Professor Marek Czosnyka University positionProfessor Professor Marek Czosnyka is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Clinical Neurosciences InstitutesHome pagehttp://www.neurosurg.cam.ac.uk Research ThemesInterestsBrain Physics summarizes physical interactions between volumes, flows and pressures in brain. Measurement, data processing and analysis, forecasting and modeling of various cerebral phenomena as autoregulation of CBF or pressure-volume compensation of CSF indicate first-line priorities of Brain Physics. Complete list of ongoing projects include: 1. Brain Autoregulation 2. Cerebrospinal fluid dynamics (hydrocephalus, IIH). Multi-modal brain monitoring (head trauma, poor grade SAH, stroke) 3. Mathematical modeling of cerebrospinal dynamics 4. Hydrodynamic properties of hydrocephalus shunts 5. Software for brain monitoring ICM+ (lead author : Dr.P.Smielewski): www.neurosurg.cam.ac.uk/icmplus NEW!: For details see 30 Lectures in Brain Physics- not only for Engineers: http://www.neurosurg.cam.ac.uk/pages/brainphys/ NEW! Brain Physics Seminars:Tuesdays at 11:00, University Neurosurgery, Old Library, Block A, Level 4, Addenbrookes Hospital- Find us at Facebook: Brain Physics Cambridge  Mathematical model of CBF dynamics and CSF circulation Click image to view full-size Research Focus
EquipmentComputational modelling Computer bedside monitoring Intracranial pressure monitoring Transcranial doppler ultrasonography Collaborators
Associated News ItemsKey publicationsCzosnyka M, Brady K, Reinhard M, Smielewski P, Steiner LA (2009), “Monitoring of cerebrovascular autoregulation: facts, myths, and missing links.” Neurocrit Care 10(3):373-86 Details Hu K, Lo MT, Peng CK, Novak V, Schmidt EA, Kumar A, Czosnyka M (2009), “Nonlinear Pressure-Flow Relationship Is Able to Detect Asymmetry of Brain Blood Circulation Associated with Midline Shift.” J Neurotrauma Details Steiner LA, Pfister D, Strebel SP, Radolovich D, Smielewski P, Czosnyka M (2009), “Near-infrared spectroscopy can monitor dynamic cerebral autoregulation in adults.” Neurocrit Care 10(1):122-8 Details Publications2014Capel C, Kasprowicz M, Czosnyka M, Baledent O, Smielewski P, Pickard JD, Czosnyka Z (2014), “Cerebrovascular time constant in patients suffering from hydrocephalus.” Neurol Res 36(3):255-61 Details Chari A, Czosnyka M, Richards HK, Pickard JD, Czosnyka ZH (2014), “Hydrocephalus shunt technology: 20 years of experience from the Cambridge Shunt Evaluation Laboratory.” J Neurosurg Details Damian MS, Czosnyka M (2014), “Near infrared spectroscopy monitoring-Opening a window on the first 24h after cardiac arrest?” Resuscitation Details Hart MG, Czosnyka M, Czosnyka ZH, Fernandes HM (2014), “Combined Intracranial Pressure Monitoring and Cerebrospinal Fluid Infusion Study to Guide Management of Slit Ventricle Syndrome.” Pediatr Neurosurg Details Lazaridis C, Desantis SM, Smielewski P, Menon DK, Hutchinson P, Pickard JD, Czosnyka M (2014), “Patient-specific thresholds of intracranial pressure in severe traumatic brain injury.” J Neurosurg Details Varsos GV, Kasprowicz M, Smielewski P, Czosnyka M (2014), “Model-based Indices Describing Cerebrovascular Dynamics.” Neurocrit Care 20(1):142-57 Details Varsos GV, Richards HK, Kasprowicz M, Reinhard M, Smielewski P, Brady KM, Pickard JD, Czosnyka M (2014), “Cessation of diastolic cerebral blood flow velocity: the role of critical closing pressure.” Neurocrit Care 20(1):40-8 Details Werndle MC, Saadoun S, Phang I, Czosnyka M, Varsos GV, Czosnyka ZH, Smielewski P, Jamous A, Bell BA, Zoumprouli A, Papadopoulos MC (2014), “Monitoring of spinal cord perfusion pressure in acute spinal cord injury: initial findings of the injured spinal cord pressure evaluation study*.” Crit Care Med 42(3):646-55 Details 2013Aries MJ, Budohoski KP, Smielewski PS, Czosnyka M, Brady KM (2013), “The authors reply.” Crit Care Med 41(1):e5 Details Budohoski KP, Czosnyka M, Kirkpatrick PJ, Smielewski P, Steiner LA, Pickard JD (2013), “Clinical relevance of cerebral autoregulation following subarachnoid haemorrhage.” Nat Rev Neurol 9(3):152-63 Details Budohoski KP, Czosnyka M, Smielewski P, Varsos GV, Kasprowicz M, Brady KM, Pickard JD, Kirkpatrick PJ (2013), “Cerebral autoregulation after subarachnoid hemorrhage: comparison of three methods.” J Cereb Blood Flow Metab 33(3):449-56 Details Czosnyka M (2013), “Increased intracranial pressure: what to do about it and when?” Crit Care Med 41(2):688 Details Czosnyka Z, Pickard JD, Czosnyka M (2013), “Hydrodynamic properties of the Certas hydrocephalus shunt.” J Neurosurg Pediatr 11(2):198-204 Details Dias C, Maia I, Cerejo A, Varsos G, Smielewski P, Paiva JA, Czosnyka M (2013), “Pressures, Flow, and Brain Oxygenation During Plateau Waves of Intracranial Pressure.” Neurocrit Care Details Eisenträger A, Sobey I, Czosnyka M (2013), “Parameter estimations for the cerebrospinal fluid infusion test.” Math Med Biol 30(2):157-74 Details Fraser CD 3rd, Brady KM, Rhee CJ, Easley RB, Kibler K, Smielewski P, Czosnyka M, Kaczka DW, Andropoulos DB, Rusin C (2013), “The frequency response of cerebral autoregulation.” J Appl Physiol (1985) 115(1):52-6 Details Haubrich C, Steiner LA, Diehl RR, Kasprowicz M, Smielewski P, Pickard JD, Czosnyka M (2013), “Doppler flow velocity and intra-cranial pressure: responses to short-term mild hypocapnia help to assess the pressure-volume relationship after head injury.” Ultrasound Med Biol 39(9):1521-6 Details Hutchinson PJ, Kolias AG, Czosnyka M, Kirkpatrick PJ, Pickard JD, Menon DK (2013), “Intracranial pressure monitoring in severe traumatic brain injury.” BMJ 346:f1000 Details Lazaridis C, Smielewski P, Steiner LA, Brady KM, Hutchinson P, Pickard JD, Czosnyka M (2013), “Optimal cerebral perfusion pressure: are we ready for it?” Neurol Res 35(2):138-48 Details Marzban C, Illian PR, Morison D, Moore A, Kliot M, Czosnyka M, Mourad PD (2013), “A method for estimating zero-flow pressure and intracranial pressure.” J Neurosurg Anesthesiol 25(1):25-32 Details Oeinck M, Neunhoeffer F, Buttler KJ, Meckel S, Schmidt B, Czosnyka M, Weiller C, Reinhard M (2013), “Dynamic cerebral autoregulation in acute intracerebral hemorrhage.” Stroke 44(10):2722-8 Details Soehle M, Gies B, Smielewski P, Czosnyka M (2013), “Reduced complexity of intracranial pressure observed in short time series of intracranial hypertension following traumatic brain injury in adults.” J Clin Monit Comput 27(4):395-403 Details Varsos GV, de Riva N, Smielewski P, Pickard JD, Brady KM, Reinhard M, Avolio A, Czosnyka M (2013), “Critical closing pressure during intracranial pressure plateau waves.” Neurocrit Care 18(3):341-8 Details Varsos GV, Richards H, Kasprowicz M, Budohoski KP, Brady KM, Reinhard M, Avolio A, Smielewski P, Pickard JD, Czosnyka M (2013), “Critical closing pressure determined with a model of cerebrovascular impedance.” J Cereb Blood Flow Metab 33(2):235-43 Details Zweifel C, Czosnyka M, Smielewski P (2013), “In reply. Transcranial Doppler derived pulsatility index in the assessment of intracranial pressure: the trend is your friend.” Neurosurgery 72(2):E320 Details 2012Aries MJ, Czosnyka M, Budohoski KP, Kolias AG, Radolovich DK, Lavinio A, Pickard JD, Smielewski P (2012), “Continuous monitoring of cerebrovascular reactivity using pulse waveform of intracranial pressure.” Neurocrit Care 17(1):67-76 Details Aries MJ, Czosnyka M, Budohoski KP, Steiner LA, Lavinio A, Kolias AG, Hutchinson PJ, Brady KM, Menon DK, Pickard JD, Smielewski P (2012), “Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury.” Crit Care Med 40(8):2456-63 Details Bouzerar R, Czosnyka M, Czosnyka Z, Balédent O (2012), “Physical phantom of craniospinal hydrodynamics.” Acta Neurochir Suppl 113:65-9 Details Brady KM, Easley RB, Kibler K, Kaczka DW, Andropoulos D, Fraser CD 3rd, Smielewski P, Czosnyka M, Adams GJ, Rhee CJ, Rusin CG (2012), “Positive end-expiratory pressure oscillation facilitates brain vascular reactivity monitoring.” J Appl Physiol (1985) 113(9):1362-8 Details Budohoski KP, Czosnyka M, de Riva N, Smielewski P, Pickard JD, Menon DK, Kirkpatrick PJ, Lavinio A (2012), “The relationship between cerebral blood flow autoregulation and cerebrovascular pressure reactivity after traumatic brain injury.” Neurosurgery 71(3):652-60; discussion 660-1 Details Budohoski KP, Czosnyka M, Kirkpatrick PJ (2012), “Cerebral compromise and multimodality monitoring after SAH.” Neurosurgery 70(3):E801-2 Details Budohoski KP, Czosnyka M, Smielewski P, Kasprowicz M, Helmy A, Bulters D, Pickard JD, Kirkpatrick PJ (2012), “Impairment of cerebral autoregulation predicts delayed cerebral ischemia after subarachnoid hemorrhage: a prospective observational study.” Stroke 43(12):3230-7 Details Budohoski KP, Reinhard M, Aries MJ, Czosnyka Z, Smielewski P, Pickard JD, Kirkpatrick PJ, Czosnyka M (2012), “Monitoring cerebral autoregulation after head injury. Which component of transcranial Doppler flow velocity is optimal?” Neurocrit Care 17(2):211-8 Details Budohoski KP, Schmidt B, Smielewski P, Kasprowicz M, Plontke R, Pickard JD, Klingelhöfer J, Czosnyka M (2012), “Non-invasively estimated ICP pulse amplitude strongly correlates with outcome after TBI.” Acta Neurochir Suppl 114:121-5 Details Budohoski KP, Zweifel C, Kasprowicz M, Sorrentino E, Diedler J, Brady KM, Smielewski P, Menon DK, Pickard JD, Kirkpatrick PJ, Czosnyka M (2012), “What comes first? The dynamics of cerebral oxygenation and blood flow in response to changes in arterial pressure and intracranial pressure after head injury.” Br J Anaesth 108(1):89-99 Details Carpenter KL, Timofeev I, Nortje J, Czosnyka M, Pickard JD, Hutchinson PJ (2012), “A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring.” Acta Neurochir Suppl 114:271-6 Details Czosnyka M, Citerio G (2012), “Brain compliance: the old story with a new 'et cetera'.” Intensive Care Med 38(6):925-7 Details Czosnyka M, Czosnyka Z, Agarwal-Harding KJ, Pickard JD (2012), “Modeling of CSF dynamics: legacy of Professor Anthony Marmarou.” Acta Neurochir Suppl 113:9-14 Details Czosnyka M, Czosnyka Z, Pickard JD (2012), “Programmable Shunt Assistant tested in Cambridge shunt evaluation laboratory.” Acta Neurochir Suppl 113:71-6 Details Czosnyka M, Richards HK, Reinhard M, Steiner LA, Budohoski K, Smielewski P, Pickard JD, Kasprowicz M (2012), “Cerebrovascular time constant: dependence on cerebral perfusion pressure and end-tidal carbon dioxide concentration.” Neurol Res 34(1):17-24 Details de Riva N, Budohoski KP, Smielewski P, Kasprowicz M, Zweifel C, Steiner LA, Reinhard M, Fábregas N, Pickard JD, Czosnyka M (2012), “Transcranial Doppler pulsatility index: what it is and what it isn't.” Neurocrit Care 17(1):58-66 Details El Sankari S, Fichten A, Gondry-Jouet C, Czosnyka M, Legars D, Deramond H, Balédent O (2012), “Correlation between tap test and CSF aqueductal stroke volume in idiopathic normal pressure hydrocephalus.” Acta Neurochir Suppl 113:43-6 Details Elsankari S, Czosnyka M, Lehmann P, Meyer ME, Deramond H, Balédent O (2012), “Cerebral Blood and CSF Flow Patterns in Patients Diagnosed for Cerebral Venous Thrombosis - An Observational Study.” J Clin Imaging Sci 2:41 Details Haubrich C, Steiner L, Kim DJ, Kasprowicz M, Smielewski P, Diehl RR, Pickard JD, Czosnyka M (2012), “How does moderate hypocapnia affect cerebral autoregulation in response to changes in perfusion pressure in TBI patients?” Acta Neurochir Suppl 114:153-6 Details Kashif FM, Verghese GC, Novak V, Czosnyka M, Heldt T (2012), “Model-based noninvasive estimation of intracranial pressure from cerebral blood flow velocity and arterial pressure.” Sci Transl Med 4(129):129ra44 Details Kasprowicz M, Bergsneider M, Czosnyka M, Hu X (2012), “Association between ICP pulse waveform morphology and ICP B waves.” Acta Neurochir Suppl 114:29-34 Details Kasprowicz M, Czosnyka M, Soehle M, Smielewski P, Kirkpatrick PJ, Pickard JD, Budohoski KP (2012), “Vasospasm shortens cerebral arterial time constant.” Neurocrit Care 16(2):213-8 Details Kasprowicz M, Diedler J, Reinhard M, Carrera E, Smielewski P, Budohoski KP, Sorrentino E, Haubrich C, Kirkpatrick PJ, Pickard JD, Czosnyka M (2012), “Time constant of the cerebral arterial bed.” Acta Neurochir Suppl 114:17-21 Details Kasprowicz M, Diedler J, Reinhard M, Carrera E, Steiner LA, Smielewski P, Budohoski KP, Haubrich C, Pickard JD, Czosnyka M (2012), “Time constant of the cerebral arterial bed in normal subjects.” Ultrasound Med Biol 38(7):1129-37 Details Kim DJ, Czosnyka Z, Kasprowicz M, Smieleweski P, Baledent O, Guerguerian AM, Pickard JD, Czosnyka M (2012), “Continuous monitoring of the Monro-Kellie doctrine: is it possible?” J Neurotrauma 29(7):1354-63 Details Lazaridis C, Czosnyka M (2012), “Cerebral blood flow, brain tissue oxygen, and metabolic effects of decompressive craniectomy.” Neurocrit Care 16(3):478-84 Details Lee JK, Yang ZJ, Wang B, Larson AC, Jamrogowicz JL, Kulikowicz E, Kibler KK, Mytar JO, Carter EL, Burman HT, Brady KM, Smielewski P, Czosnyka M, Koehler RC, Shaffner DH (2012), “Noninvasive autoregulation monitoring in a swine model of pediatric cardiac arrest.” Anesth Analg 114(4):825-36 Details Lewis PM, Smielewski P, Rosenfeld JV, Pickard JD, Czosnyka M (2012), “Monitoring of the association between cerebral blood flow velocity and intracranial pressure.” Acta Neurochir Suppl 114:147-51 Details Lewis PM, Smielewski P, Rosenfeld JV, Pickard JD, Czosnyka M (2012), “Assessment of cerebral autoregulation from respiratory oscillations in ventilated patients after traumatic brain injury.” Acta Neurochir Suppl 114:141-6 Details Lu CW, Czosnyka M, Shieh JS, Smielewska A, Pickard JD, Smielewski P (2012), “Complexity of intracranial pressure correlates with outcome after traumatic brain injury.” Brain 135(Pt 8):2399-408 Details Mytar J, Kibler KK, Easley RB, Smielewski P, Czosnyka M, Andropoulos DB, Brady KM (2012), “Static autoregulation is intact early after severe unilateral brain injury in a neonatal Swine model.” Neurosurgery 71(1):138-45 Details Reinhard M, Rutsch S, Lambeck J, Wihler C, Czosnyka M, Weiller C, Hetzel A (2012), “Dynamic cerebral autoregulation associates with infarct size and outcome after ischemic stroke.” Acta Neurol Scand 125(3):156-62 Details Rhee CJ, Kibler KK, Easley RB, Andropoulos DB, Czosnyka M, Smielewski P, Brady KM (2012), “Renovascular reactivity measured by near-infrared spectroscopy.” J Appl Physiol (1985) 113(2):307-14 Details Sánchez-Porras R, Santos E, Czosnyka M, Zheng Z, Unterberg AW, Sakowitz OW (2012), “'Long' pressure reactivity index (L-PRx) as a measure of autoregulation correlates with outcome in traumatic brain injury patients.” Acta Neurochir (Wien) 154(9):1575-81 Details Smielewski P, Czosnyka Z, Kasprowicz M, Pickard JD, Czosnyka M (2012), “ICM+: a versatile software for assessment of CSF dynamics.” Acta Neurochir Suppl 114:75-9 Details Sorrentino E, Diedler J, Kasprowicz M, Budohoski KP, Haubrich C, Smielewski P, Outtrim JG, Manktelow A, Hutchinson PJ, Pickard JD, Menon DK, Czosnyka M (2012), “Critical thresholds for cerebrovascular reactivity after traumatic brain injury.” Neurocrit Care 16(2):258-66 Details Weerakkody RA, Czosnyka M, Zweifel C, Castellani G, Smielewski P, Brady K, Pickard JD, Czosnyka Z (2012), “Near infrared spectroscopy as possible non-invasive monitor of slow vasogenic ICP waves.” Acta Neurochir Suppl 114:181-5 Details Zweifel C, Czosnyka M, Carrera E, de Riva N, Pickard JD, Smielewski P (2012), “Reliability of the blood flow velocity pulsatility index for assessment of intracranial and cerebral perfusion pressures in head-injured patients.” Neurosurgery 71(4):853-61 Details 2011Burkhart CS, Rossi A, Dell-Kuster S, Gamberini M, Möckli A, Siegemund M, Czosnyka M, Strebel SP, Steiner LA (2011), “Effect of age on intraoperative cerebrovascular autoregulation and near-infrared spectroscopy-derived cerebral oxygenation.” Br J Anaesth 107(5):742-8 Details Carrera E, Kim DJ, Castellani G, Zweifel C, Smielewski P, Pickard JD, Czosnyka M (2011), “Effect of hyper- and hypocapnia on cerebral arterial compliance in normal subjects.” J Neuroimaging 21(2):121-5 Details Carrera E, Kim DJ, Castellani G, Zweifel C, Smielewski P, Pickard JD, Kirkpatrick PJ, Czosnyka M (2011), “Cerebral arterial compliance in patients with internal carotid artery disease.” Eur J Neurol 18(5):711-8 Details Carrera E, Steiner LA, Castellani G, Smielewski P, Zweifel C, Haubrich C, Pickard JD, Menon DK, Czosnyka M (2011), “Changes in cerebral compartmental compliances during mild hypocapnia in patients with traumatic brain injury.” J Neurotrauma 28(6):889-96 Details Czosnyka Z, Owler B, Keong N, Santarius T, Baledent O, Pickard JD, Czosnyka M (2011), “Impact of duration of symptoms on CSF dynamics in idiopathic normal pressure hydrocephalus.” Acta Neurol Scand 123(6):414-8 Details Diedler J, Zweifel C, Budohoski KP, Kasprowicz M, Sorrentino E, Haubrich C, Brady KM, Czosnyka M, Pickard JD, Smielewski P (2011), “The limitations of near-infrared spectroscopy to assess cerebrovascular reactivity: the role of slow frequency oscillations.” Anesth Analg 113(4):849-57 Details Gilmore MM, Stone BS, Shepard JA, Czosnyka M, Easley RB, Brady KM (2011), “Relationship between cerebrovascular dysautoregulation and arterial blood pressure in the premature infant.” J Perinatol 31(11):722-9 Details Haubrich C, Steiner L, Kasprowicz M, Diedler J, Carrera E, Diehl RR, Smielewski P, Czosnyka M (2011), “Short-term moderate hypocapnia augments detection of optimal cerebral perfusion pressure.” J Neurotrauma 28(7):1133-7 Details Hutchinson PJ, Timofeev I, Kolias AG, Corteen EA, Czosnyka M, Menon DK, Pickard JD, Kirkpatrick PJ (2011), “Decompressive craniectomy for traumatic brain injury: the jury is still out.” Br J Neurosurg 25(3):441-2 Details Lee JK, Brady KM, Mytar JO, Kibler KK, Carter EL, Hirsch KG, Hogue CW, Easley RB, Jordan LC, Smielewski P, Czosnyka M, Shaffner DH, Koehler RC (2011), “Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia.” Crit Care Med 39(10):2337-45 Details Nasr N, Czosnyka M, Arevalo F, Hanaire H, Guidolin B, Larrue V (2011), “Autonomic neuropathy is associated with impairment of dynamic cerebral autoregulation in type 1 diabetes.” Auton Neurosci 160(1-2):59-63 Details Radolovich DK, Aries MJ, Castellani G, Corona A, Lavinio A, Smielewski P, Pickard JD, Czosnyka M (2011), “Pulsatile intracranial pressure and cerebral autoregulation after traumatic brain injury.” Neurocrit Care 15(3):379-86 Details Reinhard M, Roth M, Guschlbauer B, Czosnyka M, Timmer J, Weiller C, Hetzel A (2011), “The course of dynamic cerebral autoregulation during cervical internal carotid artery occlusion.” Neurol Res 33(9):921-6 Details Santos E, Diedler J, Sykora M, Orakcioglu B, Kentar M, Czosnyka M, Unterberg A, Sakowitz OW (2011), “Low-frequency sampling for PRx calculation does not reduce prognostication and produces similar CPPopt in intracerebral haemorrhage patients.” Acta Neurochir (Wien) 153(11):2189-95 Details Sorrentino E, Budohoski KP, Kasprowicz M, Smielewski P, Matta B, Pickard JD, Czosnyka M (2011), “Critical thresholds for transcranial Doppler indices of cerebral autoregulation in traumatic brain injury.” Neurocrit Care 14(2):188-93 Details Timofeev I, Carpenter KL, Nortje J, Al-Rawi PG, O'Connell MT, Czosnyka M, Smielewski P, Pickard JD, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ (2011), “Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients.” Brain 134(Pt 2):484-94 Details Timofeev I, Czosnyka M, Carpenter KL, Nortje J, Kirkpatrick PJ, Al-Rawi PG, Menon DK, Pickard JD, Gupta AK, Hutchinson PJ (2011), “Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location.” J Neurotrauma 28(6):849-60 Details Weerakkody RA, Czosnyka M, Schuhmann MU, Schmidt E, Keong N, Santarius T, Pickard JD, Czosnyka Z (2011), “Clinical assessment of cerebrospinal fluid dynamics in hydrocephalus. Guide to interpretation based on observational study.” Acta Neurol Scand 124(2):85-98 Details 2010Bijlenga P, Czosnyka M, Budohoski KP, Soehle M, Pickard JD, Kirkpatrick PJ, Smielewski P (2010), “"Optimal cerebral perfusion pressure" in poor grade patients after subarachnoid hemorrhage.” Neurocrit Care 13(1):17-23 Details Brady K, Joshi B, Zweifel C, Smielewski P, Czosnyka M, Easley RB, Hogue CW Jr (2010), “Real-time continuous monitoring of cerebral blood flow autoregulation using near-infrared spectroscopy in patients undergoing cardiopulmonary bypass.” Stroke 41(9):1951-6 Details Brady KM, Mytar JO, Kibler KK, Hogue CW Jr, Lee JK, Czosnyka M, Smielewski P, Easley RB (2010), “Noninvasive autoregulation monitoring with and without intracranial pressure in the naive piglet brain.” Anesth Analg 111(1):191-5 Details Carrera E, Kim DJ, Castellani G, Zweifel C, Czosnyka Z, Kasparowicz M, Smielewski P, Pickard JD, Czosnyka M (2010), “What shapes pulse amplitude of intracranial pressure?” J Neurotrauma 27(2):317-24 Details Diedler J, Czosnyka M (2010), “Merits and pitfalls of multimodality brain monitoring.” Neurocrit Care 12(3):313-6 Details Joshi B, Brady K, Lee J, Easley B, Panigrahi R, Smielewski P, Czosnyka M, Hogue CW Jr (2010), “Impaired autoregulation of cerebral blood flow during rewarming from hypothermic cardiopulmonary bypass and its potential association with stroke.” Anesth Analg 110(2):321-8 Details Kasprowicz M, Asgari S, Bergsneider M, Czosnyka M, Hamilton R, Hu X (2010), “Pattern recognition of overnight intracranial pressure slow waves using morphological features of intracranial pressure pulse.” J Neurosci Methods 190(2):310-8 Details Kasprowicz M, Schmidt E, Kim DJ, Haubrich C, Czosnyka Z, Smielewski P, Czosnyka M (2010), “Evaluation of the cerebrovascular pressure reactivity index using non-invasive finapres arterial blood pressure.” Physiol Meas 31(9):1217-28 Details Kim DJ, Carrera E, Czosnyka M, Keong N, Smielewski P, Balédent O, Sutcliffe MP, Pickard JD, Czosnyka Z (2010), “Cerebrospinal compensation of pulsating cerebral blood volume in hydrocephalus.” Neurol Res 32(6):587-92 Details Li LM, Timofeev I, Czosnyka M, Hutchinson PJ (2010), “Review article: the surgical approach to the management of increased intracranial pressure after traumatic brain injury.” Anesth Analg 111(3):736-48 Details Radolovich DK, Czosnyka M, Timofeev I, Lavinio A, Kim DJ, Jaeger M, Hutchinson P, Gupta A, Pickard JD, Smielewski P (2010), “Transient changes in brain tissue oxygen in response to modifications of cerebral perfusion pressure: an observational study.” Anesth Analg 110(1):165-73 Details Reinhard M, Neunhoeffer F, Gerds TA, Niesen WD, Buttler KJ, Timmer J, Schmidt B, Czosnyka M, Weiller C, Hetzel A (2010), “Secondary decline of cerebral autoregulation is associated with worse outcome after intracerebral hemorrhage.” Intensive Care Med 36(2):264-71 Details Weerakkody RA, Czosnyka M, Zweifel C, Castellani G, Smielewski P, Keong N, Haubrich C, Pickard J, Czosnyka Z (2010), “Slow vasogenic fluctuations of intracranial pressure and cerebral near infrared spectroscopy--an observational study.” Acta Neurochir (Wien) 152(10):1763-9 Details Zweifel C, Castellani G, Czosnyka M, Carrera E, Brady KM, Kirkpatrick PJ, Pickard JD, Smielewski P (2010), “Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage.” Stroke 41(9):1963-8 Details Zweifel C, Castellani G, Czosnyka M, Helmy A, Manktelow A, Carrera E, Brady KM, Hutchinson PJ, Menon DK, Pickard JD, Smielewski P (2010), “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients.” J Neurotrauma 27(11):1951-8 Details Zweifel C, Czosnyka M, Lavinio A, Castellani G, Kim DJ, Carrera E, Pickard JD, Kirkpatrick PJ, Smielewski P (2010), “A comparison study of cerebral autoregulation assessed with transcranial Doppler and cortical laser Doppler flowmetry.” Neurol Res 32(4):425-8 Details 2009Brady KM, Lee JK, Kibler KK, Easley RB, Koehler RC, Czosnyka M, Smielewski P, Shaffner DH (2009), “The lower limit of cerebral blood flow autoregulation is increased with elevated intracranial pressure.” Anesth Analg 108(4):1278-83 Details Brady KM, Shaffner DH, Lee JK, Easley RB, Smielewski P, Czosnyka M, Jallo GI, Guerguerian AM (2009), “Continuous monitoring of cerebrovascular pressure reactivity after traumatic brain injury in children.” Pediatrics 124(6):e1205-12 Details Castellani G, Zweifel C, Kim DJ, Carrera E, Radolovich DK, Smielewski P, Hutchinson PJ, Pickard JD, Czosnyka M (2009), “Plateau waves in head injured patients requiring neurocritical care.” Neurocrit Care 11(2):143-50 Details Kim DJ, Czosnyka Z, Keong N, Radolovich DK, Smielewski P, Sutcliffe MP, Pickard JD, Czosnyka M (2009), “Index of cerebrospinal compensatory reserve in hydrocephalus.” Neurosurgery 64(3):494-501; discussion 501-2 Details Kim DJ, Kasprowicz M, Carrera E, Castellani G, Zweifel C, Lavinio A, Smielewski P, Sutcliffe MP, Pickard JD, Czosnyka M (2009), “The monitoring of relative changes in compartmental compliances of brain.” Physiol Meas 30(7):647-59 Details Lee JK, Kibler KK, Benni PB, Easley RB, Czosnyka M, Smielewski P, Koehler RC, Shaffner DH, Brady KM (2009), “Cerebrovascular reactivity measured by near-infrared spectroscopy.” Stroke 40(5):1820-6 Details López-Magaña JA, Richards HK, Radolovich DK, Kim DJ, Smielewski P, Kirkpatrick PJ, Pickard JD, Czosnyka M (2009), “Critical closing pressure: comparison of three methods.” J Cereb Blood Flow Metab 29(5):987-93 Details Petrella G, Czosnyka M, Smielewski P, Allin D, Guazzo EP, Pickard JD, Czosnyka ZH (2009), “In vivo assessment of hydrocephalus shunt.” Acta Neurol Scand 120(5):317-23 Details Radolovich DK, Czosnyka M, Timofeev I, Lavinio A, Hutchinson P, Gupta A, Pickard JD, Smielewski P (2009), “Reactivity of brain tissue oxygen to change in cerebral perfusion pressure in head injured patients.” Neurocrit Care 10(3):274-9 Details Schmidt B, Klingelhöfer J, Perkes I, Czosnyka M (2009), “Cerebral autoregulatory response depends on the direction of change in perfusion pressure.” J Neurotrauma 26(5):651-6 Details Stoquart-Elsankari S, Lehmann P, Villette A, Czosnyka M, Meyer ME, Deramond H, Balédent O (2009), “A phase-contrast MRI study of physiologic cerebral venous flow.” J Cereb Blood Flow Metab 29(6):1208-15 Details Tseng MY, Hutchinson PJ, Richards HK, Czosnyka M, Pickard JD, Erber WN, Brown S, Kirkpatrick PJ (2009), “Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: a Phase II randomized, double-blind, placebo-controlled trial. Clinical article.” J Neurosurg 111(1):171-80 Details 2008Allin DM, Czosnyka M, Richards HK, Pickard JD, Czosnyka ZH (2008), “Investigation of the hydrodynamic properties of a new MRI-resistant programmable hydrocephalus shunt.” Cerebrospinal Fluid Res 5:8 Details Czosnyka M, Radolovich D, Balestreri M, Lavinio A, Hutchinson P, Timofeev I, Smielewski P, Pickard JD (2008), “Gender-related differences in intracranial hypertension and outcome after traumatic brain injury.” Acta Neurochir Suppl 102:25-8 Details Czosnyka M, Smielewski P, Lavinio A, Pickard JD, Panerai R (2008), “An assessment of dynamic autoregulation from spontaneous fluctuations of cerebral blood flow velocity: a comparison of two models, index of autoregulation and mean flow index.” Anesth Analg 106(1):234-9, table of contents Details Czosnyka Z, Czosnyka M, Lavinio A, Keong N, Pickard JD (2008), “Clinical testing of CSF circulation.” Eur J Anaesthesiol Suppl 42:142-5 Details Czosnyka Z, Keong N, Kim DJ, Radolovich D, Smielewski P, Lavinio A, Schmidt EA, Momjian S, Owler B, Pickard JD, Czosnyka M (2008), “Pulse amplitude of intracranial pressure waveform in hydrocephalus.” Acta Neurochir Suppl 102:137-40 Details Hu K, Peng CK, Czosnyka M, Zhao P, Novak V (2008), “Nonlinear assessment of cerebral autoregulation from spontaneous blood pressure and cerebral blood flow fluctuations.” Cardiovasc Eng 8(1):60-71 Details Lavinio A, Czosnyka Z, Czosnyka M (2008), “Cerebrospinal fluid dynamics: disturbances and diagnostics.” Eur J Anaesthesiol Suppl 42:137-41 Details Lavinio A, Ene-Iordache B, Nodari I, Girardini A, Cagnazzi E, Rasulo F, Smielewski P, Czosnyka M, Latronico N (2008), “Cerebrovascular reactivity and autonomic drive following traumatic brain injury.” Acta Neurochir Suppl 102:3-7 Details Narayanan N, Leffler CW, Czosnyka M, Daley ML (2008), “Assessment of cerebrovascular resistance with model of cerebrovascular pressure transmission.” Acta Neurochir Suppl 102:37-41 Details Pickard JD, Czosnyka Z, Czosnyka M, Owler B, Higgins JN (2008), “Coupling of sagittal sinus pressure and cerebrospinal fluid pressure in idiopathic intracranial hypertension--a preliminary report.” Acta Neurochir Suppl 102:283-5 Details Schmidt B, Weinhold M, Czosnyka M, May SA, Steinmeier R, Klingelhöfer J (2008), “Accuracy of non-invasive ICP assessment can be increased by an initial individual calibration.” Acta Neurochir Suppl 102:49-52 Details Schuhmann MU, Sood S, McAllister JP, Jaeger M, Ham SD, Czosnyka Z, Czosnyka M (2008), “Value of overnight monitoring of intracranial pressure in hydrocephalic children.” Pediatr Neurosurg 44(4):269-79 Details Smielewski P, Lavinio A, Timofeev I, Radolovich D, Perkes I, Pickard JD, Czosnyka M (2008), “ICM+, a flexible platform for investigations of cerebrospinal dynamics in clinical practice.” Acta Neurochir Suppl 102:145-51 Details Soehle M, Czosnyka M, Chatfield DA, Hoeft A, Peña A (2008), “Variability and fractal analysis of middle cerebral artery blood flow velocity and arterial blood pressure in subarachnoid hemorrhage.” J Cereb Blood Flow Metab 28(1):64-73 Details Timofeev I, Czosnyka M, Nortje J, Smielewski P, Kirkpatrick P, Gupta A, Hutchinson P (2008), “Effect of decompressive craniectomy on intracranial pressure and cerebrospinal compensation following traumatic brain injury.” J Neurosurg 108(1):66-73 Details Timofeev I, Dahyot-Fizelier C, Keong N, Nortje J, Al-Rawi PG, Czosnyka M, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ (2008), “Ventriculostomy for control of raised ICP in acute traumatic brain injury.” Acta Neurochir Suppl 102:99-104 Details Turalska M, Latka M, Czosnyka M, Pierzchala K, West BJ (2008), “Generation of very low frequency cerebral blood flow fluctuations in humans.” Acta Neurochir Suppl 102:43-7 Details 2007Brady KM, Lee JK, Kibler KK, Smielewski P, Czosnyka M, Easley RB, Koehler RC, Shaffner DH (2007), “Continuous time-domain analysis of cerebrovascular autoregulation using near-infrared spectroscopy.” Stroke 38(10):2818-25 Details Bromby A, Czosnyka Z, Allin D, Richards HK, Pickard JD, Czosnyka M (2007), “Laboratory study on "intracranial hypotension" created by pumping the chamber of a hydrocephalus shunt.” Cerebrospinal Fluid Res 4:2 Details Czosnyka M, Czosnyka Z, Keong N, Lavinio A, Smielewski P, Momjian S, Schmidt EA, Petrella G, Owler B, Pickard JD (2007), “Pulse pressure waveform in hydrocephalus: what it is and what it isn't.” Neurosurg Focus 22(4):E2 Details Czosnyka M, Smielewski P, Lavinio A, Czosnyka Z, Pickard JD (2007), “A synopsis of brain pressures: which? when? are they all useful?” Neurol Res 29(7):672-9 Details Czosnyka M, Smielewski P, Timofeev I, Lavinio A, Guazzo E, Hutchinson P, Pickard JD (2007), “Intracranial pressure: more than a number.” Neurosurg Focus 22(5):E10 Details Eide PK, Czosnyka M, Sorteberg W, Pickard JD, Smielewski P (2007), “Association between intracranial, arterial pulse pressure amplitudes and cerebral autoregulation in head injury patients.” Neurol Res 29(6):578-82 Details Eklund A, Smielewski P, Chambers I, Alperin N, Malm J, Czosnyka M, Marmarou A (2007), “Assessment of cerebrospinal fluid outflow resistance.” Med Biol Eng Comput 45(8):719-35 Details Haubrich C, Czosnyka Z, Lavinio A, Smielewski P, Diehl RR, Pickard JD, Czosnyka M (2007), “Is there a direct link between cerebrovascular activity and cerebrospinal fluid pressure-volume compensation?” Stroke 38(10):2677-80 Details Lavinio A, Schmidt EA, Haubrich C, Smielewski P, Pickard JD, Czosnyka M (2007), “Noninvasive evaluation of dynamic cerebrovascular autoregulation using Finapres plethysmograph and transcranial Doppler.” Stroke 38(2):402-4 Details Lavinio A, Timofeev I, Nortje J, Outtrim J, Smielewski P, Gupta A, Hutchinson PJ, Matta BF, Pickard JD, Menon D, Czosnyka M (2007), “Cerebrovascular reactivity during hypothermia and rewarming.” Br J Anaesth 99(2):237-44 Details Lewis PM, Smielewski P, Pickard JD, Czosnyka M (2007), “Slow oscillations in middle cerebral artery cerebral blood flow velocity and aging.” Neurol Res 29(3):260-3 Details Lewis PM, Smielewski P, Pickard JD, Czosnyka M (2007), “Dynamic cerebral autoregulation: should intracranial pressure be taken into account?” Acta Neurochir (Wien) 149(6):549-55; discussion 555 Details Soehle M, Chatfield DA, Czosnyka M, Kirkpatrick PJ (2007), “Predictive value of initial clinical status, intracranial pressure and transcranial Doppler pulsatility after subarachnoid haemorrhage.” Acta Neurochir (Wien) 149(6):575-83 Details Tseng MY, Al-Rawi PG, Czosnyka M, Hutchinson PJ, Richards H, Pickard JD, Kirkpatrick PJ (2007), “Enhancement of cerebral blood flow using systemic hypertonic saline therapy improves outcome in patients with poor-grade spontaneous subarachnoid hemorrhage.” J Neurosurg 107(2):274-82 Details Tseng MY, Hutchinson PJ, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2007), “Effects of acute pravastatin treatment on intensity of rescue therapy, length of inpatient stay, and 6-month outcome in patients after aneurysmal subarachnoid hemorrhage.” Stroke 38(5):1545-50 Details Tseng MY, Hutchinson PJ, Turner CL, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2007), “Biological effects of acute pravastatin treatment in patients after aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled trial.” J Neurosurg 107(6):1092-100 Details 2006Allin DM, Czosnyka ZH, Czosnyka M, Richards HK, Pickard JD (2006), “In vitro hydrodynamic properties of the Miethke ProGAV hydrocephalus shunt.” Cerebrospinal Fluid Res 3:9 Details Balestreri M, Czosnyka M, Hutchinson P, Steiner LA, Hiler M, Smielewski P, Pickard JD (2006), “Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury.” Neurocrit Care 4(1):8-13 Details Czosnyka M, Hutchinson PJ, Balestreri M, Hiler M, Smielewski P, Pickard JD (2006), “Monitoring and interpretation of intracranial pressure after head injury.” Acta Neurochir Suppl 96:114-8 Details Daley ML, Leffler CW, Czosnyka M, Pickard JD (2006), “Intracranial pressure monitoring: modeling cerebrovascular pressure transmission.” Acta Neurochir Suppl 96:103-7 Details Guendling K, Smielewski P, Czosnyka M, Lewis P, Nortje J, Timofeev I, Hutchinson PJ, Pickard JD (2006), “Use of ICM+ software for on-line analysis of intracranial and arterial pressures in head-injured patients.” Acta Neurochir Suppl 96:108-13 Details Hiler M, Czosnyka M, Hutchinson P, Balestreri M, Smielewski P, Matta B, Pickard JD (2006), “Predictive value of initial computerized tomography scan, intracranial pressure, and state of autoregulation in patients with traumatic brain injury.” J Neurosurg 104(5):731-7 Details Hu X, Nenov V, Glenn TC, Steiner LA, Czosnyka M, Bergsneider M, Martin N (2006), “Nonlinear analysis of cerebral hemodynamic and intracranial pressure signals for characterization of autoregulation.” IEEE Trans Biomed Eng 53(2):195-209 Details Hutchinson PJ, Corteen E, Czosnyka M, Mendelow AD, Menon DK, Mitchell P, Murray G, Pickard JD, Rickels E, Sahuquillo J, Servadei F, Teasdale GM, Timofeev I, Unterberg A, Kirkpatrick PJ (2006), “Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com).” Acta Neurochir Suppl 96:17-20 Details Hutchinson PJ, Gimson A, Al-Rawi PG, O'Connell MT, Czosnyka M, Menon DK (2006), “Microdialysis in the management of hepatic encephalopathy.” Neurocrit Care 5(3):202-5 Details Pickard JD, Spiegelhalter D, Czosnyka M (2006), “Health economics and the search for shunt-responsive symptomatic hydrocephalus in the elderly.” J Neurosurg 105(6):811-3; discussion 813-4 Details Timofeev I, Kirkpatrick PJ, Corteen E, Hiler M, Czosnyka M, Menon DK, Pickard JD, Hutchinson PJ (2006), “Decompressive craniectomy in traumatic brain injury: outcome following protocol-driven therapy.” Acta Neurochir Suppl 96:11-6 Details Tseng MY, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2006), “Effects of acute treatment with statins on cerebral autoregulation in patients after aneurysmal subarachnoid hemorrhage.” Neurosurg Focus 21(3):E10 Details 2005Balestreri M, Czosnyka M, Steiner LA, Hiler M, Schmidt EA, Matta B, Menon D, Hutchinson P, Pickard JD (2005), “Association between outcome, cerebral pressure reactivity and slow ICP waves following head injury.” Acta Neurochir Suppl 95:25-8 Details Bech-Azeddine R, Gjerris F, Waldemar G, Czosnyka M, Juhler M (2005), “Intraventricular or lumbar infusion test in adult communicating hydrocephalus? Practical consequences and clinical outcome of shunt operation.” Acta Neurochir (Wien) 147(10):1027-35; discussion 1035-6 Details Czosnyka M, Balestreri M, Steiner L, Smielewski P, Hutchinson PJ, Matta B, Pickard JD (2005), “Age, intracranial pressure, autoregulation, and outcome after brain trauma.” J Neurosurg 102(3):450-4 Details Czosnyka M, Steiner L, Balestreri M, Schmidt E, Smielewski P, Hutchinson PJ, Pickard JD (2005), “Concept of "true ICP" in monitoring and prognostication in head trauma.” Acta Neurochir Suppl 95:341-4 Details Czosnyka Z, Czosnyka M, Owler B, Momjian S, Kasprowicz M, Schmidt EA, Smielewski P, Pickard JD (2005), “Clinical testing of CSF circulation in hydrocephalus.” Acta Neurochir Suppl 95:247-51 Details Czosnyka Z, Czosnyka M, Pickard JD (2005), “CSF pulse pressure and B waves.” J Neurosurg 103(4):767-8; author reply 768 Details Czosnyka Z, van den Boogaard F, Czosnyka M, Momjian S, Gelling L, Pickard JD (2005), “The relationship between CSF circulation and cerebrovascular pressure-reactivity in normal pressure hydrocephalus.” Acta Neurochir Suppl 95:207-11 Details Czosnyka ZH, Cieslicki K, Czosnyka M, Pickard JD (2005), “Hydrocephalus shunts and waves of intracranial pressure.” Med Biol Eng Comput 43(1):71-7 Details Czosnyka ZH, Czosnyka M, Richards HK, Pickard JD (2005), “Evaluation of three new models of hydrocephalus shunts.” Acta Neurochir Suppl 95:223-7 Details Daley ML, Leffler CW, Czosnyka M, Pickard JD (2005), “Plateau waves: changes of cerebrovascular pressure transmission.” Acta Neurochir Suppl 95:327-32 Details Juniewicz H, Kasprowicz M, Czosnyka M, Czosnyka Z, Gizewski S, Dzik M, Pickard JD (2005), “Analysis of intracranial pressure during and after the infusion test in patients with communicating hydrocephalus.” Physiol Meas 26(6):1039-48 Details Kumar A, Schmidt EA, Hiler M, Smielewski P, Pickard JD, Czosnyka M (2005), “Asymmetry of critical closing pressure following head injury.” J Neurol Neurosurg Psychiatry 76(11):1570-3 Details Pickard JD, Coleman MR, Czosnyka M (2005), “Hydrocephalus, ventriculomegaly and the vegetative state: a review.” Neuropsychol Rehabil 15(3-4):224-36 Details Pickard JD, Hutchinson PJ, Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smielewski P, Chatfield DA, Aigbirhio F, Williams GB, Rice K, Clark JC, Salmond CH, Sahakian BJ, Bradley PG, Carpenter TA, Salvador R, Pena A, Gillard JH, Cunningham AS, Piechnik S, Czosnyka M, Menon DK (2005), “Imaging of cerebral blood flow and metabolism in brain injury in the ICU.” Acta Neurochir Suppl 95:459-64 Details Reinhard M, Roth M, Guschlbauer B, Harloff A, Timmer J, Czosnyka M, Hetzel A (2005), “Dynamic cerebral autoregulation in acute ischemic stroke assessed from spontaneous blood pressure fluctuations.” Stroke 36(8):1684-9 Details Schmidt B, Bocklisch SF, Pässler M, Czosnyka M, Schwarze JJ, Klingelhöfer J (2005), “Fuzzy pattern classification of hemodynamic data can be used to determine noninvasive intracranial pressure.” Acta Neurochir Suppl 95:345-9 Details Schmidt EA, Czosnyka Z, Momjian S, Czosnyka M, Bech RA, Pickard JD (2005), “Intracranial baroreflex yielding an early cushing response in human.” Acta Neurochir Suppl 95:253-6 Details Smielewski P, Czosnyka M, Steiner L, Belestri M, Piechnik S, Pickard JD (2005), “ICM+: software for on-line analysis of bedside monitoring data after severe head trauma.” Acta Neurochir Suppl 95:43-9 Details Steiner LA, Balestreri M, Johnston AJ, Coles JP, Chatfield DA, Pickard JD, Menon DK, Czosnyka M (2005), “Effects of moderate hyperventilation on cerebrovascular pressure-reactivity after head injury.” Acta Neurochir Suppl 95:17-20 Details Steiner LA, Balestreri M, Johnston AJ, Coles JP, Smielewski P, Pickard JD, Menon DK, Czosnyka M (2005), “Predicting the response of intracranial pressure to moderate hyperventilation.” Acta Neurochir (Wien) 147(5):477-83; discussion 483 Details Tseng MY, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2005), “Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial.” Stroke 36(8):1627-32 Details 2004Balestreri M, Czosnyka M, Chatfield DA, Steiner LA, Schmidt EA, Smielewski P, Matta B, Pickard JD (2004), “Predictive value of Glasgow Coma Scale after brain trauma: change in trend over the past ten years.” J Neurol Neurosurg Psychiatry 75(1):161-2 Details Balestreri M, Czosnyka M, Steiner LA, Schmidt E, Smielewski P, Matta B, Pickard JD (2004), “Intracranial hypertension: what additional information can be derived from ICP waveform after head injury?” Acta Neurochir (Wien) 146(2):131-41 Details Czosnyka M, Czosnyka Z, Momjian S, Pickard JD (2004), “Cerebrospinal fluid dynamics.” Physiol Meas 25(5):R51-76 Details Czosnyka M, Pickard JD (2004), “Monitoring and interpretation of intracranial pressure.” J Neurol Neurosurg Psychiatry 75(6):813-21 Details Czosnyka M, Richards HK, Czosnyka Z, Pickard JD (2004), “Normal-pressure hydrocephalus.” J Neurosurg 101(6):1083-4; author reply 1084 Details Kasprowicz M, Czosnyka Z, Czosnyka M, Momjian S, Juniewicz H, Pickard JD (2004), “Slight elevation of baseline intracranial pressure after fluid infusion into CSF space in patients with hydrocephalus.” Neurol Res 26(6):628-31 Details Kasprowicz M, Koszewski W, Juniewicz H, Czosnyka M (2004), “[Modeling of cerebrospinal fluid circulation with consideration of a pressure-volume curve in infusion tests of patients with suspected hydrocephalus. Preliminary report].” Neurol Neurochir Pol 38(2):109-14; discussion 115 Details Minhas PS, Smielewski P, Kirkpatrick PJ, Pickard JD, Czosnyka M (2004), “Pressure autoregulation and positron emission tomography-derived cerebral blood flow acetazolamide reactivity in patients with carotid artery stenosis.” Neurosurgery 55(1):63-7; discussion 67-8 Details Momjian S, Czosnyka Z, Czosnyka M, Pickard JD (2004), “Link between vasogenic waves of intracranial pressure and cerebrospinal fluid outflow resistance in normal pressure hydrocephalus.” Br J Neurosurg 18(1):56-61 Details Momjian S, Owler BK, Czosnyka Z, Czosnyka M, Pena A, Pickard JD (2004), “Pattern of white matter regional cerebral blood flow and autoregulation in normal pressure hydrocephalus.” Brain 127(Pt 5):965-72 Details Owler BK, Momjian S, Czosnyka Z, Czosnyka M, Péna A, Harris NG, Smielewski P, Fryer T, Donovan T, Coles J, Carpenter A, Pickard JD (2004), “Normal pressure hydrocephalus and cerebral blood flow: a PET study of baseline values.” J Cereb Blood Flow Metab 24(1):17-23 Details Owler BK, Pena A, Momjian S, Czosnyka Z, Czosnyka M, Harris NG, Smielewski P, Fryer T, Donvan T, Carpenter A, Pickard JD (2004), “Changes in cerebral blood flow during cerebrospinal fluid pressure manipulation in patients with normal pressure hydrocephalus: a methodological study.” J Cereb Blood Flow Metab 24(5):579-87 Details Reinhard M, Roth M, Müller T, Guschlbauer B, Timmer J, Czosnyka M, Hetzel A (2004), “Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation.” Stroke 35(6):1381-7 Details Soehle M, Czosnyka M, Pickard JD, Kirkpatrick PJ (2004), “Critical closing pressure in subarachnoid hemorrhage: effect of cerebral vasospasm and limitations of a transcranial Doppler-derived estimation.” Stroke 35(6):1393-8 Details Soehle M, Czosnyka M, Pickard JD, Kirkpatrick PJ (2004), “Continuous assessment of cerebral autoregulation in subarachnoid hemorrhage.” Anesth Analg 98(4):1133-9, table of contents Details Steiner LA, Balestreri M, Johnston AJ, Czosnyka M, Coles JP, Chatfield DA, Smielewski P, Pickard JD, Menon DK (2004), “Sustained moderate reductions in arterial CO2 after brain trauma time-course of cerebral blood flow velocity and intracranial pressure.” Intensive Care Med 30(12):2180-7 Details Steiner LA, Johnston AJ, Czosnyka M, Chatfield DA, Salvador R, Coles JP, Gupta AK, Pickard JD, Menon DK (2004), “Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients.” Crit Care Med 32(4):1049-54 Details 2003Balestreri M, Steiner LA, Czosnyka M (2003), “Sex-related differences and traumatic brain injury.” J Neurosurg 99(3):616; author reply 616-7 Details Czosnyka M, Czosnyka Z, Momjian S, Schmidt E (2003), “Calculation of the resistance to CSF outflow.” J Neurol Neurosurg Psychiatry 74(9):1354; author reply 1354-5 Details Czosnyka M, Czosnyka Z, Schmidt EA, Momjian S (2003), “Cerebrospinal fluid production.” J Neurosurg 99(1):206-7; author reply 207 Details Czosnyka M, Czosnyka ZH, Richards HK, Pickard JD (2003), “Hydrodynamic properties of extraventricular drainage systems.” Neurosurgery 52(3):619-23; discussion 623 Details Czosnyka M, Smielewski P, Czosnyka Z, Piechnik S, Steiner LA, Schmidt E, Gooskens I, Soehle M, Lang EW, Matta BF, Pickard JD (2003), “Continuous assessment of cerebral autoregulation: clinical and laboratory experience.” Acta Neurochir Suppl 86:581-5 Details Gooskens I, Schmidt EA, Czosnyka M, Piechnik SK, Smielewski P, Kirkpatrick PJ, Pickard JD (2003), “Pressure-autoregulation, CO2 reactivity and asymmetry of haemodynamic parameters in patients with carotid artery stenotic disease. A clinical appraisal.” Acta Neurochir (Wien) 145(7):527-32; discussion 532 Details Johnston AJ, Czosnyka M (2003), “Measuring cerebral autoregulation in stroke patients.” Stroke 34(6):e39-40; author reply e39-40 Details Kasprowicz M, Czosnyka M, Czosnyka Z, Momjian S, Smielewski P, Juniewicz H, Pickard JD (2003), “Hysteresis of the cerebrospinal pressure-volume curve in hydrocephalus.” Acta Neurochir Suppl 86:529-32 Details Lang EW, Czosnyka M, Mehdorn HM (2003), “Tissue oxygen reactivity and cerebral autoregulation after severe traumatic brain injury.” Crit Care Med 31(1):267-71 Details Minhas PS, Menon DK, Smielewski P, Czosnyka M, Kirkpatrick PJ, Clark JC, Pickard JD (2003), “Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage.” Neurosurgery 52(5):1017-22; discussion 1022-4 Details Reinhard M, Roth M, Müller T, Czosnyka M, Timmer J, Hetzel A (2003), “Cerebral autoregulation in carotid artery occlusive disease assessed from spontaneous blood pressure fluctuations by the correlation coefficient index.” Stroke 34(9):2138-44 Details Schmidt B, Czosnyka M, Raabe A, Yahya H, Schwarze JJ, Sackerer D, Sander D, Klingelhöfer J (2003), “Adaptive noninvasive assessment of intracranial pressure and cerebral autoregulation.” Stroke 34(1):84-9 Details Schmidt EA, Czosnyka M, Steiner LA, Balestreri M, Smielewski P, Piechnik SK, Matta BF, Pickard JD (2003), “Asymmetry of pressure autoregulation after traumatic brain injury.” J Neurosurg 99(6):991-8 Details Schmidt EA, Piechnik SK, Smielewski P, Raabe A, Matta BF, Czosnyka M (2003), “Symmetry of cerebral hemodynamic indices derived from bilateral transcranial Doppler.” J Neuroimaging 13(3):248-54 Details Steiner LA, Coles JP, Czosnyka M, Minhas PS, Fryer TD, Aigbirhio FI, Clark JC, Smielewski P, Chatfield DA, Donovan T, Pickard JD, Menon DK (2003), “Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury.” J Neurol Neurosurg Psychiatry 74(6):765-70 Details Steiner LA, Coles JP, Johnston AJ, Chatfield DA, Smielewski P, Fryer TD, Aigbirhio FI, Clark JC, Pickard JD, Menon DK, Czosnyka M (2003), “Assessment of cerebrovascular autoregulation in head-injured patients: a validation study.” Stroke 34(10):2404-9 Details Steiner LA, Coles JP, Johnston AJ, Czosnyka M, Fryer TD, Smielewski P, Chatfield DA, Salvador R, Aigbirhio FI, Clark JC, Menon DK, Pickard JD (2003), “Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure.” J Cereb Blood Flow Metab 23(11):1371-7 Details Steiner LA, Czosnyka M (2003), “Estimation of critical closing pressure and cerebral perfusion pressure using transcranial Doppler.” Br J Anaesth 90(3):396-7; author reply 396-7 Details Steiner LA, Johnston AJ, Chatfield DA, Czosnyka M, Coleman MR, Coles JP, Gupta AK, Pickard JD, Menon DK (2003), “The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients.” Anesth Analg 97(2):572-6, table of contents Details Steiner LA, Johnston AJ, Salvador R, Czosnyka M, Menon DK (2003), “Validation of a tonometric noninvasive arterial blood pressure monitor in the intensive care setting.” Anaesthesia 58(5):448-54 Details 2002Czosnyka M, Smielewski P, Piechnik S, Pickard JD (2002), “Clinical significance of cerebral autoregulation.” Acta Neurochir Suppl 81:117-9 Details Czosnyka Z, Czosnyka M, Richards HK, Pickard JD (2002), “Laboratory testing of hydrocephalus shunts -- conclusion of the U.K. Shunt evaluation programme.” Acta Neurochir (Wien) 144(6):525-38; discussion 538 Details Czosnyka ZH, Czosnyka M, Pickard JD (2002), “Shunt testing in-vivo: a method based on the data from the UK shunt evaluation laboratory.” Acta Neurochir Suppl 81:27-30 Details Czosnyka ZH, Czosnyka M, Whitfield PC, Donovan T, Pickard JD (2002), “Cerebral autoregulation among patients with symptoms of hydrocephalus.” Neurosurgery 50(3):526-32; discussion 532-3 Details Kett-White R, Hutchinson PJ, Al-Rawi PG, Czosnyka M, Gupta AK, Pickard JD, Kirkpatrick PJ (2002), “Cerebral oxygen and microdialysis monitoring during aneurysm surgery: effects of blood pressure, cerebrospinal fluid drainage, and temporary clipping on infarction.” J Neurosurg 96(6):1013-9 Details Kett-White R, Hutchinson PJ, Czosnyka M, al-Rawi P, Gupta A, Pickard JD, Kirkpatrick PJ (2002), “Effects of variation in cerebral haemodynamics during aneurysm surgery on brain tissue oxygen and metabolism.” Acta Neurochir Suppl 81:327-9 Details Kett-White R, Hutchinson PJ, Czosnyka M, Boniface S, Pickard JD, Kirkpatrick PJ (2002), “Multi-modal monitoring of acute brain injury.” Adv Tech Stand Neurosurg 27:87-134 Details Lang EW, Mehdorn HM, Dorsch NW, Czosnyka M (2002), “Continuous monitoring of cerebrovascular autoregulation: a validation study.” J Neurol Neurosurg Psychiatry 72(5):583-6 Details Peña A, Harris NG, Bolton MD, Czosnyka M, Pickard JD (2002), “Communicating hydrocephalus: the biomechanics of progressive ventricular enlargement revisited.” Acta Neurochir Suppl 81:59-63 Details Peña A, Owler BK, Fryer TD, Minhas P, Czosnyka M, Crawford PJ, Pickard JD (2002), “A case study of hemispatial neglect using finite element analysis and positron emission tomography.” J Neuroimaging 12(4):360-7 Details Piechnik SK, Czosnyka M, Cie?licki K, Cie?la D (2002), “Problems in application of purely linear models in cerebral circulation.” J Biomech 35(4):553-4 Details Schmidt B, Czosnyka M, Klingelhöfer J (2002), “Clinical applications of a non-invasive ICP monitoring method.” Eur J Ultrasound 16(1-2):37-45 Details Schmidt EA, Czosnyka M, Smielewski P, Piechnik SK, Pickard JD (2002), “Asymmetry of cerebral autoregulation following head injury.” Acta Neurochir Suppl 81:133-4 Details Steiner LA, Czosnyka M (2002), “Should we measure cerebral blood flow in head-injured patients?” Br J Neurosurg 16(5):429-39 Details Steiner LA, Czosnyka M (2002), “Assessing drug effects on cerebral autoregulation using the static rate of autoregulation.” Anesth Analg 95(5):1463; author reply 1463-4 Details Steiner LA, Czosnyka M, Piechnik SK, Smielewski P, Chatfield D, Menon DK, Pickard JD (2002), “Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury.” Crit Care Med 30(4):733-8 Details Taylor R, Czosnyka Z, Czosnyka M, Pickard JD (2002), “Factors determining mean ICP in hydrocephalic patients with Hakim-programmable valve: implications of the parallel arrangement of the CSF outflow resistance and shunt.” Acta Neurochir Suppl 81:23-6 Details Taylor R, Czosnyka Z, Czosnyka M, Pickard JD (2002), “A laboratory model of testing shunt performance after implantation.” Br J Neurosurg 16(1):30-5 Details Tisell M, Edsbagge M, Stephensen H, Czosnyka M, Wikkelsø C (2002), “Elastance correlates with outcome after endoscopic third ventriculostomy in adults with hydrocephalus caused by primary aqueductal stenosis.” Neurosurgery 50(1):70-7 Details 2001Czosnyka M (2001), “Pulsatility index.” J Neurosurg 94(4):685-6 Details Czosnyka M, Czosnyka ZH, Whitfield PC, Donovan T, Pickard JD (2001), “Age dependence of cerebrospinal pressure-volume compensation in patients with hydrocephalus.” J Neurosurg 94(3):482-6 Details Czosnyka M, Richards HK (2001), “Transcranial Doppler identification of changing autoregulatory thresholds after autoregulatory impairment.” Neurosurgery 49(6):1484-5 Details Czosnyka M, Smielewski P, Piechnik S, Steiner LA, Pickard JD (2001), “Cerebral autoregulation following head injury.” J Neurosurg 95(5):756-63 Details Czosnyka ZH, Czosnyka M, Richards HK, Pickard JD (2001), “Laboratory evaluation of the phoenix CRx diamond valve.” Neurosurgery 48(3):689-93; discussion 693-4 Details Piechnik SK, Czosnyka M, Harris NG, Minhas PS, Pickard JD (2001), “A model of the cerebral and cerebrospinal fluid circulations to examine asymmetry in cerebrovascular reactivity.” J Cereb Blood Flow Metab 21(2):182-92 Details Piechnik SK, Czosnyka M, Richards HK, Whitfield PC, Pickard JD (2001), “Cerebral venous blood outflow: a theoretical model based on laboratory simulation.” Neurosurgery 49(5):1214-22; discussion 1222-3 Details Schmidt EA, Czosnyka M, Gooskens I, Piechnik SK, Matta BF, Whitfield PC, Pickard JD (2001), “Preliminary experience of the estimation of cerebral perfusion pressure using transcranial Doppler ultrasonography.” J Neurol Neurosurg Psychiatry 70(2):198-204 Details Whitfield PC, Kirkpatrick PJ, Czosnyka M, Pickard JD (2001), “Management of severe traumatic brain injury by decompressive craniectomy.” Neurosurgery 49(1):225-6 Details Whitfield PC, Patel H, Hutchinson PJ, Czosnyka M, Parry D, Menon D, Pickard JD, Kirkpatrick PJ (2001), “Bifrontal decompressive craniectomy in the management of posttraumatic intracranial hypertension.” Br J Neurosurg 15(6):500-7 Details 2000Czosnyka M (2000), “Association between arterial and intracranial pressures.” Br J Neurosurg 14(2):127-8 Details Czosnyka M, Copeman J, Czosnyka Z, McConnell R, Dickinson C, Pickard JD (2000), “Post-traumatic hydrocephalus: influence of craniectomy on the CSF circulation.” J Neurol Neurosurg Psychiatry 68(2):246-8 Details Czosnyka M, Smielewski P, Piechnik S, Schmidt EA, Seeley H, al-Rawi P, Matta BF, Kirkpatrick PJ, Pickard JD (2000), “Continuous assessment of cerebral autoregulation--clinical verification of the method in head injured patients.” Acta Neurochir Suppl 76:483-4 Details Czosnyka Z, Czosnyka M, Copeman J, Pickard JD (2000), “A randomized, controlled study of a programmable shunt valve versus a conventional valve for patients with hydrocephalus.” Neurosurgery 47(5):1250-1 Details Laing RJ, Smielewski P, Czosnyka M, Quaranta N, Moffat DA (2000), “A study of perioperative lumbar cerebrospinal fluid pressure in patients undergoing acoustic neuroma surgery.” Skull Base Surg 10(4):179-85 Details Lam JM, Smielewski P, Czosnyka M, Pickard JD, Kirkpatrick PJ (2000), “Predicting delayed ischemic deficits after aneurysmal subarachnoid hemorrhage using a transient hyperemic response test of cerebral autoregulation.” Neurosurgery 47(4):819-25; discussions 825-6 Details Schmidt B, Czosnyka M, Schwarze JJ, Sander D, Gerstner W, Lumenta CB, Klingelhöfer J (2000), “Evaluation of a method for noninvasive intracranial pressure assessment during infusion studies in patients with hydrocephalus.” J Neurosurg 92(5):793-800 Details Schmidt EA, Czosnyka M, Matta BF, Gooskens I, Piechnik S, Pickard JD (2000), “Non-invasive cerebral perfusion pressure (nCPP): evaluation of the monitoring methodology in head injured patients.” Acta Neurochir Suppl 76:451-2 Details 1999Czosnyka M, Richards HK, Czosnyka Z, Piechnik S, Pickard JD, Chir M (1999), “Vascular components of cerebrospinal fluid compensation.” J Neurosurg 90(4):752-9 Details Czosnyka M, Smielewski P, Piechnik S, Al-Rawi PG, Kirkpatrick PJ, Matta BF, Pickard JD (1999), “Critical closing pressure in cerebrovascular circulation.” J Neurol Neurosurg Psychiatry 66(5):606-11 Details Czosnyka M, Smielewski P, Piechnik S, Schmidt EA, Al-Rawi PG, Kirkpatrick PJ, Pickard JD (1999), “Hemodynamic characterization of intracranial pressure plateau waves in head-injury patients.” J Neurosurg 91(1):11-9 Details Czosnyka Z, Czosnyka M, Pickard JD (1999), “Hydrodynamic performance of a new siphon preventing device: the SiphonGuard.” J Neurol Neurosurg Psychiatry 66(3):408-9 Details Iddon JL, Pickard JD, Cross JJ, Griffiths PD, Czosnyka M, Sahakian BJ (1999), “Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study.” J Neurol Neurosurg Psychiatry 67(6):723-32 Details Piechnik SK, Yang X, Czosnyka M, Smielewski P, Fletcher SH, Jones AL, Pickard JD (1999), “The continuous assessment of cerebrovascular reactivity: a validation of the method in healthy volunteers.” Anesth Analg 89(4):944-9 Details Raabe A, Czosnyka M, Piper I, Seifert V (1999), “Monitoring of intracranial compliance: correction for a change in body position.” Acta Neurochir (Wien) 141(1):31-6; discussion 35-6 Details Richards HK, Czosnyka M, Pickard JD (1999), “Assessment of critical closing pressure in the cerebral circulation as a measure of cerebrovascular tone.” Acta Neurochir (Wien) 141(11):1221-7 discussion 1226-7 Details Schmidt B, Czosnyka M, Schwarze JJ, Sander D, Gerstner W, Lumenta CB, Pickard JD, Klingelhöfer J (1999), “Cerebral vasodilatation causing acute intracranial hypertension: a method for noninvasive assessment.” J Cereb Blood Flow Metab 19(9):990-6 Details Williams EJ, Bunch CS, Carpenter TA, Downey SP, Kendall IV, Czosnyka M, Pickard JD, Martin J, Menon DK (1999), “Magnetic resonance imaging compatibility testing of intracranial pressure probes. Technical note.” J Neurosurg 91(4):706-9 Details 1998Czosnyka M, Matta BF, Smielewski P, Kirkpatrick PJ, Pickard JD (1998), “Cerebral perfusion pressure in head-injured patients: a noninvasive assessment using transcranial Doppler ultrasonography.” J Neurosurg 88(5):802-8 Details Czosnyka M, Smielewski P, Kirkpatrick P, Piechnik S, Laing R, Pickard JD (1998), “Continuous monitoring of cerebrovascular pressure-reactivity in head injury.” Acta Neurochir Suppl 71:74-7 Details Czosnyka Z, Czosnyka M, Richards H, Pickard JD (1998), “Hydrodynamic properties of hydrocephalus shunts.” Acta Neurochir Suppl 71:334-9 Details Czosnyka Z, Czosnyka M, Richards H, Pickard JD (1998), “Chhabra hydrocephalus shunt: lessons for gravitational valves.” J Neurol Neurosurg Psychiatry 65(3):406-7 Details Czosnyka Z, Czosnyka M, Richards HK, Pickard JD (1998), “Posture-related overdrainage: comparison of the performance of 10 hydrocephalus shunts in vitro.” Neurosurgery 42(2):327-33; discussion 333-4 Details Kirkpatrick PJ, Lam J, Al-Rawi P, Smielewski P, Czosnyka M (1998), “Defining thresholds for critical ischemia by using near-infrared spectroscopy in the adult brain.” J Neurosurg 89(3):389-94 Details Kirkpatrick PJ, Smielewski P, Al-Rawi P, Czosnyka M (1998), “Resolving extra- and intracranial signal changes during adult near infrared spectroscopy.” Neurol Res 20 Suppl 1:S19-22 Details Minhas PS, Smielewski P, Czosnyka M, Kirkpatrick PJ (1998), “Preoperative carbon dioxide reactivity studies do not predict the hemodynamic changes seen during carotid endarterectomy after internal carotid artery clamping.” J Stroke Cerebrovasc Dis 7(1):44-51 Details Piechnik S, Czosnyka M, Smielewski P, Pickard JD (1998), “Indices for decreased cerebral blood flow control--a modelling study.” Acta Neurochir Suppl 71:269-71 Details Price DJ, Saxena A, Czosnyka M (1998), “The relationship of vasogenic waves to ICP and cerebral perfusion pressure in head injured patients.” Acta Neurochir Suppl 71:297-9 Details Raabe A, Menon DK, Gupta S, Czosnyka M, Pickard JD (1998), “Jugular venous and arterial concentrations of serum S-100B protein in patients with severe head injury: a pilot study.” J Neurol Neurosurg Psychiatry 65(6):930-2 Details Richards HK, Czosnyka M, Whitehouse H, Pickard JD (1998), “Increase in transcranial Doppler pulsatility index does not indicate the lower limit of cerebral autoregulation.” Acta Neurochir Suppl 71:229-32 Details Schmidt B, Schwarze JJ, Czosnyka M, Sander D, Wittich I, Klingelhöfer J (1998), “A method for a simulation of continuous intracranial pressure curves.” Comput Biomed Res 31(4):231-43 Details Smielewski P, Czosnyka M, Pickard JD, Kirkpatrick P (1998), “Assessment of cerebrovascular reactivity in patients with carotid artery disease using near-infrared spectroscopy.” Acta Neurochir Suppl 71:263-5 Details 1997Czosnyka M, Czosnyka Z, Pickard JD (1997), “Laboratory testing of the Spiegelberg brain pressure monitor: a technical report.” J Neurol Neurosurg Psychiatry 63(6):732-5 Details Czosnyka M, Czosnyka Z, Whitehouse H, Pickard JD (1997), “Hydrodynamic properties of hydrocephalus shunts: United Kingdom Shunt Evaluation Laboratory.” J Neurol Neurosurg Psychiatry 62(1):43-50 Details Czosnyka M, Piechnik S, Richards HK, Kirkpatrick P, Smielewski P, Pickard JD (1997), “Contribution of mathematical modelling to the interpretation of bedside tests of cerebrovascular autoregulation.” J Neurol Neurosurg Psychiatry 63(6):721-31 Details Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD (1997), “Continuous assessment of the cerebral vasomotor reactivity in head injury.” Neurosurgery 41(1):11-7; discussion 17-9 Details Gupta AK, Menon DK, Czosnyka M, Smielewski P, Jones JG (1997), “Thresholds for hypoxic cerebral vasodilation in volunteers.” Anesth Analg 85(4):817-20 Details Gupta AK, Menon DK, Czosnyka M, Smielewski P, Kirkpatrick PJ, Jones JG (1997), “Non-invasive measurement of cerebral blood volume in volunteers.” Br J Anaesth 78(1):39-43 Details Richards HK, Kozniewska E, Czosnyka M, Pickard JD (1997), “Changes in transcranial Doppler flow velocity waveform following inhibition of nitric oxide synthesis. Experimental study in anaesthetised rabbits.” Acta Neurochir (Wien) 139(1):63-9; discussion 69-70 Details Smielewski P, Czosnyka M, Kirkpatrick P, Pickard JD (1997), “Evaluation of the transient hyperemic response test in head-injured patients.” J Neurosurg 86(5):773-8 Details Smielewski P, Czosnyka M, Pickard JD, Kirkpatrick P (1997), “Clinical evaluation of near-infrared spectroscopy for testing cerebrovascular reactivity in patients with carotid artery disease.” Stroke 28(2):331-8 Details Smielewski P, Czosnyka M, Zabolotny W, Kirkpatrick P, Richards H, Pickard JD (1997), “A computing system for the clinical and experimental investigation of cerebrovascular reactivity.” Int J Clin Monit Comput 14(3):185-98 Details 1996Czosnyka M, Czosnyka Z, Pickard JD (1996), “Laboratory testing of three intracranial pressure microtransducers: technical report.” Neurosurgery 38(1):219-24 Details Czosnyka M, Guazzo E, Whitehouse M, Smielewski P, Czosnyka Z, Kirkpatrick P, Piechnik S, Pickard JD (1996), “Significance of intracranial pressure waveform analysis after head injury.” Acta Neurochir (Wien) 138(5):531-41; discussion 541-2 Details Czosnyka M, Harland S, Piechnik S, Kirkpatrick P, Czosnyka Z, Menon D (1996), “Systematic overestimation of intracranial pressure measured using a Camino pressure monitor.” J Neurol Neurosurg Psychiatry 61(4):427-8 Details Czosnyka M, Kirkpatrick PJ, Pickard JD (1996), “Multimodal monitoring and assessment of cerebral haemodynamic reserve after severe head injury.” Cerebrovasc Brain Metab Rev 8(4):273-95 Details Czosnyka M, Richards HK, Whitehouse HE, Pickard JD (1996), “Relationship between transcranial Doppler-determined pulsatility index and cerebrovascular resistance: an experimental study.” J Neurosurg 84(1):79-84 Details Czosnyka M, Smielewski P, Kirkpatrick P, Menon DK, Pickard JD (1996), “Monitoring of cerebral autoregulation in head-injured patients.” Stroke 27(10):1829-34 Details Czosnyka M, Whitehouse H, Smielewski P, Simac S, Pickard JD (1996), “Testing of cerebrospinal compensatory reserve in shunted and non-shunted patients: a guide to interpretation based on an observational study.” J Neurol Neurosurg Psychiatry 60(5):549-58 Details Kirkpatrick PJ, Czosnyka M, Pickard JD (1996), “Multimodal monitoring in neurointensive care.” J Neurol Neurosurg Psychiatry 60(2):131-9 Details Kirkpatrick PJ, Smielewski P, Piechnik S, Pickard JD, Czosnyka M (1996), “Early effects of mannitol in patients with head injuries assessed using bedside multimodality monitoring.” Neurosurgery 39(4):714-20; discussion 720-1 Details Smielewski P, Czosnyka M, Kirkpatrick P, McEroy H, Rutkowska H, Pickard JD (1996), “Assessment of cerebral autoregulation using carotid artery compression.” Stroke 27(12):2197-203 Details Smielewski P, Kirkpatrick PJ, Richards H, Pickard JD, Czosnyka M (1996), “A feedback-controlled pump produces stable hypotension in anaesthetised rabbits.” J Cereb Blood Flow Metab 16(3):532-6 Details 1995Kirkpatrick PJ, Smielewski P, Czosnyka M, Menon DK, Pickard JD (1995), “Near-infrared spectroscopy use in patients with head injury.” J Neurosurg 83(6):963-70 Details Kirkpatrick PJ, Smielewski P, Whitfield PC, Czosnyka M, Menon D, Pickard JD (1995), “An observational study of near-infrared spectroscopy during carotid endarterectomy.” J Neurosurg 82(5):756-63 Details Richards HK, Czosnyka M, Kirkpatrick PJ, Pickard JD (1995), “Estimation of laser-Doppler flux biological zero using basilar artery flow velocity in the rabbit.” Am J Physiol 268(1 Pt 2):H213-7 Details Smielewski P, Czosnyka M, Iyer V, Piechnik S, Whitehouse H, Pickard J (1995), “Computerised transient hyperaemic response test--a method for the assessment of cerebral autoregulation.” Ultrasound Med Biol 21(5):599-611 Details Smielewski P, Czosnyka M, Roszkowski M, Walencik A (1995), “Identification of the cerebrospinal compensatory mechanisms via computer-controlled drainage of the cerebrospinal fluid.” Childs Nerv Syst 11(5):297-300 Details Smielewski P, Kirkpatrick P, Minhas P, Pickard JD, Czosnyka M (1995), “Can cerebrovascular reactivity be measured with near-infrared spectroscopy?” Stroke 26(12):2285-92 Details Zabolotny W, Czosnyka M, Walencik A (1995), “Cerebrospinal fluid pulse pressure waveform analysis in hydrocephalic children.” Childs Nerv Syst 11(7):397-9 Details 1994Berdyga J, Czernicki Z, Czosnyka M (1994), “[Evaluation of intracranial volume compensation analyzing changes of harmonic components of intracranial pressure pulse wave].” Neurol Neurochir Pol 28(2):195-9 Details Czosnyka M, Guazzo E, Iyer V, Kirkpatrick P, Smielewski P, Whitehouse H, Pickard JD (1994), “Testing of cerebral autoregulation in head injury by waveform analysis of blood flow velocity and cerebral perfusion pressure.” Acta Neurochir Suppl (Wien) 60:468-71 Details Czosnyka M, Price DJ, Williamson M (1994), “Monitoring of cerebrospinal dynamics using continuous analysis of intracranial pressure and cerebral perfusion pressure in head injury.” Acta Neurochir (Wien) 126(2-4):113-9 Details Czosnyka M, Richards H, Kirkpatrick P, Pickard J (1994), “Assessment of cerebral autoregulation with ultrasound and laser Doppler wave forms--an experimental study in anesthetized rabbits.” Neurosurgery 35(2):287-92; discussion 292-3 Details Czosnyka M, Richards H, Pickard JD, Harris N, Iyer V (1994), “Frequency-dependent properties of cerebral blood transport--an experimental study in anaesthetized rabbits.” Ultrasound Med Biol 20(4):391-9 Details Czosnyka M, Whitehouse H, Smielewski P, Kirkpatrick P, Guazzo EP, Pickard JD (1994), “Computer supported multimodal bed-side monitoring for neuro intensive care.” Int J Clin Monit Comput 11(4):223-32 Details Kirkpatrick PJ, Smielewski P, Czosnyka M, Pickard JD (1994), “Continuous monitoring of cortical perfusion by laser Doppler flowmetry in ventilated patients with head injury.” J Neurol Neurosurg Psychiatry 57(11):1382-8 Details Whitehouse HE, Czosnyka M, Pickard JD (1994), “Shunt audit: a computerized method for testing the performance characteristics of CSF shunts in vitro.” Childs Nerv Syst 10(3):158-61 Details 1993Czosnyka M, Batorski L, Roszkowski M, Tomaszewski J, Wocjan J, Walencik A, Zabolotny W (1993), “Cerebrospinal compensation in hydrocephalic children.” Childs Nerv Syst 9(1):17-22 Details Czosnyka M, Harris NG, Pickard JD, Piechnik S (1993), “CO2 cerebrovascular reactivity as a function of perfusion pressure--a modelling study.” Acta Neurochir (Wien) 121(3-4):159-65 Details Pickard JD, Czosnyka M (1993), “Management of raised intracranial pressure.” J Neurol Neurosurg Psychiatry 56(8):845-58 Details 1992Børgesen SE, Albeck MJ, Gjerris F, Czosnyka M, Laniewski P (1992), “Computerized infusion test compared to steady pressure constant infusion test in measurement of resistance to CSF outflow.” Acta Neurochir (Wien) 119(1-4):12-6 Details Czosnyka M, Pickard J, Whitehouse H, Piechnik S (1992), “The hyperaemic response to a transient reduction in cerebral perfusion pressure. A modelling study.” Acta Neurochir (Wien) 115(3-4):90-7 Details Nelson RJ, Czosnyka M, Pickard JD, Maksymowicz W, Perry S, Martin JL, Lovick AH (1992), “Experimental aspects of cerebrospinal hemodynamics: the relationship between blood flow velocity waveform and cerebral autoregulation.” Neurosurgery 31(4):705-9; discussion 709-10 Details 1990Czosnyka M, Batorski L, Laniewski P, Maksymowicz W, Koszewski W, Zaworski W (1990), “A computer system for the identification of the cerebrospinal compensatory model.” Acta Neurochir (Wien) 105(3-4):112-6 Details Czosnyka M, Maksymowicz W, Batorski L, Koszewski W, Czosnyka Z (1990), “Comparison between classic-differential and automatic shunt functioning on the basis of infusion tests.” Acta Neurochir (Wien) 106(1-2):1-8 Details Tychmanowicz K, Czernicki Z, Czosnyka M, Paw?owski G, Uchman G (1990), “Early pathomorphological changes and intracranial volume-pressure: relations following the experimental sagittal sinus occlusion.” Acta Neurochir Suppl (Wien) 51:233-5 Details Wocjan J, Batorski L, Roszkowski M, Tomaszewski J, Czosnyka M, Paw?owski G, Wo??k-Laniewski P (1990), “[Characteristics of intracranial volume-pressure relationship in hydrocephalic children with reference to age].” Neurol Neurochir Pol 24(5-6):303-8 Details 1989Maksymowicz W, Czosnyka M, Koszewski W, Szymanska A, Traczewski W (1989), “The role of cerebrospinal compensatory parameters in the estimation of functioning of implanted shunt system in patients with communicating hydrocephalus (preliminary report).” Acta Neurochir (Wien) 101(3-4):112-6 Details 1988Czosnyka M, Wollk-Laniewski P, Batorski L, Zaworski W (1988), “Analysis of intracranial pressure waveform during infusion test.” Acta Neurochir (Wien) 93(3-4):140-5 Details |