Dr Karalyn Patterson FRS, FMedSci, FBA University positionVisiting Academic DepartmentsDepartment of Clinical Neurosciences Instituteskaralyn.patterson@mrc-cbu.cam.ac.uk Home pagehttp://www.mrc-cbu.cam.ac.uk/people/... (personal home page) Research ThemeInterestsI study language and memory in adults, mainly from the perspective of the patterns of disruption to these cognitive functions that occur as a result of brain damage or disease. Research Focus
EquipmentBehavioural analysis Computational modelling Magnetic resonance imaging (MRI) Neuropsychological testing Collaborators
Associated News ItemsKey publicationsPatterson K, Fushimi T (2006), “Organisation of language in the brain: Does it matter which language you speak? Interdisciplinary Science Reviews” 31: 201-216 Patterson K, Lambon Ralph MA, Jefferies E, Woollams A, Jones R, Hodges JR, Rogers TT (2006), “‘Pre-semantic’ cognition in semantic dementia: Six deficits in search of an explanation” Journal of Cognitive Neuroscience 18:169-183 Details Kellenbach ML, Hovius M, Patterson K (2005), “A PET study of visual and semantic knowledge about objects” Cortex 41:107-118 Details Hodges JR, Patterson K, Oxbury S, Funnell E (1992), “Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy.” Brain 115 ( Pt 6):1783-806 Details Patterson K, Hodges JR (1992), “Deterioration of word meaning: implications for reading.” Neuropsychologia 30(12):1025-40 Details Patterson K, Vargha-Khadem F, Polkey CE (1989), “Reading with one hemisphere.” Brain 112 ( Pt 1):39-63 Details Publications2014Bishop DV, Nation K, Patterson K (2014), “Preface. Language in developmental and acquired disorders.” Philos Trans R Soc Lond B Biol Sci 369(1634):20130564 Details Bishop DV, Nation K, Patterson K (2014), “When words fail us: insights into language processing from developmental and acquired disorders.” Philos Trans R Soc Lond B Biol Sci 369(1634):20120403 Details Patterson K, Holland R (2014), “Patients with impaired verb-tense processing: do they know that yesterday is past?” Philos Trans R Soc Lond B Biol Sci 369(1634):20120402 Details 2013Adlam AL, de Haan M, Hodges JR, Patterson K (2013), “Memory for action sequences in semantic dementia.” Neuropsychologia 51(8):1481-7 Details Meteyard L, Quain E, Patterson K (2013), “Ever decreasing circles: Speech production in semantic dementia.” Cortex Details Sajjadi SA, Acosta-Cabronero J, Patterson K, Diaz-de-Grenu LZ, Williams GB, Nestor PJ (2013), “Diffusion tensor magnetic resonance imaging for single subject diagnosis in neurodegenerative diseases.” Brain 136(Pt 7):2253-61 Details Whitelock CF, Agyepong HN, Patterson K, Ersche KD (2013), “Signing below the dotted line: signature position as a marker of vulnerability for visuospatial processing difficulties.” Neurocase Details 2012Butler R, Patterson K, Woollams AM (2012), “In search of meaning: semantic effects on past-tense inflection.” Q J Exp Psychol (Hove) 65(8):1633-56 Details Hoffman P, Meteyard L, Patterson K (2012), “Broadly speaking: Vocabulary in semantic dementia shifts towards general, semantically diverse words.” Cortex Details Holland R, Brindley L, Shtyrov Y, Pulvermüller F, Patterson K (2012), “They played with the trade: MEG investigation of the processing of past tense verbs and their phonological twins.” Neuropsychologia 50(14):3713-20 Details Sajjadi SA, Patterson K, Arnold RJ, Watson PC, Nestor PJ (2012), “Primary progressive aphasia: a tale of two syndromes and the rest.” Neurology 78(21):1670-7 Details Woollams AM, Patterson K (2012), “The consequences of progressive phonological impairment for reading aloud.” Neuropsychologia 50(14):3469-77 Details 2011Acosta-Cabronero J, Patterson K, Fryer TD, Hodges JR, Pengas G, Williams GB, Nestor PJ (2011), “Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story.” Brain 134(Pt 7):2025-35 Details Lambon Ralph MA, Patterson K, Plaut DC (2011), “Finite case series or infinite single-case studies? Comments on "Case series investigations in cognitive neuropsychology" by Schwartz and Dell (2010).” Cogn Neuropsychol 28(7):466-74; discussion 515-20 Details 2010Adlam AL, Patterson K, Bozeat S, Hodges JR (2010), “The Cambridge Semantic Memory Test Battery: detection of semantic deficits in semantic dementia and Alzheimer's disease.” Neurocase 16(3):193-207 Details Mion M, Patterson K, Acosta-Cabronero J, Pengas G, Izquierdo-Garcia D, Hong YT, Fryer TD, Williams GB, Hodges JR, Nestor PJ (2010), “What the left and right anterior fusiform gyri tell us about semantic memory.” Brain 133(11):3256-68 Details Pengas G, Patterson K, Arnold RJ, Bird CM, Burgess N, Nestor PJ (2010), “Lost and found: bespoke memory testing for Alzheimer's disease and semantic dementia.” J Alzheimers Dis 21(4):1347-65 Details Pulvermüller F, Cooper-Pye E, Dine C, Hauk O, Nestor PJ, Patterson K (2010), “The word processing deficit in semantic dementia: all categories are equal, but some categories are more equal than others.” J Cogn Neurosci 22(9):2027-41 Details 2009Adlam AL, Patterson K, Hodges JR (2009), “"I remember it as if it were yesterday": memory for recent events in patients with semantic dementia.” Neuropsychologia 47(5):1344-51 Details Dewar BK, Patterson K, Wilson BA, Graham KS (2009), “Re-acquisition of person knowledge in semantic memory disorders.” Neuropsychol Rehabil 19(3):383-421 Details Green HA, Patterson K (2009), “Jigsaws-a preserved ability in semantic dementia.” Neuropsychologia 47(2):569-76 Details Meteyard L, Patterson K (2009), “The relation between content and structure in language production: an analysis of speech errors in semantic dementia.” Brain Lang 110(3):121-34 Details 2008Hodges JR, Martinos M, Woollams AM, Patterson K, Adlam AL (2008), “Repeat and Point: differentiating semantic dementia from progressive non-fluent aphasia.” Cortex 44(9):1265-70 Details Kipps CM, Knibb JA, Patterson K, Hodges JR (2008), “Neuropsychology of frontotemporal dementia.” Handb Clin Neurol 88:527-48 Details Woollams AM, Cooper-Pye E, Hodges JR, Patterson K (2008), “Anomia: a doubly typical signature of semantic dementia.” Neuropsychologia 46(10):2503-14 Details 2007Alladi S, Xuereb J, Bak T, Nestor P, Knibb J, Patterson K, Hodges JR (2007), “Focal cortical presentations of Alzheimer's disease.” Brain 130(Pt 10):2636-45 Details Hauk O, Patterson K, Woollams A, Cooper-Pye E, Pulvermüller F, Rogers TT (2007), “How the camel lost its hump: the impact of object typicality on event-related potential signals in object decision.” J Cogn Neurosci 19(8):1338-53 Details Patterson K (2007), “The reign of typicality in semantic memory.” Philos Trans R Soc Lond B Biol Sci 362(1481):813-21 Details Patterson K, Nestor PJ, Rogers TT (2007), “Where do you know what you know? The representation of semantic knowledge in the human brain.” Nat Rev Neurosci 8(12):976-87 Details Woollams AM, Ralph MA, Plaut DC, Patterson K (2007), “SD-squared: on the association between semantic dementia and surface dyslexia.” Psychol Rev 114(2):316-39 Details 2006Adlam AL, Patterson K, Rogers TT, Nestor PJ, Salmond CH, Acosta-Cabronero J, Hodges JR (2006), “Semantic dementia and fluent primary progressive aphasia: two sides of the same coin?” Brain 129(Pt 11):3066-80 Details Cumming TB, Graham KS, Patterson K (2006), “Repetition priming and hyperpriming in semantic dementia.” Brain Lang 98(2):221-34 Details Cumming TB, Patterson K, Verfaellie M, Graham KS (2006), “One bird with two stones: Abnormal word length effects in pure alexia and semantic dementia.” Cogn Neuropsychol 23(8):1130-61 Details Hauk O, Patterson K, Woollams A, Watling L, Pulvermüller F, Rogers TT (2006), “[Q:] When would you prefer a SOSSAGE to a SAUSAGE? [A:] At about 100 msec. ERP correlates of orthographic typicality and lexicality in written word recognition.” J Cogn Neurosci 18(5):818-32 Details Hodges JR, Erzinçlio?lu S, Patterson K (2006), “Evolution of cognitive deficits and conversion to dementia in patients with mild cognitive impairment: a very-long-term follow-up study.” Dement Geriatr Cogn Disord 21(5-6):380-91 Details Knibb JA, Xuereb JH, Patterson K, Hodges JR (2006), “Clinical and pathological characterization of progressive aphasia.” Ann Neurol 59(1):156-65 Details Rogers TT, Hocking J, Noppeney U, Mechelli A, Gorno-Tempini ML, Patterson K, Price CJ (2006), “Anterior temporal cortex and semantic memory: reconciling findings from neuropsychology and functional imaging.” Cogn Affect Behav Neurosci 6(3):201-13 Details Rogers TT, Ivanoiu A, Patterson K, Hodges JR (2006), “Semantic memory in Alzheimer's disease and the frontotemporal dementias: a longitudinal study of 236 patients.” Neuropsychology 20(3):319-35 Details 2005Davies RR, Hodges JR, Kril JJ, Patterson K, Halliday GM, Xuereb JH (2005), “The pathological basis of semantic dementia.” Brain 128(Pt 9):1984-95 Details Rogers TT, Hocking J, Mechelli A, Patterson K, Price C (2005), “Fusiform activation to animals is driven by the process, not the stimulus.” J Cogn Neurosci 17(3):434-45 Details 2004Graham NL, Patterson K, Hodges JR (2004), “When more yields less: speaking and writing deficits in nonfluent progressive aphasia.” Neurocase 10(2):141-55 Details Rogers TT, Lambon Ralph MA, Garrard P, Bozeat S, McClelland JL, Hodges JR, Patterson K (2004), “Structure and deterioration of semantic memory: a neuropsychological and computational investigation.” Psychol Rev 111(1):205-35 Details Rogers TT, Ralph MA, Hodges JR, Patterson K (2004), “Natural selection: the impact of semantic impairment on lexical and object decision.” Cogn Neuropsychol 21(2):331-52 Details Thompson SA, Graham KS, Williams G, Patterson K, Kapur N, Hodges JR (2004), “Dissociating person-specific from general semantic knowledge: roles of the left and right temporal lobes.” Neuropsychologia 42(3):359-70 Details 2003Bozeat S, Ralph MA, Graham KS, Patterson K, Wilkin H, Rowland J, Rogers TT, Hodges JR (2003), “A duck with four legs: Investigating the structure of conceptual knowledge using picture drawing in semantic dementia.” Cogn Neuropsychol 20(1):27-47 Details Graham KS, Lee AC, Brett M, Patterson K (2003), “The neural basis of autobiographical and semantic memory: new evidence from three PET studies.” Cogn Affect Behav Neurosci 3(3):234-54 Details Graham NL, Bak T, Patterson K, Hodges JR (2003), “Language function and dysfunction in corticobasal degeneration.” Neurology 61(4):493-9 Details Hovius M, Kellenbach ML, Graham KS, Hodges JR, Patterson K (2003), “What does the object decision task measure? Reflections on the basis of evidence from semantic dementia.” Neuropsychology 17(1):100-7 Details Kellenbach ML, Brett M, Patterson K (2003), “Actions speak louder than functions: the importance of manipulability and action in tool representation.” J Cogn Neurosci 15(1):30-46 Details Lambon Ralph MA, Patterson K, Graham N, Dawson K, Hodges JR (2003), “Homogeneity and heterogeneity in mild cognitive impairment and Alzheimer's disease: a cross-sectional and longitudinal study of 55 cases.” Brain 126(Pt 11):2350-62 Details Nestor PJ, Graham NL, Fryer TD, Williams GB, Patterson K, Hodges JR (2003), “Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula.” Brain 126(Pt 11):2406-18 Details Thompson SA, Patterson K, Hodges JR (2003), “Left/right asymmetry of atrophy in semantic dementia: behavioral-cognitive implications.” Neurology 61(9):1196-203 Details 2002Bozeat S, Lambon Ralph MA, Patterson K, Hodges JR (2002), “When objects lose their meaning: what happens to their use?” Cogn Affect Behav Neurosci 2(3):236-51 Details Bozeat S, Ralph MA, Patterson K, Hodges JR (2002), “The influence of personal familiarity and context on object use in semantic dementia.” Neurocase 8(1-2):127-34 Details Graham KS, Patterson K, Powis J, Drake J, Hodges JR (2002), “Multiple inputs to episodic memory: words tell another story.” Neuropsychology 16(3):380-9 Details Lee AC, Graham KS, Simons JS, Hodges JR, Owen AM, Patterson K (2002), “Regional brain activations differ for semantic features but not categories.” Neuroreport 13(12):1497-501 Details Strain E, Patterson K, Seidenberg MS (2002), “Theories of word naming interact with spelling-sound consistency.” J Exp Psychol Learn Mem Cogn 28(1):207-14; discussion 215-20 Details Thompson SA, Graham KS, Patterson K, Sahakian BJ, Hodges JR (2002), “Is knowledge of famous people disproportionately impaired in patients with early and questionable Alzheimer's disease?” Neuropsychology 16(3):344-58 Details 2001Caine D, Patterson K, Hodges JR, Heard R, Halliday G (2001), “Severe anterograde amnesia with extensive hippocampal degeneration in a case of rapidly progressive frontotemporal dementia.” Neurocase 7(1):57-64 Details Galton CJ, Gomez-Anson B, Antoun N, Scheltens P, Patterson K, Graves M, Sahakian BJ, Hodges JR (2001), “Temporal lobe rating scale: application to Alzheimer's disease and frontotemporal dementia.” J Neurol Neurosurg Psychiatry 70(2):165-73 Details Galton CJ, Patterson K, Graham K, Lambon-Ralph MA, Williams G, Antoun N, Sahakian BJ, Hodges JR (2001), “Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia.” Neurology 57(2):216-25 Details Garrard P, Ralph MA, Hodges JR, Patterson K (2001), “Prototypicality, distinctiveness, and intercorrelation: Analyses of the semantic attributes of living and nonliving concepts.” Cogn Neuropsychol 18(2):125-74 Details Graham NL, Patterson K, Hodges JR (2001), “The emergence of jargon in progressive fluent dysgraphia: The widening gap between target and response.” Cogn Neuropsychol 18(4):343-61 Details Kellenbach ML, Brett M, Patterson K (2001), “Large, colorful, or noisy? Attribute- and modality-specific activations during retrieval of perceptual attribute knowledge.” Cogn Affect Behav Neurosci 1(3):207-21 Details Patterson K, Lambon Ralph MA, Hodges JR, McClelland JL (2001), “Deficits in irregular past-tense verb morphology associated with degraded semantic knowledge.” Neuropsychologia 39(7):709-24 Details Simons JS, Graham KS, Galton CJ, Patterson K, Hodges JR (2001), “Semantic knowledge and episodic memory for faces in semantic dementia.” Neuropsychology 15(1):101-14 Details Simons JS, Graham KS, Owen AM, Patterson K, Hodges JR (2001), “Perceptual and semantic components of memory for objects and faces: a pet study.” J Cogn Neurosci 13(4):430-43 Details 2000Bird H, Lambon Ralph MA, Patterson K, Hodges JR (2000), “The rise and fall of frequency and imageability: noun and verb production in semantic dementia.” Brain Lang 73(1):17-49 Details Bozeat S, Lambon Ralph MA, Patterson K, Garrard P, Hodges JR (2000), “Non-verbal semantic impairment in semantic dementia.” Neuropsychologia 38(9):1207-15 Details Croot K, Hodges JR, Xuereb J, Patterson K (2000), “Phonological and articulatory impairment in Alzheimer's disease: a case series.” Brain Lang 75(2):277-309 Details Galton CJ, Patterson K, Xuereb JH, Hodges JR (2000), “Atypical and typical presentations of Alzheimer's disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases.” Brain 123 Pt 3:484-98 Details Graham KS, Simons JS, Pratt KH, Patterson K, Hodges JR (2000), “Insights from semantic dementia on the relationship between episodic and semantic memory.” Neuropsychologia 38(3):313-24 Details Graham NL, Patterson K, Hodges JR (2000), “The impact of semantic memory impairment on spelling: evidence from semantic dementia.” Neuropsychologia 38(2):143-63 Details Hodges JR, Bozeat S, Lambon Ralph MA, Patterson K, Spatt J (2000), “The role of conceptual knowledge in object use evidence from semantic dementia.” Brain 123 ( Pt 9):1913-25 Details Knott R, Patterson K, Hodges JR (2000), “The role of speech production in auditory-verbal short-term memory: evidence from progressive fluent aphasia.” Neuropsychologia 38(2):125-42 Details 1999Croot K, Hodges JR, Patterson K (1999), “Evidence for impaired sentence comprehension in early Alzheimer's disease.” J Int Neuropsychol Soc 5(5):393-404 Details Graham KS, Patterson K, Hodges JR (1999), “Episodic memory: new insights from the study of semantic dementia.” Curr Opin Neurobiol 9(2):245-50 Details Graham KS, Patterson K, Pratt KH, Hodges JR (1999), “Relearning and subsequent forgetting of semantic category exemplars in a case of semantic dementia.” Neuropsychology 13(3):359-80 Details Graham NL, Zeman A, Young AW, Patterson K, Hodges JR (1999), “Dyspraxia in a patient with corticobasal degeneration: the role of visual and tactile inputs to action.” J Neurol Neurosurg Psychiatry 67(3):334-44 Details Hodges JR, Patterson K, Ward R, Garrard P, Bak T, Perry R, Gregory C (1999), “The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer's disease: a comparative neuropsychological study.” Neuropsychology 13(1):31-40 Details Hodges JR, Spatt J, Patterson K (1999), “"What" and "how": evidence for the dissociation of object knowledge and mechanical problem-solving skills in the human brain.” Proc Natl Acad Sci U S A 96(16):9444-8 Details Lambon Ralph MA, Graham KS, Patterson K, Hodges JR (1999), “Is a picture worth a thousand words? Evidence from concept definitions by patients with semantic dementia.” Brain Lang 70(3):309-35 Details Patterson K, Ralph MA (1999), “Selective disorders of reading?” Curr Opin Neurobiol 9(2):235-9 Details Wilson BA, Balleny H, Patterson K, Hodges JR (1999), “Myotonic dystrophy and progressive cognitive decline: a common condition or two separate problems?” Cortex 35(1):113-21 Details 1998Croot K, Patterson K, Hodges JR (1998), “Single word production in nonfluent progressive aphasia.” Brain Lang 61(2):226-73 Details Garrard P, Patterson K, Watson PC, Hodges JR (1998), “Category specific semantic loss in dementia of Alzheimer's type. Functional-anatomical correlations from cross-sectional analyses.” Brain 121 ( Pt 4):633-46 Details Strain E, Patterson K, Graham N, Hodges JR (1998), “Word reading in Alzheimer's disease: cross-sectional and longitudinal analyses of response time and accuracy data.” Neuropsychologia 36(2):155-71 Details 1997Hodges JR, Patterson K (1997), “Semantic memory disorders.” Trends Cogn Sci 1(2):68-72 Details Patterson K, Behrmann M (1997), “Frequency and consistency effects in a pure surface dyslexic patient.” J Exp Psychol Hum Percept Perform 23(4):1217-31 Details 1996Greene JD, Patterson K, Xuereb J, Hodges JR (1996), “Alzheimer disease and nonfluent progressive aphasia.” Arch Neurol 53(10):1072-8 Details Hodges JR, Patterson K (1996), “Nonfluent progressive aphasia and semantic dementia: a comparative neuropsychological study.” J Int Neuropsychol Soc 2(6):511-24 Details Hodges JR, Patterson K, Graham N, Dawson K (1996), “Naming and knowing in dementia of Alzheimer's type.” Brain Lang 54(2):302-25 Details Ross SJ, Graham N, Stuart-Green L, Prins M, Xuereb J, Patterson K, Hodges JR (1996), “Progressive biparietal atrophy: an atypical presentation of Alzheimer's disease.” J Neurol Neurosurg Psychiatry 61(4):388-95 Details 1995Hodges JR, Graham N, Patterson K (1995), “Charting the progression in semantic dementia: implications for the organisation of semantic memory.” Memory 3(3-4):463-95 Details Hodges JR, Patterson K (1995), “Is semantic memory consistently impaired early in the course of Alzheimer's disease? Neuroanatomical and diagnostic implications.” Neuropsychologia 33(4):441-59 Details Strain E, Patterson K, Seidenberg MS (1995), “Semantic effects in single-word naming.” J Exp Psychol Learn Mem Cogn 21(5):1140-54 Details 1994Graham KS, Hodges JR, Patterson K (1994), “The relationship between comprehension and oral reading in progressive fluent aphasia.” Neuropsychologia 32(3):299-316 Details Patterson K, Graham N, Hodges JR (1994), “The impact of semantic memory loss on phonological representations.” J Cogn Neurosci 6(1):57-69 Details |