Dr Nicolas Le Novere

Nicolas Le Novere

University position

Group leader

Dr Nicolas Le Novere is pleased to consider applications from prospective PhD students.


Babraham Institute



Home page

http://lenoverelab.org/ (personal home page)

Research Themes

Systems and Computational Neuroscience

Cellular and Molecular Neuroscience


My scientific interests revolve around signal transduction in neurons, ranging from the molecular structure of membrane proteins involved in neurotransmission to modelling signalling pathways. A strong focus is the molecular and cellular basis of neuroadaptation in neurons of the basal ganglia. I also develop standards and services, including ontologies, databases and simulation software for computational systems biology.

Acetylcholine bound to the nicotinic receptor alpha7 subunit
Acetylcholine bound to the nicotinic receptor alpha7 subunit
Click image to view full-size

Research Focus


synaptic plasticity

systems biology



neural circuit

Clinical conditions


Alzheimer's disease

Parkinson's disease



Computational modelling



Phillip Hawkins

Len Stephens

United Kingdom

Richard Adams Web: http://csbe.bio.ed.ac.uk/adams.php

Douglas Kell Web: http://dbkgroup.org/dbk.htm

allyson lister Web: http://www.cs.ncl.ac.uk/people/...

Nick Luscombe Web: http://luscombelab.org/

pedro Mendes Web: http://www.comp-sys-bio.org/tiki-in...


Jean-Antoine Girault Web: http://ifr-bi.snv.jussieu.fr/unites_...

Mike Hucka Web: http://sbml.org

Hiroaki Kitano Web: http://www.symbio.jst.go.jp/symbio2...

Associated News Items

Key publications

Edelstein SJ, Stefan MI, Le Novère N (2010), “Ligand depletion in vivo modulates the dynamic range and cooperativity of signal transduction.” PLoS One 5(1):e8449 Details

Le Novère N, Hucka M, Mi H, Moodie S, Schreiber F, Sorokin A, Demir E, Wegner K, Aladjem MI, Wimalaratne SM, Bergman FT, Gauges R, Ghazal P, Kawaji H, Li L, Matsuoka Y, Villéger A, Boyd SE, Calzone L, Courtot M, Dogrusoz U, Freeman TC, Funahashi A, Ghosh S, Jouraku A, Kim S, Kolpakov F, Luna A, Sahle S, Schmidt E, Watterson S, Wu G, Goryanin I, Kell DB, Sander C, Sauro H, Snoep JL, Kohn K, Kitano H (2009), “The Systems Biology Graphical Notation.” Nat Biotechnol 27(8):735-41 Details

Stefan MI, Edelstein SJ, Le Novère N (2008), “An allosteric model of calmodulin explains differential activation of PP2B and CaMKII.” Proc Natl Acad Sci U S A 105(31):10768-73 Details

Fernandez E, Schiappa R, Girault JA, Le Novère N (2006), “DARPP-32 is a robust integrator of dopamine and glutamate signals” PLoS Computational Biology 2(12):e176 Details

Le Novère N, Bornstein B, Broicher A, Courtot M, Donizelli M, Dharuri H, Li L, Sauro H, Schilstra M, Shapiro B, Snoep JL, Hucka M (2006), “BioModels Database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems.” Nucleic Acids Res 34(Database issue):D689-91 Details

Le Novère N, Finney A, Hucka M, Bhalla U, Campagne F, Collado-Vides J, Crampin E, Halstead M, Klipp E, Mendes P, Nielsen P, Sauro H, Shapiro B, Snoep JL, Spence HD, Wanner BL (2005), “Minimum Information Requested In the Annotation of biochemical Models (MIRIAM)” Nature Biotechnology 23:1509-1515 Details



Jupp S, Malone J, Bolleman J, Brandizi M, Davies M, Garcia L, Gaulton A, Gehant S, Laibe C, Redaschi N, Wimalaratne SM, Martin M, Le Novère N, Parkinson H, Birney E, Jenkinson AM (2014), “The EBI RDF platform: linked open data for the life sciences.” Bioinformatics Details


Ajmera I, Swat M, Laibe C, Novère NL, Chelliah V (2013), “The impact of mathematical modeling on the understanding of diabetes and related complications.” CPT Pharmacometrics Syst Pharmacol 2:e54 Details

Büchel F, Rodriguez N, Swainston N, Wrzodek C, Czauderna T, Keller R, Mittag F, Schubert M, Glont M, Golebiewski M, van Iersel M, Keating S, Rall M, Wybrow M, Hermjakob H, Hucka M, Kell DB, Müller W, Mendes P, Zell A, Chaouiya C, Saez-Rodriguez J, Schreiber F, Laibe C, Dräger A, Le Novère N (2013), “Path2Models: large-scale generation of computational models from biochemical pathway maps.” BMC Syst Biol 7:116 Details

Chaouiya C, Bérenguier D, Keating SM, Naldi A, van Iersel MP, Rodriguez N, Dräger A, Büchel F, Cokelaer T, Kowal B, Wicks B, Gonçalves E, Dorier J, Page M, Monteiro PT, von Kamp A, Xenarios I, de Jong H, Hucka M, Klamt S, Thieffry D, Le Novère N, Saez-Rodriguez J, Helikar T (2013), “SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools.” BMC Syst Biol 7:135 Details

Chelliah V, Laibe C, Le Novère N (2013), “BioModels Database: a repository of mathematical models of biological processes.” Methods Mol Biol 1021:189-99 Details

Edelstein SJ, Le Novère N (2013), “Cooperativity of allosteric receptors.” J Mol Biol 425(9):1424-32 Details

Juty N, Le Novère N, Hermjakob H, Laibe C (2013), “Towards the collaborative curation of the registry underlying Identifiers.org.” Database (Oxford) 2013:bat017 Details

Keating SM, Le Novère N (2013), “Supporting SBML as a model exchange format in software applications.” Methods Mol Biol 1021:201-25 Details

Keller R, Dörr A, Tabira A, Funahashi A, Ziller MJ, Adams R, Rodriguez N, Le Novère N, Hiroi N, Planatscher H, Zell A, Dräger A (2013), “The systems biology simulation core algorithm.” BMC Syst Biol 7:55 Details

Knüpfer C, Beckstein C, Dittrich P, Le Novère N (2013), “Structure, function, and behaviour of computational models in systems biology.” BMC Syst Biol 7:43 Details

Le Novère N, Endler L (2013), “Using chemical kinetics to model biochemical pathways.” Methods Mol Biol 1021:147-67 Details

Mattioni M, Le Novère N (2013), “Integration of biochemical and electrical signaling-multiscale model of the medium spiny neuron of the striatum.” PLoS One 8(7):e66811 Details

Stefan MI, Le Novère N (2013), “Cooperative binding.” PLoS Comput Biol 9(6):e1003106 Details

Thiele I, Swainston N, Fleming RM, Hoppe A, Sahoo S, Aurich MK, Haraldsdottir H, Mo ML, Rolfsson O, Stobbe MD, Thorleifsson SG, Agren R, Bölling C, Bordel S, Chavali AK, Dobson P, Dunn WB, Endler L, Hala D, Hucka M, Hull D, Jameson D, Jamshidi N, Jonsson JJ, Juty N, Keating S, Nookaew I, Le Novère N, Malys N, Mazein A, Papin JA, Price ND, Selkov E Sr, Sigurdsson MI, Simeonidis E, Sonnenschein N, Smallbone K, Sorokin A, van Beek JH, Weichart D, Goryanin I, Nielsen J, Westerhoff HV, Kell DB, Mendes P, Palsson BØ (2013), “A community-driven global reconstruction of human metabolism.” Nat Biotechnol 31(5):419-25 Details

von Eichborn J, Dunkel M, Gohlke BO, Preissner SC, Hoffmann MF, Bauer JM, Armstrong JD, Schaefer MH, Andrade-Navarro MA, Le Novere N, Croning MD, Grant SG, van Nierop P, Smit AB, Preissner R (2013), “SynSysNet: integration of experimental data on synaptic protein-protein interactions with drug-target relations.” Nucleic Acids Res 41(Database issue):D834-40 Details


Adams RR, Tsorman N, Stratford K, Akman OE, Gilmore S, Juty N, Le Novère N, Millar AJ, Millar AJ (2012), “The Input Signal Step Function (ISSF), a standard method to encode input signals in SBML models with software support, applied to circadian clock models.” J Biol Rhythms 27(4):328-32 Details

Büchel F, Wrzodek C, Mittag F, Dräger A, Eichner J, Rodriguez N, Le Novère N, Zell A (2012), “Qualitative translation of relations from BioPAX to SBML qual.” Bioinformatics 28(20):2648-53 Details

Dumousseau M, Rodriguez N, Juty N, Novère NL (2012), “MELTING, a flexible platform to predict the melting temperatures of nucleic acids.” BMC Bioinformatics 13:101 Details

Juty N, Le Novère N, Laibe C (2012), “Identifiers.org and MIRIAM Registry: community resources to provide persistent identification.” Nucleic Acids Res 40(Database issue):D580-6 Details

Li L, Stefan MI, Le Novère N (2012), “Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII.” PLoS One 7(9):e43810 Details

Mattioni M, Cohen U, Le Novère N (2012), “Neuronvisio: A Graphical User Interface with 3D Capabilities for NEURON.” Front Neuroinform 6:20 Details

Stefan MI, Marshall DP, Le Novère N (2012), “Structural analysis and stochastic modelling suggest a mechanism for calmodulin trapping by CaMKII.” PLoS One 7(1):e29406 Details

van Iersel MP, Villéger AC, Czauderna T, Boyd SE, Bergmann FT, Luna A, Demir E, Sorokin A, Dogrusoz U, Matsuoka Y, Funahashi A, Aladjem MI, Mi H, Moodie SL, Kitano H, Le Novère N, Schreiber F (2012), “Software support for SBGN maps: SBGN-ML and LibSBGN.” Bioinformatics 28(15):2016-21 Details

Zhukova A, Adams R, Laibe C, Le Novère N (2012), “LibKiSAO: a Java library for Querying KiSAO.” BMC Res Notes 5:520 Details


Courtot M, Juty N, Knüpfer C, Waltemath D, Zhukova A, Dräger A, Dumontier M, Finney A, Golebiewski M, Hastings J, Hoops S, Keating S, Kell DB, Kerrien S, Lawson J, Lister A, Lu J, Machne R, Mendes P, Pocock M, Rodriguez N, Villeger A, Wilkinson DJ, Wimalaratne S, Laibe C, Hucka M, Le Novère N (2011), “Controlled vocabularies and semantics in systems biology.” Mol Syst Biol 7:543 Details

Dräger A, Rodriguez N, Dumousseau M, Dörr A, Wrzodek C, Le Novère N, Zell A, Hucka M (2011), “JSBML: a flexible Java library for working with SBML.” Bioinformatics 27(15):2167-8 Details

Le Novère N, Hucka M, Anwar N, Bader GD, Demir E, Moodie S, Sorokin A (2011), “Meeting report from the first meetings of the Computational Modeling in Biology Network (COMBINE).” Stand Genomic Sci 5(2):230-42 Details

Schulz M, Krause F, Le Novère N, Klipp E, Liebermeister W (2011), “Retrieval, alignment, and clustering of computational models based on semantic annotations.” Mol Syst Biol 7:512 Details

Waltemath D, Adams R, Beard DA, Bergmann FT, Bhalla US, Britten R, Chelliah V, Cooling MT, Cooper J, Crampin EJ, Garny A, Hoops S, Hucka M, Hunter P, Klipp E, Laibe C, Miller AK, Moraru I, Nickerson D, Nielsen P, Nikolski M, Sahle S, Sauro HM, Schmidt H, Snoep JL, Tolle D, Wolkenhauer O, Le Novère N (2011), “Minimum Information About a Simulation Experiment (MIASE).” PLoS Comput Biol 7(4):e1001122 Details

Waltemath D, Adams R, Bergmann FT, Hucka M, Kolpakov F, Miller AK, Moraru II, Nickerson D, Sahle S, Snoep JL, Le Novère N (2011), “Reproducible computational biology experiments with SED-ML--the Simulation Experiment Description Markup Language.” BMC Syst Biol 5:198 Details


Baldi BF, Hoyer C, Le Novère N (2010), “Schizophrenic: forever young?” Genome Med 2(5):32 Details

Demir E, Cary MP, Paley S, Fukuda K, Lemer C, Vastrik I, Wu G, D'Eustachio P, Schaefer C, Luciano J, Schacherer F, Martinez-Flores I, Hu Z, Jimenez-Jacinto V, Joshi-Tope G, Kandasamy K, Lopez-Fuentes AC, Mi H, Pichler E, Rodchenkov I, Splendiani A, Tkachev S, Zucker J, Gopinath G, Rajasimha H, Ramakrishnan R, Shah I, Syed M, Anwar N, Babur O, Blinov M, Brauner E, Corwin D, Donaldson S, Gibbons F, Goldberg R, Hornbeck P, Luna A, Murray-Rust P, Neumann E, Ruebenacker O, Samwald M, van Iersel M, Wimalaratne S, Allen K, Braun B, Whirl-Carrillo M, Cheung KH, Dahlquist K, Finney A, Gillespie M, Glass E, Gong L, Haw R, Honig M, Hubaut O, Kane D, Krupa S, Kutmon M, Leonard J, Marks D, Merberg D, Petri V, Pico A, Ravenscroft D, Ren L, Shah N, Sunshine M, Tang R, Whaley R, Letovksy S, Buetow KH, Rzhetsky A, Schachter V, Sobral BS, Dogrusoz U, McWeeney S, Aladjem M, Birney E, Collado-Vides J, Goto S, Hucka M, Le Novère N, Maltsev N, Pandey A, Thomas P, Wingender E, Karp PD, Sander C, Bader GD (2010), “The BioPAX community standard for pathway data sharing.” Nat Biotechnol 28(9):935-42 Details

Henkel R, Endler L, Peters A, Le Novère N, Waltemath D (2010), “Ranked retrieval of Computational Biology models.” BMC Bioinformatics 11:423 Details

Hucka M, Le Novère N (2010), “Software that goes with the flow in systems biology.” BMC Biol 8:140 Details

Li C, Courtot M, Le Novère N, Laibe C (2010), “BioModels.net Web Services, a free and integrated toolkit for computational modelling software.” Brief Bioinform 11(3):270-7 Details

Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010), “BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models.” BMC Syst Biol 4:92 Details

Tolle DP, Le Novère N (2010), “Brownian diffusion of AMPA receptors is sufficient to explain fast onset of LTP.” BMC Syst Biol 4:25 Details

Tolle DP, Le Novère N (2010), “Meredys, a multi-compartment reaction-diffusion simulator using multistate realistic molecular complexes.” BMC Syst Biol 4:24 Details


Endler L, Rodriguez N, Juty N, Chelliah V, Laibe C, Li C, Le Novère N (2009), “Designing and encoding models for synthetic biology.” J R Soc Interface 6 Suppl 4:S405-17 Details

Stefan MI, Edelstein SJ, Le Novère N (2009), “Computing phenomenologic Adair-Klotz constants from microscopic MWC parameters.” BMC Syst Biol 3:68 Details

Wolkenhauer O, Fell D, De Meyts P, Blüthgen N, Herzel H, Le Novère N, Höfer T, Schürrle K, van Leeuwen I (2009), “SysBioMed report: advancing systems biology for medical applications.” IET Syst Biol 3(3):131-6 Details


Guerlet G, Taly A, Prado de Carvalho L, Martz A, Jiang R, Specht A, Le Novère N, Grutter T (2008), “Comparative models of P2X2 receptor support inter-subunit ATP-binding sites.” Biochem Biophys Res Commun 375(3):405-9 Details

Herrgård MJ, Swainston N, Dobson P, Dunn WB, Arga KY, Arvas M, Blüthgen N, Borger S, Costenoble R, Heinemann M, Hucka M, Le Novère N, Li P, Liebermeister W, Mo ML, Oliveira AP, Petranovic D, Pettifer S, Simeonidis E, Smallbone K, Spasić I, Weichart D, Brent R, Broomhead DS, Westerhoff HV, Kirdar B, Penttilä M, Klipp E, Palsson BØ, Sauer U, Oliver SG, Mendes P, Nielsen J, Kell DB (2008), “A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.” Nat Biotechnol 26(10):1155-60 Details

Le Novère N (2008), “Neurological disease: are systems approaches the way forward?” Pharmacopsychiatry 41 Suppl 1:S28-31 Details

Le Novère N, Li L, Girault JA (2008), “DARPP-32: molecular integration of phosphorylation potential.” Cell Mol Life Sci 65(14):2125-7 Details

Shimizu TS, Le Novère N (2008), “Looking inside the box: bacterial transistor arrays.” Mol Microbiol 69(1):5-9 Details

Taylor CF, Field D, Sansone SA, Aerts J, Apweiler R, Ashburner M, Ball CA, Binz PA, Bogue M, Booth T, Brazma A, Brinkman RR, Michael Clark A, Deutsch EW, Fiehn O, Fostel J, Ghazal P, Gibson F, Gray T, Grimes G, Hancock JM, Hardy NW, Hermjakob H, Julian RK Jr, Kane M, Kettner C, Kinsinger C, Kolker E, Kuiper M, Le Novère N, Leebens-Mack J, Lewis SE, Lord P, Mallon AM, Marthandan N, Masuya H, McNally R, Mehrle A, Morrison N, Orchard S, Quackenbush J, Reecy JM, Robertson DG, Rocca-Serra P, Rodriguez H, Rosenfelder H, Santoyo-Lopez J, Scheuermann RH, Schober D, Smith B, Snape J, Stoeckert CJ Jr, Tipton K, Sterk P, Untergasser A, Vandesompele J, Wiemann S (2008), “Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project.” Nat Biotechnol 26(8):889-96 Details


Laibe C, Le Novère N (2007), “MIRIAM Resources: tools to generate and resolve robust cross-references in Systems Biology.” BMC Syst Biol 1:58 Details

Le Novère N (2007), “The long journey to a Systems Biology of neuronal function.” BMC Syst Biol 1:28 Details

Rodriguez N, Donizelli M, Le Novère N (2007), “SBMLeditor: effective creation of models in the Systems Biology Markup language (SBML).” BMC Bioinformatics 8:79 Details


Donizelli M, Djite MA, Le Novère N (2006), “LGICdb: a manually curated sequence database after the genomes.” Nucleic Acids Res 34(Database issue):D267-9 Details

Le Novère N (2006), “Model storage, exchange and integration.” BMC Neurosci 7 Suppl 1:S11 Details

Schapira AH, Bezard E, Brotchie J, Calon F, Collingridge GL, Ferger B, Hengerer B, Hirsch E, Jenner P, Le Novère N, Obeso JA, Schwarzschild MA, Spampinato U, Davidai G (2006), “Novel pharmacological targets for the treatment of Parkinson's disease.” Nat Rev Drug Discov 5(10):845-54 Details

Schilstra MJ, Li L, Matthews J, Finney A, Hucka M, Le Novère N (2006), “CellML2SBML: conversion of CellML into SBML.” Bioinformatics 22(8):1018-20 Details


Taly A, Delarue M, Grutter T, Nilges M, Le Novère N, Corringer PJ, Changeux JP (2005), “Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism.” Biophys J 88(6):3954-65 Details


Grutter T, Le Novère N, Changeux JP (2004), “Rational understanding of nicotinic receptors drug binding.” Curr Top Med Chem 4(6):645-50 Details

Le Novère N, Donizelli M (2004), “The Molecular Pages of the mesotelencephalic dopamine consortium (DopaNet).” BMC Bioinformatics 5:174 Details

Sallette J, Bohler S, Benoit P, Soudant M, Pons S, Le Novère N, Changeux JP, Corringer PJ (2004), “An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine.” J Biol Chem 279(18):18767-75 Details


Champtiaux N, Gotti C, Cordero-Erausquin M, David DJ, Przybylski C, Léna C, Clementi F, Moretti M, Rossi FM, Le Novère N, McIntosh JM, Gardier AM, Changeux JP (2003), “Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice.” J Neurosci 23(21):7820-9 Details

Courtois V, Chatelain G, Han ZY, Le Novère N, Brun G, Lamonerie T (2003), “New Otx2 mRNA isoforms expressed in the mouse brain.” J Neurochem 84(4):840-53 Details

Grutter T, Prado de Carvalho L, Le Novère N, Corringer PJ, Edelstein S, Changeux JP (2003), “An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors.” EMBO J 22(9):1990-2003 Details

Han ZY, Zoli M, Cardona A, Bourgeois JP, Changeux JP, Le Novère N (2003), “Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]alpha-bungarotoxin binding sites in the brain of Macaca mulatta.” J Comp Neurol 461(1):49-60 Details

Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, Kitano H, Arkin AP, Bornstein BJ, Bray D, Cornish-Bowden A, Cuellar AA, Dronov S, Gilles ED, Ginkel M, Gor V, Goryanin II, Hedley WJ, Hodgman TC, Hofmeyr JH, Hunter PJ, Juty NS, Kasberger JL, Kremling A, Kummer U, Le Novère N, Loew LM, Lucio D, Mendes P, Minch E, Mjolsness ED, Nakayama Y, Nelson MR, Nielsen PF, Sakurada T, Schaff JC, Shapiro BE, Shimizu TS, Spence HD, Stelling J, Takahashi K, Tomita M, Wagner J, Wang J, SBML Forum (2003), “The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models.” Bioinformatics 19(4):524-31 Details


Ferrari R, Le Novère N, Picciotto MR, Changeux JP, Zoli M (2002), “Acute and long-term changes in the mesolimbic dopamine pathway after systemic or local single nicotine injections.” Eur J Neurosci 15(11):1810-8 Details

Fruchart-Gaillard C, Gilquin B, Antil-Delbeke S, Le Novère N, Tamiya T, Corringer PJ, Changeux JP, Ménez A, Servent D (2002), “Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor.” Proc Natl Acad Sci U S A 99(5):3216-21 Details

Le Novère N, Corringer PJ, Changeux JP (2002), “The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences.” J Neurobiol 53(4):447-56 Details

Le Novère N, Grutter T, Changeux JP (2002), “Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.” Proc Natl Acad Sci U S A 99(5):3210-5 Details


Duke TA, Le Novère N, Bray D (2001), “Conformational spread in a ring of proteins: a stochastic approach to allostery.” J Mol Biol 308(3):541-53 Details

Lacombe B, Becker D, Hedrich R, DeSalle R, Hollmann M, Kwak JM, Schroeder JI, Le Novère N, Nam HG, Spalding EP, Tester M, Turano FJ, Chiu J, Coruzzi G (2001), “The identity of plant glutamate receptors.” Science 292(5521):1486-7 Details

Le Novère N (2001), “MELTING, computing the melting temperature of nucleic acid duplex.” Bioinformatics 17(12):1226-7 Details

Le Novère N, Changeux JP (2001), “The Ligand Gated Ion Channel database: an example of a sequence database in neuroscience.” Philos Trans R Soc Lond B Biol Sci 356(1412):1121-30 Details

Le Novère N, Changeux JP (2001), “LGICdb: the ligand-gated ion channel database.” Nucleic Acids Res 29(1):294-5 Details

Le Novère N, Shimizu TS (2001), “STOCHSIM: modelling of stochastic biomolecular processes.” Bioinformatics 17(6):575-6 Details


Corringer PJ, Le Novère N, Changeux JP (2000), “Nicotinic receptors at the amino acid level.” Annu Rev Pharmacol Toxicol 40:431-58 Details

Han ZY, Le Novère N, Zoli M, Hill JA Jr, Champtiaux N, Changeux JP (2000), “Localization of nAChR subunit mRNAs in the brain of Macaca mulatta.” Eur J Neurosci 12(10):3664-74 Details

Rogner UC, Spyropoulos DD, Le Novère N, Changeux JP, Avner P (2000), “Control of neurulation by the nucleosome assembly protein-1-like 2.” Nat Genet 25(4):431-5 Details

Shimizu TS, Le Novère N, Levin MD, Beavil AJ, Sutton BJ, Bray D (2000), “Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis.” Nat Cell Biol 2(11):792-6 Details


Le Novère N, Changeux JP (1999), “The Ligand Gated Ion Channel Database.” Nucleic Acids Res 27(1):340-2 Details

Le Novère N, Corringer PJ, Changeux JP (1999), “Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation.” Biophys J 76(5):2329-45 Details

le Novère N, Zoli M, Léna C, Ferrari R, Picciotto MR, Merlo-Pich E, Changeux JP (1999), “Involvement of alpha6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion.” Neuroreport 10(12):2497-501 Details

Léna C, de Kerchove D'Exaerde A, Cordero-Erausquin M, Le Novère N, del Mar Arroyo-Jimenez M, Changeux JP (1999), “Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons.” Proc Natl Acad Sci U S A 96(21):12126-31 Details

Lukas RJ, Changeux JP, Le Novère N, Albuquerque EX, Balfour DJ, Berg DK, Bertrand D, Chiappinelli VA, Clarke PB, Collins AC, Dani JA, Grady SR, Kellar KJ, Lindstrom JM, Marks MJ, Quik M, Taylor PW, Wonnacott S (1999), “International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits.” Pharmacol Rev 51(2):397-401 Details

Marubio LM, del Mar Arroyo-Jimenez M, Cordero-Erausquin M, Léna C, Le Novère N, de Kerchove d'Exaerde A, Huchet M, Damaj MI, Changeux JP (1999), “Reduced antinociception in mice lacking neuronal nicotinic receptor subunits.” Nature 398(6730):805-10 Details


Changeux JP, Bertrand D, Corringer PJ, Dehaene S, Edelstein S, Léna C, Le Novère N, Marubio L, Picciotto M, Zoli M (1998), “Brain nicotinic receptors: structure and regulation, role in learning and reinforcement.” Brain Res Brain Res Rev 26(2-3):198-216 Details


Beeri R, Le Novère N, Mervis R, Huberman T, Grauer E, Changeux JP, Soreq H (1997), “Enhanced hemicholinium binding and attenuated dendrite branching in cognitively impaired acetylcholinesterase-transgenic mice.” J Neurochem 69(6):2441-51 Details


Changeux JP, Bessis A, Bourgeois JP, Corringer PJ, Devillers-Thiery A, Eiselé JL, Kerszberg M, Léna C, Le Novère N, Picciotto M, Zoli M (1996), “Nicotinic receptors and brain plasticity.” Cold Spring Harb Symp Quant Biol 61:343-62 Details

Le Novère N, Zoli M, Changeux JP (1996), “Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain.” Eur J Neurosci 8(11):2428-39 Details


Bessis A, Salmon AM, Zoli M, Le Novère N, Picciotto M, Changeux JP (1995), “Promoter elements conferring neuron-specific expression of the beta 2-subunit of the neuronal nicotinic acetylcholine receptor studied in vitro and in transgenic mice.” Neuroscience 69(3):807-19 Details

Le Novère N, Changeux JP (1995), “Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells.” J Mol Evol 40(2):155-72 Details

Li XM, Zoli M, Finnman UB, Le Novère N, Changeux JP, Fuxe K (1995), “A single (-)-nicotine injection causes change with a time delay in the affinity of striatal D2 receptors for antagonist, but not for agonist, nor in the D2 receptor mRNA levels in the rat substantia nigra.” Brain Res 679(1):157-67 Details

Picciotto MR, Zoli M, Léna C, Bessis A, Lallemand Y, Le Novère N, Vincent P, Pich EM, Brûlet P, Changeux JP (1995), “Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain.” Nature 374(6517):65-7 Details

Zoli M, Le Novère N, Hill JA Jr, Changeux JP (1995), “Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems.” J Neurosci 15(3 Pt 1):1912-39 Details