Dr Maria Angeles FernandezUniversity positionResearch Associate DepartmentsDepartment of Medical Genetics InstitutesARUK - Drug Discovery Institute http://cambridge-ddi.alzheimersresearchuk.org/ Home pagehttps://es.linkedin.com/in/mari... (personal home page) Research ThemeInterestsMy main interest is the study of signalling pathways and molecular mechanisms involved in neurodegenerative diseases like Alzheimer's and Huntington's disease, and its use as a target for the possible therapy of these diseases. Actually, my research is focused in the study of autophagy as a therapeutic tool for the treatment of disorders associated with protein accumulation. Research Focus
EquipmentCell culture Confocal microscopy Fluorescence microscopy Immunohistochemistry Microscopy Protein purification Recombinant protein expression Collaborators
Associated News ItemsKey publicationsMA Mena, J Perucho, M Fernandez-Estevez and J García de Yebenes (2015), “Autophagy pathways in Huntginton´s Disease” Toxicity and autophagy in neurodenegenerative disorders. Current topics in neurotoxicity. Springer International Publishing. pp. 79-89 M. Fernandez-Estevez, M.J. Casarejos, J.L. Sendon, J.G. Caldentey, C. Ruiz, A. Gomez, J. Perucho, J.G.de Yebenes, M.A. Mena. (2014), “Trehalose Reverses Cell Malfunction in Fibroblasts from Normal and Huntington's Disease Patients Caused by Proteosome Inhibition” Plos ONE 25;9(2) Perucho J., Casarejos M.J., Gómez A., Ruíz C., Fernández-Estévez M., Muñoz M.P., García de Yébenes J., Mena M.A (2013), “Striatal Infusion of Glial Conditioned Medium Diminishes Huntingtin Pathology in R6/1 Mice” Plos ONE 12;8(9) Publications2014Del Reino P, Alsina-Beauchamp D, Escós A, Cerezo-Guisado MI, Risco A, Aparicio N, Zur R, Fernandez-Estévez M, Collantes E, Montans J, Cuenda A. (2014), “Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer” Cancer Research 74(21):6150-60 2013Casararejos MJ, Perucho J, Gomez A, Muñoz MP, Fernandez-Estevez M, Sagredo O, Fernandez Ruiz J, Guzman M, Garcia de Yebenes J and Mena M A. (2013), “Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy” J Alzheimer Dis 35(3):525-39 |