Mr Jasdip Singh Dulai
My research is orientated towards the more commonly observed nociceptive pain pathway, with a specific interest in inflammation. Using both in silico screening (docking models) and in vitro (electrophysiology) to validate findings.
The overall aim of my PhD project is to identify potential 'druggable' pocket(s) and novel small molecule chemical scaffolds as potential, selective inhibitors of acid-sensing ion channel 3 (ASIC3).
Electrophysiological recording techniques
Whole cell patch clamp
Associated News Items
Dulai JS, Smith ESJ, Rahman T (2020), “Acid-Sensing Ion Channel 3: An Analgesic Target” Channels
Wichmann L, Dulai JS, Marles-Wright J, Maxeiner S, Szczesniak PP, Manzini I, Althaus M (2019), “An extracellular acidic cleft confers profound H+-sensitivity to epithelial sodium channels containing the δ-subunit in Xenopus laevis” J Biol Chem 294(33): 12507-12520