Dr Jelle van den Ameele


I am a neurologist with an interest in developmental neurobiology and mitochondrial genetics. Thanks to a Wellcome Trust Postdoctoral Training Fellowship for Clinicians, I work in the laboratory of Professor Andrea Brand at the Gurdon Institute, where we study development of the Drosophila central nervous system, an established reductionist model of development of the mammalian brain. I am particularly intrigued by the interactions between metabolism and differentiation of neural stem cells. Better understanding of the role of mitochondrial metabolism during normal development will advance our understanding of mitochondrial disorders, neurodegeneration and cancer.

In addition, I am interested in the transcriptional and epigenetic changes that occur during normal and pathological brain development. In the lab, we develop novel DamID-based technologies to study chromatin regulation and gene expression in a cell-type specific manner.

Research Focus



Neural stem cells



Clinical conditions


Genetic disorders

Mitochondrial diseases


No equipment indicated


No collaborators listed

Associated News Items



    Aloia L, McKie MA, Vernaz G, Cordero-Espinoza L, Aleksieva N, van den Ameele J, Antonica F, Font-Cunill B, Raven A, Aiese Cigliano R, Belenguer G, Mort RL, Brand AH, Zernicka-Goetz M, Forbes SJ, Miska EA, Huch M (2019), “Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration” Nat Cell Biol doi: 10.1038/s41556-019-0402-6

    Bonnefont J, Tiberi L, van den Ameele J, Potier D, Gaber ZB, Lin X, Bilheu A, Herpoel A, Velez Bravo FD, Guillemot F, Aerts S, Vanderhaeghen P (2019), “Cortical Neurogenesis Requires Bcl6-Mediated Transcriptional Repression of Multiple Self-Renewal-Promoting Extrinsic Pathways” Neuron Sep 25;103:1-13

    van den Ameele J*, Krautz R*, Brand AH (2019), “TaDa! Analyzing cell-type specific chromatin in vivo with Targeted DamID” Curr Opin Neurobiol 56:160–166

    van den Ameele J, Brand AH (2019), “Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation” eLife 8:e47887. doi: 10.7554/eLife.47887

    van den Ameele J, Li AYZ, Ma H, Chinnery PF (2019), “Mitochondrial heteroplasmy beyond the oocyte bottleneck” Semin Cell Dev Biol doi: 10.1016/j.semcdb.2019.10.001


    Cheetham SW*, Gruhn WH*, van den Ameele J*, Krautz R*, Southall TD, Kobayashi T, Surani MA, Brand AH. (2018), “Targeted DamID reveals differential binding of mammalian pluripotency factors. ” Development 145(20).

    Keogh MJ, Wei W, Aryaman J, Walker L, van den Ameele J, Coxhead J, Wilson I, Bashton M, Beck J, West J, Chen R, Haudenschild C, Bartha G, Luo S, Morris CM, Jones NJ, Attems J, Chinnery PF. (2018), “High prevalence of focal and multi-focal somatic genetic variants in the human brain. ” Nat Commun 9(1):4257.

    van den Ameele J*, Jedlickova I*, Pristoupilova A, Sieben A, Van Mossevelde S, Ceuterick-de Groote C, Hulkova H, Matej R, Meurs A, Van Broeckhoven C, Berkovic SF, Santens P, Kmoch S, Dermaut B (2018), “Teenage-onset progressive myoclonic epilepsy due to a familial C9orf72 repeat expansion” Neurology 90 (8)


    Lambert N, Wermenbol L, Pichon B, Acosta S, van den Ameele J, Perazzolo C, Messina D, Musumeci F, Dessars B, De Leener A, Abramowicz M, Vilain C (2014), “A familial heterozygous null mutation of MET in autism spectrum disorder” Autism Res 7(5):617-22

    Tiberi L, Bonnefont J, van den Ameele J, Le Bon SD, Herpoel A, Bilheu A, Baron BW, Vanderhaeghen P (2014), “A Bcl6/BCoR/Sirt1 complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signalling” Cancer Cell 26(6):797-812

    van den Ameele J, Tiberi L, Vanderhaeghen P, Espuny-Camacho I (2014), “Thinking out of the dish: what to learn about cortical development using pluripotent stem cells” Trends Neurosci 37(6):334-42


    Dimidschstein J, Passante L, Dufour A, van den Ameele J, Tiberi L, Hrechdakian T, Adams R, Klein R, Chichung Lie D, Jossin D, Vanderhaeghen P (2013), “Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration” Neuron 79(6):1123-35


    Tiberi L*, van den Ameele J*, Dimidschstein J, Piccirilli J, Gall D, Herpoel A, Bilheu A, Bonnefont J, Iacovino M, Kyba M, Bouschet T, Vanderhaeghen P (2012), “Bcl6 induces neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets” Nat Neurosci 15(12):1627-35

    Tiberi L, Vanderhaeghen P, van den Ameele J (2012), “Cortical Neurogenesis and Morphogens: Diversity of Cues, Sources and Functions” Curr Opin Cell Biol 24(2):269-76

    van den Ameele J*, Tiberi L*, Bondue A*, Paulissen C, Herpoel A, Iacovino M, Kyba M, Blanpain C, Vanderhaeghen P (2012), “Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin” Embo Rep 13(4):355-62

    van den Ameele J, Sieben A, Van den Broecke C, Boterberg T, Defreyne L, Achten E, Lammens M, Hemelsoet D (2012), “Late-onset post-irradiation vasculopathy of the posterior cerebral vasculature” Acta Neurol Belg 112(1):101-4


    Pittock SJ, Debruyne J, Krecke K, Giannini C, van den Ameele J, De Herdt V, McKeon A, Fealey RD, Weinshenker BG, Aksamit AJ, Krueger BR, Shuster EA, Keegan BM (2010), “Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)” Brain 133(9):2626-34


    Gaspard N, Bouschet T, Herpoel A, Naeije G, van den Ameele J, Vanderhaeghen P (2009), “Generation of cortical neurons from mouse embryonic stem cells” Nat Protoc 4(10):1454-63


    Gaspard N, Bouschet T, Hourez R, Dimidschstein J, Naeije G, van den Ameele J, Espuny-Camacho I, Herpoel A, Passante L, Schiffmann SN, Gaillard A, Vanderhaeghen P (2008), “An intrinsic mechanism of corticogenesis from embryonic stem cells” Nature 455(7211):351-7

    van den Ameele J, Van Landegem W, Wuyts W, De Bleecker J (2008), “Recurrent post-infectious rhabdomyolysis in muscle CPT-II deficiency caused by a novel missense mutation” Acta Neurol Belg 108(4):155-60