Dr Jelle van den Ameele


University position

Wellcome Clinical Research Career Development Fellow

Dr Jelle van den Ameele is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Mitochondrial Biology Unit, MRC

Home page

http://www.mrc-mbu.cam.ac.uk/people/... (personal home page)

Research Themes

Developmental Neuroscience

Cellular and Molecular Neuroscience

Interests

I am a neurologist with an interest in developmental neurobiology and mitochondrial genetics. In the lab, we study how cells and tissues respond to mitochondrial dysfunction, focusing on neural stem cells and the brain. Our goal is to identify novel determinants of tissue-specific phenotypes of mitochondrial and neurodegenerative diseases and to uncover potential therapeutic targets to treat these disorders.

We use a wide range of techniques and model systems, but mostly take advantage of the powerful genetics of Drosophila. We combine targeted genetic manipulations with confocal and super-resolution imaging, biosensors, and innovative DamID-based sequencing approaches to study the metabolism, transcriptional and epigenetic changes of different cell-types within the brain of a living organism affected by mitochondrial dysfunction.

I also participate in the clinical research programme related to the mitochondrial genetics clinic in Addenbrooke’s.

Research Focus

Keywords

Mitochondria

Neural stem cells

Differentiation

DamID

Clinical conditions

Genetic disorders

Mitochondrial diseases

Equipment

Confocal microscopy

Drosophila genetics

In utero electroporation

Live imaging

Mouse genetics

Targeted DamID, DamID-seq

Collaborators

No collaborators listed

Associated News Items


    Publications

    2020

    van den Ameele J*, Fuge J*, Pitceathly RDS, Berry S, McIntyre Z, Hanna MG, Lee M, Chinnery PF (2020), “Chronic pain is common in mitochondrial disease” Neuromuscul Disord https://doi.org/10.1016/j.nmd.2020.02.017

    van den Ameele J, Li AYZ, Ma H, Chinnery PF (2020), “Mitochondrial heteroplasmy beyond the oocyte bottleneck” Semin Cell Dev Biol 97:156-166. doi: 10.1016/j.semcdb.2019.10.001.

    2019

    Aloia L, McKie MA, Vernaz G, Cordero-Espinoza L, Aleksieva N, van den Ameele J, Antonica F, Font-Cunill B, Raven A, Aiese Cigliano R, Belenguer G, Mort RL, Brand AH, Zernicka-Goetz M, Forbes SJ, Miska EA, Huch M (2019), “Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration” Nat Cell Biol doi: 10.1038/s41556-019-0402-6

    Bonnefont J, Tiberi L, van den Ameele J, Potier D, Gaber ZB, Lin X, Bilheu A, Herpoel A, Velez Bravo FD, Guillemot F, Aerts S, Vanderhaeghen P (2019), “Cortical Neurogenesis Requires Bcl6-Mediated Transcriptional Repression of Multiple Self-Renewal-Promoting Extrinsic Pathways” Neuron Sep 25;103:1-13

    van den Ameele J*, Krautz R*, Brand AH (2019), “TaDa! Analyzing cell-type specific chromatin in vivo with Targeted DamID” Curr Opin Neurobiol 56:160–166

    van den Ameele J, Brand AH (2019), “Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation” eLife 8:e47887. doi: 10.7554/eLife.47887

    2018

    Cheetham SW*, Gruhn WH*, van den Ameele J*, Krautz R*, Southall TD, Kobayashi T, Surani MA, Brand AH. (2018), “Targeted DamID reveals differential binding of mammalian pluripotency factors. ” Development 145(20).

    Keogh MJ, Wei W, Aryaman J, Walker L, van den Ameele J, Coxhead J, Wilson I, Bashton M, Beck J, West J, Chen R, Haudenschild C, Bartha G, Luo S, Morris CM, Jones NJ, Attems J, Chinnery PF. (2018), “High prevalence of focal and multi-focal somatic genetic variants in the human brain. ” Nat Commun 9(1):4257.

    van den Ameele J*, Jedlickova I*, Pristoupilova A, Sieben A, Van Mossevelde S, Ceuterick-de Groote C, Hulkova H, Matej R, Meurs A, Van Broeckhoven C, Berkovic SF, Santens P, Kmoch S, Dermaut B (2018), “Teenage-onset progressive myoclonic epilepsy due to a familial C9orf72 repeat expansion” Neurology 90 (8)

    2014

    Lambert N, Wermenbol L, Pichon B, Acosta S, van den Ameele J, Perazzolo C, Messina D, Musumeci F, Dessars B, De Leener A, Abramowicz M, Vilain C (2014), “A familial heterozygous null mutation of MET in autism spectrum disorder” Autism Res 7(5):617-22

    Tiberi L, Bonnefont J, van den Ameele J, Le Bon SD, Herpoel A, Bilheu A, Baron BW, Vanderhaeghen P (2014), “A Bcl6/BCoR/Sirt1 complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signalling” Cancer Cell 26(6):797-812

    van den Ameele J, Tiberi L, Vanderhaeghen P, Espuny-Camacho I (2014), “Thinking out of the dish: what to learn about cortical development using pluripotent stem cells” Trends Neurosci 37(6):334-42

    2013

    Dimidschstein J, Passante L, Dufour A, van den Ameele J, Tiberi L, Hrechdakian T, Adams R, Klein R, Chichung Lie D, Jossin D, Vanderhaeghen P (2013), “Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration” Neuron 79(6):1123-35

    2012

    Tiberi L*, van den Ameele J*, Dimidschstein J, Piccirilli J, Gall D, Herpoel A, Bilheu A, Bonnefont J, Iacovino M, Kyba M, Bouschet T, Vanderhaeghen P (2012), “Bcl6 induces neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets” Nat Neurosci 15(12):1627-35

    Tiberi L, Vanderhaeghen P, van den Ameele J (2012), “Cortical Neurogenesis and Morphogens: Diversity of Cues, Sources and Functions” Curr Opin Cell Biol 24(2):269-76

    van den Ameele J*, Tiberi L*, Bondue A*, Paulissen C, Herpoel A, Iacovino M, Kyba M, Blanpain C, Vanderhaeghen P (2012), “Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin” Embo Rep 13(4):355-62

    van den Ameele J, Sieben A, Van den Broecke C, Boterberg T, Defreyne L, Achten E, Lammens M, Hemelsoet D (2012), “Late-onset post-irradiation vasculopathy of the posterior cerebral vasculature” Acta Neurol Belg 112(1):101-4

    2010

    Pittock SJ, Debruyne J, Krecke K, Giannini C, van den Ameele J, De Herdt V, McKeon A, Fealey RD, Weinshenker BG, Aksamit AJ, Krueger BR, Shuster EA, Keegan BM (2010), “Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)” Brain 133(9):2626-34

    2009

    Gaspard N, Bouschet T, Herpoel A, Naeije G, van den Ameele J, Vanderhaeghen P (2009), “Generation of cortical neurons from mouse embryonic stem cells” Nat Protoc 4(10):1454-63

    2008

    Gaspard N, Bouschet T, Hourez R, Dimidschstein J, Naeije G, van den Ameele J, Espuny-Camacho I, Herpoel A, Passante L, Schiffmann SN, Gaillard A, Vanderhaeghen P (2008), “An intrinsic mechanism of corticogenesis from embryonic stem cells” Nature 455(7211):351-7

    van den Ameele J, Van Landegem W, Wuyts W, De Bleecker J (2008), “Recurrent post-infectious rhabdomyolysis in muscle CPT-II deficiency caused by a novel missense mutation” Acta Neurol Belg 108(4):155-60