Dr Joseph Polex Wolf

Interests

I'm a Postdoctoral Research Associate based in Dr Giles Yeo's group within the Institute of Metabolic Science. Our group investigates the neural control of energy homeostasis, with focus on the genetic influences mediating hypothalamic food intake pathways. My current work focuses on the role of the non-coding RNA cluster SNORD116 in Prader-Willi Syndrome. I am investigating the molecular mechanisms linking the loss of SNORD116 transcripts to the hyperphagia and obesity evident in Prader-Willi patients.

Research Focus

Equipment

Bioinformatics

Calcium imaging

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

In-Situ Hybridisation

Metabolic Phenotyping

Neuronal Culture

Next-Gen Sequencing and Transcriptomics