Dr Juan Jose Perez Moreno

Interests

In neurons, endoplasmic reticulum (ER) is not only found in the cell body, but also extends into dendrites and axonal presynaptic terminals. Axonal ER comprises a tubular network of mainly smooth ER, whose function is still poorly understood. In humans, mutations of several axonal ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease.

Using Drosophila as model system, we try to understand the functional consequences of disrupting the axonal ER presence or continuity.

Research Focus

Keywords

Endoplasmic reticulum

Axon

Neuromuscular junction

Neurodegeneration

Clinical conditions

Genetics disorders

Hereditary spastic paraplegia

Hydrocephalus

Movement disorders

Equipment

Behavioural analysis

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Microscopy

Recombinant protein expression

Collaborators

No collaborators listed

Associated News Items


    Publications

    2019

    Pérez-Moreno JJ, O'Kane CJ (2019), “GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila” G3 9(2):453-462

    2017

    Pérez-Moreno JJ, Espina-Zambrano AG, García-Calderón CB, Estrada B (2017), “Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction” J Cell Sci 130(5):950-962

    2014

    Pérez-Moreno JJ, Bischoff M, Martín-Bermudo MD, Estrada B (2014), “The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila.” J Cell Sci 127(14):3162-73