Dr Luca Peruzzotti-Jametti University positionSenior Research Associate Dr Luca Peruzzotti-Jametti is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Clinical Neurosciences Home pagehttps://scholar.google.com/citatio... Research ThemesInterestsResearch in our group is focused on the understanding of inflammation in central nervous system (CNS) diseases. Over the past years, our research in regenerative neuroimmunology led to novel experimental advanced therapeutics with neural stem cells, acellular therapeutics (e.g., extracellular vesicles), and small molecules for the treatment of ischemic stroke, spinal cord injury, and progressive multiple sclerosis (MS). Our most recent work is focusing on cellular metabolism and mitochondria to find novel ways to modulate chronic inflammation and favour CNS regeneration. To this aim, we apply unique tools to model metabolic/mitochondrial dysfunctions in vitro (using human cells and gene editing techniques) and in vivo (with animal disease models), as well as cutting edge techniques to detect metabolic changes in rodent/human cells and tissues. Research Focus
EquipmentBehavioural analysis Calcium imaging Cell culture Confocal microscopy Enzyme assays Fluorescence microscopy Immunohistochemistry Microscopy Seahorse, EAE (experimental autoimmune encephalomyelitis). Collaborators
Associated News ItemsKey publicationsKrzak G, Willis CM, Smith JA, Pluchino S, and Peruzzotti-Jametti L (2021), “Succinate Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation” Trends in Immunology Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel Á, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021), “Neural stem cells traffic functional mitochondria via extracellular vesicles” PLOS Biology Peruzzotti-Jametti L, Willis C, Hamel R, Krzak G and Pluchino S (2021), “Metabolic control of smoldering neuroinflammation” Frontiers in Immunology Pluchino S, Smith JA, Peruzzotti-Jametti L. (2020), “Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis.” Trends in Molecular Medicine Peruzzotti-Jametti L, Bernstock JD, Vicario N, Costa ASH, Kwok C, Leonardi T, Booty L, Bicci I, Balzarotti B, Volpe G, Mallucci G, Manferrari G, Iraci N, Braga A, Hallenbeck JM, Murphy MP, Edenhofer F, Frezza C and Pluchino S. (2018), “Macrophage-derived extracellular succinate licenses neural stem cells to ameliorate chronic neuroinflammation. ” Cell Stem Cell Peruzzotti-Jametti L, Pluchino S. (2018), “Targeting Mitochondrial Metabolism in Neuroinflammation: Towards a Therapy for Progressive Multiple Sclerosis.” Trends in Molecular Medicine Iraci N, Gaude E, Leonardi T, Costa ASH, Cossetti C, Peruzzotti-Jametti L, Bernstock JD, Saini HK, Gelati M, Vescovi AL, Bastos C, Faria N, Occhipinti LG, Enright AJ, Frezza C, Pluchino S (2017), “Extracellular vesicles are independent metabolic units with asparaginase activity. ” Nature Chemical Biology Spescha RD, Klohs J, Semerano A, Giacalone G, Derungs RS, Reiner MF, Rodriguez Gutierrez D, Mendez-Carmona N, Glanzmann M, Savarese G, Kränkel N, Akhmedov A, Keller S, Mocharla P, Kaufmann MR, Wenger RH, Vogel J, Kulic L, Nitsch RM, Beer JH, Peruzzotti-Jametti L, Sessa M, Luscher TF, Camici GG. (2015), “Post-Ischemic Silencing of p66Shc Reduces Ischaemia/Reperfusion Brain Injury and its Expression Correlates to Clinical Outcome in Stroke.” European Heart Journal Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, Waldo AL, Ezekowitz MD, Weitz JI, Špinar J, Ruzyllo W, Ruda M, Koretsune Y, Betcher J, Shi M, Grip LT, Patel SP, Patel I, Hanyok JJ, Mercuri M, Antman EM; ENGAGE AF-TIMI 48 Investigators (..Comi G, Peruzzotti L, Cuccia C..) (2013), “Edoxaban versus warfarin in patients with atrial fibrillation” New England Journal of Medicine Publications2022Joshua D Bernstock, Kyung-Don Kang, Neil V Klinger, Hannah E Olsen, Sam Gary, Stacie K Totsch, Gelare Ghajar-Rahimi, David Segar, Eric M Thompson, Victor Darley-Usmar, Bryan T Mott, Luca Peruzzotti-Jametti, Gregory K Friedman (2022), “Targeting oncometabolism to maximize immunotherapy in malignant brain tumors” Oncogene |