Mr Jasdip Singh DulaiUniversity positionPhD student DepartmentsHome pageResearch ThemesInterestsMy research is orientated towards the more commonly observed nociceptive pain pathway, with a specific interest in inflammation. Using both in silico screening (docking models) and in vitro (electrophysiology) to validate findings. The overall aim of my PhD project is to identify potential 'druggable' pocket(s) and novel small molecule chemical scaffolds as potential, selective inhibitors of acid-sensing ion channel 3 (ASIC3). Research Focus
EquipmentCell culture Computational modelling Electrophysiological recording techniques Whole cell patch clamp Collaborators
Associated News ItemsPublications2020Dulai JS, Smith ESJ, Rahman T (2020), “Acid-Sensing Ion Channel 3: An Analgesic Target” Channels 2019Wichmann L, Dulai JS, Marles-Wright J, Maxeiner S, Szczesniak PP, Manzini I, Althaus M (2019), “An extracellular acidic cleft confers profound H+-sensitivity to epithelial sodium channels containing the ?-subunit in Xenopus laevis” J Biol Chem 294(33): 12507-12520 |