Professor Mike Edwardson University positionProfessor DepartmentsHome pagehttp://www.phar.cam.ac.uk/researc... (personal home page) Research ThemeInterestsMy research involves imaging of biomolecules using atomic force microscopy (AFM). AFM permits the visualization of single molecules under near-physiological conditions. I am currently studying the effects of activation on the behaviour of ionotropic glutamate receptors.  The AFM image shows neurotransmitter-containing vesicles docked at the plasma membrane of a PC12 cell. Click image to view full-size Research Focus
EquipmentAtomic force microscopy (AFM) Cell culture Confocal microscopy Protein purification Recombinant protein expression Collaborators
Associated News ItemsKey publicationsDawe GB, Kadir MF, Venskutonytė R, Perozzo AM, Yan Y, Alexander RPD, Navarrete C., Santander EA, Arsenault M, Fuentes C, Aurousseau MRP, Frydenvang K, Barrera NP, Kastrup JS, Edwardson JM and Bowie D (2019), “Nanoscale mobility of the apo state and TARP stoichiometry dictate the gating behavior of alternatively-spliced AMPA receptors” Neuron 102: 976-992 Bao H, Goldschen-Ohm M, Jeggle P, Chanda B, Edwardson JM and Chapman ER (2016), “Exocytotic fusion pores are composed of both lipids and proteins” Nat Struct Mol Biol 23: 67-73 Srivats S, Balasuriya D, Pasche M, Vistal G, Edwardson JM, Taylor CW and Murrell-Lagnado RD (2016), “Sigma1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1” J Cell Biol 213: 65-79 Liu H, Bai H, Xue R, Takahashi H, Edwardson JM and Chapman ER (2014), “Linker mutations dissociate the function of synaptotagmin I during evoked and spontaneous release and reveal membrane penetration as a step during excitation-secretion coupling” Nat Neurosci 17: 670-677 |