Dr Laith Alexander

Laith Alexander

University position

PhD student
Supervised by Professor Angela Roberts, Dr Hannah Clarke

Departments

Department of Physiology, Development and Neuroscience

Research Theme

Cognitive and Behavioural Neuroscience

Interests

My research focuses on the neurobiology of emotion and emotional regulation. In particular, I am interested in how prefrontal cortical regions (area 25 and 32) subserve the regulation of emotional states. Using sophisticated techniques in behavioural psychology, neuropharmacology and cardiovascular monitoring I am attempting to understand how dysfunctions in these regions contribute to the core aspects of Major Depressive Disorder: enhanced 'negative' emotion (low mood and anxiety) and reduced 'positive' emotion (anhedonia).

Research Focus

Keywords

prefrontal cortex

amygdala

hippocampus

anxiety

anhedonia

Clinical conditions

Anxiety disorders

Depressive disorders

Equipment

Behavioural analysis

Cardiovascular monitoring

Magnetic resonance imaging (MRI)

Neuropharmacology

Neuropsychological testing

Positron Emission Tomography (PET)

Collaborators

Cambridge

Hannah Clarke

Angela Roberts

Associated News Items


Key publications

Alexander L, Gaskin PLR, Sawiak SJ, Fryer TD, Hong YT, Cockcroft GJ, Clarke HF, Roberts AC (2019), “Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex” Neuron 101(2): 307-320

Publications

2019

Alexander L, Clarke HF, Roberts AC (2019), “A Focus on the Functions of Area 25” Brain Sci

Zeredo JL, Quah SKL, Wallis CU, Alexander L, Cockcroft GJ, Santangelo AM, Xia J, Shiba Y, Dalley JW, Cardinal RN, Roberts AC, Clarke HF (2019), “Glutamate within the marmoset anterior hippocampus interacts with area 25 to regulate the behavioral and cardiovascular correlates of high-trait anxiety” J Neurosci

2017

Wallis CU, Cardinal RN, Alexander L, Roberts AC, Clarke HF (2017), “Opposing roles of primate areas 25 and 32 and their putative rodent homologs in the regulation of negative emotion” PNAS