Oligodendrocytes are the myelinating cells of the CNS, important for neural communication, neuronal survival as well as learning and memory. My work is focused on understanding how myelin functions and the molecular components regulating its generation. This is important for diseases where myelination fails such Leukodystrophies or myelin is damaged such as Multiple Sclerosis, Stroke, Intracerebral hemorrhage and traumatic brain injuries. I am particularly interested in mechanisms regulating programmed cell death, iron/ haem homeostasis, protein synthesis and exosome biology in myelinating glia and their progenitors.
