Dr Jonathan Kanen University positionResearch Associate DepartmentsInstitutesBehavioural and Clinical Neuroscience Institute Home pagehttps://www.gatescambridge.org/biograp... Research ThemeInterestsI have defended my PhD as a Gates Cambridge Scholar, received the Angharad Dodds John Bursary in Mental Health and Neuropsychiatry to conduct postdoctoral research, and am an MD candidate in the United States. Much of my work has centred on the neurochemical modulation of affective and behavioural control, with a special emphasis on serotonin. I seek to connect pharmacological challenge studies with deficits in psychiatric disorders, and have a particular interest in obsessive-compulsive disorder (OCD). I am comparing deficits in behavioural flexibility across compulsive disorders with the goal of informing the refinement of psychiatric classification and treatment. I am also interested in the possibility of revising maladaptive associations by harnessing the process of memory reconsolidation or through the use of psychedelic drugs. Research Focus
EquipmentBehavioural analysis Computational modelling Magnetic resonance imaging (MRI) Neuropsychological testing Collaborators
Associated News ItemsPublications2023Luo Q, Kanen JW, Bari A, Skandali N, Langley C, Knudsen GM, Alsio J, Phillips BU, Sahakian BJ, Cardinal RN, Robbins TW (2023), “Common roles for serotonin in rats and humans for computations underlying flexible decision-making” bioRxiv Xu T, Zhou X, Kanen JW, Wang L, Chen Z, Zhang R, Jiao G, Feng Z, Zhao W, Yao S, Becker B (2023), “Angiotensin blockade enhances motivational reward learning via enhancing ventral striatal prediction error and frontostriatal communication” Molecular Psychiatry Zuhlsdorff K, Verdejo-Roman J, Clark L, Albein-Urios N, Soriano-Mas C, Cardinal RN, Robbins TW, Dalley JW, Verdejo-Garcia A, Kanen JW (2023), “Computational modelling of reinforcement learning and functional neuroimaging of probabilistic reversal dissociates compulsive behaviors in Gambling and Cocaine Use Disorders” bioRxiv 2022Kanen JW, Luo Q, Rostami Kandroodi M, Cardinal RN, Robbins TW, Nutt DJ, Carhart-Harris RL, den Ouden HEM (2022), “Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans” Psychological Medicine Kanen JW, Robbins TW, Trofimova IN (2022), “Harnessing temperament to elucidate the complexities of serotonin function” Current Opinion in Behavioral Sciences Trofimova IN, Bajaj S, Bashkatov SA, Blair J, Chan RCK, Clemens B, Corr PJ, Cyniak-Cieciura M, Demidova L, Filippi CA, Fox NA, Garipova M, Habel U, Haines N, Heym N, Hunter K, Jones NA, Kanen JW, Kirenskaya A, Kumari V, Lenzoni S, Letcher P, Lui SSY, Mathur A, McNaughton N, Mize KD, Netter P, Olsson CA, Patton GC, Paul K, Pickering A, Pine DS, Premkumar P, Raine A, Reuter M, Robbins TW, Sanson AV, Spry E, Storozheva Z, Sulis WH, Sumich A, Tkachenko AA, Valadez E, Wacker J, Wagels L, Wang L, Zawadzki B (2022), “What's next for the neurobiology of temperament, personality and psychopathology?” Current Opinion in Behavioral Sciences Yang R, Ma Y, Pan B-B, Bhatt M, Lohrenz T, Gu H-G, Kanen JW, Camerer C, Montague R (2022), “Dynamic neural reconfiguration for distinct strategies during competitive social interactions” Neuroimage 2021Kanen JW, Apergis-Schoute AM, Yellowlees R, Arntz FE, van der Flier FE, Price A, Cardinal RN, Christmas DM, Clark L, Sahakian BJ, Crockett MJ, Robbins TW (2021), “Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans” Molecular Psychiatry Kanen JW, Arntz FE, Yellowlees R, Cardinal RN, Price A, Christmas DM, Apergis-Schoute AM, Sahakian BJ, Robbins TW (2021), “Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality” Translational Psychiatry Kanen JW, Arntz FE, Yellowlees R, Christmas DM, Price A, Apergis-Schoute AM, Sahakian BJ, Cardinal RN, Robbins TW (2021), “Effect of tryptophan depletion on conditioned threat memory expression: role of intolerance of uncertainty” Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Marzuki AA, Tomi? I, Ip HYS, Gottwald J, Kanen JW, Kaser M, Sule A, Conway-Morris A, Sahakian BJ, Robbins TW (2021), “Environmental stochasticity promotes altered latent decision-making in adolescents with OCD” JAMA Network Open 2020Kanen JW, Arntz FE, Yellowlees R, Cardinal RN, Price A, Christmas DM, Sahakian BJ, Apergis-Schoute AM, Robbins TW (2020), “Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis” Journal of Psychopharmacology Luo Q, Zhang L, Huang C-C, Zheng Y, Kanen JW, Zhao Q, Yao Y, Quinlan EB, Jia T, Banaschewski T, Bokde ALW, Bromberg U, Büchel C, Flor H,11, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot J-L, Martinot M-LP, Nees F, Orfanos DP, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Sahakian BJ, Schumann G, Li F, Feng J, Desrivičres S, Robbins TW and the IMAGEN consortium (2020), “Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway” BMC Medicine 2019Kanen JW, Ersche KD, Fineberg NA, Robbins TW, Cardinal RN (2019), “Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents” Psychopharmacology 2018de Voogd LD, Kanen JW, Neville DA, Roelofs K, Fernández G, Hermans EJ (2018), “Eye-Movement Intervention Enhances Extinction via Amygdala Deactivation” Journal of Neuroscience 2017Hermans EJ, Kanen JW, Tambini A, Fernández G, Davachi L, Phelps EA (2017), “Persistence of amygdala-hippocampal connectivity and multi-voxel correlation structures during awake rest after fear learning predicts long-term expression of fear” Cerebral Cortex 2015Kanen JW, Nazir R, Sedky K, Pradhan, B (2015), “The effects of mindfulness-based interventions on sleep disturbance: a meta-analysis” Adolescent Psychiatry 2014Steinfurth ECK, Kanen JW, Raio CM, Clem R, Huganir R, Phelps EA (2014), “Recent and remote Pavlovian fear memories can be modified with extinction training during reconsolidation in humans” Learning & Memory 2013Schiller D, Kanen JW, LeDoux JE, Monfils MH, Phelps EA (2013), “Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvement” Proceedings of the National Academy of Sciences |