Dr Juan Jose Perez Moreno


In neurons, endoplasmic reticulum (ER) is not only found in the cell body, but also extends into dendrites and axonal presynaptic terminals. Axonal ER comprises a tubular network of mainly smooth ER, whose function is still poorly understood. In humans, mutations of several axonal ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease.

Using Drosophila as model system, we try to understand the functional consequences of disrupting the axonal ER presence or continuity.

Research Focus


Endoplasmic reticulum


Neuromuscular junction


Clinical conditions

Genetic disorders

Genetics disorders

Hereditary spastic paraplegia

Movement disorders

Movement disorders

Spinocerebellar ataxia


Behavioural analysis

Confocal microscopy

Fluorescence microscopy



Recombinant protein expression


No collaborators listed

Associated News Items

    Key publications

    Oliva MK, Pérez-Moreno JJ, O'Shaughnessy J, Wardill TJ, O'Kane CJ (2020), “Endoplasmic reticulum (ER) lumenal indicators in Drosophila reveal effects of HSP-related mutations on ER calcium dynamics” Frontiers in Neuroscience 14:816

    Öztürk Z, O’Kane CJ, Pérez-Moreno JJ (2020), “Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration” Frontiers in Neuroscience 14:48

    Pérez-Moreno JJ, O'Kane CJ (2019), “GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila” G3: Genes, Genomes, Genetics 9(2):453-462

    Pérez-Moreno JJ, Espina-Zambrano AG, García-Calderón CB, Estrada B (2017), “Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction” Journal of Cell Science 130(5):950-962

    Pérez-Moreno JJ, Bischoff M, Martín-Bermudo MD, Estrada B (2014), “The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila.” Journal of Cell Science 127(14):3162-73