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Department
  • Medicine
  • Research Focus

    Keywords

  • Positron Emission Tomography
  • Magnetic Resonance Imaging
  • TBI
  • Neurocritical Care
  • Clinical Conditions

  • Traumatic brain injury
  • Equipment & Techniques

  • Positron Emission Tomography (PET)
  • Magnetic resonance imaging (MRI)
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    Professor Jonathan Coles

    University Position
    Professor

    Interests

    As a clinician specialising within Neurointensive care my research interests are focused on describing the pathophysiology of head injury and optimising patient outcome. Using the combined facilities of the Wolfson Brain Imaging and Neurosciences Critical Care Unit at Addenbrooke's Hospital patients undergo structural and functional imaging studies using positron emission tomography and magnetic resonance imaging. I have used such imaging tools to define the incidence, temporal evolution and impact on outcome of cerebral ischaemia following head injury. Other work has addressed the impact of clinical interventions aimed at controlling intracranial pressure such as hyperventilation and elevation of cerebral perfusion pressure. Current research is aimed at using imaging techniques to define the temporal pattern and metabolic correlates of neuronal loss after human head injury. Such data will be crucial in the development and implementation of successful neuroprotective therapies.

    Key Publications

    Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury.

    DOI: http://doi.org/10.1093/brain/awad056
    Journal: Brain
    E-pub date: 1 Aug 2023
    Authors: RE Woodrow, S Winzeck, AI Luppi, IR Kelleher-Unger, LRB Spindler, JTL Wilson, VFJ Newcombe, JP Coles, CENTER-TBI MRI Substudy Participants and Investigators, DK Menon, EA Stamatakis

    Serum biomarkers identify critically ill traumatic brain injury patients for MRI

    DOI: http://doi.org/10.1186/s13054-022-04250-3
    Journal: Critical Care
    E-pub date: 29 Nov 2022
    Authors: S Richter, S Winzeck, E Czeiter, K Amrein, EN Kornaropoulos, J Verheyden, G Sugar, Z Yang, K Wang, AIR Maas, E Steyerberg, A Büki, VFJ Newcombe, DK Menon, K Amrein, N Andelic, L Andreassen, A Anke, P Azouvi, B Bellander, H Benali, A Buki, A Caccioppola, E Calappi, M Carbonara, G Citerio, H Clusmann, M Coburn, J Coles, M Correia, E Czeiter, V De Keyser, V Degos, B Depreitere, L Eikenes, E Ezer, K Foks, S Frisvold, D Galanaud, A Ghuysen, B Glocker, A Haberg, I Haitsma, E Helseth, PJ Hutchinson, E Kornaropoulos, N Kovács, A Kowark, S Laureys, D Ledoux, H Lingsma, AIR Maas, G Manley, DK Menon, T Menovsky, B Misset, V Muraleedharan, I Nakken, V Newcombe, W Nordhøy, J Nyirádi, F Ortolano, PM Parizel, V Perlbarg, P Persona, W Peul, JP Posti, L Puybasset, S Richter, C Roe, O Roise, R Rossaint, S Rossi, D Rueckert, T Skandsen, A Sorinola, E Stamatakis, EW Steyerberg, N Stocchetti, R Takala, V Tamás, O Tenovuo, Z Vámos, G Van der Steen, W Van Hecke, TV Vyvere, J Verheyden, A Vik, V Volovici, LT Westlye, G Williams, S Winzeck, P Ylén, T Zoerle

    Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.

    DOI: http://doi.org/10.1093/brain/awab255
    Journal: Brain
    E-pub date: 16 Dec 2021
    Authors: J Hermanides, YT Hong, M Trivedi, J Outtrim, F Aigbirhio, PJ Nestor, M Guilfoyle, S Winzeck, VFJ Newcombe, T Das, MM Correia, KLH Carpenter, PJA Hutchinson, AK Gupta, TD Fryer, JD Pickard, DK Menon, JP Coles

    Spatial and Temporal Pattern of Ischemia and Abnormal Vascular Function Following Traumatic Brain Injury.

    DOI: http://doi.org/10.1001/jamaneurol.2019.3854
    Journal: JAMA Neurol
    E-pub date: 1 Mar 2020
    Authors: Y Launey, TD Fryer, YT Hong, LA Steiner, J Nortje, TV Veenith, PJ Hutchinson, A Ercole, AK Gupta, FI Aigbirhio, JD Pickard, JP Coles, DK Menon

    Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury.

    DOI: http://doi.org/10.1001/jamaneurol.2016.0091
    Journal: JAMA Neurol
    E-pub date: 1 May 2016
    Authors: TV Veenith, EL Carter, T Geeraerts, J Grossac, VFJ Newcombe, J Outtrim, GS Gee, V Lupson, R Smith, FI Aigbirhio, TD Fryer, YT Hong, DK Menon, JP Coles

    Incidence and mechanisms of cerebral ischemia in early clinical head injury.

    DOI: http://doi.org/10.1097/01.WCB.0000103022.98348.24
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Feb 2004
    Authors: JP Coles, TD Fryer, P Smielewski, DA Chatfield, LA Steiner, AJ Johnston, SPMJ Downey, GB Williams, F Aigbirhio, PJ Hutchinson, K Rice, TA Carpenter, JC Clark, JD Pickard, DK Menon

    Publications

    Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.

    DOI: http://doi.org/10.1093/brain/awac321
    Journal: Brain
    E-pub date: 21 Nov 2022
    Authors: EJ Needham, AL Ren, RJ Digby, EJ Norton, S Ebrahimi, JG Outtrim, DA Chatfield, AE Manktelow, MM Leibowitz, VFJ Newcombe, R Doffinger, G Barcenas-Morales, C Fonseca, MJ Taussig, RM Burnstein, RJ Samanta, C Dunai, N Sithole, NJ Ashton, H Zetterberg, M Gisslén, A Edén, E Marklund, PJM Openshaw, J Dunning, MJ Griffiths, J Cavanagh, G Breen, SR Irani, A Elmer, N Kingston, C Summers, JR Bradley, LS Taams, BD Michael, ET Bullmore, KGC Smith, PA Lyons, AJ Coles, DK Menon, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility

    Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

    DOI: http://doi.org/10.1093/braincomms/fcaa198
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients.

    DOI: http://doi.org/10.1089/neu.2020.7300
    Journal: J Neurotrauma
    E-pub date: 15 May 2021
    Authors: SA Dijkland, IRAR Helmrich, D Nieboer, M van der Jagt, DWJ Dippel, DK Menon, N Stocchetti, AIR Maas, HF Lingsma, EW Steyerberg, CENTER-TBI Participants and Investigators

    Neuroanatomical substrates of generalized brain dysfunction in COVID-19.

    DOI: http://doi.org/10.1007/s00134-020-06241-w
    Journal: Intensive Care Med
    E-pub date: 1 Jan 2021
    Authors: VFJ Newcombe, LRB Spindler, T Das, S Winzeck, K Allinson, EA Stamatakis, DK Menon, Cambridge NeuroCovid Imaging Collaborators

    Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury.

    DOI: http://doi.org/10.1136/jnnp-2020-324492
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 2 Dec 2020
    Authors: L Wilson, L Horton, K Kunzmann, BJ Sahakian, VF Newcombe, EA Stamatakis, N von Steinbuechel, K Cunitz, A Covic, A Maas, D Van Praag, D Menon, CENTER-TBI participants and investigators

    Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study.

    DOI: http://doi.org/10.1016/S2215-0366(20)30287-X
    Journal: Lancet Psychiatry
    E-pub date: 1 Oct 2020
    Authors: A Varatharaj, N Thomas, MA Ellul, NWS Davies, TA Pollak, EL Tenorio, M Sultan, A Easton, G Breen, M Zandi, JP Coles, H Manji, R Al-Shahi Salman, DK Menon, TR Nicholson, LA Benjamin, A Carson, C Smith, MR Turner, T Solomon, R Kneen, SL Pett, I Galea, RH Thomas, BD Michael, CoroNerve Study Group

    Depression following traumatic brain injury is characterised by dominant and recurring brain loops in self-referential areas

    DOI: http://doi.org/10.1101/2020.08.14.20175000
    Journal:
    E-pub date: 1 Aug 2020
    Authors: I Pappas, L Moreno-López, E Carroll, A Manktelow, J Outtrim, J Coles, V Newcombe, B Sahakian, D Menon, E Stamatakis

    Synaptic loss in primary tauopathies revealed by [11C]UCB-J positron emission tomography

    DOI: http://doi.org/10.1101/2020.01.24.20018697
    Journal:
    E-pub date: 1 Aug 2020
    Authors: N Holland, S Jones, G Savulich, J Wiggins, Y Hong, T Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, F Hezemans, F Aigbirhio, J Coles, J O’Brien, J Rowe

    Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.

    DOI: http://doi.org/10.1093/brain/awaa033
    Journal: Brain
    E-pub date: 1 Mar 2020
    Authors: WR Bevan-Jones, TE Cope, PS Jones, SS Kaalund, L Passamonti, K Allinson, O Green, YT Hong, TD Fryer, R Arnold, JP Coles, FI Aigbirhio, AJ Larner, K Patterson, JT O'Brien, JB Rowe

    Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.: weak correlations were observed between our cohorts of controls for each ligand (supplementary figure 1)

    DOI: http://doi.org/10.1101/525642
    Journal:
    E-pub date: 1 Aug 2019
    Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, Y Hong, T Fryer, R Arnold, J Coles, F Aigbirhio, A Larner, K Patterson, J O'Brien, J Rowe

    In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.

    DOI: http://doi.org/10.1002/acn3.683
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Feb 2019
    Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FI Aigbirhio, JT O'Brien, JB Rowe

    [18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

    DOI: http://doi.org/10.1136/jnnp-2017-316402
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Oct 2018
    Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, TD Fryer, R Arnold, KSJ Allinson, JP Coles, FI Aigbirhio, K Patterson, JT O'Brien, JB Rowe

    [18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

    DOI: http://doi.org/10.1002/acn3.631
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Oct 2018
    Authors: RW Bevan-Jones, TE Cope, SP Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FA Aigbirhio, K Patterson, JT O'Brien, JB Rowe

    Neural correlates of visual memory in patients with diffuse axonal injury.

    DOI: http://doi.org/10.1080/02699052.2017.1341998
    Journal: Brain Inj
    E-pub date: 1 Aug 2017
    Authors: J Lauer, L Moreno-López, A Manktelow, EL Carroll, JG Outtrim, JP Coles, VF Newcombe, BJ Sahakian, DK Menon, EA Stamatakis

    [18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.

    DOI: http://doi.org/10.1002/acn3.366
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Dec 2016
    Authors: WR Bevan Jones, TE Cope, L Passamonti, TD Fryer, YT Hong, F Aigbirhio, JJ Kril, SL Forrest, K Allinson, JP Coles, P Simon Jones, MG Spillantini, JR Hodges, JT O'Brien, JB Rowe

    Dynamic Changes in White Matter Abnormalities Correlate With Late Improvement and Deterioration Following TBI: A Diffusion Tensor Imaging Study.

    DOI: http://doi.org/10.1177/1545968315584004
    Journal: Neurorehabil Neural Repair
    E-pub date: 1 Jan 2016
    Authors: VFJ Newcombe, MM Correia, C Ledig, MG Abate, JG Outtrim, D Chatfield, T Geeraerts, AE Manktelow, E Garyfallidis, JD Pickard, BJ Sahakian, PJA Hutchinson, D Rueckert, JP Coles, GB Williams, DK Menon

    Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study.

    DOI: http://doi.org/10.1227/NEU.0000000000000575
    Journal: Neurosurgery
    E-pub date: 1 Jan 2015
    Authors: AIR Maas, DK Menon, EW Steyerberg, G Citerio, F Lecky, GT Manley, S Hill, V Legrand, A Sorgner, CENTER-TBI Participants and Investigators

    Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging.

    DOI: http://doi.org/10.1038/jcbfm.2013.11
    Journal: Journal of Cerebral Blood Flow and Metabolism
    E-pub date: 1 Jun 2013
    Authors: VFJ Newcombe, GB Williams, JG Outtrim, D Chatfield, M Gulia Abate, T Geeraerts, A Manktelow, H Room, L Mariappen, PJ Hutchinson, JP Coles, DK Menon