Jonathan Kanen

Jonathan Kanen

University position

PhD student
Supervised by Trevor Robbins

Departments

Department of Psychology

Institutes

Behavioural and Clinical Neuroscience Institute

Home page

https://www.gatescambridge.org/members...

Research Theme

Cognitive and Behavioural Neuroscience

Interests

I am an MD/PhD candidate and Gates Cambridge scholar.

The brain chemical serotonin is implicated in a wide range of affective and behavioural processes and is a key drug target in numerous psychiatric disorders, however its exact role is not well understood. Characterising its function more precisely is therefore an important scientific endeavour. I investigate the contribution of serotonin in three domains: emotional memory, behavioural flexibility, and processing social information. I have a particular interest in obsessive-compulsive disorder (OCD) as well as memory reconsolidation.

Research Focus

Keywords

serotonin

compulsivity

memory reconsolidation

emotional memory

behavioural flexibility

Clinical conditions

Addiction

Anxiety disorders

Depressive disorders

Obsessive compulsive disorder

Phobias

Post-traumatic stress disorder

Equipment

Behavioural analysis

Magnetic resonance imaging (MRI)

Neuropsychological testing

Collaborators

Cambridge

Annemieke Apergis-Scoute

Rudolf Cardinal

Trevor Robbins

Barbara Sahakian

Associated News Items


    Key publications

    Kanen JW, Ersche KD, Fineberg NA, Robbins TW, Cardinal RN (2019), “Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents” Psychopharmacology

    de Voogd LD, Kanen JW, Neville DA, Roelofs K, Fern├índez G, Hermans EJ (2018), “Eye-Movement Intervention Enhances Extinction via Amygdala Deactivation” Journal of Neuroscience

    Schiller D, Kanen JW, LeDoux JE, Monfils MH, Phelps EA (2013), “Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvement” Proceedings of the National Academy of Sciences

    Publications

    2020

    Kanen JW, Apergis-Schoute AM, Yellowlees R, Arntz FE, van der Flier FE, Price A, Cardinal RN, Christmas DM, Clark L, Sahakian BJ, Crockett MJ, Robbins TW (2020), “Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans” bioRxiv

    Kanen JW, Arntz FE, Yellowlees R, Cardinal RN, Price A, Christmas DM, Sahakian BJ, Apergis-Schoute AM, Robbins TW (2020), “Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis” Journal of Psychopharmacology

    Kanen JW, Arntz FE, Yellowlees R, Christmas DM, Price A, Apergis-Schoute AM, Sahakian BJ, Cardinal RN, Robbins TW (2020), “Effect of tryptophan depletion on conditioned threat memory expression: role of intolerance of uncertainty” bioRxiv

    2019

    Kanen JW, Arntz FE, Yellowlees R, Cardinal RN, Price A, Christmas DM, Apergis-Schoute AM, Sahakian BJ, Robbins TW (2019), “Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality” bioRxiv

    2016

    Hermans EJ, Kanen JW, Tambini A, Fern├índez G, Davachi L, Phelps EA (2016), “Persistence of amygdala-hippocampal connectivity and multi-voxel correlation structures during awake rest after fear learning predicts long-term expression of fear” Cerebral Cortex

    2015

    Kanen JW, Nazir R, Sedky K, Pradhan, B (2015), “The effects of mindfulness-based interventions on sleep disturbance: a meta-analysis” Adolescent Psychiatry

    2014

    Steinfurth ECK, Kanen JW, Raio CM, Clem R, Huganir R, Phelps EA (2014), “Recent and remote Pavlovian fear memories can be modified with extinction training during reconsolidation in humans” Learning & Memory