Dr Michel Goedert University positionHead, Division of Neurobiology Dr Michel Goedert is pleased to consider applications from prospective PhD students. InstitutesMedical Research Council Laboratory of Molecular Biology Home pagehttp://www2.mrc-lmb.cam.ac.uk/NB/Goed... (personal home page) Research ThemesInterestsAlzheimer's disease and Parkinson's disease are characterized by the presence of abnormal filamentous assemblies within some nerve cells. Similar assemblies are found in related disorders, including progressive supranuclear palsy, dementia with Lewy bodies, multiple system atrophy, corticobasal degeneration and Pick's disease. The events leading to filament formation or the mere presence of filaments are believed to produce nerve cell degeneration. Our work has shown that the intraneuronal filaments found in these diseases are made of either microtubule-associated protein tau or alpha-synuclein. Mutations in the tau gene cause inherited forms of frontotemporal dementia and parkinsonism, whereas mutations in the alpha-synuclein gene cause familial forms of Parkinson's disease and dementia with Lewy bodies. Current work is aimed at developing experimental animal models of tauopathies and alpha-synucleinopathies and at identifying disease modifiers. Research Focus
EquipmentFluorescence microscopy FPLC/HPLC Immunohistochemistry Microscopy Protein purification Collaborators
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Publications2014Ahmed Z, Cooper J, Murray TK, Garn K, McNaughton E, Clarke H, Parhizkar S, Ward MA, Cavallini A, Jackson S, Bose S, Clavaguera F, Tolnay M, Lavenir I, Goedert M, Hutton ML, O'Neill MJ (2014), “A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.” Acta Neuropathol 127(5):667-83 Details Clavaguera F, Hench J, Lavenir I, Schweighauser G, Frank S, Goedert M, Tolnay M (2014), “Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice.” Acta Neuropathol 127(2):299-301 Details Flach K, Ramminger E, Hilbrich I, Arsalan-Werner A, Albrecht F, Herrmann L, Goedert M, Arendt T, Holzer M (2014), “Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.” Biochim Biophys Acta 1842(9):1527-1538 Details Herva ME, Zibaee S, Fraser G, Barker RA, Goedert M, Spillantini MG (2014), “Anti-amyloid compounds inhibit ?-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA).” J Biol Chem 289(17):11897-905 Details Iovino M, Pfisterer U, Holton JL, Lashley T, Swingler RJ, Calo L, Treacy R, Revesz T, Parmar M, Goedert M, Muqit MM, Spillantini MG (2014), “The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons.” Acta Neuropathol 127(2):283-95 Details 2013Clavaguera F, Akatsu H, Fraser G, Crowther RA, Frank S, Hench J, Probst A, Winkler DT, Reichwald J, Staufenbiel M, Ghetti B, Goedert M, Tolnay M (2013), “Brain homogenates from human tauopathies induce tau inclusions in mouse brain.” Proc Natl Acad Sci U S A 110(23):9535-40 Details Clavaguera F, Lavenir I, Falcon B, Frank S, Goedert M, Tolnay M (2013), “"Prion-like" templated misfolding in tauopathies.” Brain Pathol 23(3):342-9 Details Goedert M, Spillantini MG, Del Tredici K, Braak H (2013), “100 years of Lewy pathology.” Nat Rev Neurol 9(1):13-24 Details Hastings MH, Goedert M (2013), “Circadian clocks and neurodegenerative diseases: time to aggregate?” Curr Opin Neurobiol 23(5):880-7 Details Hoffmann NA, Dorostkar MM, Blumenstock S, Goedert M, Herms J (2013), “Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.” Acta Neuropathol Commun 1(1):82 Details Jenner P, Morris HR, Robbins TW, Goedert M, Hardy J, Ben-Shlomo Y, Bolam P, Burn D, Hindle JV, Brooks D (2013), “Parkinson's disease--the debate on the clinical phenomenology, aetiology, pathology and pathogenesis.” J Parkinsons Dis 3(1):1-11 Details Klingstedt T, Shirani H, Åslund KO, Cairns NJ, Sigurdson CJ, Goedert M, Nilsson KP (2013), “The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates.” Chemistry 19(31):10179-92 Details Mellone M, Kestoras D, Andrews MR, Dassie E, Crowther RA, Stokin GB, Tinsley J, Horne G, Goedert M, Tolkovsky AM, Spillantini MG (2013), “Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies.” J Neurosci 33(46):18175-89 Details Morris KL, Zibaee S, Chen L, Goedert M, Sikorski P, Serpell LC (2013), “The structure of cross-? tapes and tubes formed by an octapeptide, ?S?1.” Angew Chem Int Ed Engl 52(8):2279-83 Details Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, Clavaguera F, Sinnreich M, Kappos L, Goedert M, Tolnay M, Winkler DT (2013), “Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.” PLoS One 8(5):e62459 Details Spillantini MG, Goedert M (2013), “Tau pathology and neurodegeneration.” Lancet Neurol 12(6):609-22 Details 2012Bull ND, Guidi A, Goedert M, Martin KR, Spillantini MG (2012), “Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau.” PLoS One 7(4):e34724 Details Goedert M, Ghetti B, Spillantini MG (2012), “Frontotemporal dementia: implications for understanding Alzheimer disease.” Cold Spring Harb Perspect Med 2(2):a006254 Details Schaeffer V, Goedert M (2012), “Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy.” Autophagy 8(11):1686-7 Details Schaeffer V, Lavenir I, Ozcelik S, Tolnay M, Winkler DT, Goedert M (2012), “Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy.” Brain 135(Pt 7):2169-77 Details Schön C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Steinbach S, Seeliger MW, Arzberger T, Goedert M, Kretzschmar HA, Schmidt B, Herms J (2012), “Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.” PLoS One 7(12):e53547 Details Yoshida H, Goedert M (2012), “Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.” J Neurochem 120(1):165-76 Details 2011Gasparini L, Crowther RA, Martin KR, Berg N, Coleman M, Goedert M, Spillantini MG (2011), “Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability.” Neurobiol Aging 32(3):419-33 Details Goedert M, Spillantini MG (2011), “Pathogenesis of the tauopathies.” J Mol Neurosci 45(3):425-31 Details 2010Chambraud B, Sardin E, Giustiniani J, Dounane O, Schumacher M, Goedert M, Baulieu EE (2010), “A role for FKBP52 in Tau protein function.” Proc Natl Acad Sci U S A 107(6):2658-63 Details Clavaguera F, Goedert M, Tolnay M (2010), “[Induction and spreading of tau pathology in a mouse model of Alzheimer's disease].” Med Sci (Paris) 26(2):121-4 Details Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M (2010), “Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.” Proc Natl Acad Sci U S A 107(17):7969-74 Details Garcia-Reitböck P, Anichtchik O, Bellucci A, Iovino M, Ballini C, Fineberg E, Ghetti B, Della Corte L, Spano P, Tofaris GK, Goedert M, Spillantini MG (2010), “SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease.” Brain 133(Pt 7):2032-44 Details Goedert M, Clavaguera F, Tolnay M (2010), “The propagation of prion-like protein inclusions in neurodegenerative diseases.” Trends Neurosci 33(7):317-25 Details Hampton DW, Webber DJ, Bilican B, Goedert M, Spillantini MG, Chandran S (2010), “Cell-mediated neuroprotection in a mouse model of human tauopathy.” J Neurosci 30(30):9973-83 Details Scattoni ML, Gasparini L, Alleva E, Goedert M, Calamandrei G, Spillantini MG (2010), “Early behavioural markers of disease in P301S tau transgenic mice.” Behav Brain Res 208(1):250-7 Details Zibaee S, Fraser G, Jakes R, Owen D, Serpell LC, Crowther RA, Goedert M (2010), “Human beta-synuclein rendered fibrillogenic by designed mutations.” J Biol Chem 285(49):38555-67 Details 2009Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M (2009), “Transmission and spreading of tauopathy in transgenic mouse brain.” Nat Cell Biol 11(7):909-13 Details Goedert M (2009), “Oskar Fischer and the study of dementia.” Brain 132(Pt 4):1102-11 Details Masuda M, Hasegawa M, Nonaka T, Oikawa T, Yonetani M, Yamaguchi Y, Kato K, Hisanaga S, Goedert M (2009), “Inhibition of alpha-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies.” FEBS Lett 583(4):787-91 Details Yamashita M, Nonaka T, Arai T, Kametani F, Buchman VL, Ninkina N, Bachurin SO, Akiyama H, Goedert M, Hasegawa M (2009), “Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.” FEBS Lett 583(14):2419-24 Details 2008Delobel P, Lavenir I, Fraser G, Ingram E, Holzer M, Ghetti B, Spillantini MG, Crowther RA, Goedert M (2008), “Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy.” Am J Pathol 172(1):123-31 Details Kovacs GG, Majtenyi K, Spina S, Murrell JR, Gelpi E, Hoftberger R, Fraser G, Crowther RA, Goedert M, Budka H, Ghetti B (2008), “White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration.” J Neuropathol Exp Neurol 67(10):963-75 Details Radde R, Duma C, Goedert M, Jucker M (2008), “The value of incomplete mouse models of Alzheimer's disease.” Eur J Nucl Med Mol Imaging 35 Suppl 1:S70-4 Details Spina S, Farlow MR, Unverzagt FW, Kareken DA, Murrell JR, Fraser G, Epperson F, Crowther RA, Spillantini MG, Goedert M, Ghetti B (2008), “The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family.” Brain 131(Pt 1):72-89 Details Velasco A, Fraser G, Delobel P, Ghetti B, Lavenir I, Goedert M (2008), “Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene].” FEBS Lett 582(6):901-6 Details Ye L, Velasco A, Fraser G, Beach TG, Sue L, Osredkar T, Libri V, Spillantini MG, Goedert M, Lockhart A (2008), “In vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain.” J Neurochem 105(4):1428-37 Details 2007Goedert M, Ghetti B (2007), “Alois Alzheimer: his life and times.” Brain Pathol 17(1):57-62 Details Ishii A, Nonaka T, Taniguchi S, Saito T, Arai T, Mann D, Iwatsubo T, Hisanaga S, Goedert M, Hasegawa M (2007), “Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.” FEBS Lett 581(24):4711-7 Details Magnani E, Fan J, Gasparini L, Golding M, Williams M, Schiavo G, Goedert M, Amos LA, Spillantini MG (2007), “Interaction of tau protein with the dynactin complex.” EMBO J 26(21):4546-54 Details Spina S, Murrell JR, Yoshida H, Ghetti B, Bermingham N, Sweeney B, Dlouhy SR, Crowther RA, Goedert M, Keohane C (2007), “The novel Tau mutation G335S: clinical, neuropathological and molecular characterization.” Acta Neuropathol 113(4):461-70 Details Virdee K, Yoshida H, Peak-Chew S, Goedert M (2007), “Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily.” FEBS Lett 581(14):2657-62 Details Zibaee S, Jakes R, Fraser G, Serpell LC, Crowther RA, Goedert M (2007), “Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein.” J Mol Biol 374(2):454-64 Details Zibaee S, Makin OS, Goedert M, Serpell LC (2007), “A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclein, Abeta, and tau using the amino acid sequence alone.” Protein Sci 16(5):906-18 Details 2006Broersen K, van den Brink D, Fraser G, Goedert M, Davletov B (2006), “Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation.” Biochemistry 45(51):15610-6 Details Delobel P, Lavenir I, Ghetti B, Holzer M, Goedert M (2006), “Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1.” Am J Pathol 168(3):878-87 Details Goedert M, Klug A, Crowther RA (2006), “Tau protein, the paired helical filament and Alzheimer's disease.” J Alzheimers Dis 9(3 Suppl):195-207 Details Goedert M, Spillantini MG (2006), “A century of Alzheimer's disease.” Science 314(5800):777-81 Details Goedert M, Spillantini MG (2006), “Frontotemporal lobar degeneration through loss of progranulin function.” Brain 129(Pt 11):2808-10 Details Masuda M, Dohmae N, Nonaka T, Oikawa T, Hisanaga S, Goedert M, Hasegawa M (2006), “Cysteine misincorporation in bacterially expressed human alpha-synuclein.” FEBS Lett 580(7):1775-9 Details Masuda M, Suzuki N, Taniguchi S, Oikawa T, Nonaka T, Iwatsubo T, Hisanaga S, Goedert M, Hasegawa M (2006), “Small molecule inhibitors of alpha-synuclein filament assembly.” Biochemistry 45(19):6085-94 Details Spillantini MG, Murrell JR, Goedert M, Farlow M, Klug A, Ghetti B (2006), “Mutations in the tau gene (MAPT) in FTDP-17: the family with Multiple System Tauopathy with Presenile Dementia (MSTD).” J Alzheimers Dis 9(3 Suppl):373-80 Details Tofaris GK, Garcia Reitböck P, Humby T, Lambourne SL, O'Connell M, Ghetti B, Gossage H, Emson PC, Wilkinson LS, Goedert M, Spillantini MG (2006), “Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.” J Neurosci 26(15):3942-50 Details Yoshida H, Craxton M, Jakes R, Zibaee S, Tavaré R, Fraser G, Serpell LC, Davletov B, Crowther RA, Goedert M (2006), “Synuclein proteins of the pufferfish Fugu rubripes: sequences and functional characterization.” Biochemistry 45(8):2599-607 Details Yoshida H, Goedert M (2006), “Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope.” J Neurochem 99(1):154-64 Details 2005Feijoo C, Campbell DG, Jakes R, Goedert M, Cuenda A (2005), “Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly.” J Cell Sci 118(Pt 2):397-408 Details Goedert M (2005), “Tau gene mutations and their effects.” Mov Disord 20 Suppl 12:S45-52 Details Goedert M, Jakes R (2005), “Mutations causing neurodegenerative tauopathies.” Biochim Biophys Acta 1739(2-3):240-50 Details Sabio G, Arthur JS, Kuma Y, Peggie M, Carr J, Murray-Tait V, Centeno F, Goedert M, Morrice NA, Cuenda A (2005), “p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.” EMBO J 24(6):1134-45 Details Taniguchi S, Suzuki N, Masuda M, Hisanaga S, Iwatsubo T, Goedert M, Hasegawa M (2005), “Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.” J Biol Chem 280(9):7614-23 Details Yamaguchi K, Cochran EJ, Murrell JR, Polymeropoulos MH, Shannon KM, Crowther RA, Goedert M, Ghetti B (2005), “Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene.” Acta Neuropathol 110(3):298-305 Details 2004Bellucci A, Westwood AJ, Ingram E, Casamenti F, Goedert M, Spillantini MG (2004), “Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein.” Am J Pathol 165(5):1643-52 Details Choi W, Zibaee S, Jakes R, Serpell LC, Davletov B, Crowther RA, Goedert M (2004), “Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein.” FEBS Lett 576(3):363-8 Details Cohen P, Goedert M (2004), “GSK3 inhibitors: development and therapeutic potential.” Nat Rev Drug Discov 3(6):479-87 Details Goedert M (2004), “Tau protein and neurodegeneration.” Semin Cell Dev Biol 15(1):45-9 Details Holzer M, Craxton M, Jakes R, Arendt T, Goedert M (2004), “Tau gene (MAPT) sequence variation among primates.” Gene 341:313-22 Details Sabio G, Reuver S, Feijoo C, Hasegawa M, Thomas GM, Centeno F, Kuhlendahl S, Leal-Ortiz S, Goedert M, Garner C, Cuenda A (2004), “Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2.” Biochem J 380(Pt 1):19-30 Details Takao M, Ghetti B, Yoshida H, Piccardo P, Narain Y, Murrell JR, Vidal R, Glazier BS, Jakes R, Tsutsui M, Spillantini MG, Crowther RA, Goedert M, Koto A (2004), “Early-onset dementia with Lewy bodies.” Brain Pathol 14(2):137-47 Details Yoshida H, Hastie CJ, McLauchlan H, Cohen P, Goedert M (2004), “Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK).” J Neurochem 90(2):352-8 Details 2003Berriman J, Serpell LC, Oberg KA, Fink AL, Goedert M, Crowther RA (2003), “Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure.” Proc Natl Acad Sci U S A 100(15):9034-8 Details Goedert M (2003), “Neurodegenerative tauopathy in the worm.” Proc Natl Acad Sci U S A 100(17):9653-5 Details Kar S, Fan J, Smith MJ, Goedert M, Amos LA (2003), “Repeat motifs of tau bind to the insides of microtubules in the absence of taxol.” EMBO J 22(1):70-7 Details van Herpen E, Rosso SM, Serverijnen LA, Yoshida H, Breedveld G, van de Graaf R, Kamphorst W, Ravid R, Willemsen R, Dooijes D, Majoor-Krakauer D, Kros JM, Crowther RA, Goedert M, Heutink P, van Swieten JC (2003), “Variable phenotypic expression and extensive tau pathology in two families with the novel tau mutation L315R.” Ann Neurol 54(5):573-81 Details 2002Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, Yoshida H, Holzer M, Craxton M, Emson PC, Atzori C, Migheli A, Crowther RA, Ghetti B, Spillantini MG, Goedert M (2002), “Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.” J Neurosci 22(21):9340-51 Details Buée-Scherrer V, Goedert M (2002), “Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells.” FEBS Lett 515(1-3):151-4 Details David DC, Layfield R, Serpell L, Narain Y, Goedert M, Spillantini MG (2002), “Proteasomal degradation of tau protein.” J Neurochem 83(1):176-85 Details Delobel P, Flament S, Hamdane M, Jakes R, Rousseau A, Delacourte A, Vilain JP, Goedert M, Buée L (2002), “Functional characterization of FTDP-17 tau gene mutations through their effects on Xenopus oocyte maturation.” J Biol Chem 277(11):9199-205 Details Rosso SM, van Herpen E, Deelen W, Kamphorst W, Severijnen LA, Willemsen R, Ravid R, Niermeijer MF, Dooijes D, Smith MJ, Goedert M, Heutink P, van Swieten JC (2002), “A novel tau mutation, S320F, causes a tauopathy with inclusions similar to those in Pick's disease.” Ann Neurol 51(3):373-6 Details Syme CD, Blanch EW, Holt C, Jakes R, Goedert M, Hecht L, Barron LD (2002), “A Raman optical activity study of rheomorphism in caseins, synucleins and tau. New insight into the structure and behaviour of natively unfolded proteins.” Eur J Biochem 269(1):148-56 Details Uversky VN, Li J, Souillac P, Millett IS, Doniach S, Jakes R, Goedert M, Fink AL (2002), “Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins.” J Biol Chem 277(14):11970-8 Details Yoshida H, Crowther RA, Goedert M (2002), “Functional effects of tau gene mutations deltaN296 and N296H.” J Neurochem 80(3):548-51 Details Yoshida H, Goedert M (2002), “Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.” Biochemistry 41(51):15203-11 Details 2001Goedert M (2001), “Alpha-synuclein and neurodegenerative diseases.” Nat Rev Neurosci 2(7):492-501 Details Goedert M (2001), “Parkinson's disease and other alpha-synucleinopathies.” Clin Chem Lab Med 39(4):308-12 Details Goedert M (2001), “The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases.” Curr Opin Genet Dev 11(3):343-51 Details Goedert M, Jakes R, Anthony Crowther R, Grazia Spillantini M (2001), “Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as ?-Synucleinopathies.” Methods Mol Med 62:33-59 Details Goedert M, Spillantini MG (2001), “Tau gene mutations and neurodegeneration.” Biochem Soc Symp (67):59-71 Details Goedert M, Spillantini MG, Serpell LC, Berriman J, Smith MJ, Jakes R, Crowther RA (2001), “From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases.” Philos Trans R Soc Lond B Biol Sci 356(1406):213-27 Details Götz J, Tolnay M, Barmettler R, Ferrari A, Bürki K, Goedert M, Probst A, Nitsch RM (2001), “Human tau transgenic mice. Towards an animal model for neuro- and glialfibrillary lesion formation.” Adv Exp Med Biol 487:71-83 Details Hartmann AM, Rujescu D, Giannakouros T, Nikolakaki E, Goedert M, Mandelkow EM, Gao QS, Andreadis A, Stamm S (2001), “Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors.” Mol Cell Neurosci 18(1):80-90 Details Lee VM, Goedert M, Trojanowski JQ (2001), “Neurodegenerative tauopathies.” Annu Rev Neurosci 24:1121-59 Details Neumann M, Schulz-Schaeffer W, Crowther RA, Smith MJ, Spillantini MG, Goedert M, Kretzschmar HA (2001), “Pick's disease associated with the novel Tau gene mutation K369I.” Ann Neurol 50(4):503-13 Details Spillantini MG, Goedert M (2001), “Tau and Parkinson disease.” JAMA 286(18):2324-6 Details Spillantini MG, Goedert M (2001), “Tau gene mutations and tau pathology in frontotemporal dementia and parkinsonism linked to chromosome 17.” Adv Exp Med Biol 487:21-37 Details Woods YL, Cohen P, Becker W, Jakes R, Goedert M, Wang X, Proud CG (2001), “The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.” Biochem J 355(Pt 3):609-15 Details 2000Crowther RA, Daniel SE, Goedert M (2000), “Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain.” Neurosci Lett 292(2):128-30 Details Crowther RA, Goedert M (2000), “Abnormal tau-containing filaments in neurodegenerative diseases.” J Struct Biol 130(2-3):271-9 Details Duff K, Knight H, Refolo LM, Sanders S, Yu X, Picciano M, Malester B, Hutton M, Adamson J, Goedert M, Burki K, Davies P (2000), “Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes.” Neurobiol Dis 7(2):87-98 Details Fleming Y, Armstrong CG, Morrice N, Paterson A, Goedert M, Cohen P (2000), “Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.” Biochem J 352 Pt 1:145-54 Details Ghetti B, Murrell JR, Zolo P, Spillantini MG, Goedert M (2000), “Progress in hereditary tauopathies: a mutation in the Tau gene (G389R) causes a Pick disease-like syndrome.” Ann N Y Acad Sci 920:52-62 Details Giasson BI, Jakes R, Goedert M, Duda JE, Leight S, Trojanowski JQ, Lee VM (2000), “A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease.” J Neurosci Res 59(4):528-33 Details Goedert M, Ghetti B, Spillantini MG (2000), “Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process.” Ann N Y Acad Sci 920:74-83 Details Goedert M, Satumtira S, Jakes R, Smith MJ, Kamibayashi C, White CL 3rd, Sontag E (2000), “Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations.” J Neurochem 75(5):2155-62 Details Goedert M, Spillantini MG (2000), “Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease.” Biochim Biophys Acta 1502(1):110-21 Details Götz J, Barmettler R, Ferrari A, Goedert M, Probst A, Nitsch RM (2000), “In vivo analysis of wild-type and FTDP-17 tau transgenic mice.” Ann N Y Acad Sci 920:126-33 Details Probst A, Götz J, Wiederhold KH, Tolnay M, Mistl C, Jaton AL, Hong M, Ishihara T, Lee VM, Trojanowski JQ, Jakes R, Crowther RA, Spillantini MG, Bürki K, Goedert M (2000), “Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein.” Acta Neuropathol 99(5):469-81 Details Rizzini C, Goedert M, Hodges JR, Smith MJ, Jakes R, Hills R, Xuereb JH, Crowther RA, Spillantini MG (2000), “Tau gene mutation K257T causes a tauopathy similar to Pick's disease.” J Neuropathol Exp Neurol 59(11):990-1001 Details Serpell LC, Berriman J, Jakes R, Goedert M, Crowther RA (2000), “Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation.” Proc Natl Acad Sci U S A 97(9):4897-902 Details Smith MJ, Crowther RA, Goedert M (2000), “The natural osmolyte trimethylamine N-oxide (TMAO) restores the ability of mutant tau to promote microtubule assembly.” FEBS Lett 484(3):265-70 Details Spillantini MG, Goedert M (2000), “The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.” Ann N Y Acad Sci 920:16-27 Details Spillantini MG, Goedert M (2000), “Tau mutations in familial frontotemporal dementia.” Brain 123 ( Pt 5):857-9 Details Spillantini MG, Van Swieten JC, Goedert M (2000), “Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).” Neurogenetics 2(4):193-205 Details Spillantini MG, Yoshida H, Rizzini C, Lantos PL, Khan N, Rossor MN, Goedert M, Brown J (2000), “A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies.” Ann Neurol 48(6):939-43 Details Varani L, Spillantini MG, Goedert M, Varani G (2000), “Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics.” Nucleic Acids Res 28(3):710-9 Details Yasuda M, Takamatsu J, D'Souza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Varani G, Iwatsubo T, Goedert M, Schellenberg DG, Tanaka C (2000), “A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)” Ann Neurol 47(4):422-9 Details 1999Börsch-Haubold AG, Ghomashchi F, Pasquet S, Goedert M, Cohen P, Gelb MH, Watson SP (1999), “Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways.” Eur J Biochem 265(1):195-203 Details Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo M, Spillantini MG, Tagliavini F, Goedert M, Ghetti B (1999), “Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau.” J Neuropathol Exp Neurol 58(6):667-77 Details Craxton M, Goedert M (1999), “Alternative splicing of synaptotagmins involving transmembrane exon skipping.” FEBS Lett 460(3):417-22 Details Eyers PA, van den IJssel P, Quinlan RA, Goedert M, Cohen P (1999), “Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.” FEBS Lett 451(2):191-6 Details Goedert M (1999), “Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.” Philos Trans R Soc Lond B Biol Sci 354(1386):1101-18 Details Goedert M (1999), “Alzheimer's disease. Pinning down phosphorylated tau.” Nature 399(6738):739-40 Details Goedert M, Hasegawa M (1999), “The tauopathies: toward an experimental animal model.” Am J Pathol 154(1):1-6 Details Goedert M, Jakes R, Crowther RA (1999), “Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments.” FEBS Lett 450(3):306-11 Details Goedert M, Klug A (1999), “Tau protein and the paired helical filament of Alzheimer's disease.” Brain Res Bull 50(5-6):469-70 Details Goedert M, Spillantini MG, Crowther RA, Chen SG, Parchi P, Tabaton M, Lanska DJ, Markesbery WR, Wilhelmsen KC, Dickson DW, Petersen RB, Gambetti P (1999), “Tau gene mutation in familial progressive subcortical gliosis.” Nat Med 5(4):454-7 Details Hall-Jackson CA, Eyers PA, Cohen P, Goedert M, Boyle FT, Hewitt N, Plant H, Hedge P (1999), “Paradoxical activation of Raf by a novel Raf inhibitor.” Chem Biol 6(8):559-68 Details Hall-Jackson CA, Goedert M, Hedge P, Cohen P (1999), “Effect of SB 203580 on the activity of c-Raf in vitro and in vivo.” Oncogene 18(12):2047-54 Details Hasegawa M, Cuenda A, Spillantini MG, Thomas GM, Buée-Scherrer V, Cohen P, Goedert M (1999), “Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.” J Biol Chem 274(18):12626-31 Details Hasegawa M, Smith MJ, Iijima M, Tabira T, Goedert M (1999), “FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10.” FEBS Lett 443(2):93-6 Details Jakes R, Crowther RA, Lee VM, Trojanowski JQ, Iwatsubo T, Goedert M (1999), “Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein.” Neurosci Lett 269(1):13-6 Details Mirra SS, Murrell JR, Gearing M, Spillantini MG, Goedert M, Crowther RA, Levey AI, Jones R, Green J, Shoffner JM, Wainer BH, Schmidt ML, Trojanowski JQ, Ghetti B (1999), “Tau pathology in a family with dementia and a P301L mutation in tau.” J Neuropathol Exp Neurol 58(4):335-45 Details Murrell JR, Spillantini MG, Zolo P, Guazzelli M, Smith MJ, Hasegawa M, Redi F, Crowther RA, Pietrini P, Ghetti B, Goedert M (1999), “Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits.” J Neuropathol Exp Neurol 58(12):1207-26 Details Rizzu P, Van Swieten JC, Joosse M, Hasegawa M, Stevens M, Tibben A, Niermeijer MF, Hillebrand M, Ravid R, Oostra BA, Goedert M, van Duijn CM, Heutink P (1999), “High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands.” Am J Hum Genet 64(2):414-21 Details Spillantini MG, Tolnay M, Love S, Goedert M (1999), “Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia.” Acta Neuropathol 97(6):585-94 Details Thomas GM, Frame S, Goedert M, Nathke I, Polakis P, Cohen P (1999), “A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin.” FEBS Lett 458(2):247-51 Details Varani L, Hasegawa M, Spillantini MG, Smith MJ, Murrell JR, Ghetti B, Klug A, Goedert M, Varani G (1999), “Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17.” Proc Natl Acad Sci U S A 96(14):8229-34 Details 1998Cohen P, Goedert M (1998), “Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid.” Chem Biol 5(7):R161-4 Details Crowther RA, Jakes R, Spillantini MG, Goedert M (1998), “Synthetic filaments assembled from C-terminally truncated alpha-synuclein.” FEBS Lett 436(3):309-12 Details Eyers PA, Craxton M, Morrice N, Cohen P, Goedert M (1998), “Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution.” Chem Biol 5(6):321-8 Details Goedert M (1998), “Neurofibrillary pathology of Alzheimer's disease and other tauopathies.” Prog Brain Res 117:287-306 Details Goedert M, Crowther RA, Spillantini MG (1998), “Tau mutations cause frontotemporal dementias.” Neuron 21(5):955-8 Details Goedert M, Jakes R, Crowther RA, Hasegawa M, Smith MJ, Spillantini MG (1998), “Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases.” Biochem Soc Trans 26(3):463-71 Details Goedert M, Spillantini MG (1998), “Lewy body diseases and multiple system atrophy as alpha-synucleinopathies.” Mol Psychiatry 3(6):462-5 Details Goedert M, Spillantini MG, Davies SW (1998), “Filamentous nerve cell inclusions in neurodegenerative diseases.” Curr Opin Neurobiol 8(5):619-32 Details Hasegawa M, Smith MJ, Goedert M (1998), “Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly.” FEBS Lett 437(3):207-10 Details Jensen PH, Nielsen MS, Jakes R, Dotti CG, Goedert M (1998), “Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.” J Biol Chem 273(41):26292-4 Details Lawler S, Fleming Y, Goedert M, Cohen P (1998), “Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro.” Curr Biol 8(25):1387-90 Details Qi Z, Zhu X, Goedert M, Fujita DJ, Wang JH (1998), “Effect of heparin on phosphorylation site specificity of neuronal Cdc2-like kinase.” FEBS Lett 423(2):227-30 Details Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M (1998), “Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.” Neurosci Lett 251(3):205-8 Details Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998), “alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.” Proc Natl Acad Sci U S A 95(11):6469-73 Details Spillantini MG, Goedert M (1998), “Tau protein pathology in neurodegenerative diseases.” Trends Neurosci 21(10):428-33 Details Spillantini MG, Murrell JR, Goedert M, Farlow MR, Klug A, Ghetti B (1998), “Mutation in the tau gene in familial multiple system tauopathy with presenile dementia.” Proc Natl Acad Sci U S A 95(13):7737-41 Details Trojanowski JQ, Goedert M, Iwatsubo T, Lee VM (1998), “Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia.” Cell Death Differ 5(10):832-7 Details 1997Chevallier N, Jiracek J, Vincent B, Baur CP, Spillantini MG, Goedert M, Dive V, Checler F (1997), “Examination of the role of endopeptidase 3.4.24.15 in A beta secretion by human transfected cells.” Br J Pharmacol 121(3):556-62 Details Chevallier N, Vizzavona J, Marambaud P, Baur CP, Spillantini M, Fulcrand P, Martinez J, Goedert M, Vincent JP, Checler F (1997), “Cathepsin D displays in vitro beta-secretase-like specificity.” Brain Res 750(1-2):11-9 Details Craxton M, Olsen A, Goedert M (1997), “Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location.” Genomics 42(1):165-9 Details Cuenda A, Cohen P, Buée-Scherrer V, Goedert M (1997), “Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38).” EMBO J 16(2):295-305 Details Cuenda A, Goedert M, Craxton M, Jakes R, Cohen P (1997), “Activation of the novel MAP kinase homologue SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6).” Biochem Soc Trans 25(4):S569 Details Goedert M (1997), “Familial Parkinson's disease. The awakening of alpha-synuclein.” Nature 388(6639):232-3 Details Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P (1997), “Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.” EMBO J 16(12):3563-71 Details Goedert M, Hasegawa J, Craxton M, Leversha MA, Clegg S (1997), “Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization.” Genomics 41(3):501-2 Details Goedert M, Hasegawa M, Jakes R, Lawler S, Cuenda A, Cohen P (1997), “Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases.” FEBS Lett 409(1):57-62 Details Hasegawa M, Crowther RA, Jakes R, Goedert M (1997), “Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation.” J Biol Chem 272(52):33118-24 Details Lawler S, Cuenda A, Goedert M, Cohen P (1997), “SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK).” FEBS Lett 414(1):153-8 Details Murrell JR, Koller D, Foroud T, Goedert M, Spillantini MG, Edenberg HJ, Farlow MR, Ghetti B (1997), “Familial multiple-system tauopathy with presenile dementia is localized to chromosome 17.” Am J Hum Genet 61(5):1131-8 Details Sergeant N, David JP, Goedert M, Jakes R, Vermersch P, Buée L, Lefranc D, Wattez A, Delacourte A (1997), “Two-dimensional characterization of paired helical filament-tau from Alzheimer's disease: demonstration of an additional 74-kDa component and age-related biochemical modifications.” J Neurochem 69(2):834-44 Details Spillantini MG, Goedert M, Crowther RA, Murrell JR, Farlow MR, Ghetti B (1997), “Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments.” Proc Natl Acad Sci U S A 94(8):4113-8 Details Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997), “Alpha-synuclein in Lewy bodies.” Nature 388(6645):839-40 Details Tolnay M, Spillantini MG, Goedert M, Ulrich J, Langui D, Probst A (1997), “Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons.” Acta Neuropathol 93(5):477-84 Details 1996Andrä K, Abramowski D, Duke M, Probst A, Wiederhold KH, Bürki K, Goedert M, Sommer B, Staufenbiel M (1996), “Expression of APP in transgenic mice: a comparison of neuron-specific promoters.” Neurobiol Aging 17(2):183-90 Details Buée-Scherrer V, Condamines O, Mourton-Gilles C, Jakes R, Goedert M, Pau B, Delacourte A (1996), “AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease.” Brain Res Mol Brain Res 39(1-2):79-88 Details Ghetti B, Piccardo P, Spillantini MG, Ichimiya Y, Porro M, Perini F, Kitamoto T, Tateishi J, Seiler C, Frangione B, Bugiani O, Giaccone G, Prelli F, Goedert M, Dlouhy SR, Tagliavini F (1996), “Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.” Proc Natl Acad Sci U S A 93(2):744-8 Details Goedert M (1996), “Tau protein and the neurofibrillary pathology of Alzheimer's disease.” Ann N Y Acad Sci 777:121-31 Details Goedert M, Baur CP, Ahringer J, Jakes R, Hasegawa M, Spillantini MG, Smith MJ, Hill F (1996), “PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans.” J Cell Sci 109 ( Pt 11):2661-72 Details Goedert M, Jakes R, Spillantini MG, Hasegawa M, Smith MJ, Crowther RA (1996), “Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.” Nature 383(6600):550-3 Details Goedert M, Marsh S, Carter N (1996), “Localization of the human kinesin light chain gene (KNS2) to chromosome 14q32.3 by fluorescence in situ hybridization.” Genomics 32(1):173-5 Details Goedert M, Spillantini MG, Hasegawa M, Jakes R, Crowther RA, Klug A (1996), “Molecular dissection of the neurofibrillary lesions of Alzheimer's disease.” Cold Spring Harb Symp Quant Biol 61:565-73 Details Hasegawa M, Jakes R, Crowther RA, Lee VM, Ihara Y, Goedert M (1996), “Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.” FEBS Lett 384(1):25-30 Details Litersky JM, Johnson GV, Jakes R, Goedert M, Lee M, Seubert P (1996), “Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.” Biochem J 316 ( Pt 2):655-60 Details Mertens S, Craxton M, Goedert M (1996), “SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases.” FEBS Lett 383(3):273-6 Details Probst A, Tolnay M, Langui D, Goedert M, Spillantini MG (1996), “Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment.” Acta Neuropathol 92(6):588-96 Details Roses AD, Einstein G, Gilbert J, Goedert M, Han SH, Huang D, Hulette C, Masliah E, Pericak-Vance MA, Saunders AM, Schmechel DE, Strittmatter WJ, Weisgraber KH, Xi PT (1996), “Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism.” Ann N Y Acad Sci 777:146-57 Details Spillantini MG, Crowther RA, Goedert M (1996), “Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles.” Acta Neuropathol 92(1):42-8 Details 1995Craxton M, Goedert M (1995), “Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain.” FEBS Lett 361(2-3):196-200 Details Goedert M (1995), “Molecular dissection of the neurofibrillary lesions of Alzheimer's disease.” Arzneimittelforschung 45(3A):403-9 Details Goedert M, Jakes R, Qi Z, Wang JH, Cohen P (1995), “Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase.” J Neurochem 65(6):2804-7 Details Goedert M, Jakes R, Spillantini MG, Crowther RA, Cohen P, Vanmechelen E, Probst A, Götz J, Bürki K (1995), “Tau protein in Alzheimer's disease.” Biochem Soc Trans 23(1):80-5 Details Goedert M, Jakes R, Vanmechelen E (1995), “Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.” Neurosci Lett 189(3):167-9 Details Goedert M, Spillantini MG, Jakes R, Crowther RA, Vanmechelen E, Probst A, Götz J, Bürki K, Cohen P (1995), “Molecular dissection of the paired helical filament.” Neurobiol Aging 16(3):325-34 Details Götz J, Probst A, Spillantini MG, Schäfer T, Jakes R, Bürki K, Goedert M (1995), “Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform.” EMBO J 14(7):1304-13 Details Huang DY, Weisgraber KH, Goedert M, Saunders AM, Roses AD, Strittmatter WJ (1995), “ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation.” Neurosci Lett 192(3):209-12 Details Jakes R, Harrington CR, Spillantini MG, Goedert M, Klug A (1995), “Characterisation of an antibody relevant to the neuropathology of Alzheimer disease.” Alzheimer Dis Assoc Disord 9(1):47-51 Details Seubert P, Mawal-Dewan M, Barbour R, Jakes R, Goedert M, Johnson GV, Litersky JM, Schenk D, Lieberburg I, Trojanowski JQ (1995), “Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.” J Biol Chem 270(32):18917-22 Details Sperber BR, Leight S, Goedert M, Lee VM (1995), “Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells.” Neurosci Lett 197(2):149-53 Details Spillantini MG, Divane A, Goedert M (1995), “Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35.” Genomics 27(2):379-81 Details 1994Crowther RA, Olesen OF, Smith MJ, Jakes R, Goedert M (1994), “Assembly of Alzheimer-like filaments from full-length tau protein.” FEBS Lett 337(2):135-8 Details Fawcett JW, Mathews G, Housden E, Goedert M, Matus A (1994), “Regenerating sciatic nerve axons contain the adult rather than the embryonic pattern of microtubule associated proteins.” Neuroscience 61(4):789-804 Details Goedert M, Jakes R, Crowther RA, Cohen P, Vanmechelen E, Vandermeeren M, Cras P (1994), “Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein.” Biochem J 301 ( Pt 3):871-7 Details Goedert M, Strittmatter WJ, Roses AD (1994), “Alzheimer's disease. Risky apolipoprotein in brain.” Nature 372(6501):45-6 Details Huang DY, Goedert M, Jakes R, Weisgraber KH, Garner CC, Saunders AM, Pericak-Vance MA, Schmechel DE, Roses AD, Strittmatter WJ (1994), “Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.” Neurosci Lett 182(1):55-8 Details Jakes R, Spillantini MG, Goedert M (1994), “Identification of two distinct synucleins from human brain.” FEBS Lett 345(1):27-32 Details Otvos L Jr, Feiner L, Lang E, Szendrei GI, Goedert M, Lee VM (1994), “Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.” J Neurosci Res 39(6):669-73 Details Strittmatter WJ, Saunders AM, Goedert M, Weisgraber KH, Dong LM, Jakes R, Huang DY, Pericak-Vance M, Schmechel D, Roses AD (1994), “Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.” Proc Natl Acad Sci U S A 91(23):11183-6 Details Strittmatter WJ, Weisgraber KH, Goedert M, Saunders AM, Huang D, Corder EH, Dong LM, Jakes R, Alberts MJ, Gilbert JR (1994), “Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype.” Exp Neurol 125(2):163-71; discussion 172-4 Details 1993Bramblett GT, Goedert M, Jakes R, Merrick SE, Trojanowski JQ, Lee VM (1993), “Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.” Neuron 10(6):1089-99 Details Goedert M (1993), “Tau protein and the neurofibrillary pathology of Alzheimer's disease.” Trends Neurosci 16(11):460-5 Details Goedert M, Jakes R, Crowther RA, Six J, Lübke U, Vandermeeren M, Cras P, Trojanowski JQ, Lee VM (1993), “The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.” Proc Natl Acad Sci U S A 90(11):5066-70 Details Lee JH, Goedert M, Hill WD, Lee VM, Trojanowski JQ (1993), “Tau proteins are abnormally expressed in olfactory epithelium of Alzheimer patients and developmentally regulated in human fetal spinal cord.” Exp Neurol 121(1):93-105 Details Lo MM, Fieles AW, Norris TE, Dargis PG, Caputo CB, Scott CW, Lee VM, Goedert M (1993), “Human tau isoforms confer distinct morphological and functional properties to stably transfected fibroblasts.” Brain Res Mol Brain Res 20(3):209-20 Details Robertson J, Loviny TL, Goedert M, Jakes R, Murray KJ, Anderton BH, Hanger DP (1993), “Phosphorylation of tau by cyclic-AMP-dependent protein kinase.” Dementia 4(5):256-63 Details 1992Biernat J, Mandelkow EM, Schröter C, Lichtenberg-Kraag B, Steiner B, Berling B, Meyer H, Mercken M, Vandermeeren A, Goedert M (1992), “The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.” EMBO J 11(4):1593-7 Details Crowther RA, Olesen OF, Jakes R, Goedert M (1992), “The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease.” FEBS Lett 309(2):199-202 Details Goedert M, Cohen ES, Jakes R, Cohen P (1992), “p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected].” FEBS Lett 312(1):95-9 Details Goedert M, Spillantini MG, Cairns NJ, Crowther RA (1992), “Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms.” Neuron 8(1):159-68 Details Goedert M, Spillantini MG, Crowther RA (1992), “Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system.” Proc Natl Acad Sci U S A 89(5):1983-7 Details Gustke N, Steiner B, Mandelkow EM, Biernat J, Meyer HE, Goedert M, Mandelkow E (1992), “The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs.” FEBS Lett 307(2):199-205 Details Potier MC, Kuo WL, Dutriaux A, Gray J, Goedert M (1992), “Construction and characterization of a yeast artificial chromosome library containing 1.5 equivalents of human chromosome 21.” Genomics 14(2):481-3 Details 1991Dingus J, Obar RA, Hyams JS, Goedert M, Vallee RB (1991), “Use of a heat-stable microtubule-associated protein class-specific antibody to investigate the mechanism of microtubule binding.” J Biol Chem 266(28):18854-60 Details Goedert M, Crowther RA, Garner CC (1991), “Molecular characterization of microtubule-associated proteins tau and MAP2.” Trends Neurosci 14(5):193-9 Details Goedert M, Sisodia SS, Price DL (1991), “Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease.” Curr Opin Neurobiol 1(3):441-7 Details Goedert M, Spillantini MG, Crowther RA (1991), “Tau proteins and neurofibrillary degeneration.” Brain Pathol 1(4):279-86 Details Goedert M, Spillantini MG, Jakes R (1991), “Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tau.” Neurosci Lett 126(2):149-54 Details Wright AF, Goedert M, Hastie ND (1991), “Familial Alzheimer's disease. Beta amyloid resurrected.” Nature 349(6311):653-4 Details 1990Goedert M, Jakes R (1990), “Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.” EMBO J 9(13):4225-30 Details Goedert M, Spillantini MG (1990), “Molecular neuropathology of Alzheimer's disease: in situ hybridization studies.” Cell Mol Neurobiol 10(1):159-74 Details Hanley MR, Cheung WT, Hawkins P, Poyner D, Benton HP, Blair L, Jackson TR, Goedert M (1990), “The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action.” Ciba Found Symp 150:23-38; discussion 38-46 Details Kindler S, Schulz B, Goedert M, Garner CC (1990), “Molecular structure of microtubule-associated protein 2b and 2c from rat brain.” J Biol Chem 265(32):19679-84 Details Spillantini MG, Goedert M, Jakes R, Klug A (1990), “Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease.” Proc Natl Acad Sci U S A 87(10):3947-51 Details Spillantini MG, Goedert M, Jakes R, Klug A (1990), “Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease.” Proc Natl Acad Sci U S A 87(10):3952-6 Details 1989Allen SJ, Dawbarn D, Spillantini MG, Goedert M, Wilcock GK, Moss TH, Semenenko FM (1989), “Distribution of beta-nerve growth factor receptors in the human basal forebrain.” J Comp Neurol 289(4):626-40 Details Crowther T, Goedert M, Wischik CM (1989), “The repeat region of microtubule-associated protein tau forms part of the core of the paired helical filament of Alzheimer's disease.” Ann Med 21(2):127-32 Details Goedert M (1989), “Radioligand-binding assays for study of neurotensin receptors.” Methods Enzymol 168:462-81 Details Goedert M, Crowther RA (1989), “Amyloid plaques, neurofibrillary tangles and their relevance for the study of Alzheimer's disease.” Neurobiol Aging 10(5):405-6; discussion 412-4 Details Goedert M, Fine A, Dawbarn D, Wilcock GK, Chao MV (1989), “Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease.” Brain Res Mol Brain Res 5(1):1-7 Details Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (1989), “Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease.” Neuron 3(4):519-26 Details Goedert M, Spillantini MG, Potier MC, Ulrich J, Crowther RA (1989), “Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.” EMBO J 8(2):393-9 Details Spillantini MG, Aloe L, Alleva E, De Simone R, Goedert M, Levi-Montalcini R (1989), “Nerve growth factor mRNA and protein increase in hypothalamus in a mouse model of aggression.” Proc Natl Acad Sci U S A 86(21):8555-9 Details Spillantini MG, Hunt SP, Ulrich J, Goedert M (1989), “Expression and cellular localization of amyloid beta-protein precursor transcripts in normal human brain and in Alzheimer's disease.” Brain Res Mol Brain Res 6(2-3):143-50 Details 1988Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A (1988), “Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.” Proc Natl Acad Sci U S A 85(11):4051-5 Details Jackson TR, Blair LA, Marshall J, Goedert M, Hanley MR (1988), “The mas oncogene encodes an angiotensin receptor.” Nature 335(6189):437-40 Details Rogers J, Goedert M, Wilson PW (1988), “An extra sequence in the lambda EMBL3 polylinker.” Nucleic Acids Res 16(4):1633 Details 1987Goedert M (1987), “Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.” EMBO J 6(12):3627-32 Details Goedert M, Hunt SP (1987), “The cellular localization of preprotachykinin A messenger RNA in the bovine nervous system.” Neuroscience 22(3):983-92 Details Hunt SP, Goedert M (1987), “The cellular localization of mRNA in neurobiology.” Biochem Soc Trans 15(1):133 Details 1986Goedert M (1986), “Molecular cloning of the chicken nerve growth factor gene: mRNA distribution in developing and adult tissues.” Biochem Biophys Res Commun 141(3):1116-22 Details Goedert M, Fine A, Hunt SP, Ullrich A (1986), “Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease.” Brain Res 387(1):85-92 Details 1985Emson PC, Horsfield PM, Goedert M, Rossor MN, Hawkes CH (1985), “Neurotensin in human brain: regional distribution and effects of neurological illness.” Brain Res 347(2):239-44 Details Fitzgerald M, Wall PD, Goedert M, Emson PC (1985), “Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section.” Brain Res 332(1):131-41 Details Goedert M, Hunt SP, Mantyh PW, Emson PC (1985), “The ontogenetic development of neurotensin-like immunoreactivity and neurotensin receptors in the cat striatum.” Brain Res 352(1):127-31 Details Goedert M, Iversen SD, Emson PC (1985), “The effects of chronic neuroleptic treatment on neurotensin-like immunoreactivity in the rat central nervous system.” Brain Res 335(2):334-6 Details Goedert M, Lightman SL, Mantyh PW, Hunt SP, Emson PC (1985), “Neurotensin-like immunoreactivity and neurotensin receptors in the rat hypothalamus and in the neurointermediate lobe of the pituitary gland.” Brain Res 358(1-2):59-69 Details Goedert M, Schwartz WN, Williams BJ (1985), “The comparative distribution of [Lys8-Asn9]-neurotensin8-13-like immunoreactivity in chicken and rat tissues.” Brain Res 342(2):259-65 Details Hunter JC, Goedert M, Pinnock RD (1985), “Mammalian tachykinin-induced hydrolysis of inositol phospholipids in rat brain slices.” Biochem Biophys Res Commun 127(2):616-22 Details Reeve JG, Goedert M, Emson PC, Bleehen NM (1985), “Neurotensin in human small cell lung carcinoma.” Recent Results Cancer Res 99:175-6 Details 1984Bannon MJ, Goedert M (1984), “Changes in substance P concentrations after protein synthesis inhibition provide an index of substance P utilization.” Brain Res 301(1):184-6 Details Bannon MJ, Goedert M, Williams B (1984), “The possible relation of glutathione, melanin and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) to Parkinson's disease.” Biochem Pharmacol 33(17):2697-8 Details Goedert M, Hunter JC, Ninkovic M (1984), “Evidence for neurotensin as a non-adrenergic, non-cholinergic neurotransmitter in guinea pig ileum.” Nature 311(5981):59-62 Details Goedert M, Lightman SL, Emson PC (1984), “Neurotensin in the rat anterior pituitary gland: effects of endocrinological manipulations.” Brain Res 299(1):160-3 Details Goedert M, Mantyh PW, Emson PC, Hunt SP (1984), “Inverse relationship between neurotensin receptors and neurotensin-like immunoreactivity in cat striatum.” Nature 307(5951):543-6 Details Goedert M, Mantyh PW, Hunt SP, Emson PC (1984), “Localization of specific neurotensin binding sites in the rat adrenal gland.” Brain Res 299(2):389-92 Details Goedert M, Otten U, Hunt SP, Bond A, Chapman D, Schlumpf M, Lichtensteiger W (1984), “Biochemical and anatomical effects of antibodies against nerve growth factor on developing rat sensory ganglia.” Proc Natl Acad Sci U S A 81(5):1580-4 Details Goedert M, Pinnock RD, Downes CP, Mantyh PW, Emson PC (1984), “Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices.” Brain Res 323(1):193-7 Details Goedert M, Pittaway K, Emson PC (1984), “Neurotensin receptors in the rat striatum: lesion studies.” Brain Res 299(1):164-8 Details Goedert M, Pittaway K, Williams BJ, Emson PC (1984), “Specific binding of tritiated neurotensin to rat brain membranes: characterization and regional distribution.” Brain Res 304(1):71-81 Details Goedert M, Reeve JG, Emson PC, Bleehen NM (1984), “Neurotensin in human small cell lung carcinoma.” Br J Cancer 50(2):179-83 Details Goedert M, Sturmey N, Williams BJ, Emson PC (1984), “The comparative distribution of xenopsin- and neurotensin-like immunoreactivity in Xenopus laevis and rat tissues.” Brain Res 308(2):273-80 Details Mantyh PW, Goedert M, Hunt SP (1984), “Autoradiographic visualization of receptor binding sites for substance P in the gastrointestinal tract of the guinea pig.” Eur J Pharmacol 100(1):133-4 Details Mantyh PW, Pinnock RD, Downes CP, Goedert M, Hunt SP (1984), “Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS.” Nature 309(5971):795-7 Details Marley PD, Lightman SL, Forsling ML, Todd K, Goedert M, Rehfeld JF, Emson PC (1984), “Localization and actions of cholecystokinin in the rat pituitary neurointermediate lobe.” Endocrinology 114(5):1902-11 Details 1983Bannon MJ, Elliott PJ, Alpert JE, Goedert M, Iversen SD, Iversen LL (1983), “Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones.” Nature 306(5945):791-2 Details Goedert M, Emson PC (1983), “The regional distribution of neurotensin-like immunoreactivity in central and peripheral tissues of the cat.” Brain Res 272(2):291-7 Details Goedert M, Mantyh PW, Hunt SP, Emson PC (1983), “Mosaic distribution of neurotensin-like immunoreactivity in the cat striatum.” Brain Res 274(1):176-9 Details Goedert M, Reynolds GP, Emson PC (1983), “Neurotensin in the adrenal medulla.” Neurosci Lett 35(2):155-60 Details Nagy JI, Iversen LL, Goedert M, Chapman D, Hunt SP (1983), “Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat.” J Neurosci 3(2):399-406 Details 1982Emson PC, Goedert M, Benton H, St-Pierre S, Rioux F (1982), “The regional distribution and chromatographic characterization of neurotensin-like immunoreactivity in the rat.” Adv Biochem Psychopharmacol 33:477-85 Details Emson PC, Goedert M, Horsfield P, Rioux F, St Pierre S (1982), “The regional distribution and chromatographic characterisation of neurotensin-like immunoreactivity in the rat central nervous system.” J Neurochem 38(4):992-9 Details Emson PC, Goedert M, Williams B, Ninkovic M, Hunt SP (1982), “Neurotensin: regional distribution, characterization, and inactivation.” Ann N Y Acad Sci 400:198-215 Details Goedert M, Lightman SL, Nagy JI, Marley PD, Emson PC (1982), “Neurotensin in the rat anterior pituitary gland.” Nature 298(5870):163-5 Details Goedert M, Nagy JI, Emson PC (1982), “The origin of substance P in the rat submandibular gland and its major duct.” Brain Res 252(2):327-33 Details Mayer N, Lembeck F, Goedert M, Otten U (1982), “Effects of antibodies against nerve growth factor on the postnatal development of substance P-containing sensory neurons.” Neurosci Lett 29(1):47-52 Details Nagy JI, Goedert M, Hunt SP, Bond A (1982), “The nature of the substance P-containing nerve fibres in taste papillae of the rat tongue.” Neuroscience 7(12):3137-51 Details 1981Goedert M, Otten U, Metz H (1981), “Endogenous opioid peptides.” Bull Soc Sci Med Grand Duche Luxemb 118(1):7-17 Details Goedert M, Stoeckel K, Otten U (1981), “Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons.” Proc Natl Acad Sci U S A 78(9):5895-8 Details Otten U, Goedert M, Baumann JB, Girard J (1981), “Stimulation of the pituitary-adrenocortical axis and induction of tyrosine hydroxylase by nerve growth factor are not dependent on mouse submaxillary gland isorenin.” Brain Res 217(1):207-11 Details 1980Goedert M, Otten U, Schäfer T, Schwab M, Thoenen H (1980), “Immunosympathectomy: lack of evidence for a complement-mediated cytotoxic mechanism.” Brain Res 201(2):399-409 Details Goedert M, Otten U, Suda K, Heitz PU, Stalder GA, Obrecht JP, Holzach P, Allgöwer M (1980), “Dopamine, norepinephrine and serotonin production by an intestinal carcinoid tumor.” Cancer 45(1):104-7 Details Otten U, Goedert M, Mayer N, Lembeck F (1980), “Requirement of nerve growth factor for development of substance P-containing sensory neurones.” Nature 287(5778):158-9 Details 1979Otten U, Goedert M, Schwab M, Thibault J (1979), “Immunization of adult rats against 2.5 S NGF: effects on the peripheral sympathetic nervous system.” Brain Res 176(1):79-90 Details 1978Goedert M (1978), “Nerve growth factor: its growing importance for neurobiology and medicine.” Bull Soc Sci Med Grand Duche Luxemb 115(2):69-74 Details Goedert M, Otten U, Thoenen H (1978), “Biochemical effects of antibodies against nerve growth factor on developing and differentiated sympathetic ganglia.” Brain Res 148(1):264-8 Details Goedert M, Otten U, Thoenen H (1978), “Biochemical effects of nerve growth factor and its antibody on the vas defferens and the adrenal medulla.” Neurosci Lett 8(1):71-6 Details 1977Goedert M, Bühler FR (1977), “Nerve-growth-factor antibodies in idiopathic orthostatic hypotension?” N Engl J Med 297(6):336-7 Details |