I am an MD candidate from the USA and a Gates Cambridge scholar working on my PhD in the Department of Psychology.
The brain chemical serotonin is implicated in a wide range of affective and behavioural processes and is a key drug target in numerous psychiatric disorders, however its exact role is not well understood. Characterizing its function more precisely is therefore an important scientific endeavor. I will investigate the contribution of serotonin in three domains: emotional memory, behavioural flexibility, and processing social information. I have a particular interest in Obsessive-Compulsive Disorder as well as memory reconsolidation.
Magnetic resonance imaging (MRI)
Associated News Items
Kanen JW, Arntz FE, Yellowlees R, Cardinal RN, Price A, Christmas DM, Apergis-Schoute AM, Sahakian BJ, Robbins TW (2019), “Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality” bioRxiv
Kanen JW, Ersche KD, Fineberg NA, Robbins TW, Cardinal RN (2019), “Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents” Psychopharmacology
de Voogd LD, Kanen JW, Neville DA, Roelofs K, Fernández G, Hermans EJ (2018), “Eye-Movement Intervention Enhances Extinction via Amygdala Deactivation” Journal of Neuroscience
Hermans EJ, Kanen JW, Tambini A, Fernández G, Davachi L, Phelps EA (2016), “Persistence of amygdala-hippocampal connectivity and multi-voxel correlation structures during awake rest after fear learning predicts long-term expression of fear” Cerebral Cortex
Kanen JW, Nazir R, Sedky K, Pradhan, B (2015), “The effects of mindfulness-based interventions on sleep disturbance: a meta-analysis” Adolescent Psychiatry
Steinfurth ECK, Kanen JW, Raio CM, Clem R, Huganir R, Phelps EA (2014), “Recent and remote Pavlovian fear memories can be modified with extinction training during reconsolidation in humans” Learning & Memory
Schiller D, Kanen JW, LeDoux JE, Monfils MH, Phelps EA (2013), “Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvement” Proceedings of the National Academy of Sciences