Dr Luca Peruzzotti-Jametti


My research focuses on the mechanisms driving chronic CNS damage in conditions of neuroinflammation, such as multiple sclerosis (MS). Currently I am studying how progression works in MS by focusing on the link between immune cell metabolism and chronic neuroinflammation.

Research Focus




Progressive multiple sclerosis



Clinical conditions

Multiple sclerosis



Behavioural analysis

Calcium imaging

Cell culture

Confocal microscopy

Enzyme assays

Fluorescence microscopy






Christian Frezza

Joanne Jones

Mike Murphy

Stefano Pluchino

United Kingdom

Zoltan Takats Web: http://z.takats@imperial.ac.uk

Amy Vincent Web: http://Amy.Vincent@newcastle.ac.uk



Marie-Eve Tremblay Web: http://evetremblay@uvic.ca

Associated News Items

    Key publications

    Pluchino S, Smith JA, Peruzzotti-Jametti L. (2020), “Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis.” Trends in Molecular Medicine

    Peruzzotti-Jametti L, Bernstock JD, Vicario N, Costa ASH, Kwok C, Leonardi T, Booty L, Bicci I, Balzarotti B, Volpe G, Mallucci G, Manferrari G, Iraci N, Braga A, Hallenbeck JM, Murphy MP, Edenhofer F, Frezza C and Pluchino S. (2018), “Macrophage-derived extracellular succinate licenses neural stem cells to ameliorate chronic neuroinflammation. ” Cell Stem Cell

    Peruzzotti-Jametti L, Pluchino S. (2018), “Targeting Mitochondrial Metabolism in Neuroinflammation: Towards a Therapy for Progressive Multiple Sclerosis.” Trends in Molecular Medicine

    Iraci N, Gaude E, Leonardi T, Costa ASH, Cossetti C, Peruzzotti-Jametti L, Bernstock JD, Saini HK, Gelati M, Vescovi AL, Bastos C, Faria N, Occhipinti LG, Enright AJ, Frezza C, Pluchino S (2017), “Extracellular vesicles are independent metabolic units with asparaginase activity. ” Nature Chemical Biology

    Spescha RD, Klohs J, Semerano A, Giacalone G, Derungs RS, Reiner MF, Rodriguez Gutierrez D, Mendez-Carmona N, Glanzmann M, Savarese G, Kränkel N, Akhmedov A, Keller S, Mocharla P, Kaufmann MR, Wenger RH, Vogel J, Kulic L, Nitsch RM, Beer JH, Peruzzotti-Jametti L, Sessa M, Luscher TF, Camici GG. (2015), “Post-Ischemic Silencing of p66Shc Reduces Ischaemia/Reperfusion Brain Injury and its Expression Correlates to Clinical Outcome in Stroke.” European Heart Journal

    Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, Waldo AL, Ezekowitz MD, Weitz JI, Špinar J, Ruzyllo W, Ruda M, Koretsune Y, Betcher J, Shi M, Grip LT, Patel SP, Patel I, Hanyok JJ, Mercuri M, Antman EM; ENGAGE AF-TIMI 48 Investigators (..Comi G, Peruzzotti L, Cuccia C..). (2013), “Edoxaban versus warfarin in patients with atrial fibrillation. ” New England Journal of Medicine