Dr Luca Peruzzotti-Jametti


University position

Senior Research Associate

Dr Luca Peruzzotti-Jametti is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Email

lp429@cam.ac.uk

Home page

https://scholar.google.com/citatio...

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience

Interests

Research in our group is focused on the understanding of inflammation in central nervous system (CNS) diseases. Over the past years, our research in regenerative neuroimmunology led to novel experimental advanced therapeutics with neural stem cells, acellular therapeutics (e.g., extracellular vesicles), and small molecules for the treatment of ischemic stroke, spinal cord injury, and progressive multiple sclerosis (MS).

Our most recent work is focusing on cellular metabolism and mitochondria to find novel ways to modulate chronic inflammation and favour CNS regeneration. To this aim, we apply unique tools to model metabolic/mitochondrial dysfunctions in vitro (using human cells and gene editing techniques) and in vivo (with animal disease models), as well as cutting edge techniques to detect metabolic changes in rodent/human cells and tissues.

Research Focus

Keywords

Immunometabolism

Neuroinflammation

Progressive multiple sclerosis

Microglia/macrophages

Mitochondria

Clinical conditions

Multiple sclerosis

Stroke

Equipment

Behavioural analysis

Calcium imaging

Cell culture

Confocal microscopy

Enzyme assays

Fluorescence microscopy

Immunohistochemistry

Microscopy

Seahorse, EAE (experimental autoimmune encephalomyelitis).

Collaborators

Cambridge

Joanne Jones

Thomas Krieg

Mike Murphy

Stefano Pluchino

United Kingdom

Touraj Ehtezazi Web: https://www.ljmu.ac.uk/about-u...

Zoltan Takats Web: https://www.imperial.ac.uk/people/...

Amy Vincent Web: https://www.newcastle-mitochondria.com/amy-vin...

International

Angelo D'Alessandro Web: https://medschool.cuanschutz.edu/biochem...

Christian Frezza Web: https://www.cecad.uni-koeln.de/researc...

Roberta Magliozzi Web: https://www.dnbm.univr.it/?ent=pe...

Marie-Eve Tremblay Web: https://www.uvic.ca/medsci/...

Carlo Viscomi Web: https://www.biomed.unipd.it/people/...

Associated News Items


Key publications

Krzak G, Willis CM, Smith JA, Pluchino S, and Peruzzotti-Jametti L (2021), “Succinate Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation” Trends in Immunology

Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel Á, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021), “Neural stem cells traffic functional mitochondria via extracellular vesicles” PLOS Biology

Peruzzotti-Jametti L, Willis C, Hamel R, Krzak G and Pluchino S (2021), “Metabolic control of smoldering neuroinflammation” Frontiers in Immunology

Pluchino S, Smith JA, Peruzzotti-Jametti L. (2020), “Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis.” Trends in Molecular Medicine

Peruzzotti-Jametti L, Bernstock JD, Vicario N, Costa ASH, Kwok C, Leonardi T, Booty L, Bicci I, Balzarotti B, Volpe G, Mallucci G, Manferrari G, Iraci N, Braga A, Hallenbeck JM, Murphy MP, Edenhofer F, Frezza C and Pluchino S. (2018), “Macrophage-derived extracellular succinate licenses neural stem cells to ameliorate chronic neuroinflammation. ” Cell Stem Cell

Peruzzotti-Jametti L, Pluchino S. (2018), “Targeting Mitochondrial Metabolism in Neuroinflammation: Towards a Therapy for Progressive Multiple Sclerosis.” Trends in Molecular Medicine

Iraci N, Gaude E, Leonardi T, Costa ASH, Cossetti C, Peruzzotti-Jametti L, Bernstock JD, Saini HK, Gelati M, Vescovi AL, Bastos C, Faria N, Occhipinti LG, Enright AJ, Frezza C, Pluchino S (2017), “Extracellular vesicles are independent metabolic units with asparaginase activity. ” Nature Chemical Biology

Spescha RD, Klohs J, Semerano A, Giacalone G, Derungs RS, Reiner MF, Rodriguez Gutierrez D, Mendez-Carmona N, Glanzmann M, Savarese G, Kränkel N, Akhmedov A, Keller S, Mocharla P, Kaufmann MR, Wenger RH, Vogel J, Kulic L, Nitsch RM, Beer JH, Peruzzotti-Jametti L, Sessa M, Luscher TF, Camici GG. (2015), “Post-Ischemic Silencing of p66Shc Reduces Ischaemia/Reperfusion Brain Injury and its Expression Correlates to Clinical Outcome in Stroke.” European Heart Journal

Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, Waldo AL, Ezekowitz MD, Weitz JI, Špinar J, Ruzyllo W, Ruda M, Koretsune Y, Betcher J, Shi M, Grip LT, Patel SP, Patel I, Hanyok JJ, Mercuri M, Antman EM; ENGAGE AF-TIMI 48 Investigators (..Comi G, Peruzzotti L, Cuccia C..) (2013), “Edoxaban versus warfarin in patients with atrial fibrillation” New England Journal of Medicine

Publications

2022

Joshua D Bernstock, Kyung-Don Kang, Neil V Klinger, Hannah E Olsen, Sam Gary, Stacie K Totsch, Gelare Ghajar-Rahimi, David Segar, Eric M Thompson, Victor Darley-Usmar, Bryan T Mott, Luca Peruzzotti-Jametti, Gregory K Friedman (2022), “Targeting oncometabolism to maximize immunotherapy in malignant brain tumors” Oncogene