Dr Juan Jose Perez Moreno
In neuronal cells, the endoplasmic reticulum (ER) shows physical continuity between the cell body and the presynaptic terminals. The role of this structure (the axonal ER) it is poorly understood, although in humans, mutations of several axonal ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease.
Using Drosophila as model system, we try to understand the functional consequences of disrupting the axonal ER presence or continuity.
No collaborators listed
Associated News Items
Pérez-Moreno JJ, Espina-Zambrano AG, García-Calderón CB, Estrada B (2017), “Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction” J Cell Sci 130(5):950-962
Pérez-Moreno JJ, Bischoff M, Martín-Bermudo MD, Estrada B (2014), “The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila.” J Cell Sci 127(14):3162-73