Jonathan Kanen University positionPhD student DepartmentsInstitutesBehavioural and Clinical Neuroscience Institute Home pagehttps://www.gatescambridge.org/members... Research ThemeInterestsI am an MD/PhD candidate and Gates Cambridge scholar. The brain chemical serotonin is implicated in a wide range of affective and behavioural processes and is a key drug target in numerous psychiatric disorders, however its exact role is not well understood. Characterising its function more precisely is therefore an important scientific endeavour. I investigate the contribution of serotonin in three domains: emotional memory, behavioural flexibility, and processing social information. I have a particular interest in obsessive-compulsive disorder (OCD) as well as memory reconsolidation. Research Focus
EquipmentBehavioural analysis Magnetic resonance imaging (MRI) Neuropsychological testing Collaborators
Associated News ItemsKey publicationsKanen JW, Ersche KD, Fineberg NA, Robbins TW, Cardinal RN (2019), “Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents” Psychopharmacology de Voogd LD, Kanen JW, Neville DA, Roelofs K, Fernández G, Hermans EJ (2018), “Eye-Movement Intervention Enhances Extinction via Amygdala Deactivation” Journal of Neuroscience Schiller D, Kanen JW, LeDoux JE, Monfils MH, Phelps EA (2013), “Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvement” Proceedings of the National Academy of Sciences Publications2020Kanen JW, Apergis-Schoute AM, Yellowlees R, Arntz FE, van der Flier FE, Price A, Cardinal RN, Christmas DM, Clark L, Sahakian BJ, Crockett MJ, Robbins TW (2020), “Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans” bioRxiv Kanen JW, Arntz FE, Yellowlees R, Cardinal RN, Price A, Christmas DM, Sahakian BJ, Apergis-Schoute AM, Robbins TW (2020), “Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis” Journal of Psychopharmacology Kanen JW, Arntz FE, Yellowlees R, Christmas DM, Price A, Apergis-Schoute AM, Sahakian BJ, Cardinal RN, Robbins TW (2020), “Effect of tryptophan depletion on conditioned threat memory expression: role of intolerance of uncertainty” bioRxiv 2019Kanen JW, Arntz FE, Yellowlees R, Cardinal RN, Price A, Christmas DM, Apergis-Schoute AM, Sahakian BJ, Robbins TW (2019), “Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality” bioRxiv 2016Hermans EJ, Kanen JW, Tambini A, Fernández G, Davachi L, Phelps EA (2016), “Persistence of amygdala-hippocampal connectivity and multi-voxel correlation structures during awake rest after fear learning predicts long-term expression of fear” Cerebral Cortex 2015Kanen JW, Nazir R, Sedky K, Pradhan, B (2015), “The effects of mindfulness-based interventions on sleep disturbance: a meta-analysis” Adolescent Psychiatry 2014Steinfurth ECK, Kanen JW, Raio CM, Clem R, Huganir R, Phelps EA (2014), “Recent and remote Pavlovian fear memories can be modified with extinction training during reconsolidation in humans” Learning & Memory |