Professor John Griffiths

John Griffiths

University position


Professor John Griffiths is pleased to consider applications from prospective PhD students.


Department of Oncology


Cancer Research UK, Cambridge Research Institute

Home page (personal home page)

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience


My work involves the use and development of Magnetic Resonance methods for understanding the biology of cancer and the determination of tumour-associated MR parameters for diagnosis, prognosis and monitoring of therapy.

Research Focus



magnetic resonance

Clinical conditions



Magnetic resonance imaging (MRI)


No collaborators listed

Associated News Items

    Key publications

    McPhail LD, Chung Y-L, Madhu B, Clark S, Griffiths JR, Kelland LR, Robinson SP (2005), “Tumour dose response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid, using in vivo magnetic resonance spectroscopy” Clin Cancer Res 11:3705-3713 Details

    Chung Y-L, Troy H, Banerji U, Jackson LE, Walton MI, Stubbs M, Griffiths JR, Judson IR, Leach MO, Workman P and Ronen SM (2003), “Magnetic Resonance Spectroscopic pharmacodynamic markers of Hsp90 inhibitor, 17-allylamino-17-demethoxygeldanamycin (17AAG) in human colon cancer models” JNCI 95:1624-1633

    Griffiths JR, McSheehy PMJ, Robinson SP, Troy H, Chung Y-L, Leek RD, Williams KJ, Stratford IJ, Harris AL, Stubbs M (2002), “Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 Wild-type tumors and tumors deficient in hypoxia-inducible factor-1 (HIF-1): Evidence of an anabolic role for the HIF-1 pathway” Cancer Res 62:688-695



    Bapiro TE, Frese KK, Courtin A, Bramhall JL, Madhu B, Cook N, Neesse A, Griffiths JR, Tuveson DA, Jodrell DI, Richards FM (2014), “Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.” Br J Cancer 111(2):318-25 Details

    Jauhiainen A, Madhu B, Narita M, Narita M, Griffiths J, Tavaré S (2014), “Normalization of metabolomics data with applications to correlation maps.” Bioinformatics 30(15):2155-61 Details

    Lin G, Hill DK, Andrejeva G, Boult JK, Troy H, Fong AC, Orton MR, Panek R, Parkes HG, Jafar M, Koh DM, Robinson SP, Judson IR, Griffiths JR, Leach MO, Eykyn TR, Chung YL (2014), “Dichloroacetate induces autophagy in colorectal cancer cells and tumours.” Br J Cancer 111(2):375-85 Details

    Schelhaas S, Wachsmuth L, Viel T, Honess DJ, Heinzmann K, Smith DM, Hermann S, Wagner S, Kuhlmann MT, Müller-Tidow C, Kopka K, Schober O, Schäfers M, Schneider R, Aboagye EO, Griffiths J, Faber C, Jacobs AH (2014), “Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-18F-Fluorothymidine PET and Diffusion-Weighted MR Imaging.” J Nucl Med 55(6):983-988 Details

    Zecchini V, Madhu B, Russell R, Pértega-Gomes N, Warren A, Gaude E, Borlido J, Stark R, Ireland-Zecchini H, Rao R, Scott H, Boren J, Massie C, Asim M, Brindle K, Griffiths J, Frezza C, Neal DE, Mills IG (2014), “Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.” EMBO J 33(12):1365-82 Details


    Arias-Mendoza F, Payne GS, Zakian K, Stubbs M, O'Connor OA, Mojahed H, Smith MR, Schwarz AJ, Shukla-Dave A, Howe F, Poptani H, Lee SC, Pettengel R, Schuster SJ, Cunningham D, Heerschap A, Glickson JD, Griffiths JR, Koutcher JA, Leach MO, Brown TR (2013), “Noninvasive phosphorus magnetic resonance spectroscopic imaging predicts outcome to first-line chemotherapy in newly diagnosed patients with diffuse large B-cell lymphoma.” Acad Radiol 20(9):1122-9 Details

    Baker LC, Boult JK, Jamin Y, Gilmour LD, Walker-Samuel S, Burrell JS, Ashcroft M, Howe FA, Griffiths JR, Raleigh JA, van der Kogel AJ, Robinson SP (2013), “Evaluation and immunohistochemical qualification of carbogen-induced ΔR₂ as a noninvasive imaging biomarker of improved tumor oxygenation.” Int J Radiat Oncol Biol Phys 87(1):160-7 Details

    Cannon DT, Howe FA, Whipp BJ, Ward SA, McIntyre DJ, Ladroue C, Griffiths JR, Kemp GJ, Rossiter HB (2013), “Muscle metabolism and activation heterogeneity by combined 31P chemical shift and T2 imaging, and pulmonary O2 uptake during incremental knee-extensor exercise.” J Appl Physiol (1985) 115(6):839-49 Details


    Beloueche-Babari M, Arunan V, Troy H, te Poele RH, te Fong AC, Jackson LE, Payne GS, Griffiths JR, Judson IR, Workman P, Leach MO, Chung YL (2012), “Histone deacetylase inhibition increases levels of choline kinase α and phosphocholine facilitating noninvasive imaging in human cancers.” Cancer Res 72(4):990-1000 Details

    Julià-Sapé M, Coronel I, Majós C, Candiota AP, Serrallonga M, Cos M, Aguilera C, Acebes JJ, Griffiths JR, Arús C (2012), “Prospective diagnostic performance evaluation of single-voxel 1H MRS for typing and grading of brain tumours.” NMR Biomed 25(4):661-73 Details

    McIntyre DJ, Madhu B, Lee SH, Griffiths JR (2012), “Magnetic resonance spectroscopy of cancer metabolism and response to therapy.” Radiat Res 177(4):398-435 Details

    McLean MA, Sun A, Bradstreet TE, Schaeffer AK, Liu H, Iannone R, Herman G, Railkar RA, Joubert I, Gillard JH, Price SJ, Griffiths JR (2012), “Repeatability of edited lactate and other metabolites in astrocytoma at 3T.” J Magn Reson Imaging 36(2):468-75 Details

    Rodrigues LM, Chung YL, Al Saffar NM, Sharp SY, Jackson LE, Banerji U, Stubbs M, Leach MO, Griffiths JR, Workman P (2012), “Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.” BMC Res Notes 5:250 Details

    Sala E, Kataoka MY, Priest AN, Gill AB, McLean MA, Joubert I, Graves MJ, Crawford RA, Jimenez-Linan M, Earl HM, Hodgkin C, Griffiths JR, Lomas DJ, Brenton JD (2012), “Advanced ovarian cancer: multiparametric MR imaging demonstrates response- and metastasis-specific effects.” Radiology 263(1):149-59 Details


    Bapiro TE, Richards FM, Goldgraben MA, Olive KP, Madhu B, Frese KK, Cook N, Jacobetz MA, Smith DM, Tuveson DA, Griffiths JR, Jodrell DI (2011), “A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.” Cancer Chemother Pharmacol 68(5):1243-53 Details

    Bell LK, Ainsworth NL, Lee SH, Griffiths JR (2011), “MRI & MRS assessment of the role of the tumour microenvironment in response to therapy.” NMR Biomed 24(6):612-35 Details

    Golinska M, Troy H, Chung YL, McSheehy PM, Mayr M, Yin X, Ly L, Williams KJ, Airley RE, Harris AL, Latigo J, Perumal M, Aboagye EO, Perrett D, Stubbs M, Griffiths JR (2011), “Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas.” BMC Cancer 11:198 Details

    McIntyre DJ, Howe FA, Ladroue C, Lofts F, Stubbs M, Griffiths JR (2011), “Can localised (19)F magnetic resonance spectroscopy pharmacokinetics of 5FU in colorectal metastases predict clinical response?” Cancer Chemother Pharmacol 68(1):29-36 Details

    McLean MA, Barrett T, Gnanapragasam VJ, Priest AN, Joubert I, Lomas DJ, Neal DE, Griffiths JR, Sala E (2011), “Prostate cancer metabolite quantification relative to water in 1H-MRSI in vivo at 3 Tesla.” Magn Reson Med 65(4):914-9 Details

    Tortajada S, Fuster-Garcia E, Vicente J, Wesseling P, Howe FA, Julià-Sapé M, Candiota AP, Monleón D, Moreno-Torres A, Pujol J, Griffiths JR, Wright A, Peet AC, Martínez-Bisbal MC, Celda B, Arús C, Robles M, García-Gómez JM (2011), “Incremental Gaussian Discriminant Analysis based on Graybill and Deal weighted combination of estimators for brain tumour diagnosis.” J Biomed Inform 44(4):677-87 Details


    Biswas S, Troy H, Leek R, Chung YL, Li JL, Raval RR, Turley H, Gatter K, Pezzella F, Griffiths JR, Stubbs M, Harris AL (2010), “Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts.” J Oncol 2010:757908 Details

    Fellows GA, Wright AJ, Sibtain NA, Rich P, Opstad KS, McIntyre DJ, Bell BA, Griffiths JR, Howe FA (2010), “Combined use of neuroradiology and 1H-MR spectroscopy may provide an intervention limiting diagnosis of glioblastoma multiforme.” J Magn Reson Imaging 32(5):1038-44 Details

    Filler AG, Whiteside GT, Bacon M, Frederickson M, Howe FA, Rabinowitz MD, Sokoloff AJ, Deacon TW, Abell C, Munglani R, Griffiths JR, Bell BA, Lever AM (2010), “Tri-partite complex for axonal transport drug delivery achieves pharmacological effect.” BMC Neurosci 11:8 Details

    Opstad KS, Wright AJ, Bell BA, Griffiths JR, Howe FA (2010), “Correlations between in vivo (1)H MRS and ex vivo (1)H HRMAS metabolite measurements in adult human gliomas.” J Magn Reson Imaging 31(2):289-97 Details

    Priest AN, Gill AB, Kataoka M, McLean MA, Joubert I, Graves MJ, Griffiths JR, Crawford RA, Earl H, Brenton JD, Lomas DJ, Sala E (2010), “Dynamic contrast-enhanced MRI in ovarian cancer: Initial experience at 3 tesla in primary and metastatic disease.” Magn Reson Med 63(4):1044-9 Details

    Sala E, Priest AN, Kataoka M, Graves MJ, McLean MA, Joubert I, Griffiths JR, Crawford RA, Jimenez-Linan M, Earl HM, Brenton JD, Lomas DJ (2010), “Apparent diffusion coefficient and vascular signal fraction measurements with magnetic resonance imaging: feasibility in metastatic ovarian cancer at 3 Tesla: technical development.” Eur Radiol 20(2):491-6 Details

    Stubbs M, Griffiths JR (2010), “The altered metabolism of tumors: HIF-1 and its role in the Warburg effect.” Adv Enzyme Regul 50(1):44-55 Details

    Wright AJ, Fellows GA, Griffiths JR, Wilson M, Bell BA, Howe FA (2010), “Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers.” Mol Cancer 9:66 Details


    Howe FA, Syms RR, Ahmad MM, Rodrigues LM, Griffiths JR, Young IR (2009), “In vivo 31P magnetic resonance spectroscopy using a needle microcoil.” Magn Reson Med 61(5):1238-41 Details

    Mayr M, Grainger D, Mayr U, Leroyer AS, Leseche G, Sidibe A, Herbin O, Yin X, Gomes A, Madhu B, Griffiths JR, Xu Q, Tedgui A, Boulanger CM (2009), “Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques.” Circ Cardiovasc Genet 2(4):379-88 Details

    Mayr M, Liem D, Zhang J, Li X, Avliyakulov NK, Yang JI, Young G, Vondriska TM, Ladroue C, Madhu B, Griffiths JR, Gomes A, Xu Q, Ping P (2009), “Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts.” J Mol Cell Cardiol 46(2):268-77 Details

    McLean MA, Priest AN, Joubert I, Lomas DJ, Kataoka MY, Earl H, Crawford R, Brenton JD, Griffiths JR, Sala E (2009), “Metabolic characterization of primary and metastatic ovarian cancer by 1H-MRS in vivo at 3T.” Magn Reson Med 62(4):855-61 Details


    Chung YL, Troy H, Kristeleit R, Aherne W, Jackson LE, Atadja P, Griffiths JR, Judson IR, Workman P, Leach MO, Beloueche-Babari M (2008), “Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts.” Neoplasia 10(4):303-13 Details

    Howe FA, McPhail LD, Griffiths JR, McIntyre DJ, Robinson SP (2008), “Vessel size index magnetic resonance imaging to monitor the effect of antivascular treatment in a rodent tumor model.” Int J Radiat Oncol Biol Phys 71(5):1470-6 Details

    Kalber TL, Waterton JC, Griffiths JR, Ryan AJ, Robinson SP (2008), “Longitudinal in vivo susceptibility contrast MRI measurements of LS174T colorectal liver metastasis in nude mice.” J Magn Reson Imaging 28(6):1451-8 Details

    Leech SH, Evans CA, Shaw L, Wong CH, Connolly J, Griffiths JR, Whetton AD, Corfe BM (2008), “Proteomic analyses of intermediate filaments reveals cytokeratin8 is highly acetylated--implications for colorectal epithelial homeostasis.” Proteomics 8(2):279-88 Details

    Madhu B, Robinson SP, Howe FA, Griffiths JR (2008), “Effect of Gd-DTPA-BMA on choline signals of HT29 tumors detected by in vivo 1H MRS.” J Magn Reson Imaging 28(5):1201-8 Details

    Mayr M, Yusuf S, Weir G, Chung YL, Mayr U, Yin X, Ladroue C, Madhu B, Roberts N, De Souza A, Fredericks S, Stubbs M, Griffiths JR, Jahangiri M, Xu Q, Camm AJ (2008), “Combined metabolomic and proteomic analysis of human atrial fibrillation.” J Am Coll Cardiol 51(5):585-94 Details

    Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung YL, Madhu B, Quax PH, Hu Y, Griffiths JR, Xu Q (2008), “Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice.” Circ Res 102(9):1046-56 Details

    Opstad KS, Bell BA, Griffiths JR, Howe FA (2008), “Toward accurate quantification of metabolites, lipids, and macromolecules in HRMAS spectra of human brain tumor biopsies using LCModel.” Magn Reson Med 60(5):1237-42 Details

    Opstad KS, Bell BA, Griffiths JR, Howe FA (2008), “An assessment of the effects of sample ischaemia and spinning time on the metabolic profile of brain tumour biopsy specimens as determined by high-resolution magic angle spinning (1)H NMR.” NMR Biomed 21(10):1138-47 Details

    Opstad KS, Bell BA, Griffiths JR, Howe FA (2008), “An investigation of human brain tumour lipids by high-resolution magic angle spinning 1H MRS and histological analysis.” NMR Biomed 21(7):677-85 Details

    Opstad KS, Griffiths JR, Bell BA, Howe FA (2008), “Apparent T(2) relaxation times of lipid and macromolecules: a study of high-grade tumor spectra.” J Magn Reson Imaging 27(1):178-84 Details

    Porstmann T, Santos CR, Griffiths B, Cully M, Wu M, Leevers S, Griffiths JR, Chung YL, Schulze A (2008), “SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.” Cell Metab 8(3):224-36 Details

    Wright AJ, Arús C, Wijnen JP, Moreno-Torres A, Griffiths JR, Celda B, Howe FA (2008), “Automated quality control protocol for MR spectra of brain tumors.” Magn Reson Med 59(6):1274-81 Details


    McPhail LD, Griffiths JR, Robinson SP (2007), “Assessment of tumor response to the vascular disrupting agents 5,6-dimethylxanthenone-4-acetic acid or combretastatin-A4-phosphate by intrinsic susceptibility magnetic resonance imaging.” Int J Radiat Oncol Biol Phys 69(4):1238-45 Details

    Robinson SP, Howe FA, Griffiths JR, Ryan AJ, Waterton JC (2007), “Susceptibility contrast magnetic resonance imaging determination of fractional tumor blood volume: a noninvasive imaging biomarker of response to the vascular disrupting agent ZD6126.” Int J Radiat Oncol Biol Phys 69(3):872-9 Details


    Al-Saffar NM, Troy H, Ramírez de Molina A, Jackson LE, Madhu B, Griffiths JR, Leach MO, Workman P, Lacal JC, Judson IR, Chung YL (2006), “Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.” Cancer Res 66(1):427-34 Details

    Cullis ER, Kalber TL, Ashton SE, Cartwright JE, Griffiths JR, Ryan AJ, Robinson SP (2006), “Tumour overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126.” Microvasc Res 71(2):76-84 Details

    Julià-Sapé M, Acosta D, Majós C, Moreno-Torres A, Wesseling P, Acebes JJ, Griffiths JR, Arús C (2006), “Comparison between neuroimaging classifications and histopathological diagnoses using an international multicenter brain tumor magnetic resonance imaging database.” J Neurosurg 105(1):6-14 Details

    Madhu B, Waterton JC, Griffiths JR, Ryan AJ, Robinson SP (2006), “The response of RIF-1 fibrosarcomas to the vascular-disrupting agent ZD6126 assessed by in vivo and ex vivo 1H magnetic resonance spectroscopy.” Neoplasia 8(7):560-7 Details

    McPhail LD, McIntyre DJ, Ludwig C, Kestell P, Griffiths JR, Kelland LR, Robinson SP (2006), “Rat tumor response to the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid as measured by dynamic contrast-enhanced magnetic resonance imaging, plasma 5-hydroxyindoleacetic acid levels, and tumor necrosis.” Neoplasia 8(3):199-206 Details

    Tate AR, Underwood J, Acosta DM, Julià-Sapé M, Majós C, Moreno-Torres A, Howe FA, van der Graaf M, Lefournier V, Murphy MM, Loosemore A, Ladroue C, Wesseling P, Luc Bosson J, Cabañas ME, Simonetti AW, Gajewicz W, Calvar J, Capdevila A, Wilkins PR, Bell BA, Rémy C, Heerschap A, Watson D, Griffiths JR, Arús C (2006), “Development of a decision support system for diagnosis and grading of brain tumours using in vivo magnetic resonance single voxel spectra.” NMR Biomed 19(4):411-34 Details

    Workman P, Aboagye EO, Chung YL, Griffiths JR, Hart R, Leach MO, Maxwell RJ, McSheehy PM, Price PM, Zweit J, Cancer Research UK Pharmacodynamic/Pharmacokinetic Technologies Advisory Committee (2006), “Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies.” J Natl Cancer Inst 98(9):580-98 Details


    Howe FA, Connelly JP, Robinson SP, Springett R, Griffiths JR (2005), “The effects of tumour blood flow and oxygenation modifiers on subcutaneous tumours as determined by NIRS.” Adv Exp Med Biol 566:75-81 Details

    Kalber TL, Smith CJ, Howe FA, Griffiths JR, Ryan AJ, Waterton JC, Robinson SP (2005), “A longitudinal study of R2* and R2 magnetic resonance imaging relaxation rate measurements in murine liver after a single administration of 3 different iron oxide-based contrast agents.” Invest Radiol 40(12):784-91 Details

    Mayr M, Chung YL, Mayr U, Yin X, Ly L, Troy H, Fredericks S, Hu Y, Griffiths JR, Xu Q (2005), “Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism.” Arterioscler Thromb Vasc Biol 25(10):2135-42 Details

    Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, Downward J, Schulze A (2005), “PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.” Oncogene 24(43):6465-81 Details

    Robinson SP, Kalber TL, Howe FA, McIntyre DJ, Griffiths JR, Blakey DC, Whittaker L, Ryan AJ, Waterton JC (2005), “Acute tumor response to ZD6126 assessed by intrinsic susceptibility magnetic resonance imaging.” Neoplasia 7(5):466-74 Details


    Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR (2004), “Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.” Clin Cancer Res 10(11):3863-70 Details

    Kostourou V, Troy H, Murray JF, Cullis ER, Whitley GS, Griffiths JR, Robinson SP (2004), “Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo.” Neoplasia 6(4):401-11 Details

    Mayr M, Chung YL, Mayr U, McGregor E, Troy H, Baier G, Leitges M, Dunn MJ, Griffiths JR, Xu Q (2004), “Loss of PKC-delta alters cardiac metabolism.” Am J Physiol Heart Circ Physiol 287(2):H937-45 Details

    Mayr M, Mayr U, Chung YL, Yin X, Griffiths JR, Xu Q (2004), “Vascular proteomics: linking proteomic and metabolomic changes.” Proteomics 4(12):3751-61 Details

    Mayr M, Metzler B, Chung YL, McGregor E, Mayr U, Troy H, Hu Y, Leitges M, Pachinger O, Griffiths JR, Dunn MJ, Xu Q (2004), “Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice.” Am J Physiol Heart Circ Physiol 287(2):H946-56 Details

    Mayr M, Siow R, Chung YL, Mayr U, Griffiths JR, Xu Q (2004), “Proteomic and metabolomic analysis of vascular smooth muscle cells: role of PKCdelta.” Circ Res 94(10):e87-96 Details

    McIntyre DJ, Ludwig C, Pasan A, Griffiths JR (2004), “A method for interleaved acquisition of a vascular input function for dynamic contrast-enhanced MRI in experimental rat tumours.” NMR Biomed 17(3):132-43 Details

    McIntyre DJ, Robinson SP, Howe FA, Griffiths JR, Ryan AJ, Blakey DC, Peers IS, Waterton JC (2004), “Single dose of the antivascular agent, ZD6126 (N-acetylcolchinol-O-phosphate), reduces perfusion for at least 96 hours in the GH3 prolactinoma rat tumor model.” Neoplasia 6(2):150-7 Details

    Nöth U, Rodrigues LM, Robinson SP, Jork A, Zimmermann U, Newell B, Griffiths JR (2004), “In vivo determination of tumor oxygenation during growth and in response to carbogen breathing using 15C5-loaded alginate capsules as fluorine-19 magnetic resonance imaging oxygen sensors.” Int J Radiat Oncol Biol Phys 60(3):909-19 Details

    Opstad KS, Murphy MM, Wilkins PR, Bell BA, Griffiths JR, Howe FA (2004), “Differentiation of metastases from high-grade gliomas using short echo time 1H spectroscopy.” J Magn Reson Imaging 20(2):187-92 Details

    Robinson SP, Griffiths JR (2004), “Current issues in the utility of 19F nuclear magnetic resonance methodologies for the assessment of tumour hypoxia.” Philos Trans R Soc Lond B Biol Sci 359(1446):987-96 Details

    Rodrigues LM, Howe FA, Griffiths JR, Robinson SP (2004), “Tumor R2* is a prognostic indicator of acute radiotherapeutic response in rodent tumors.” J Magn Reson Imaging 19(4):482-8 Details


    Chung YL, Troy H, Banerji U, Jackson LE, Walton MI, Stubbs M, Griffiths JR, Judson IR, Leach MO, Workman P, Ronen SM (2003), “Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models.” J Natl Cancer Inst 95(21):1624-33 Details

    Griffiths JR, Stubbs M (2003), “Opportunities for studying cancer by metabolomics: preliminary observations on tumors deficient in hypoxia-inducible factor 1.” Adv Enzyme Regul 43:67-76 Details

    Howe FA, Robinson SP, Rodrigues LM, Stubbs M, Griffiths JR (2003), “Issues in GRE & SE magnetic resonance imaging to probe tumor oxygenation.” Adv Exp Med Biol 530:441-8 Details

    Kostourou V, Robinson SP, Whitley GS, Griffiths JR (2003), “Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging.” Cancer Res 63(16):4960-6 Details

    Ladroue C, Howe FA, Griffiths JR, Tate AR (2003), “Independent component analysis for automated decomposition of in vivo magnetic resonance spectra.” Magn Reson Med 50(4):697-703 Details

    Robinson SP, Rijken PF, Howe FA, McSheehy PM, van der Sanden BP, Heerschap A, Stubbs M, van der Kogel AJ, Griffiths JR (2003), “Tumor vascular architecture and function evaluated by non-invasive susceptibility MRI methods and immunohistochemistry.” J Magn Reson Imaging 17(4):445-54 Details

    Tate AR, Majós C, Moreno A, Howe FA, Griffiths JR, Arús C (2003), “Automated classification of short echo time in in vivo 1H brain tumor spectra: a multicenter study.” Magn Reson Med 49(1):29-36 Details


    Cudlip SA, Howe FA, Griffiths JR, Bell BA (2002), “Magnetic resonance neurography of peripheral nerve following experimental crush injury, and correlation with functional deficit.” J Neurosurg 96(4):755-9 Details

    Griffiths JR, McSheehy PM, Robinson SP, Troy H, Chung YL, Leek RD, Williams KJ, Stratford IJ, Harris AL, Stubbs M (2002), “Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway.” Cancer Res 62(3):688-95 Details

    Rodrigues LM, Robinson SP, McSheehy PM, Stubbs M, Griffiths JR (2002), “Enhanced uptake of ifosfamide into GH3 prolactinomas with hypercapnic hyperoxic gases monitored in vivo by (31)P MRS.” Neoplasia 4(6):539-43 Details

    Stubbs M, Robinson SP, Hui C, Price NM, Rodrigues LM, Howe FA, Griffiths JR (2002), “The importance of tumor metabolism in cancer prognosis and therapy; pre-clinical studies on rodent tumors with agents that improve tumor oxygenation.” Adv Enzyme Regul 42:131-41 Details