Dr Janet Kumita

University position

Principal Research Associate

Dr Janet Kumita is pleased to consider applications from prospective PhD students.

Departments

Department of Chemistry

Institutes

Centre for Misfolding Diseases

Email

jrk38@cam.ac.uk

Home page

https://www.ch.cam.ac.uk/person/...

Research Theme

Cellular and Molecular Neuroscience

Interests

Protein misfolding is associated with a wide range of human disorders including Alzheimer’s and Parkinson's diseases, systemic amyloidosis and Motor Neurone Disease. Due to the prevalence of these disorders it is crucial to increase our understanding, at a molecular level, of the mechanisms by which disease-related peptides and proteins aberrantly behave. As the process of amyloid formation results in the population of a highly heterogeneous array of different protein conformers, it is extremely difficult to resolve how specific misfolded protein states evoke detrimental cellular responses. With this challenge in mind, we aim to define these elusive structural attributes using techniques, such as biomolecular NMR and fluorescence microscopy, to relate protein structural characteristics with their influence on cellular trafficking, homeostasis and cell-to-cell transfer processes, factors that are crucial in disease progression.

Research Focus

Keywords

TDP-43

alpha-synuclein

lysozyme

extracellular chaperones

Abeta1-42

Clinical conditions

Alzheimer's disease

Motor Neurone Disease

Parkinson's disease

Equipment

Cell culture

Fluorescence microscopy

Protein purification

Recombinant protein expression

Collaborators

Cambridge

Christopher Dobson

Laura Itzhaki

Tuomas Knowles

Michele Vendruscolo

Associated News Items