3 in regulated exocytosis.” Biochem J 294 ( Pt 2):325-8 Details

    MacLean CM, Marciniak SJ, Hall DV, Edwardson JM (1993), “Involvement of a phosphoprotein on the zymogen granule membrane in the control of regulated exocytosis in the exocrine pancreas.” J Cell Sci 106 ( Pt 2):663-70 Details

    Waschulewski IH, Hall DV, Kern HF, Edwardson JM (1993), “Effects of the immunosuppressants cyclosporin A and FK 506 on exocytosis in the rat exocrine pancreas in vitro.” Br J Pharmacol 108(4):892-900 Details


    Creutz CE, Moss S, Edwardson JM, Hide I, Gomperts B (1992), “Differential recognition of secretory vesicles by annexins. European Molecular Biology Organization Course "Advanced Techniques for Studying Secretion".” Biochem Biophys Res Commun 184(1):347-52 Details

    Edwardson JM, Daniels-Holgate PU (1992), “Reconstitution in vitro of a membrane-fusion event involved in constitutive exocytosis. A role for cytosolic proteins and a GTP-binding protein, but not for Ca2+.” Biochem J 285 ( Pt 2):383-5 Details

    Edwardson JM, Dean PM (1992), “Inhibition of alloxan-induced hyperglycaemia by compounds of similar molecular structure.” Biochem Pharmacol 44(11):2111-5 Details

    MacLean CM, Edwardson JM (1992), “Fusion between rat pancreatic zymogen granules and plasma membranes. Modulation by a GTP-binding protein.” Biochem J 286 ( Pt 3):747-53 Details


    Edwardson JM, Daniels-Holgate PU (1990), “Characteristics of a cell-free assay for the delivery of proteins to the plasma membrane.” FEBS Lett 265(1-2):107-9 Details

    Edwardson JM, Vickery C, Christy LJ (1990), “Rat pancreatic acini permeabilised with streptolysin O secrete amylase at Ca2+ concentrations in the micromolar range, when provided with ATP and GTP gamma S.” Biochim Biophys Acta 1053(1):32-6 Details


    Daniels PU, Edwardson JM (1989), “Influenza neuraminidase is delivered directly to the apical surface of MDCK cell monolayers.” FEBS Lett 244(1):57-60 Details

    Daniels-Holgate PU, Edwardson JM (1989), “Transport of influenza virus envelope proteins from the Golgi complex to the apical plasma membrane in MDCK cells: pH-controlled interaction with a cycling receptor is not involved.” FEBS Lett 249(2):407-10 Details

    Nadin CY, Rogers J, Tomlinson S, Edwardson JM (1989), “A specific interaction in vitro between pancreatic zymogen granules and plasma membranes: stimulation by G-protein activators but not by Ca2+.” J Cell Biol 109(6 Pt 1):2801-8 Details


    Daniels PU, Edwardson JM (1988), “Intracellular processing and transport of influenza-virus envelope proteins in Madin-Darby canine kidney cells. Effects of the carboxylic ionophores monensin and nigericin.” Biochem J 252(3):693-700 Details

    Edwardson JM, Woodman PG (1988), “Cell-free reconstitution of the insertion of a newly synthesised glycoprotein into the plasma membrane.” Prog Clin Biol Res 270:343-54 Details


    Woodman PG, Edwardson JM (1986), “A cell-free assay for the insertion of a viral glycoprotein into the plasma membrane.” J Cell Biol 103(5):1829-35 Details


    Edwardson JM, Phillips NI, Kirby N, Fowler LJ (1985), “A monoclonal antibody to rabbit brain GABA transaminase.” J Neurochem 44(6):1679-84 Details

    Kirby N, Fowler LJ, Edwardson JM, Phillips NI (1985), “Purification and properties of rabbit brain and liver 4-aminobutyrate aminotransferases isolated by monoclonal-antibody immunoadsorbent chromatography.” Biochem J 230(2):481-8 Details


    Edwardson JM (1984), “Effects of monensin on the processing and intracellular transport of influenza virus haemagglutinin in infected MDCK cells.” J Cell Sci 65:209-21 Details


    Bindslev N, Cuthbert AW, Edwardson JM, Skadhauge E (1982), “Kinetics of amiloride action in the hen coprodaeum in vitro.” Pflugers Arch 392(4):340-6 Details

    Cuthbert AW, Edwardson JM, Bindslev N, Skadhauge E (1982), “Identification of potential components of the transport mechanism for Na+ in the hen colon and coprodaeum.” Pflugers Arch 392(4):347-51 Details


    Cuthbert AW, Edwardson JM (1981), “Benzamil binding to kidney cell membranes.” Biochem Pharmacol 30(11):1175-83 Details

    Edwardson JM, Fanestil DD, Ellory JC, Cuthbert AW (1981), “Extraction of a [3H]benzamil binding component from kidney cell membranes.” Biochem Pharmacol 30(11):1185-9 Details

    Whitesell L, Edwardson JM, Cuthbert AW (1981), “Adhesive properties of MDCK cell membranes possible role in epithelial histogenesis.” J Cell Sci 51:255-71 Details


    Aceves J, Cuthbert AW, Edwardson JM (1979), “Estimation of the density of sodium entry sites in frog skin epithelium from the uptake of [3H]benzamil.” J Physiol 295:477-90 Details

    Cuthbert AW, Edwardson JM (1979), “Diuretic receptor or acceptor? [proceedings].” J Physiol 291:67P Details

    Cuthbert AW, Edwardson JM (1979), “Synthesis, properties and biological activity of tritiated N-benzylamidino-3,5-diamino-6-chloro-pyrazine carboxamide -- a new ligand for epithelial sodium channels.” J Pharm Pharmacol 31(6):382-6 Details


    Aceves J, Cuthbert AW, Edwardson JM (1978), “A new ligand for epithelial sodium channels [proceedings].” J Physiol 282:24P-26P Details