Dr Juan Jose Perez Moreno University positionVisiting Researcher Departmentsjuanjo.perez-moreno@gen.cam.ac.uk Home pagehttp://www.gen.cam.ac.uk/researc... Research ThemesInterestsIn neurons, endoplasmic reticulum (ER) is not only found in the cell body, but also extends into dendrites and axonal presynaptic terminals. Axonal ER comprises a tubular network of mainly smooth ER, whose function is still poorly understood. In humans, mutations of several axonal ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease. Using Drosophila as model system, we try to understand the functional consequences of disrupting the axonal ER presence or continuity. Research Focus
EquipmentBehavioural analysis Confocal microscopy Fluorescence microscopy Immunohistochemistry Microscopy Recombinant protein expression CollaboratorsNo collaborators listed Associated News ItemsKey publicationsOliva MK, Pérez-Moreno JJ, O'Shaughnessy J, Wardill TJ, O'Kane CJ (2020), “Endoplasmic reticulum (ER) lumenal indicators in Drosophila reveal effects of HSP-related mutations on ER calcium dynamics” Frontiers in Neuroscience 14:816 Öztürk Z, O’Kane CJ, Pérez-Moreno JJ (2020), “Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration” Frontiers in Neuroscience 14:48 Pérez-Moreno JJ, O'Kane CJ (2019), “GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila” G3: Genes, Genomes, Genetics 9(2):453-462 Pérez-Moreno JJ, Espina-Zambrano AG, García-Calderón CB, Estrada B (2017), “Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction” Journal of Cell Science 130(5):950-962 Pérez-Moreno JJ, Bischoff M, Martín-Bermudo MD, Estrada B (2014), “The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila.” Journal of Cell Science 127(14):3162-73 |