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Institute
  • Neurology Unit
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    Dr Karalyn Patterson FRS, FMedSci, FBA

    University Position
    Visiting Scientist

    Interests

    I study language and memory in adults, mainly from the perspective of the patterns of disruption to these cognitive functions that occur as a result of brain damage or disease.

    Key Publications

    Temporal lobe perceptual predictions for speech are instantiated in motor cortex and reconciled by inferior frontal cortex.

    DOI: http://doi.org/10.1016/j.celrep.2023.112422
    Journal: Cell Rep
    E-pub date: 30 May 2023
    Authors: TE Cope, E Sohoglu, KA Peterson, PS Jones, C Rua, L Passamonti, W Sedley, B Post, J Coebergh, CR Butler, P Garrard, K Abdel-Aziz, M Husain, TD Griffiths, K Patterson, MH Davis, JB Rowe

    Evidence for causal top-down frontal contributions to predictive processes in speech perception.

    DOI: http://doi.org/10.1038/s41467-017-01958-7
    Journal: Nat Commun
    E-pub date: 18 Dec 2017
    Authors: TE Cope, E Sohoglu, W Sedley, K Patterson, PS Jones, J Wiggins, C Dawson, M Grube, RP Carlyon, TD Griffiths, MH Davis, JB Rowe

    Publications

    Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

    DOI: http://doi.org/10.1093/brain/awad078
    Journal: Brain
    E-pub date: 1 Aug 2023
    Authors: M Malpetti, TE Cope, D Street, PS Jones, FH Hezemans, E Mak, KA Tsvetanov, T Rittman, WR Bevan-Jones, K Patterson, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1136/jnnp-2020-324903
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2021
    Authors: AG Murley, MA Rouse, ITS Coyle-Gilchrist, PS Jones, W Li, J Wiggins, C Lansdall, P Vázquez Rodríguez, A Wilcox, K Patterson, JB Rowe

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.

    DOI: http://doi.org/10.1136/jnnp-2020-323698
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Mar 2021
    Authors: M Malpetti, T Rittman, PS Jones, TE Cope, L Passamonti, WR Bevan-Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia

    DOI: http://doi.org/10.1101/2020.05.11.20098046
    Journal:
    E-pub date: 1 Aug 2020
    Authors: M Malpetti, T Rittman, S Jones, T Cope, L Passamonti, R Bevan-Jones, K Patterson, T Fryer, Y Hong, F Aigbirhio, J O’Brien, J Rowe

    Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity.

    DOI: http://doi.org/10.1016/j.cortex.2019.12.025
    Journal: Cortex
    E-pub date: 1 May 2020
    Authors: TE Cope, Y Shtyrov, LJ MacGregor, R Holland, F Pulvermüller, JB Rowe, K Patterson

    Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1093/brain/awaa097
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: AG Murley, I Coyle-Gilchrist, MA Rouse, PS Jones, W Li, J Wiggins, C Lansdall, PV Rodríguez, A Wilcox, KA Tsvetanov, K Patterson, MA Lambon Ralph, JB Rowe

    Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.

    DOI: http://doi.org/10.1093/brain/awaa033
    Journal: Brain
    E-pub date: 1 Mar 2020
    Authors: WR Bevan-Jones, TE Cope, PS Jones, SS Kaalund, L Passamonti, K Allinson, O Green, YT Hong, TD Fryer, R Arnold, JP Coles, FI Aigbirhio, AJ Larner, K Patterson, JT O'Brien, JB Rowe

    [18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

    DOI: http://doi.org/10.1136/jnnp-2017-316402
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Oct 2018
    Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, TD Fryer, R Arnold, KSJ Allinson, JP Coles, FI Aigbirhio, K Patterson, JT O'Brien, JB Rowe

    [18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

    DOI: http://doi.org/10.1002/acn3.631
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Oct 2018
    Authors: RW Bevan-Jones, TE Cope, SP Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FA Aigbirhio, K Patterson, JT O'Brien, JB Rowe

    Artificial grammar learning in vascular and progressive non-fluent aphasias.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2017.08.022
    Journal: Neuropsychologia
    E-pub date: 1 Sep 2017
    Authors: TE Cope, B Wilson, H Robson, R Drinkall, L Dean, M Grube, PS Jones, K Patterson, TD Griffiths, JB Rowe, CI Petkov

    The word processing deficit in semantic dementia: all categories are equal, but some categories are more equal than others.

    DOI: http://doi.org/10.1162/jocn.2009.21339
    Journal: J Cogn Neurosci
    E-pub date: 1 Sep 2010
    Authors: F Pulvermüller, E Cooper-Pye, C Dine, O Hauk, PJ Nestor, K Patterson

    How the camel lost its hump: the impact of object typicality on event-related potential signals in object decision.

    DOI: http://doi.org/10.1162/jocn.2007.19.8.1338
    Journal: J Cogn Neurosci
    E-pub date: 31 Aug 2007
    Authors: O Hauk, K Patterson, A Woollams, E Cooper-Pye, F Pulvermüller, TT Rogers

    Temporal lobe lesions and semantic impairment: a comparison of herpes simplex virus encephalitis and semantic dementia.

    DOI: http://doi.org/10.1093/brain/awl344
    Journal: Brain
    E-pub date: 1 Apr 2007
    Authors: U Noppeney, K Patterson, LK Tyler, H Moss, EA Stamatakis, P Bright, C Mummery, CJ Price

    [Q:] When would you prefer a SOSSAGE to a SAUSAGE? [A:] At about 100 msec. ERP correlates of orthographic typicality and lexicality in written word recognition.

    DOI: http://doi.org/10.1162/jocn.2006.18.5.818
    Journal: J Cogn Neurosci
    E-pub date: 1 May 2006
    Authors: O Hauk, K Patterson, A Woollams, L Watling, F Pulvermüller, TT Rogers

    Regional brain activations differ for semantic features but not categories.

    DOI: http://doi.org/10.1097/00001756-200208270-00002
    Journal: Neuroreport
    E-pub date: 27 Aug 2002
    Authors: ACH Lee, KS Graham, JS Simons, JR Hodges, AM Owen, K Patterson

    Perceptual and semantic components of memory for objects and faces: a pet study.

    DOI: http://doi.org/10.1162/08989290152001862
    Journal: J Cogn Neurosci
    E-pub date: 15 May 2001
    Authors: JS Simons, KS Graham, AM Owen, K Patterson, JR Hodges

    Insights from semantic dementia on the relationship between episodic and semantic memory.

    DOI: http://doi.org/10.1016/s0028-3932(99)00073-1
    Journal: Neuropsychologia
    E-pub date: 1 Aug 2000
    Authors: KS Graham, JS Simons, KH Pratt, K Patterson, JR Hodges