Dr Maria Angeles Fernandez

University position

Research Associate


Department of Medical Genetics


Cambridge Institute for Medical Research (CIMR)



Home page

https://es.linkedin.com/in/mari... (personal home page)

Research Theme

Cellular and Molecular Neuroscience


My main interest is the study of signalling pathways and molecular mechanisms involved in neurodegenerative diseases like Alzheimer's and Huntington's disease, and its use as a target for the possible therapy of these diseases.

Actually, my research is focused in the study of autophagy as a therapeutic tool for the treatment of disorders associated with protein accumulation.

Research Focus




Neurodegenerative DIseases

Drug Discovery

Signalling Pathways

Clinical conditions

Alzheimer's disease


Huntington's disease

Parkinson's disease


Cell culture

Confocal microscopy

Fluorescence microscopy



Protein purification

Recombinant protein expression


No collaborators listed

Associated News Items

    Key publications

    MA Mena, J Perucho, M Fernandez-Estevez and J García de Yebenes (2015), “Autophagy pathways in Huntginton´s Disease” Toxicity and autophagy in neurodenegenerative disorders. Current topics in neurotoxicity. Springer International Publishing. pp. 79-89

    M. Fernandez-Estevez, M.J. Casarejos, J.L. Sendon, J.G. Caldentey, C. Ruiz, A. Gomez, J. Perucho, J.G.de Yebenes, M.A. Mena. (2014), “Trehalose Reverses Cell Malfunction in Fibroblasts from Normal and Huntington's Disease Patients Caused by Proteosome Inhibition” Plos ONE 25;9(2)

    Perucho J., Casarejos M.J., Gómez A., Ruíz C., Fernández-Estévez M., Muñoz M.P., García de Yébenes J., Mena M.A (2013), “Striatal Infusion of Glial Conditioned Medium Diminishes Huntingtin Pathology in R6/1 Mice” Plos ONE 12;8(9)



    Del Reino P, Alsina-Beauchamp D, Escós A, Cerezo-Guisado MI, Risco A, Aparicio N, Zur R, Fernandez-Estévez M, Collantes E, Montans J, Cuenda A. (2014), “Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38? and p38?, linking inflammation and cancer in colitis-associated colon cancer” Cancer Research 74(21):6150-60


    Casararejos MJ, Perucho J, Gomez A, Muñoz MP, Fernandez-Estevez M, Sagredo O, Fernandez Ruiz J, Guzman M, Garcia de Yebenes J and Mena M A. (2013), “Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy” J Alzheimer Dis 35(3):525-39