Dr James Stefaniak


I am a neuroscientist and psychiatrist interested in cognition and its impairment following acute (e.g. stroke) and progressive (e.g. dementia) brain damage as well as psychiatric disorders. I am particularly interested in the neural mechanisms underlying inter-individual variability in cognitive performance during both the pre-symptomatic phase of dementia and during recovery post-stroke, and the potential for novel techniques to aid in diagnosis and prognosis of such conditions.

Research Focus







Clinical conditions

Alzheimer's disease


Cognitive impairment


Language disorders



Cross-sectional and cohort studies


Magnetic resonance imaging (MRI)

Multivariate Pattern Analysis

Neuropsychological testing

Voxel Based Morphometry



Matthew Lambon Ralph

John O'Brien

United Kingdom

Fatemeh Geranmayeh Web: http://fatemeh.geranmayeh00@imperial....

Tim Griffiths Web: http://tim.griffiths@ncl.ac.uk

Li Su Web: http://l.su@sheffield.ac.uk

Associated News Items



    Stefaniak JD, Geranmayeh F, Lambon Ralph MA (2022), “The multidimensional nature of aphasia recovery post-stroke” Brain doi: 10.1093/brain/awab377. Online ahead of print


    Stefaniak JD*, Alyahya RSW*, Lambon Ralph MA. * = Joint first authors. (2021), “Language networks in aphasia and health: a 1000 participant Activation Likelihood Estimate analysis.” NeuroImage 233, 117960

    Stefaniak JD, Lambon Ralph MA, De Dios Perez B, Griffiths TD, Grube M. (2021), “Auditory beat perception is related to speech output fluency in post-stroke aphasia.” Sci Rep doi: 10.1038/s41598-021-82809-w


    Low A, Mak E, Malpetti M, Passamonti L, Nicastro N, Stefaniak JD, Savulich G, Chouliaras L, Su L, Rowe JB, Markus HS, O’Brien JT. (2020), “In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.” J Neurol Neurosurg Psychiatry 92(1), 45-52

    Low A, Mak E, Stefaniak JD, Malpetti M, Nicastro N, Savulich G, Chouliaras L, Markus HS, Rowe JB, O’Brien JT. (2020), “Peak width of skeletonized mean diffusivity as a marker of diffuse cerebrovascular damage.” Front. Neurosci 14:238

    Low A, Su L, Stefaniak JD, Mak E, Dounavi ME, Muniz-Terrera G, Ritchie K, Ritchie CW, Markus HS, O’Brien JT. (2020), “Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.” Neurobiol Aging 98, 124-133

    Stefaniak JD, Halai AD, Lambon Ralph MA. (2020), “The neural and neurocomputational bases of recovery from post-stroke aphasia.” Nat Rev Neurol 16(1), 43-55


    Stefaniak JD*, Su L*, Mak E, Bahaei NS, Wells K, Ritchie K, Waldman A, Ritchie CW, O’Brien JT. * = Joint first authors. (2018), “Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer’s Disease.” Alzheimers Dement 14(2), 253-258

    Stefaniak JD, Parkes LM, Parry-Jones AR, Potter GM, Vail A, Jovanovic A, Smith CJ. (2018), “Enzyme replacement therapy and white matter hyperintensity progression in Fabry disease.” Neurology 91(15), 1413-1422


    Cipriani A, Saunders K, Attenburrow MJ, Stefaniak J, Panchal P, Stockton S, Lane TA, Tunbridge EM, Geddes JR, Harrison PJ. (2016), “A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development.” Mol Psychiatry 21(10), 1324-32

    Stefaniak J, O’Brien J. (2016), “Imaging of neuroinflammation in dementia: a review.” J Neurol Neurosurg Psychiatry 87(1), 21-28