Dr Luca Peruzzotti-Jametti


University position

Senior Research Associate

Dr Luca Peruzzotti-Jametti is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Email

lp429@cam.ac.uk

Home page

https://scholar.google.com/citatio...

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience

Interests

My research focuses on the mechanisms driving chronic CNS damage in conditions of neuroinflammation, such as multiple sclerosis (MS). Currently I am studying how progression works in MS by focusing on the link between immune cell metabolism and chronic neuroinflammation.

Research Focus

Keywords

Immunometabolism

Neuroinflammation

Progressive multiple sclerosis

Microglia/macrophages

Mitochondria

Clinical conditions

Multiple sclerosis

Stroke

Equipment

Behavioural analysis

Calcium imaging

Cell culture

Confocal microscopy

Enzyme assays

Fluorescence microscopy

Immunohistochemistry

Microscopy

Seahorse, EAE (experimental autoimmune encephalomyelitis), MCAO (stroke).

Collaborators

Cambridge

Christian Frezza

Joanne Jones

Mike Murphy

Stefano Pluchino

United Kingdom

Zoltan Takats Web: http://z.takats@imperial.ac.uk

International

Angelo D'Alessandro Web: http://ANGELO.DALESSANDRO@CUANSCHUTZ.EDU

Marie-Eve Tremblay Web: http://evetremblay@uvic.ca

Associated News Items


Key publications

Krzak G, Willis CM, Smith JA, Pluchino S, and Peruzzotti-Jametti L (2021), “Succinate Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation” Trends in Immunology

Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel Á, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021), “Neural stem cells traffic functional mitochondria via extracellular vesicles” PLOS Biology

Peruzzotti-Jametti L, Willis C, Hamel R, Krzak G and Pluchino S (2021), “Metabolic control of smoldering neuroinflammation” Frontiers in Immunology

Pluchino S, Smith JA, Peruzzotti-Jametti L. (2020), “Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis.” Trends in Molecular Medicine

Peruzzotti-Jametti L, Bernstock JD, Vicario N, Costa ASH, Kwok C, Leonardi T, Booty L, Bicci I, Balzarotti B, Volpe G, Mallucci G, Manferrari G, Iraci N, Braga A, Hallenbeck JM, Murphy MP, Edenhofer F, Frezza C and Pluchino S. (2018), “Macrophage-derived extracellular succinate licenses neural stem cells to ameliorate chronic neuroinflammation. ” Cell Stem Cell

Peruzzotti-Jametti L, Pluchino S. (2018), “Targeting Mitochondrial Metabolism in Neuroinflammation: Towards a Therapy for Progressive Multiple Sclerosis.” Trends in Molecular Medicine

Iraci N, Gaude E, Leonardi T, Costa ASH, Cossetti C, Peruzzotti-Jametti L, Bernstock JD, Saini HK, Gelati M, Vescovi AL, Bastos C, Faria N, Occhipinti LG, Enright AJ, Frezza C, Pluchino S (2017), “Extracellular vesicles are independent metabolic units with asparaginase activity. ” Nature Chemical Biology

Spescha RD, Klohs J, Semerano A, Giacalone G, Derungs RS, Reiner MF, Rodriguez Gutierrez D, Mendez-Carmona N, Glanzmann M, Savarese G, Kränkel N, Akhmedov A, Keller S, Mocharla P, Kaufmann MR, Wenger RH, Vogel J, Kulic L, Nitsch RM, Beer JH, Peruzzotti-Jametti L, Sessa M, Luscher TF, Camici GG. (2015), “Post-Ischemic Silencing of p66Shc Reduces Ischaemia/Reperfusion Brain Injury and its Expression Correlates to Clinical Outcome in Stroke.” European Heart Journal

Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, Waldo AL, Ezekowitz MD, Weitz JI, Špinar J, Ruzyllo W, Ruda M, Koretsune Y, Betcher J, Shi M, Grip LT, Patel SP, Patel I, Hanyok JJ, Mercuri M, Antman EM; ENGAGE AF-TIMI 48 Investigators (..Comi G, Peruzzotti L, Cuccia C..) (2013), “Edoxaban versus warfarin in patients with atrial fibrillation” New England Journal of Medicine