Dr Joyce Whittington University positionSenior Research Associate DepartmentsHome pageResearch ThemesInterestsEarly research on specific learning disabilities - dyslexia - and associated cognitve deficits. For the last 10 years research has focussed on various prevalence, cognitive and behavioural aspects of Prader-Willi syndrome. Most of the latter is described in: Whittington JE, Holland AJ. Prader-Willi Syndrome:Development and Manifestations. Cambridge University Press, Cambridge 2004 Research Focus
EquipmentCross-sectional and cohort studies Collaborators
Associated News ItemsKey publicationsWebb T, Maina EN, Soni S, Whittington J, Boer H, Clarke D, Holland A (2008), “In search of the psychosis gene in people with Prader-Willi syndrome.” Am J Med Genet A 146(7):843-53 Details Whittington JE, Holland AJ, Webb T, Butler JV, Clarke DJ, Boer H (2004), “Cognitive abilities and genotype in a population-based sample of people with Prader-Willi syndrome” Journal of Intellectual Disability Research 48:172-187 Whittington JE, Holland AJ, Webb T, Butler JV, Clarke DJ, Boer H (2002), “Relationship between clinical and genetic diagnosis of Prader-Willi syndrome” Journal of Medical Genetics 39:926-932 Whittington JE, Holland AJ, Webb T, Butler JV, Clarke DJ, Boer H (2001), “Population prevalence and estimated birth incidence and mortality rate for people with Prader-Willi Syndrome in one UK Health Region” Journal of Medical Genetics 38:792-798 Publications2012Goldstone AP, Holland AJ, Butler JV, Whittington JE (2012), “Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome.” Int J Obes (Lond) Details 2011Whittington J, Holland T (2011), “Recognition of emotion in facial expression by people with Prader-Willi syndrome.” J Intellect Disabil Res 55(1):75-84 Details 2010Butler JV, Whittington JE, Holland AJ, McAllister CJ, Goldstone AP (2010), “The transition between the phenotypes of Prader-Willi syndrome during infancy and early childhood.” Dev Med Child Neurol 52(6):e88-93 Details McAllister CJ, Whittington JE, Holland AJ (2010), “Development of the eating behaviour in Prader-Willi Syndrome: advances in our understanding.” Int J Obes (Lond) Details Whittington J, Holland A (2010), “Neurobehavioral phenotype in Prader-Willi syndrome.” Am J Med Genet C Semin Med Genet 154C(4):438-47 Details 2009Holland A, Whittington J, Cohen O, Curfs L, Delahaye F, Dudley O, Horsthemke B, Lindgren AC, Nourissier C, Sharma N, Vogels A (2009), “The European Prader-Willi Syndrome Clinical Research Database: an aid in the investigation of a rare genetically determined neurodevelopmental disorder.” J Intellect Disabil Res 53(6):538-47 Details Whittington J, Holland A, Webb T (2009), “Relationship between the IQ of people with Prader-Willi syndrome and that of their siblings: evidence for imprinted gene effects.” J Intellect Disabil Res 53(5):411-8 Details 2008Dudley O, McManus B, Vogels A, Whittington J, Muscatelli F (2008), “Cross-cultural comparisons of obesity and growth in Prader-Willi syndrome.” J Intellect Disabil Res 52(Pt 5):426-36 Details Soni S, Whittington J, Holland AJ, Webb T, Maina EN, Boer H, Clarke D (2008), “The phenomenology and diagnosis of psychiatric illness in people with Prader-Willi syndrome.” Psychol Med 38(10):1505-14 Details Whittington JE, Butler JV, Holland AJ (2008), “Pre-, peri- and postnatal complications in Prader-Willi syndrome in a UK sample.” Early Hum Dev 84(5):331-6 Details 2007Maina EN, Webb T, Soni S, Whittington J, Boer H, Clarke D, Holland A (2007), “Analysis of candidate imprinted genes in PWS subjects with atypical genetics: a possible inactivating mutation in the SNURF/SNRPN minimal promoter.” J Hum Genet 52(4):297-307 Details Soni S, Whittington J, Holland AJ, Webb T, Maina E, Boer H, Clarke D (2007), “The course and outcome of psychiatric illness in people with Prader-Willi syndrome: implications for management and treatment.” J Intellect Disabil Res 51(Pt 1):32-42 Details Whittington JE, Butler JV, Holland AJ (2007), “Changing rates of genetic subtypes of Prader-Willi syndrome in the UK.” Eur J Hum Genet 15(1):127-30 Details 2006Webb T, Whittington J, Holland AJ, Soni S, Boer H, Clarke D, Horsthemke B (2006), “CD36 expression and its relationship with obesity in blood cells from people with and without Prader-Willi syndrome.” Clin Genet 69(1):26-32 Details 2005Stauder JE, Boer H, Gerits RH, Tummers A, Whittington J, Curfs LM (2005), “Differences in behavioural phenotype between parental deletion and maternal uniparental disomy in Prader-Willi syndrome: an ERP study.” Clin Neurophysiol 116(6):1464-70 Details 2004Veltman MW, Thompson RJ, Roberts SE, Thomas NS, Whittington J, Bolton PF (2004), “Prader-Willi syndrome--a study comparing deletion and uniparental disomy cases with reference to autism spectrum disorders.” Eur Child Adolesc Psychiatry 13(1):42-50 Details Whittington J, Holland A, Webb T, Butler J, Clarke D, Boer H (2004), “Academic underachievement by people with Prader-Willi syndrome.” J Intellect Disabil Res 48(Pt 2):188-200 Details Whittington J, Holland A, Webb T, Butler J, Clarke D, Boer H (2004), “Cognitive abilities and genotype in a population-based sample of people with Prader-Willi syndrome.” J Intellect Disabil Res 48(Pt 2):172-87 Details 2003Holland A, Whittington J, Hinton E (2003), “The paradox of Prader-Willi syndrome: a genetic model of starvation.” Lancet 362(9388):989-91 Details Holland AJ, Whittington JE, Butler J, Webb T, Boer H, Clarke D (2003), “Behavioural phenotypes associated with specific genetic disorders: evidence from a population-based study of people with Prader-Willi syndrome.” Psychol Med 33(1):141-53 Details 2002Boer H, Holland A, Whittington J, Butler J, Webb T, Clarke D (2002), “Psychotic illness in people with Prader Willi syndrome due to chromosome 15 maternal uniparental disomy.” Lancet 359(9301):135-6 Details Butler JV, Whittington JE, Holland AJ, Boer H, Clarke D, Webb T (2002), “Prevalence of, and risk factors for, physical ill-health in people with Prader-Willi syndrome: a population-based study.” Dev Med Child Neurol 44(4):248-55 Details Clarke DJ, Boer H, Whittington J, Holland A, Butler J, Webb T (2002), “Prader-Willi syndrome, compulsive and ritualistic behaviours: the first population-based survey.” Br J Psychiatry 180:358-62 Details Webb T, Whittington J, Clarke D, Boer H, Butler J, Holland A (2002), “A study of the influence of different genotypes on the physical and behavioral phenotypes of children and adults ascertained clinically as having PWS.” Clin Genet 62(4):273-81 Details |