Professor Karen Ersche University positionProfessor Professor Karen Ersche is pleased to consider applications from prospective PhD students. DepartmentsInstitutesBehavioural and Clinical Neuroscience Institute Home pagehttps://www.psychiatry.cam.ac.uk/karen-e... (personal home page) Research ThemesInterestsMy research focuses on the neuropsychological correlates and neurochemical processes underlying addictive behaviour and the translation of this knowledge into therapeutic interventions. This work involves a combination of approaches including neuroimaging, neuropsychological testing, and pharmacological intervention. My present project investigates the question of causality, namely whether the neurobiological abnormalities seen in stimulant-dependent individuals are an effect of their long-term exposure to potentially neurotoxic drugs or whether these are the result of a genetic predisposition. I believe that a better understanding of the underlying mechanisms involved in drug addiction has the potential to clarify the health risks associated with drug abuse and to facilitate a more rational development of therapeutic interventions. It may also help to reduce the widespread stigma attached to people who have become dependent on drugs, thus further improving their prospects of recovery. Research Focus
EquipmentBehavioural analysis Magnetic resonance imaging (MRI) Neuropsychological testing Positron Emission Tomography (PET) Randomised control trials CollaboratorsNo collaborators listed Associated News Items
Key publicationsErsche KD (2020), “Resilience to trauma: just a matter of control?” Science 367 (6479):734-735. PDF Ersche KD, Gillan CM, Jones PS, Williams GB, Ward LHE, Luijten M, deWit S, Sahakian BJ, Bullmore ET, Robbins TW (2016), “Carrots and sticks fail to change behavior in cocaine addiction. ” Science 352 (6292):1468-1471 PDF Ersche KD, Jones PS, Williams GB, Turton AJ, Robbins TW, Bullmore ET (2012), “Abnormal brain structure implicated in stimulant drug addiction.” Science 335(6068):601-4 PDF Details Publications2023Graczyk MM, Sahakian BJ, Robbins TW & Ersche KD (2023), “Genotype-by-diagnosis interaction influences self-control in human cocaine addiction” Translational Psychiatry Lim TV & Ersche KD (2023), “Theory-driven computational models of drug addiction in humans: fruitful or futile?” Addiction Neuroscience 5: 100066 PDF Savulich G, Ferry-Bolder E, Lim TV, Mak E & Ersche KD (2023), “The “Resilient Brain”: Challenging key characteristics associated with the concept of resilience” Psychological Medicine 2022Agunbiade K, Fonville L, McGonigle J, Elliott R, Ersche KD, Flechais R, Orban C, Murphy A, Smith DG, Suckling J, Taylor EM, Deakin B, Robbins TW, Nutt DJ, Lingford-Hughes AR, Paterson LM, ICCAM Consortium (2022), “Alterations in white matter microstructure in alcohol and alcohol-polydrug dependence: Associations with lifetime alcohol and nicotine exposure.” Addiction Biology 27:e13207 Fernando J, Stochl J, Ersche KD (2022), “Drug Use in Night Owls May Increase the Risk for Mental Health Problems. ” Frontiers in Neuroscience 15:819566 PDF Nestor LJ and Ersche KD (2022), “Abnormal brain networks related to drug and non-drug reward anticipation and outcome processing in stimulant use disorder: A functional connectomics approach” Biological Psychiatry: CNNI PDF Oechsner M, Mak E, Ersche KD (2022), “Detecting Small Vessel Pathology in Cocaine Use Disorder” Frontiers in Neuroscience PDF Vamvakopoulou IA, Fonville L, Hayes A, McGonigle J, Elliott R, Ersche KD, Flechais R, Orban C, Murphy A, Smith DG, Suckling J, Taylor EM, Deakin B, Robbins TW, Nutt DJ, Lingford-Hughes AR and Paterson LM on behalf of ICCAM consortium (2022), “Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence” Frontiers Psychiatry Verdejo-Garcia A, Rezapour T, Giddens E, Khojasteh Zonoozi A, Rafei P, Berry J, Caracuel A, Copersino ML, Field M, Garland EL, Lorenzetti V, Malloy-Diniz L, Manning V, Marceau EM, Pennington DL, Strickland JC, Wiers R, Fairhead R, Anderson A, Bell M, Boendermaker WJ, Brooks S, Bruno R, Campanella S, Cousijn J, Cox WM, Dean AC, Ersche KD, Franken I, Froeliger B, Gamito P, Gladwin TE, Goncalves PD, Houben K, Jacobus J, Jones A, Kaag AM, Lindenmeyer J, McGrath E, Nardo T, Oliveira J, Pennington CR, Perrykkad K, Piercy H, Rupp CI, Schulte MHJ, Squeglia LM, Staiger P, Stein DJ, Stein J, Stein M, Stoops WW, Sweeney M, Witkiewitz K, Woods SP, Yi R, Zhao M, Ekhtiari H. (2022), “Cognitive training and remediation interventions for substance use disorders: a Delphi consensus study” Addiction Zhukovsky P, Savulich GJ, Morgan S, Dalley JW, Williams GB, Ersche KD (2022), “Morphometric similarity deviations in stimulant use disorder point towards abnormal brain ageing ” Brains Communications PDF 2021Bland AR, Ersche KD (2021), “Deficits in recognizing female facial expressions related to social network in cocaine-addicted men Drug and Alcohol Dependence” Drug and Alcohol Dependence PDF Breedon JR, Ziauddeen H, Stochl J, Ersche KD (2021), “Feeding the addiction: Narrowing of goals to habits” European Neuropsychopharmacology PDF Ersche KD, Lim TV, Murley AG, Rua C, Vaghi MM, White TL, Williams GB, Robbins TW (2021), “Reduced glutamate turnover in the putamen is linked with automatic habits in human cocaine addiction. ” Biological Psychiatry PDF Lim TV, Cardinal RN, Bullmore ET, Robbins TW, Ersche KD (2021), “Impaired learning from negative feedback in stimulant use disorder: Dopaminergic modulation” International Journal of Neurpspychopharmacology Orban C, McGonigle, J, Flechais R, Paterson L, Elliott R, Erritzoe D, Ersche KD, Murphy A, Nestor L, Passetti F, Reed L, Santos-Ribeiro A, Smith DG, Suckling J, Taylor E, Waldman A, Wing V, Deakin B, Robbins TW; Nutt DJ; Lingford-Hughes, A (2021), “Chronic alcohol exposure differentially modulates structural and functional properties of amygdala: a cross-sectional study” Addiction Biology Savulich G, Bowden-Jones O, Stephenson R, Brühl AB, Ersche KD, Robbins TW, Sahakian BJ (2021), “ "Hot" and "Cold" Cognition in Users of Club Drugs/Novel Psychoactive Substances. ” Frontiers in Psychiatry 12:60575 Zhukovsky P, Morein-Zamir S, Ziauddeen H, Fernandez-Egea E, Meng C, Regenthal R, Sahakian JB, Bullmore ET, Robbins TW, Dalley JW & Ersche KD (2021), “Prefrontal cortex activation and stopping performance underlie the beneficial effects of atomoxetine on response inhibition in healthy and cocaine use disorder volunteers ” Biological Psychiatry: CNNI PDF 2020Ersche KD, Meng C, Ziauddeen H, Stochl J, Williams GB, Bullmore ET, Robbins TW (2020), “Brain networks underlying vulnerability and resilience to drug addiction.” Proceedings of the National Academy of Sciences of USA 17(26):15253-15261 PDF Nestor LJ, Suckling J, Ersche KD, Murphy A, McGonigle J, Orban C, Paterson LM, Reed L, Taylor E, Flechais R, Smith D, Bullmore ET, Elliott R, Deakin B, Rabiner I, Lingford Hughes A, Sahakian BJ, Robbins TW, Nutt DJ; ICCAM Consortium (2020), “Disturbances across whole brain networks during reward anticipation in an abstinent addiction population.” NeuroImage Clinical 27:102297 Overmeyer R, Fürtjes S, Ersche KD, Ehrlich S, Endrass T (2020), “Self-regulation is negatively associated with habit tendencies: A validation of the German Creature of Habit Scale” Personality and Individual Differences 163: 110029. PDF Teichert J, Rowe JB, Ersche KD, Skandali N, Sacher J, Aigner A, Regenthal R (2020), “Validation of an Atomoxetine/Escitalopram HPLC Method in Plasma for Therapeutic Drug Monitoring Applications in Neuroscience Research” International Journal of Clinical Pharmacology and Therapeutics 58(8): 426-438. Zhukovsky P, Morein-Zamir S, Meng C, Dalley JW, Ersche KD (2020), “Network failures: When incentives trigger impulsive responses” Human Brain Mapping 41(8):2216-2228 2019Dalley JW, Ersche KD (2019), “Neural circuitry and mechanisms of waiting impulsivity: relevance to addiction” Philosophical Transactions B 374(1766):20180145 PDF Ersche KD, Ward LHE, TV Lim, Lumsden RJ, Sawiak SJ, Robbins TW, Stochl J (2019), “Impulsivity and compulsivity are differentially associated with automaticity and routine on the Creature of Habit Scale” Personality and Individual Differences 150:109493. PDF Just AL, Meng C, Smith DG, Bullmore ET, Robbins TW, Ersche KD (2019), “Effects of familial risk and stimulant drug use on the anticipation of monetary reward: an fMRI study” Translational Psychiatry 9(1):65. PDF Kanen JW, Ersche KD, Fineberg NA, Robbins TW, Cardinal RN (2019), “ Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: Remediating effects of dopaminergic D2/3 receptor agents” Psychopharmacology 236(8):2337-2358 Lim TV, Cardinal RN, Savulich G, Jones PS, Moustafa AA, Robbins TW, Ersche KD (2019), “Impairments in reinforcement learning do not explain enhanced habit formation in cocaine use disorder” Psychopharmacology 236(8):2359-2371. PDF Luijtchen M, Gillan CM, de Wit S, Franken IHA, Robbins TW, Ersche KD (2019), “Goal-directed and habitual control in smokers” Nicotine and Tobacco Research 22(2), 188/195. PDF Medic N, Kochunov P, Ziauddeen H, Ersche KD, Nathan PJ, Ronan L, Fletcher PC (2019), “BMI-related cortical morphometry changes are associated with altered white matter structure” International Journal of Obesity 43(3):523-532. Murray GK, Knolle F, Ersche KD, CraigKJ, Abbott S, Shabbir SS, Fineberg NA, Suckling J, Sahakian BJBullmore ET, Robbins TW (2019), “Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder” Psychopharmacology 236(8):2325-2336 2018Morris LS, Kwangyeol B, Tait R, Nestor LJ, Murphy A, McGonigle J, Orban C, Reed L, Taylor EM, Flechais RS, Paterson LM, Smith DG, Bullmore ET, Ersche KD, Suckling J, Elliott R, Deakin JW, Rabiner I, Lingford-Hughes AR, Nutt DJ, Sahakian BJ, Robbins TW, Voon V and ICCAM Platform (2018), “Effects of naltrexone on functional network properties in substance and alcohol use disorders.” Addiction Biology 23(1):425-436 Nestor LJ, Paterson LM, Murphy A, McGonigle J, Orban C, Reed L, Taylor E, Flechais R, Smith D, Bullmore ET, Ersche KD, Suckling J, Elliott R, Deakin B, Rabiner I, Lingford Hughes A, Sahakian BJ, Robbins TW, Nutt DJ; ICCAM Consortium (2018), “Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and polysubstance-dependent individuals.” European Journal of Neuroscience e-pub 6 Nov 2018 2017Edward S and Ersche KD (2017), “The diverse facets and emerging potential of addiction research” Current Opinion in Behavioral Sciences 13: 4-5 Ersche KD, Acosta-Cabronero J, Jones SP, Ziauddeen H, van Swelm R, Laarakkers C, Raha-Chowdhury R, Williams GB (2017), “Disrupted iron regulation in the brain and periphery in cocaine addiction.” Translational Psychiatry 7: e1040 PDF Ersche KD, Doeffinger R (2017), “Inflammation and Infection in Cocaine Addiction” Current Opinion in Behavioral Sciences 13: 203-209 PDF Ersche KD, Lim TV, Ward LHE, Robbins TW, Stochl J (2017), “Creature of Habit: A self-report measure of habitual routines and automatic tendencies in everyday life” Personality and Individual Differences 116:73-85 PDF McGonigle J, Murphy A, Paterson LM, Reed LJ, Nestor L, Nash J, Elliott R, Ersche KD, Flechais RS, Newbould R, Orban C, Smith DG, Taylor EM, Waldman AD, Robbins TW, Deakin JW, Nutt DJ, Lingford-Hughes AR, Suckling J; ICCAM Platform (2017), “The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part B: fMRI description.” Journal of Pharmacology 31: 3-16 Murphy A, Nestor LJ, McGonigle J, PatersonL, Boyapati V, Ersche KD, Flechais RS, Kuchibatla S, Metastasio A, Orban C, Passetti F, Reed L, Smith DG, Suckling J, Taylor EM, Robbins TW, Lingford Hughes AM, Nutt DJ, Deakin JFW and Elliott R ICCAM Consortium (2017), “Acute D3 antagonist GSK598809 selectively enhances neural response during monetary reward anticipation in drug and alcohol dependence” Neuropsychopharmacology 2017 Jan 25. Nestor LJ, Murphy A, McGonigle J, Orban C, Lawrence Reed, Talyor EM, Flechais RS, Paterson LM, Smith DG, Bullmore ET, Ersche KD, Suckling J, Tait R, Elliott R, Deakin JW, Rabiner I, Lingford-Hughes AR, Nutt DJ, Sahakian BJ, Robbins TW and ICCAM Platform (2017), “Acute naltrexone does not remediate neural deficits of reward anticipation in long-term abstinent alcoholics and polysubstance abusers on a monetary incentive delay task.” Addiction Biology 22:1576-1589. Passamonti L, Luijten M, Ziauddeen H, Coyle-Gilchrist IT, Rittman T, Brain AS, Regenthal R, Franken IH, Sahakian BJ, Bullmore ET, Robbins TW, Ersche KD (2017), “Atomoxetine reduces attentional bias to drug-related cues in cocaine dependent Individuals” Psychopharmacology 234:2289-2297. PDF Savulich G, Riccelli R, Passamonti L, Correia M, Deakin JFW, Elliott R, Flechais RS, Lingford-Hughes AR, McGonigle J, Murphy A, Nutt DJ, Orban C, Paterson LM, Reed LJ, Smith DG, Tait R, Taylor EM, Suckling S, Sahakian BJ, Robbins TW and Ersche KD ICCAM Platform (2017), “Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recovery” Translational Psychiatry 2016Ersche KD, Gillan CM, Jones PS, Williams GB, Ward LHE, Luijten M, deWit S, Sahakian BJ, Bullmore ET, Robbins TW (2016), “Carrots and sticks fail to change behavior in cocaine addiction.” Science 352 (6292):1468-1471 PDF Medic N, Ziauddeen H, Ersche KD, Farooqi I, Bullmore ET, Nathan P, Ronan L, and Fletcher PC (2016), “Increased Body Mass Index is Associated with Specific Regional Alterations in Brain Structure ” International Journal of Obesity 40: 1177-82 Nestor LJ, Murphy A, McGonigle J, Orban C, Reed L, Taylor E, Flechais R, Paterson LM, Smith D, Bullmore ET, Ersche KD, Suckling J, Tait R, Elliott R, Deakin B, Rabiner I, Lingford-Hughes A, Nutt DJ, Sahakian B, Robbins TW; ICCAM Consortium. (2016), “Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task.” Addiction Biology 2016 Sep 6 Taylor EM, Murphy A, Boyapati V, Ersche KD, Flechais R, Kuchibatla S, McGonigle J, Metastasio A, Nestor L, Orban C, Passetti F, Paterson L, Smith DG, Suckling J, Tait R, Lingford-Hughes AR, Robbins TW, Nutt DJ, Deakin WJF, Elliott R, ICCAM Platform (2016), “Impulsivity in abstinent alcohol and poly-drug dependence: a multi-dimensional approach” Psychopharmacology 223:1487-99 2015Ersche KD, Hagan CC, Smith DG, Jones PS, Calder AJ, Williams GB (2015), “In the face of threat: neural and endocrine correlates of impaired facial emotion recognition in cocaine dependence. ” Translational Psychiatry e570 PDF Morein-Zamir S, Simon Jones P, Bullmore ET, Robbins TW, Ersche KD (2015), “Take it or leave it: prefrontal control in recreational cocaine users.” Translational Psychiatry e582. PDF Paterson LM, Flechais RSA, Murphy A, Reed LJ, SAbbott S, Boyapati V, Elliott R, Erritzoe, Ersche KD, Faluyi Y, Faravelli L, Fernandez-Egea E , Kalk , Kuchibatla SS, McGonigle J, Metastasio A, Mick I, Nestor L, Orban C, Passetti F, Rabiner EA, Smith DG, Suckling J, Tait R, Taylor EM, Waldman AD, Robbins TW, Deakin JFW, Nutt DJ, Lingford-Hughes AR, ICCAM Platform (2015), “The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description” Journal of Psychopharmacology 29 (9): 943-60 Whitelock CF, Agyepong HN, Patterson K, Ersche KD (2015), “Signing below the dotted line: signature position as a marker of vulnerability for visuospatial processing difficulties.” Neurocase 21(1):67-72 PDF Details 2014Billing L and Ersche KD (2014), “Cocaine’s Appetite for Fat and the Consequences on Body Weight” The American Journal of Drug and Alcohol Abuse 41(2):115-8 PDF Ersche KD (2014), “Paying attention to biased attention in drug addiction.” CNS Spectr 19(3):213-4 PDF Details Ersche KD, Hagan CC, Smith DG, Abbott S, Jones PS, Apergis-Schoute AM, Döffinger R (2014), “Aberrant disgust responses and immune reactivity in cocaine-dependent men.” Biol Psychiatry 75(2):140-7 PDF Details Patel AX, Kundu P, Rubinov M, Jones PS, Vértes PE, Ersche KD, Suckling J, Bullmore ET (2014), “A wavelet method for modeling and despiking motion artifacts from resting-state fMRI time series.” Neuroimage 95:287-304 Details Smith DG, Ersche KD (2014), “Using a drug-word Stroop task to differentiate recreational from dependent drug use.” CNS Spectr 19(3):247-55 Details Smith DG, Simon Jones P, Bullmore ET, Robbins TW, Ersche KD (2014), “Enhanced orbitofrontal cortex function and lack of attentional bias to cocaine cues in recreational stimulant users.” Biol Psychiatry 75(2):124-31 Details 2013Ersche KD (2013), “Intoxicants and Compulsive Behaviour - A Neuroscientific Perspective” In "Intoxication and Society: Problematic Pleasures of Drugs and Alcohol"; Edited by Jonathan Herring, Ciaran Regan, Darin Weinberg and Phil Withington Palgrave Macmillan Ersche KD (2013), “Neurobiological correlates of the familial risk for stimulant drug dependence.” Neuropsychopharmacology 38(1):238-9 PDF Details Ersche KD, Jones PS, Williams GB, Robbins TW, Bullmore ET (2013), “Cocaine dependence: a fast-track for brain ageing?” Mol Psychiatry 18(2):134-5 PDF Details Ersche KD, Jones PS, Williams GB, Smith DG, Bullmore ET, Robbins TW (2013), “Distinctive personality traits and neural correlates associated with stimulant drug use versus familial risk of stimulant dependence.” Biol Psychiatry 74(2):137-44 PDF Details Ersche KD, Stochl J, Woodward JM, Fletcher PC (2013), “The skinny on cocaine: insights into eating behavior and body weight in cocaine-dependent men.” Appetite 71:75-80 PDF Details Ersche KD, Williams GB, Robbins TW, Bullmore ET (2013), “Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience.” Curr Opin Neurobiol 23(4):615-24 PDF Details Morein-Zamir S, Simon Jones P, Bullmore ET, Robbins TW, Ersche KD (2013), “Prefrontal hypoactivity associated with impaired inhibition in stimulant-dependent individuals but evidence for hyperactivation in their unaffected siblings.” Neuropsychopharmacology 38(10):1945-53 Details Smith DG, Jones PS, Bullmore ET, Robbins TW, Ersche KD (2013), “Cognitive control dysfunction and abnormal frontal cortex activation in stimulant drug users and their biological siblings.” Transl Psychiatry 3:e257 Details Smith DG, Jones PS, Williams GB, Bullmore ET, Robbins TW, Ersche KD (2013), “Overlapping decline in orbitofrontal gray matter volume related to cocaine use and body mass index.” Addict Biol Details 2012Ersche KD, Cumming P, Craig KJ, Müller U, Fineberg NA, Bullmore ET, Robbins TW (2012), “Amisulpride-induced acute akathisia in OCD: an example of dysfunctional dopamine-serotonin interactions?” J Psychopharmacol 26(6):887-90 PDF Details Ersche KD, Jones PS, Williams GB, Turton AJ, Robbins TW, Bullmore ET (2012), “Abnormal brain structure implicated in stimulant drug addiction.” Science 335 (6068): 601-4 PDF Ersche KD, Turton AJ, Chamberlain SR, Müller U, Bullmore ET, Robbins TW (2012), “Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence.” Am J Psychiatry 169(9):926-36 PDF Details Ersche KD, Turton AJ, Croudace T, Stochl J (2012), “Who Do You Think Is in Control in Addiction? A Pilot Study on Drug-related Locus of Control Beliefs.” Addict Disord Their Treat 11(4):173-223 PDF Details Meunier D, Ersche KD, Craig KJ, Fornito A, Merlo-Pich E, Fineberg NA, Shabbir SS, Robbins TW, Bullmore ET (2012), “Brain functional connectivity in stimulant drug dependence and obsessive-compulsive disorder.” Neuroimage 59(2):1461-8 Details Robbins TW, Gillan CM, Smith DG, de Wit S, Ersche KD (2012), “Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry.” Trends Cogn Sci 16(1):81-91 Details 2011Ersche KD & Robbins TW (2011), “Neurobiological correlates of drug dependence” Neurobiology of Addiction edited by Adinoff B. and Stein E. pp 9-35 Ersche KD, Barnes A, Jones PS, Morein-Zamir S, Robbins TW, Bullmore ET (2011), “Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence.” Brain 134(Pt 7):2013-24 PDF Details Ersche KD, Roiser JP, Abbott S, Craig KJ, Müller U, Suckling J, Ooi C, Shabbir SS, Clark L, Sahakian BJ, Fineberg NA, Merlo-Pich EV, Robbins TW, Bullmore ET (2011), “Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist.” Biol Psychiatry 70(8):754-62 PDF Details Ersche KD, Roiser JP, Lucas M, Domenici E, Robbins TW, Bullmore ET (2011), “Peripheral biomarkers of cognitive response to dopamine receptor agonist treatment.” Psychopharmacology (Berl) 214(4):779-89 PDF Details Ersche, KD (2011), “The Neuropsychology of Stimulant and Opiate Dependence: Neuroimaging and Neuropsychological Studies” In: Phelps E.A., Robbins T.W. and Delgado M. Affect, Learning and Decision Making Attention and Performance XXII Oxford University Press Gorodetzky H, Sahakian BJ, Robbins TW, Ersche KD (2011), “Differences in self-reported decision-making styles in stimulant-dependent and opiate-dependent individuals.” Psychiatry Res 186(2-3):437-40 Details 2010Ersche KD, Bullmore ET, Craig KJ, Shabbir SS, Abbott S, Müller U, Ooi C, Suckling J, Barnes A, Sahakian BJ, Merlo-Pich EV, Robbins TW (2010), “Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence.” Arch Gen Psychiatry 67(6):632-44 PDF Details Ersche KD, Turton AJ, Pradhan S, Bullmore ET, Robbins TW (2010), “Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits.” Biol Psychiatry 68(8):770-3 PDF Details Morein-Zamir S, Craig KJ, Ersche KD, Abbott S, Muller U, Fineberg NA, Bullmore ET, Sahakian BJ, Robbins TW (2010), “Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation.” Psychopharmacology (Berl) 212(3):357-67 Details 2009Meunier D, Lambiotte R, Fornito A, Ersche KD, Bullmore ET (2009), “Hierarchical modularity in human brain functional networks.” Front Neuroinform 3:37 Details 2008DeVito EE, Blackwell AD, Kent L, Ersche KD, Clark L, Salmond CH, Dezsery AM, Sahakian BJ (2008), “The effects of methylphenidate on decision making in attention-deficit/hyperactivity disorder.” Biol Psychiatry 64(7):636-9 Details Ersche KD, Nutt DJ (2008), “Neurocognition and social cognition in middle aged and older adult drug users: vulnerability and consequences” U.K. Government Foresight Review PDF Ersche KD, Roiser JP, Robbins TW, Sahakian BJ (2008), “Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans.” Psychopharmacology (Berl) 197(3):421-31 PDF Details Robbins TW, Ersche KD, Everitt BJ (2008), “Drug addiction and the memory systems of the brain.” Ann N Y Acad Sci 1141:1-21 Details 2007Ersche KD, Sahakian BJ (2007), “The neuropsychology of amphetamine and opiate dependence: implications for treatment.” Neuropsychol Rev 17(3):317-36 PDF Details Everitt BJ, Hutcheson DM, Ersche KD, Pelloux Y, Dalley JW, Robbins TW (2007), “The orbital prefrontal cortex and drug addiction in laboratory animals and humans.” Ann N Y Acad Sci 1121:576-97 Details 2006Clark L, Robbins TW, Ersche KD, Sahakian BJ (2006), “Reflection impulsivity in current and former substance users.” Biol Psychiatry 60(5):515-22 Details Ersche KD, Clark L, London M, Robbins TW, Sahakian BJ (2006), “Profile of executive and memory function associated with amphetamine and opiate dependence.” Neuropsychopharmacology 31(5):1036-47 PDF Details Ersche KD, Fletcher PC, Roiser JP, Fryer TD, London M, Robbins TW, Sahakian BJ (2006), “Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteers.” Psychopharmacology (Berl) 188(3):364-73 PDF Details 2005Ersche KD, Fletcher PC, Lewis SJ, Clark L, Stocks-Gee G, London M, Deakin JB, Robbins TW, Sahakian BJ (2005), “Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals.” Psychopharmacology (Berl) 180(4):612-23 PDF Details Ersche KD, Roiser JP, Clark L, London M, Robbins TW, Sahakian BJ (2005), “Punishment induces risky decision-making in methadone-maintained opiate users but not in heroin users or healthy volunteers.” Neuropsychopharmacology 30(11):2115-24 PDF Details |