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EMAIL ls514@cam.ac.uk
College Clare Hall
Department
  • Psychiatry
    • Research Theme Lifelong Brain Development and Brain Ageing Brains and Machines Adaptive Brain Computations
    Research Focus

    Keywords

  • EEG/MEG
  • 7T MRI
  • Dementia

    • Clinical Conditions

  • Dementia

    • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Positron Emission Tomography (PET)

    • Back

    Professor Li Su

    University Position
    Principal Research Associate
    Professor Li Su is pleased to consider applications from prospective PhD students.

    Interests

    I lead Artificial Intelligence and Computational Neuroscience group. I am Chair of Neuroimaging in Neuroscience Institute at University of Sheffield and Principal Research Fellow (Professor Grade 11) at Department of Psychiatry at University of Cambridge. I am also a Fellow at Clare Hall, Cambridge (https://www.clarehall.cam.ac.uk/our-people/professor-li-su).

    Key Publications

    Early microglial activation and peripheral inflammation in dementia with Lewy bodies.

    DOI: http://doi.org/10.1093/brain/awy265
    Journal: Brain
    E-pub date: 1 Dec 2018
    Authors: A Surendranathan, L Su, E Mak, L Passamonti, YT Hong, R Arnold, P Vázquez Rodríguez, WR Bevan-Jones, SAE Brain, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    Publications

    CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1136/jnnp-2021-327462
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2022
    Authors: A Low, MA Prats-Sedano, JD Stefaniak, EF McKiernan, SF Carter, M-E Douvani, E Mak, L Su, O Stupart, G Muniz, K Ritchie, CW Ritchie, HS Markus, JT O'Brien

    Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study.

    DOI: http://doi.org/10.1177/0271678X211020863
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Nov 2021
    Authors: M-E Dounavi, A Low, EF McKiernan, E Mak, G Muniz-Terrera, K Ritchie, CW Ritchie, L Su, JT O'Brien

    Simulating a Community Mental Health Service During the COVID-19 Pandemic: Effects of Clinician-Clinician Encounters, Clinician-Patient-Family Encounters, Symptom-Triggered Protective Behaviour, and Household Clustering.

    DOI: http://doi.org/10.3389/fpsyt.2021.620842
    Journal: Front Psychiatry
    E-pub date: 1 Aug 2021
    Authors: RN Cardinal, CE Meiser-Stedman, DM Christmas, AC Price, C Denman, BR Underwood, S Chen, S Banerjee, SR White, L Su, TJ Ford, SR Chamberlain, CM Walsh

    Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals.

    DOI: http://doi.org/10.1007/s00415-020-10383-8
    Journal: J Neurol
    E-pub date: 1 May 2021
    Authors: X Liu, M-E Dounavi, K Ritchie, K Wells, CW Ritchie, L Su, G Muniz-Terrera, JT O'Brien

    Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study.

    DOI: http://doi.org/10.1016/j.neuroimage.2021.117749
    Journal: Neuroimage
    E-pub date: 1 Apr 2021
    Authors: E Mak, M-E Dounavi, A Low, SF Carter, E McKiernan, GB Williams, PS Jones, I Carriere, GT Muniz, K Ritchie, C Ritchie, L Su, JT O'Brien

    Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.10.029
    Journal: Neurobiol Aging
    E-pub date: 1 Feb 2021
    Authors: A Low, L Su, JD Stefaniak, E Mak, M-E Dounavi, G Muniz-Terrera, K Ritchie, CW Ritchie, HS Markus, JT O'Brien

    The prognostic role of microglia and tau PET in Alzheimer’s disease

    DOI: http://doi.org/10.1002/alz.039817
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan‐Jones, L Su, YT Hong, TD Fryer, FI Aigbirho, JT O'Brien, JB Rowe

    Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study.

    DOI: http://doi.org/10.1136/jnnp-2020-323823
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 21 Oct 2020
    Authors: K Ritchie, I Carrière, S Gregory, T Watermeyer, S Danso, L Su, CW Ritchie, JT O'Brien

    In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.

    DOI: http://doi.org/10.1136/jnnp-2020-323894
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 11 Sep 2020
    Authors: A Low, E Mak, M Malpetti, L Passamonti, N Nicastro, JD Stefaniak, G Savulich, L Chouliaras, L Su, JB Rowe, HS Markus, JT O'Brien

    Simulating a community mental health service during the COVID-19 pandemic: effects of clinician–clinician encounters, clinician–patient–family encounters, symptom-triggered protective behaviour, and household clustering

    DOI: http://doi.org/10.1101/2020.04.27.20081505
    Journal:
    E-pub date: 1 Aug 2020
    Authors: R Cardinal, C Meiser-Stedman, D Christmas, A Price, C Denman, B Underwood, S Chen, S Banerjee, S White, L Su, T Ford, S Chamberlain, C Walsh

    Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia.

    DOI: http://doi.org/10.3233/JAD-200238
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2020
    Authors: A McKeever, AF Paris, J Cullen, L Hayes, CW Ritchie, K Ritchie, AD Waldman, K Wells, A Busza, I Carriere, JT O'Brien, L Su

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awaa088
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Asymmetrical atrophy of thalamic subnuclei in Alzheimer’s disease and amyloid-positive mild cognitive impairment is associated with key clinical features.

    DOI: http://doi.org/10.1016/j.dadm.2019.08.001
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: A Low, E Mak, M Malpetti, L Chouliaras, N Nicastro, L Su, N Holland, T Rittman, PV Rodríguez, L Passamonti, WR Bevan-Jones, PS Jones, JB Rowe, JT O'Brien

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

    DOI: http://doi.org/10.1101/19011189
    Journal:
    E-pub date: 8 Nov 2019
    Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    In vivo coupling of tau pathology and cortical thinning in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.dadm.2018.08.005
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Aug 2018
    Authors: E Mak, RAI Bethlehem, R Romero-Garcia, S Cervenka, T Rittman, S Gabel, A Surendranathan, RW Bevan-Jones, L Passamonti, P Vázquez Rodríguez, L Su, R Arnold, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1212/WNL.0000000000005610
    Journal: Neurology
    E-pub date: 29 May 2018
    Authors: L Passamonti, PV Rodríguez, YT Hong, KSJ Allinson, WR Bevan-Jones, D Williamson, PS Jones, R Arnold, RJ Borchert, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    The midlife cognitive profiles of adults at high risk of late-onset Alzheimer’s disease: The PREVENT study.

    DOI: http://doi.org/10.1016/j.jalz.2017.02.008
    Journal: Alzheimers Dement
    E-pub date: 1 Oct 2017
    Authors: K Ritchie, I Carrière, L Su, JT O'Brien, S Lovestone, K Wells, CW Ritchie

    Relating dynamic brain states to dynamic machine states: Human and machine solutions to the speech recognition problem.

    DOI: http://doi.org/10.1371/journal.pcbi.1005617
    Journal: PLoS Comput Biol
    E-pub date: 1 Sep 2017
    Authors: C Wingfield, L Su, X Liu, C Zhang, P Woodland, A Thwaites, E Fonteneau, WD Marslen-Wilson

    18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1093/brain/aww340
    Journal: Brain
    E-pub date: 1 Mar 2017
    Authors: L Passamonti, P Vázquez Rodríguez, YT Hong, KSJ Allinson, D Williamson, RJ Borchert, S Sami, TE Cope, WR Bevan-Jones, PS Jones, R Arnold, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Whole-brain patterns of (1)H-magnetic resonance spectroscopy imaging in Alzheimer’s disease and dementia with Lewy bodies.

    DOI: http://doi.org/10.1038/tp.2016.140
    Journal: Transl Psychiatry
    E-pub date: 30 Aug 2016
    Authors: L Su, AM Blamire, R Watson, J He, L Hayes, JT O'Brien

    Cortical and Subcortical Changes in Alzheimer’s Disease: A Longitudinal and Quantitative MRI Study.

    DOI: http://doi.org/10.2174/1567205013666151116141416
    Journal: Curr Alzheimer Res
    E-pub date: 1 Aug 2016
    Authors: L Su, AM Blamire, R Watson, J He, B Aribisala, JT O'Brien

    Tissue microstructural changes in dementia with Lewy bodies revealed by quantitative MRI.

    DOI: http://doi.org/10.1007/s00415-014-7541-2
    Journal: J Neurol
    E-pub date: 1 Jan 2015
    Authors: L Su, AM Blamire, R Watson, J He, B Aribisala, JT O'Brien