Dr Jonathan GilleyUniversity positionSenior Research Associate DepartmentsDepartment of Clinical Neurosciences InstitutesCambridge Centre for Brain Repair Home pageResearch ThemeInterestsMy principle research area is investigation of the molecular mechanisms involved in axon degeneration after injury and in disease. Research Focus
EquipmentBehavioural analysis Cell culture Fluorescence microscopy Microscopy molecular biology mouse genetics Collaborators
Associated News ItemsKey publicationsGilley J, Orsomando G, Nascimento-Ferreira I, Coleman MP (2015), “Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons” Cell Reports 10(12): 1974-1981 Gilley J, Coleman MP (2010), “Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.” PLoS Biol 8(1):e1000300 Details Gilley J, Coffer PJ, Ham J (2003), “FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons.” J Cell Biol 162(4):613-22 Details Publications2016Clark DE, Waszkowycz B, Wong M, Lockey PM, Adalbert R, Gilley J, Clark J, Coleman MP (2016), “Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies” ioorganic & Medicinal Chemistry Letters Gilley J, Ando K, Seereeram A, Rodríguez-Martín T, Pooler AM, Sturdee L, Anderton BH, Brion J-P, Hanger DP, Coleman MP (2016), “Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice” Neurobiology of Aging 39: 1-18 Rodríguez-Martín T, Pooler AM, Lau DHW, Mórotz GM, De Vos KJ, Gilley J, Coleman MP, Hanger DP (2016), “Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons” Neurobiology of disease 85: 1-10 2015Di Stefano M, Nascimento-Ferreira I, Orsomando G, Mori V, Gilley J, Brown R, Janeckova L, Vargas ME, Worrell LA, Loreto A, Tickle J, Patrick J, Webster JRM, Marangoni M, Carpi FM, Pucciarelli S, Rossi F, Meng W, Sagasti A, Ribchester RR, Magni G, Coleman MP, Conforti L (2015), “A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration” Cell Death & Differentiation 22(5): 731-742 2014Conforti L, Gilley J, Coleman MP (2014), “Wallerian degeneration: an emerging axon death pathway linking injury and disease.” Nat Rev Neurosci 15(6):394-409 Details 2013Evans C, Cook SJ, Coleman MP, Gilley J (2013), “MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling.” PLoS One 8(10):e76505 Details Gilley J, Adalbert R, Yu G, Coleman MP (2013), “Rescue of peripheral and CNS axon defects in mice lacking NMNAT2.” J Neurosci 33(33):13410-24 Details Milde S, Gilley J, Coleman MP (2013), “Axonal trafficking of NMNAT2 and its roles in axon growth and survival in vivo.” Bioarchitecture 3(5):133-40 Details Milde S, Gilley J, Coleman MP (2013), “Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.” PLoS Biol 11(4):e1001539 Details 2011Gilley J, Adalbert R, Coleman MP (2011), “Modelling early responses to neurodegenerative mutations in mice.” Biochem Soc Trans 39(4):933-8 Details Gilley J, Seereeram A, Ando K, Mosely S, Andrews S, Kerschensteiner M, Misgeld T, Brion JP, Anderton B, Hanger DP, Coleman MP (2011), “Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse.” Neurobiol Aging Details Hughes R, Gilley J, Kristiansen M, Ham J (2011), “The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons.” BMC Neurosci 12:69 Details 2010Andrews S, Gilley J, Coleman MP (2010), “Difference Tracker: ImageJ plugins for fully automated analysis of multiple axonal transport parameters.” J Neurosci Methods 193(2):281-7 Details Babetto E, Beirowski B, Janeckova L, Brown R, Gilley J, Thomson D, Ribchester RR, Coleman MP (2010), “Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.” J Neurosci 30(40):13291-304 Details 2009Beirowski B, Babetto E, Gilley J, Mazzola F, Conforti L, Janeckova L, Magni G, Ribchester RR, Coleman MP (2009), “Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo.” J Neurosci 29(3):653-68 Details Conforti L, Wilbrey A, Morreale G, Janeckova L, Beirowski B, Adalbert R, Mazzola F, Di Stefano M, Hartley R, Babetto E, Smith T, Gilley J, Billington RA, Genazzani AA, Ribchester RR, Magni G, Coleman M (2009), “Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice.” J Cell Biol 184(4):491-500 Details Towers E, Gilley J, Randall R, Hughes R, Kristiansen M, Ham J (2009), “The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons.” Nucleic Acids Res 37(9):3044-60 Details 2007Adalbert R, Gilley J, Coleman MP (2007), “Abeta, tau and ApoE4 in Alzheimer's disease: the axonal connection.” Trends Mol Med 13(4):135-42 Details 2005Gilley J, Ham J (2005), “Evidence for increased complexity in the regulation of Bim expression in sympathetic neurons: involvement of novel transcriptional and translational mechanisms.” DNA Cell Biol 24(9):563-73 Details Ham J, Towers E, Gilley J, Terzano S, Randall R (2005), “BH3-only proteins: key regulators of neuronal apoptosis.” Cell Death Differ 12(8):1015-20 Details 2001Gilley J, Fried M (2001), “One INK4 gene and no ARF at the Fugu equivalent of the human INK4A/ARF/INK4B tumour suppressor locus.” Oncogene 20(50):7447-52 Details 1999Gilley J, Fried M (1999), “Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes.” Hum Mol Genet 8(7):1313-20 Details 1998Gilley J, Fried M (1998), “Evolution of U24 and U36 snoRNAs encoded within introns of vertebrate rpL7a gene homologs: unique features of mammalian U36 variants.” DNA Cell Biol 17(7):591-602 Details 1997Armes N, Gilley J, Fried M (1997), “The comparative genomic structure and sequence of the surfeit gene homologs in the puffer fish Fugu rubripes and their association with CpG-rich islands.” Genome Res 7(12):1138-52 Details Gilley J, Armes N, Fried M (1997), “Fugu genome is not a good mammalian model.” Nature 385(6614):305-6 Details |