Professor Jesus Perez


My research activity is mainly focused on early detection and intervention in psychosis and the history of psychiatry. I am particularly interested in the epidemiological apects of young people at high-risk of developing psychosis and with first-episode psychosis. This includes clinical antecedents and sociodemographic characteristics of these populations. I am also keen in understanding the factors associated with diagnostic stability of first-episode psychotic disorders, especially first-episode mania. Part of my research is dedicated to service development within the NHS.

I am the Lead Consultant Psychiatrist of the award-winning CAMEO Early Intervention in Psychosis Services; Lead Clinical Director of NIHR CRN: Eastern (National Institute for Health Research Clinical Research Network: Eastern); and Honorary Professor at the UEA (University of East Anglia).

Research Focus


High-risk for psychosis

First-episode psychosis


Bipolar disorder

History of psychiatry

Clinical conditions

Bipolar disorder



Cross-sectional and cohort studies

Neuropsychological testing

Randomised control trials


No collaborators listed

Associated News Items



Modinos G, Allen P, Zugman A, Danai D, Azis M, Samson C, Bonoldi I, Quinn B, Gifford G, Smart S, Antoniades M, Bossong MJ, Broome MR, Perez J, Howes OD, Stone JM, Grace A, McGuire P (2019), “Altered hyppocampal-striatal-midbrain function in subjects at clinical high risk of psychosis” Schizophr Bull

Montejo AL, Calama J, Rico-Villademoros F, Montejo L, González García N, Pérez J; SALSEX Working Study Group (2019), “A Real-World Study on Antidepressant-Associated Sexual Dysfunction in 2144 Outpatients: The SALSEX I Study” Arch Sex Behav Feb 21

Osimo EF, Goujon MJ, Perez J, Murray GK. (2019), “Can typical and atypical antipsychotics show differential effectiveness in treating paranoia and hallucinations in schizophrenia?” BMJ Case Rep Mar 31;12(3). pii: e228573.

Scoriels L, Zimbron J, Garcia-León N, Coll-Negre M, Giro M, Perez J, Jones PB, Fernandez-Egea E (2019), “Cross-sectional study of diet patterns in early and chronic schizophrenia” Schizophr Res April 11

Treise C, Brown RJ, Perez J (2019), “Towards a Multi-Level Phenomenology of Delusional Disorder: The Dissociative Thought-Script” Psychopathology May 14;52(1):50-58


Allan S, Cella M, Wykes T, Perez J (2018), “Cognitive remediation therapy for psychotic major depressive disorder” Prim Care Companion CNS Disord June 14

Bhattacharyya S, Wilson R, Appiah-Kusi E, O'Neill A, Brammer M, Perez J, Murray R, Allen P, Bossong MG, McGuire P (2018), “Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis: A Randomized Clinical Trial” JAMA Psychiatry Aug 29

Bossong MG, Antoniades M, Azis M, Samson C, Quinn B, Bonoldi I, Modinos G, Perez J, Howes OD, Stone JM, Allen P, McGuire P (2018), “Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis” JAMA Psychiatry Nov 14

Clay F, Allan S, Lai S, Laverty S, Jagger G, Treise C, Perez J (2018), “The over-35s: early intervention in psychosis services entering uncharted territory” BJPsych Bull May 24:1-4

Georgiadis A, Duschinsky R, Perez J, Jones PB, Russo D, Knight C, Soneson E, Dixon-Woods M (2018), “Coproducing healthcare service improvement for people with common mental health disorders including psychotic experiences: a study protocol of a multiperspective qualitative study” BMJ Open Nov 8;8(11):e026064

Modinos G, Şimşek F, Azis M, Bossong M, Bonoldi I, Samson C, Quinn B, Perez J, Broome MR, Zelaya F, Lythgoe DJ, Howes OD, Stone JM, Grace AA, Allen P, McGuire P (2018), “Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis” Neuropsychopharmacology Jan 30

Perez J, Jin H, Russo D, Stochl J, Painter M, Byford S, Jones PB (2018), “Improving the detection of individual at risk of developing psychosis in primary mental health care” Schizophr Bull April

Sevilla-Llewellyn-Jones J, Camino G, Russo DA, Painter M, Montejo AL, Ochoa S, Jones PB, Perez J (2018), “Clinically significant personality traits in individuals at high risk of developing psychosis” Psychiatry Res Jan 12;261:498-503

Solmi F, Mohammadi, Perez J, Hameed Y, Jones PB, Kirkbride J (2018), “Predictors of disengagement from Early Intervention in Psychosis services” Br J Psychiatry June

Wykes T, Joyce E, Velikonja T, Watson A, Aarons G, Birchwood M, Cella M, Dopson S, Fowler D, Greenwood K, Johnson S, McCrone P, Perez J, Pickles A, Reeder C, Rose D, Singh S, Stringer D, Taylor M, Taylor R, Upthegrove R (2018), “The CIRCuiTS study (Implementation of cognitive remediation in early intervention services): protocol for a randomised controlled trial” Trials Mar 15;19(1):183


Allen P, Azis M, Modinos G, Bossong MG, Bonoldi I, Samson C, Quinn B, Kempton MJ, Howes OD, Stone JM, Calem M, Perez J, Bhattacharayya S, Broome MR, Grace AA, Zelaya F, McGuire P (2017), “Increased Resting Hippocampal and Basal Ganglia Perfusion in People at Ultra High Risk for Psychosis: Replication in a Second Cohort.” Schizophr Bull Dec 17

Bukenaite A, Stochl J, Mossaheb N, Schäfer MR, Klier CM, Becker J, Schloegelhofer M, Papageorgiou K, Montejo AL, Russo DA, Jones PB, Amminger GP, Perez J (2017), “Usefulness of the CAPE-P15 for detecting people at ultra-high risk for psychosis: Psychometric properties and cut-off values” Schizophr Res Feb 26

Fontalba-Navas A, Lucas-Borja ME, Gil-Aguilar V, Arrebola JP, Pena-Andreu JM, Perez J (2017), “Incidence and risk factors for post-traumatic stress disorder in a population affected by a severe flood” Public Health Mar;144:96-102

Kirkbride JB, Hameed Y, Ioannidis K, Ankireddypalli G, Crane CM, Nasir M, Kabacs N, Metastasio A, Jenkins O, Espandian A, Spyridi S, Ralevic D, Siddabattuni S, Walden B, Adeoye A, Perez J, Jones PB (2017), “Ethnic Minority Status, Age-at-Immigration and Psychosis Risk in Rural Environments: Evidence From the SEPEA Study” Schizophr Bull May 17

Kirkbride JB, Hameed Y, Wright L, Russell K, Knight C, Perez J, Jones PB (2017), “Waiting time variation in Early Intervention Psychosis services: longitudinal evidence from the SEPEA naturalistic cohort study” Soc Psychiatry Psychiatr Epidemiol Feb 18

Modinos G, Simsek F, Horder J, Bossong M, Bonoldi I, Azis M, Perez J, Broome M, Lythgoe DJ, Stone JM, Howes OD, Murphy DG, Grace AA, Allen P, McGuire P (2017), “Cortical GABA In Subjects At Ultra-High Risk Of Psychosis: Relationship To Negative Prodromal Symptoms” Int J Neuropsychopharmacol Aug 19

Montejo ÁL, Arango C, Bernardo M, Carrasco JL, Crespo-Facorro B, Cruz JJ, Del Pino-Montes J, García-Escudero MA, García-Rizo C, González-Pinto A, Hernández AI, Martín-Carrasco M, Mayoral-Cleries F, Mayoral-van Son J, Mories MT, Pachiarotti I, Pérez J, Ros S, Vieta E (2017), “Multidisciplinary consensus on the therapeutic recommendations for iatrogenic hyperprolactinemia secondary to antipsychotics” Front Neuroendocrinol Feb 21

Perez J, Russo DA, Stochl J, Clarke J, Martin Z, Jassi C, French P, Fowler D, Jones PB (2017), “Common mental disorder including psychotic experiences: Trailblazing a new recovery pathway within the Improving Access to Psychological Therapies programme in England” Early Interv Psychiatry May 16

Richardson L, Hameed Y, Perez J, Jones PB, Kirkbride JB (2017), “Association of Environment With the Risk of Developing Psychotic Disorders in Rural Populations: Findings from the Social Epidemiology of Psychoses in East Anglia Study” JAMA Psychiatry Nov 29

Russo DA, Stochl J, Hodgekins J, Iglesias-González M, Chipps P, Painter M, Jones PB, Perez J (2017), “Attachment styles and clinical correlates in people at ultra high risk for psychosis” Br J Psychol April 24


Fusar-Poli P, Cappucciati M, Rutigliano G, Lee TY, Beverly Q, Bonoldi I, Lelli J, Kaar SJ, Gago E, Rocchetti M, Patel R, Bhavsar V, Tognin S, Badger S, Calem M, Lim K, Kwon JS, Perez J, McGuire P (2016), “Towards a Standard Psychometric Diagnostic Interview for Subjects at Ultra High Risk of Psychosis: CAARMS versus SIPS” Psychiatry Journal

Kirkbride JB, Hameed Y, Ankireddypalli G, Ioannidis K, Crane CM, Nasir M, Kabacs N, Metastasio A, Jenkins O, Espandian A, Spyridi S, Ralevic D, Siddabattuni S, Walden B, Adeoye A, Perez J, Jones PB (2016), “The Epidemiology of First-Episode Psychosis in Early Intervention in Psychosis Services: Findings From the Social Epidemiology of Psychoses in East Anglia [SEPEA] Study” Am J Psychiatry Oct 24

Kirkbride JB, Perez J, Jones PB (2016), “Neighbourhood communalities and ultra-high risk psychosis: An emergent literature” Schizophr Res Jun 22

Lennox BR, Palmer-Cooper EC, Pollak T, Hainsworth J, Marks J, Jacobson L, Lang B, Fox H, Ferry B, Scoriels L, Crowley H, Jones PB, Harrison PJ, Vincent A; PPiP study team. (2016), “Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study” Lancet Psychiatry Dec 6

Madeira L, Bonoldi I, Rocchetti M, Brandizzi M, Samson C, Azis M, Queen B, Bossong M, Allen P, Perez J, Howes OD, McGuire P, Fusar-Poli P (2016), “Prevalence and implications of Truman symptoms in subjects at ultra high risk for psychosis” Psychiatry Res Apr 30;238:270-6.

Madeira L, Bonoldi I, Rocchetti M, Samson C, Azis M, Queen B, Bossong M, Perez J, Stone J, Allen P, Howes OD, McGuire P, Raballo A, Fusar-Poli P, Ballerini M, Stanghellini G (2016), “An initial investigation of abnormal bodily phenomena in subjects at ultra high risk for psychosis: Their prevalence and clinical implications.” Compr Psychiatry Apr;66:39-45

Perez J, Jones PB (2016), “Intensive community outreach for those at ultra high risk of psychosis: dilution, not solution - Authors' reply” Lancet Psychiatry Jan;3(1):18-19

Perez J, Russo DA, Stochl J, Shelley GF, Crane CM, Painter M, Kirkbride JB, Croudace TJ, Jones PB (2016), “Understanding causes of and developing effective interventions for schizophrenia and other psychoses.” Southampton (UK): NIHR Journals Library

Tohen M, Khalsa HK, Salvatore P, Zarate CA Jr, Strakowski SM, Perez J, Baldessarini RJ (2016), “The McLean-Harvard First-Episode Project: early course in 114 cases of first-episode nonaffective psychoses” J Clin Psychiatry May 10


Baldessarini RJ, Perez J, Salvatore P, Trede K, Maggini C (2015), “History of Bipolar Manic-Depressive Disorder.” In A Yildiz, P Ruiz, C Nemeroff (Eds.), The Bipolar Book: History, Neurobiology and Treatment (pp 3-19). New York: Oxford University Press

Fusar-Poli P, Cappucciati M, Borgwardt S, Woods SW, Addington J, Nelson B, Nieman DH, Stahl DR, Rutigliano G, Riecher-Rössler A, Simon AE, Mizuno M, Lee TY, Kwon JS, Lam MM, Perez J, Keri S, Amminger P, Metzler S, Kawohl W, Rössler W, Lee J, Labad J, Ziermans T, An SK, Liu CC, Woodberry KA, Braham A, Corcoran C, McGorry P, Yung AR, McGuire PK (2015), “Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk: A Meta-analytical Stratification” JAMA Psychiatry Dec 30

Mishara A, Bonoldi I, Allen P, Rutigliano G, Perez J, Fusar-Poli P, McGuire P (2015), “Neurobiological Models of Self-Disorders in Early Schizophrenia.” Schizophr Bull Sep 18

Morcillo C, Stochl J, Russo DA, Zambrana A, Ratnayake N, Jones PB, Perez J (2015), “First-Rank Symptoms and Premorbid Adjustment in Young Individuals at Increased Risk of Developing Psychosis.” Psychopathology Details

Pérez J (2015), “Women of the Surrey County Lunatic Asylum: first photographic portraits of mental illness (1852).” Arch Womens Ment Health Sep 19

Perez J, Jin H, Russo DA, Stochl J, Painter M, Shelley G, Jackson E, Crane C, Graffy JP, Croudace TJ, Byford S, Jones PB (2015), “Clinical effectiveness and cost-effectiveness of tailored intensive liaison between primary and secondary care to identify individuals at risk of a first psychotic illness (the LEGs study): a cluster-randomised controlled trial.” Lancet Psychiatry Details

Russo DA, Stochl J, Painter M, Shelley GF, Jones PB, Perez J (2015), “Use of the Theory of Planned Behaviour to assess factors influencing the identification of students at clinical high-risk for psychosis in 16+ Education.” BMC Health Serv Sep 23;15(1):411

Sahakian BJ, Bruhl AB, Cook J, Killikelly C, Savulich G, Piercy T, Hafizi S, Perez J, Fernandez-Egea E, Suckling J, Jones PB (2015), “The impact of neuroscience on society: cognitive enhancement in neuropsychiatric disorders and in healthy people.” Philos Trans R Soc Lond B Biol Sci 370(1677) Details

Stochl J, Jones PB, Perez J, Khandaker GM, Böhnke JR, Croudace TJ (2015), “Effects of ignoring clustered data structure in confirmatory factor analysis of ordered polytomous items: a simulation study based on PANSS.” Int J Methods Psychiatr Res Details

Teufel C, Subramaniam N, Dobler V, Perez J, Finnemann J, Mehta PR, Goodyer IM, Fletcher PC (2015), “Shift toward prior knowledge confers a perceptual advantage in early psychosis and psychosis-prone healthy individuals.” Proc Natl Acad Sci U S A Oct 12


Kirkbride JB, Stochl J, Zimbrón J, Crane CM, Metastasio A, Aguilar E, Webster R, Theegala S, Kabacs N, Jones PB, Perez J (2014), “Social and spatial heterogeneity in psychosis proneness in a multilevel case-prodrome-control study.” Acta Psychiatr Scand Details

Russo DA, Stochl J, Painter M, Dobler V, Jackson E, Jones PB, Perez J (2014), “Trauma history characteristics associated with mental states at clinical high risk for psychosis.” Psychiatry Res Details

Russo DA, Stochl J, Painter M, Jones PB, Perez J (2014), “Substance use in people at clinical high-risk for psychosis.” BMC Psychiatry 14(1):2 Details

Stochl J, Jones PB, Plaistow J, Reininghaus U, Priebe S, Perez J, Croudace TJ (2014), “Multilevel ordinal factor analysis of the Positive and Negative Syndrome Scale (PANSS).” Int J Methods Psychiatr Res Details

Stochl J, Khandaker GM, Lewis G, Perez J, Goodyer IM, Zammit S, Sullivan S, Croudace TJ, Jones PB (2014), “Mood, anxiety and psychotic phenomena measure a common psychopathological factor.” Psychol Med :1-11 Details


Hui C, Morcillo C, Russo DA, Stochl J, Shelley GF, Painter M, Jones PB, Perez J (2013), “Psychiatric morbidity, functioning and quality of life in young people at clinical high risk for psychosis.” Schizophr Res Details

Kirkbride JB, Jackson D, Perez J, Fowler D, Winton F, Coid JW, Murray RM, Jones PB (2013), “A population-level prediction tool for the incidence of first-episode psychosis: translational epidemiology based on cross-sectional data.” BMJ Open 3(2) Details

Perez J (2013), “Review: about one in five people with first-episode psychosis have a history of deliberate self-harm.” Evid Based Ment Health Details

Perez J, Faedda GL, Baldessarini RJ (2013), “Electricity rendered useful for mental illness: tribute to Richard Lovett” Br J Psychiatry 203(4):241

Pérez J, Girón-Irueste F, Gurpegui M, Baldessarini RJ, de Leon J (2013), “The lions of granada maristan.” Am J Psychiatry 170(2):152-3 Details

Perez J, Russo DA, Stochl J, Byford S, Zimbron J, Graffy JP, Painter M, Croudace TJ, Jones PB (2013), “Comparison of high and low intensity contact between secondary and primary care to detect people at ultra-high risk for psychosis: study protocol for a theory-based, cluster randomized controlled trial.” Trials 14(1):222 Details

Salvatore P, Baldessarini RJ, Khalsa HM, Vázquez G, Perez J, Faedda GL, Amore M, Maggini C, Tohen M (2013), “Antecedents of manic versus other first psychotic episodes in 263 bipolar I disorder patients.” Acta Psychiatr Scand Details


Pérez J (2012), “"On paroxysmal anxiety" by Édouard Brissaud (1890).” J Clin Psychiatry 73(5):616 Details

Pérez J (2012), “What if DSM 5 Attenuated Psychosis Syndrome Did Not Refer to Risk, but a forme fruste.” Psychopathology Details

Perez J (2012), “[Influence of Religion in the Phenomenology of Anxiety: The Salvation of Mankind in post-Reformation Western Europe]” Rev Hist Psicol 33(2):61-80

Pérez J, Baldessarini RJ, Undurraga J, Sánchez-Moreno J (2012), “Origins of Psychiatric Hospitalization in Medieval Spain.” Psychiatr Q Details

Stochl J, Croudace T, Perez J, Birchwood M, Lester H, Marshall M, Amos T, Sharma V, Fowler D, Jones PB, The National Eden Study Team (2012), “Usefulness of EQ-5D for evaluation of health-related quality of life in young adults with first-episode psychosis.” Qual Life Res Details

Zimbrón J, Ruiz de Azúa S, Khandaker GM, Gandamaneni PK, Crane CM, González-Pinto A, Stochl J, Jones PB, Pérez J (2012), “Clinical and sociodemographic comparison of people at high-risk for psychosis and with first-episode psychosis.” Acta Psychiatr Scand Details


Agius M, Perez J (2011), “Do large studies of the use of antipsychotics help us choose the most effective treatments for schizophrenia?” CEPiP 1:69-73

Cheng F, Kirkbride JB, Lennox BR, Perez J, Masson K, Lawrence K, Hill K, Feeley L, Painter M, Murray GK, Gallagher O, Bullmore ET, Jones PB (2011), “Administrative incidence of psychosis assessed in an early intervention service in England: first epidemiological evidence from a diverse, rural and urban setting.” Psychol Med 41(5):949-58 Details

Kabacs N, Memon A, Obinwa T, Stochl J, Perez J (2011), “Lithium in drinking water and suicide rates across the East of England.” Br J Psychiatry 198(5):406-7 Details

Pérez J, Baldessarini RJ, Cruz N, Salvatore P, Vieta E (2011), “Andrés Piquer-Arrufat (1711-1772): contributions of an eighteenth-century spanish physician to the concept of manic-depressive illness.” Harv Rev Psychiatry 19(2):68-77 Details

Russo DA, Stochl J, Croudace TJ, Graffy JP, Youens J, Jones PB, Perez J (2011), “Use of the theory of planned behaviour to assess factors influencing the identification of individuals at ultra-high risk for psychosis in primary care.” Early Interv Psychiatry Details

Salvatore P, Baldessarini RJ, Tohen M, Khalsa HM, Sanchez-Toledo JP, Zarate CA Jr, Vieta E, Maggini C (2011), “McLean-Harvard International First-Episode Project: two-year stability of ICD-10 diagnoses in 500 first-episode psychotic disorder patients.” J Clin Psychiatry 72(2):183-93 Details


Baldessarini RJ, Bolzani L, Cruz N, Jones PB, Lai M, Lepri B, Perez J, Salvatore P, Tohen M, Tondo L, Vieta E (2010), “Onset-age of bipolar disorders at six international sites.” J Affect Disord 121(1-2):143-6 Details

Baldessarini RJ, Salvatore P, Khalsa HM, Gebre-Medhin P, Imaz H, González-Pinto A, Perez J, Cruz N, Maggini C, Tohen M (2010), “Morbidity in 303 first-episode bipolar I disorder patients.” Bipolar Disord 12(3):264-70 Details


Salvatore P, Baldessarini RJ, Tohen M, Khalsa HM, Sanchez-Toledo JP, Zarate CA Jr, Vieta E, Maggini C (2009), “McLean-Harvard International First-Episode Project: two-year stability of DSM-IV diagnoses in 500 first-episode psychotic disorder patients.” J Clin Psychiatry 70(4):458-66 Details


Montoya A, Gilaberte I, Costi M, Pérez Sánchez Toledo J, González Pinto A, Ma Haro J, Comes M, Vieta E (2007), “[Bipolar disorder in Spain: functional status and resource use on the basis of the Spanish sample of the observational, Pan European EMBLEM study].” Vertex 18(71):13-9 Details

Montoya A, Pérez Sánchez Toledo J, Gilaberte I, González-Pinto A, Haro JM, Vieta E, Tohen M (2007), “Patterns of drug treatment for manic episode in the clinical practice. Outcomes of the Spanish sample in the EMBLEM Study.” Actas Esp Psiquiatr 35(5):315-22 Details