Dr Janet Kumita
MRC Career Development Award Fellow
Dr Janet Kumita is pleased to consider applications from prospective PhD students.
My research group uses a multidisciplinary approach, including biophysics, cell biology and protein engineering, to study the molecular processes underlying protein self-assembly, in particular aberrant amyloid fibril formation related to disorders including Parkinson’s disease, Amyotrophic Lateral Sclerosis and systemic amyloidosis, and more recently to study the phenomena of liquid-liquid phase separation (LLPS) in biology and its relevance to cellular protein quality control mechanisms. Our main areas of study are: 1) Establishing a structure-function relationship between biomolecular condensates and protein degradation; 2) Defining the structural characteristics of amyloid-related aggregates and determining how these species alter cellular quality control mechanisms and cell-to-cell transfer processes - factors that are crucial in neurodegenerative disease progression; and 3) Understanding protein homeostasis in ageing and disease.
Recombinant protein expression
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