Mr Laith Alexander
My research focuses on the neurobiology of emotion and emotional regulation. In particular, I am interested in how prefrontal cortical regions (area 25 and 32) subserve the regulation of emotional states. Using sophisticated techniques in behavioural psychology, neuropharmacology and cardiovascular monitoring I am attempting to understand how dysfunctions in these regions contribute to the core aspects of Major Depressive Disorder: enhanced 'negative' emotion (low mood and anxiety) and reduced 'positive' emotion (anhedonia).
Magnetic resonance imaging (MRI)
Positron Emission Tomography (PET)
Associated News Items
Alexander L, Gaskin PLR, Sawiak SJ, Fryer TD, Hong YT, Cockcroft GJ, Clarke HF, Roberts AC (2019), “Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex” Neuron 101(2): 307-320
Zeredo JL, Quah SKL, Wallis CU, Alexander L, Cockcroft GJ, Santangelo AM, Xia J, Shiba Y, Dalley JW, Cardinal RN, Roberts AC, Clarke HF (2019), “Glutamate within the marmoset anterior hippocampus interacts with area 25 to regulate the behavioral and cardiovascular correlates of high-trait anxiety” J Neurosci
Wallis CU, Cardinal RN, Alexander L, Roberts AC, Clarke HF (2017), “Opposing roles of primate areas 25 and 32 and their putative rodent homologs in the regulation of negative emotion” PNAS