Professor Jean-Claude Baron![]() University positionProfessor DepartmentsDepartment of Clinical Neurosciences InstitutesHome pagehttp://www.neurology.cam.ac.uk/stroke/... (personal home page) Research ThemesInterestsMy research focuses on the pathophysiology of ischaemic stroke and the mechanisms underlying subsequent deterioration or recovery, including neuronal damage, tissue inflammation and long-term plasticity processes. In terms of methodology, my approach is characterized by 1) combining brain imaging, both structural and functional (PET and fMRI) and assessment of performance measured using behavioural, cognitive or psychophysical tools; and 2) undertaking parallel studies in stroke patients and animal models, in the latter including microPET, in vitro autoradiographic and post mortem histopathologic techniques to inform the human studies. ![]() Mapping the hypoxic brain tissue in the acute stage of stroke using PET and a selective hypoxia tracer Click image to view full-size Research Focus
EquipmentBehavioural analysis Computerised tomography Cross-sectional and cohort studies Haemodynamic monitoring Magnetic resonance imaging (MRI) Microscopy Positron Emission Tomography (PET) Collaborators
Associated News ItemsKey publicationsCalautti C, Naccarato M, Jones PS, Day DJ, Carpenter TA, Bullmore ET, Warburton EA, Baron JC (2007), “The relationship between motor deficit and hemisphere activation balance after stroke” NeuroImage 34:322-331 Takasawa M, Beech JS, Fryer TDF, Hughes JL Igase K, Jones PS, Smith R, Aigbirihio FI, Menon DK, Clark JC, Baron J-C (2007), “Imaging of Brain Hypoxia in Permanent and Temporary MCA Occlusion in the Rat Using 18F-Fluoromisonidazole and PET” J Cereb Blood Flow Metab 27:679-89 Guadagno JV, Jones PS, Fryer TD, Barret O, Aigbirhio FI, Carpenter TA, Price CJ, Gillard JH, Warburton EA, Baron JC (2006), “Local relationships between restricted water diffusion and oxygen consumption in the ischaemic human brain” Stroke 37:1741-48 Details Publications2014Alawneh JA, Moustafa RR, Marrapu ST, Jensen-Kondering U, Morris RS, Jones PS, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2014), “Diffusion and perfusion correlates of the 18F-MISO PET lesion in acute stroke: pilot study.” Eur J Nucl Med Mol Imaging 41(4):736-44 Details Baron JC, Farid K, Dolan E, Turc G, Marrapu ST, O'Brien E, Aigbirhio FI, Fryer TD, Menon DK, Warburton EA, Hong YT (2014), “Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symptomatic intracerebral hemorrhage.” J Cereb Blood Flow Metab 34(5):753-8 Details Baron JC, Yamauchi H, Fujioka M, Endres M (2014), “Selective neuronal loss in ischemic stroke and cerebrovascular disease.” J Cereb Blood Flow Metab 34(1):2-18 Details Charidimou A, Jaunmuktane Z, Baron JC, Burnell M, Varlet P, Peeters A, Xuereb J, Jäger R, Brandner S, Werring DJ (2014), “White matter perivascular spaces: an MRI marker in pathology-proven cerebral amyloid angiopathy?” Neurology 82(1):57-62 Details Cheng B, Forkert ND, Zavaglia M, Hilgetag CC, Golsari A, Siemonsen S, Fiehler J, Pedraza S, Puig J, Cho TH, Alawneh J, Baron JC, Ostergaard L, Gerloff C, Thomalla G (2014), “Influence of Stroke Infarct Location on Functional Outcome Measured by the Modified Rankin Scale.” Stroke Details Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJ, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK (2014), “Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.” JAMA Neurol 71(1):23-31 Details Seners P, Turc G, Oppenheim C, Baron JC (2014), “Incidence, causes and predictors of neurological deterioration occurring within 24?h following acute ischaemic stroke: a systematic review with pathophysiological implications.” J Neurol Neurosurg Psychiatry Details Seners P, Turc G, Tisserand M, Legrand L, Labeyrie MA, Calvet D, Meder JF, Mas JL, Oppenheim C, Baron JC (2014), “Unexplained early neurological deterioration after intravenous thrombolysis: incidence, predictors, and associated factors.” Stroke 45(7):2004-9 Details Sharma N, Baron JC (2014), “Effects of healthy ageing on activation pattern within the primary motor cortex during movement and motor imagery: an fMRI study.” PLoS One 9(6):e88443 Details Tisserand M, Malherbe C, Turc G, Legrand L, Edjlali M, Labeyrie MA, Seners P, Mas JL, Méder JF, Baron JC, Oppenheim C (2014), “Is white matter more prone to diffusion lesion reversal after thrombolysis?” Stroke 45(4):1167-9 Details 2013Agarwal S, Scoffings DJ, Jones PS, Marrapu ST, Barry PJ, O'Brien EW, Baron JC, Warburton EA (2013), “Interaction of age with the ischaemic penumbra, leptomeningeal collateral circulation and haemodynamic variables in acute stroke: a pilot study.” J Neurol Neurosurg Psychiatry 84(3):271-6 Details Apoil M, Turc G, Tisserand M, Calvet D, Naggara O, Domigo V, Baron JC, Oppenheim C, Touzé E (2013), “Clinical and magnetic resonance imaging predictors of very early neurological response to intravenous thrombolysis in patients with middle cerebral artery occlusion.” J Am Heart Assoc 2(6):e000511 Details Baron JC, Macrae IM, Adams HP Jr, Dirnagl U (2013), “ESC-BRAIN: experimental and clinical stroke research--do they connect?. meeting report of the ESC-BRAIN joint symposium held in London and Shanghai in May 2013.” Cerebrovasc Dis 36(4):306-21 Details Carrera E, Jones PS, Morris RS, Alawneh J, Hong YT, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2013), “Is neural activation within the rescued penumbra impeded by selective neuronal loss?” Brain 136(Pt 6):1816-29 Details Charidimou A, Baron JC, Werring DJ (2013), “Cerebral amyloid angiopathy and transient focal neurological episodes.” Cerebrovasc Dis 36(3):245-6 Details Charidimou A, Baron JC, Werring DJ (2013), “Transient focal neurological episodes, cerebral amyloid angiopathy, and intracerebral hemorrhage risk: looking beyond TIAs.” Int J Stroke 8(2):105-8 Details Charidimou A, Jäger RH, Fox Z, Peeters A, Vandermeeren Y, Laloux P, Baron JC, Werring DJ (2013), “Prevalence and mechanisms of cortical superficial siderosis in cerebral amyloid angiopathy.” Neurology 81(7):626-32 Details Charidimou A, Meegahage R, Fox Z, Peeters A, Vandermeeren Y, Laloux P, Baron JC, Jäger HR, Werring DJ (2013), “Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study.” J Neurol Neurosurg Psychiatry 84(6):624-9 Details Charidimou A, Peeters AP, Jäger R, Fox Z, Vandermeeren Y, Laloux P, Baron JC, Werring DJ (2013), “Cortical superficial siderosis and intracerebral hemorrhage risk in cerebral amyloid angiopathy.” Neurology 81(19):1666-73 Details Chollet F, Cramer SC, Stinear C, Kappelle LJ, Baron JC, Weiller C, Azouvi P, Hommel M, Sabatini U, Moulin T, Tardy J, Valenti M, Montgomery S, Adams H Jr (2013), “Pharmacological therapies in post stroke recovery: recommendations for future clinical trials.” J Neurol Details Clatworthy PL, Warburton EA, Tolhurst DJ, Baron JC (2013), “Visual contrast sensitivity deficits in 'normal' visual field of patients with homonymous visual field defects due to stroke: a pilot study.” Cerebrovasc Dis 36(5-6):329-35 Details del Campo N, Fryer TD, Hong YT, Smith R, Brichard L, Acosta-Cabronero J, Chamberlain SR, Tait R, Izquierdo D, Regenthal R, Dowson J, Suckling J, Baron JC, Aigbirhio FI, Robbins TW, Sahakian BJ, Müller U (2013), “A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.” Brain 136(Pt 11):3252-70 Details Ejaz S, Williamson DJ, Ahmed T, Sitnikov S, Hong YT, Sawiak SJ, Fryer TD, Aigbirhio FI, Baron JC (2013), “Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study.” Neurobiol Dis 51:120-32 Details Hermitte L, Cho TH, Ozenne B, Nighoghossian N, Mikkelsen IK, Ribe L, Baron JC, Østergaard L, Derex L, Hjort N, Fiehler J, Pedraza S, Hermier M, Maucort-Boulch D, Berthezène Y (2013), “Very low cerebral blood volume predicts parenchymal hematoma in acute ischemic stroke.” Stroke 44(8):2318-20 Details Saver JL, Jovin TG, Smith WS, Albers GW, Baron JC, Boltze J, Broderick JP, Davis LA, Demchuk AM, DeSena S, Fiehler J, Gorelick PB, Hacke W, Holt B, Jahan R, Jing H, Khatri P, Kidwell CS, Lees KR, Lev MH, Liebeskind DS, Luby M, Lyden P, Megerian JT, Mocco J, Muir KW, Rowley HA, Ruedy RM, Savitz SI, Sipelis VJ, Shimp SK 3rd, Wechsler LR, Wintermark M, Wu O, Yavagal DR, Yoo AJ, STAIR VIII Consortium (2013), “Stroke treatment academic industry roundtable: research priorities in the assessment of neurothrombectomy devices.” Stroke 44(12):3596-601 Details Sharma N, Baron JC (2013), “Does motor imagery share neural networks with executed movement: a multivariate fMRI analysis.” Front Hum Neurosci 7:564 Details Williamson DJ, Ejaz S, Sitnikov S, Fryer TD, Sawiak SJ, Burke P, Baron JC, Aigbirhio FI (2013), “A comparison of four PET tracers for brain hypoxia mapping in a rodent model of stroke.” Nucl Med Biol 40(3):338-44 Details Wintermark M, Albers GW, Broderick JP, Demchuk AM, Fiebach JB, Fiehler J, Grotta JC, Houser G, Jovin TG, Lees KR, Lev MH, Liebeskind DS, Luby M, Muir KW, Parsons MW, von Kummer R, Wardlaw JM, Wu O, Yoo AJ, Alexandrov AV, Alger JR, Aviv RI, Bammer R, Baron JC, Calamante F, Campbell BC, Carpenter TC, Christensen S, Copen WA, Derdeyn CP, Haley EC Jr, Khatri P, Kudo K, Lansberg MG, Latour LL, Lee TY, Leigh R, Lin W, Lyden P, Mair G, Menon BK, Michel P, Mikulik R, Nogueira RG, Ostergaard L, Pedraza S, Riedel CH, Rowley HA, Sanelli PC, Sasaki M, Saver JL, Schaefer PW, Schellinger PD, Tsivgoulis G, Wechsler LR, White PM, Zaharchuk G, Zaidat OO, Davis SM, Donnan GA, Furlan AJ, Hacke W, Kang DW, Kidwell C, Thijs VN, Thomalla G, Warach SJ, Stroke Imaging Research (STIR) and Virtual International Stroke Trials Archive (VISTA)-Imaging Investigators (2013), “Acute Stroke Imaging Research Roadmap II.” Stroke 44(9):2628-39 Details 2012Baron JC, Jones T (2012), “Oxygen metabolism, oxygen extraction and positron emission tomography: Historical perspective and impact on basic and clinical neuroscience.” Neuroimage 61(2):492-504 Details Caroli A, Prestia A, Chen K, Ayutyanont N, Landau SM, Madison CM, Haense C, Herholz K, Nobili F, Reiman EM, Jagust WJ, Frisoni GB, EADC-PET Consortium, NEST-DD, and Alzheimer's Disease Neuroimaging Initiative (2012), “Summary metrics to assess Alzheimer disease-related hypometabolic pattern with 18F-FDG PET: head-to-head comparison.” J Nucl Med 53(4):592-600 Details Charidimou A, Peeters A, Fox Z, Gregoire SM, Vandermeeren Y, Laloux P, Jäger HR, Baron JC, Werring DJ (2012), “Spectrum of transient focal neurological episodes in cerebral amyloid angiopathy: multicentre magnetic resonance imaging cohort study and meta-analysis.” Stroke 43(9):2324-30 Details Fouquet M, Desgranges B, La Joie R, Rivière D, Mangin JF, Landeau B, Mézenge F, Pélerin A, de La Sayette V, Viader F, Baron JC, Eustache F, Chételat G (2012), “Role of hippocampal CA1 atrophy in memory encoding deficits in amnestic Mild Cognitive Impairment.” Neuroimage 59(4):3309-15 Details Geva S, Baron JC, Jones PS, Price CJ, Warburton EA (2012), “A comparison of VLSM and VBM in a cohort of patients with post-stroke aphasia.” Neuroimage Clin 1(1):37-47 Details Geva S, Jones PS, Crinion JT, Price CJ, Baron JC, Warburton EA (2012), “The effect of aging on the neural correlates of phonological word retrieval.” J Cogn Neurosci 24(11):2135-46 Details Hughes JL, Jones PS, Beech JS, Wang D, Menon DK, Aigbirhio FI, Fryer TD, Baron JC (2012), “A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation.” Neuroimage 59(3):2007-16 Details Jensen-Kondering U, Baron JC (2012), “Oxygen imaging by MRI: can blood oxygen level-dependent imaging depict the ischemic penumbra?” Stroke 43(8):2264-9 Details Jones T, Rabiner EA, PET Research Advisory Company (2012), “The development, past achievements, and future directions of brain PET.” J Cereb Blood Flow Metab 32(7):1426-54 Details Lewis DH, Toney LK, Baron JC (2012), “Nuclear medicine in cerebrovascular disease.” Semin Nucl Med 42(6):387-405 Details Pomeroy VM, Rowe P, Baron JC, Clark A, Sealy R, Ugbolue UC, Kerr A, SWIFT Cast Investigators (2012), “The SWIFT Cast trial protocol: a randomized controlled evaluation of the efficacy of an ankle-foot cast on walking recovery early after stroke and the neural-biomechanical correlates of response.” Int J Stroke 7(1):86-93 Details 2011Agarwal S, Jones PS, Alawneh JA, Antoun NM, Barry PJ, Carrera E, Cotter PE, O'Brien EW, Salih I, Scoffings DJ, Baron JC, Warburton EA (2011), “Does perfusion computed tomography facilitate clinical decision making for thrombolysis in unselected acute patients with suspected ischaemic stroke?” Cerebrovasc Dis 32(3):227-33 Details Alawneh JA, Jones PS, Mikkelsen IK, Cho TH, Siemonsen S, Mouridsen K, Ribe L, Morris RS, Hjort N, Antoun N, Gillard JH, Fiehler J, Nighoghossian N, Warburton EA, Ostergaard L, Baron JC (2011), “Infarction of 'non-core-non-penumbral' tissue after stroke: multivariate modelling of clinical impact.” Brain 134(Pt 6):1765-76 Details Baron JC (2011), “Stroke: Predicting outcome after ischemic stroke-hard but achievable.” Nat Rev Neurol 7(5):253-4 Details Bousser MG, Amarenco P, Chamorro A, Fisher M, Ford I, Fox KM, Hennerici MG, Mattle HP, Rothwell PM, de Cordoüe A, Fratacci MD, PERFORM Study Investigators (2011), “Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial.” Lancet 377(9782):2013-22 Details Carrera E, Jones PS, Alawneh JA, Klærke Mikkelsen I, Cho TH, Siemonsen S, Guadagno JV, Mouridsen K, Ribe L, Hjort N, Fryer TD, Carpenter TA, Aigbirhio FI, Fiehler J, Nighoghossian N, Warburton EA, Ostergaard L, Baron JC (2011), “Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?” Stroke 42(6):1602-7 Details Carrera E, Jones PS, Iglesias S, Guadagno JV, Warburton EA, Fryer TD, Aigbirhio FI, Baron JC (2011), “The vascular mean transit time: a surrogate for the penumbra flow threshold?” J Cereb Blood Flow Metab 31(4):1027-35 Details Geva S, Jones PS, Crinion JT, Price CJ, Baron JC, Warburton EA (2011), “The neural correlates of inner speech defined by voxel-based lesion-symptom mapping.” Brain 134(Pt 10):3071-82 Details Gregoire SM, Charidimou A, Gadapa N, Dolan E, Antoun N, Peeters A, Vandermeeren Y, Laloux P, Baron JC, Jäger HR, Werring DJ (2011), “Acute ischaemic brain lesions in intracerebral haemorrhage: multicentre cross-sectional magnetic resonance imaging study.” Brain 134(Pt 8):2376-86 Details Hong YT, Beech JS, Smith R, Baron JC, Fryer TD (2011), “Parametric mapping of [18F]fluoromisonidazole positron emission tomography using basis functions.” J Cereb Blood Flow Metab 31(2):648-57 Details Landt J, D'Abrera JC, Holland AJ, Aigbirhio FI, Fryer TD, Canales R, Hong YT, Menon DK, Baron JC, Zaman SH (2011), “Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar ?-amyloid in adults with down syndrome: safety, acceptability, and feasibility.” Arch Neurol 68(7):890-6 Details Mevel K, Desgranges B, Baron JC, Landeau B, de La Sayette V, Viader F, Eustache F, Chételat G (2011), “Which SPM method should be used to extract hippocampal measures in early Alzheimer's disease?” J Neuroimaging 21(4):310-6 Details Moustafa RR, Momjian-Mayor I, Jones PS, Morbelli S, Day DJ, Aigbirhio FI, Fryer TD, Warburton EA, Baron JC (2011), “Microembolism versus hemodynamic impairment in rosary-like deep watershed infarcts: a combined positron emission tomography and transcranial Doppler study.” Stroke 42(11):3138-43 Details Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI (2011), “Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling.” J Cereb Blood Flow Metab 31(12):2334-42 Details Takasawa M, Beech JS, Fryer TD, Jones PS, Ahmed T, Smith R, Aigbirhio FI, Baron JC (2011), “Single-subject statistical mapping of acute brain hypoxia in the rat following middle cerebral artery occlusion: a microPET study.” Exp Neurol 229(2):251-8 Details 2010Atack JR, Wong DF, Fryer TD, Ryan C, Sanabria S, Zhou Y, Dannals RF, Eng WS, Gibson RE, Burns HD, Vega JM, Vessy L, Scott-Stevens P, Beech JS, Baron JC, Sohal B, Schrag ML, Aigbirhio FI, McKernan RM, Hargreaves RJ (2010), “Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.” J Pharmacol Exp Ther 332(1):17-25 Details Calautti C, Jones PS, Guincestre JY, Naccarato M, Sharma N, Day DJ, Carpenter TA, Warburton EA, Baron JC (2010), “The neural substrates of impaired finger tapping regularity after stroke.” Neuroimage 50(1):1-6 Details Calautti C, Jones PS, Naccarato M, Sharma N, Day DJ, Bullmore ET, Warburton EA, Baron JC (2010), “The relationship between motor deficit and primary motor cortex hemispheric activation balance after stroke: longitudinal fMRI study.” J Neurol Neurosurg Psychiatry 81(7):788-92 Details Chételat G, Villemagne VL, Pike KE, Baron JC, Bourgeat P, Jones G, Faux NG, Ellis KA, Salvado O, Szoeke C, Martins RN, Ames D, Masters CL, Rowe CC, Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) Research Group (2010), “Larger temporal volume in elderly with high versus low beta-amyloid deposition.” Brain 133(11):3349-58 Details Clatworthy PL, Williams GB, Acosta-Cabronero J, Jones SP, Harding SG, Johansen-Berg H, Baron JC (2010), “Probabilistic tractography of the optic radiations--an automated method and anatomical validation.” Neuroimage 49(3):2001-12 Details Hughes JL, Beech JS, Jones PS, Wang D, Menon DK, Baron JC (2010), “Mapping selective neuronal loss and microglial activation in the salvaged neocortical penumbra in the rat.” Neuroimage 49(1):19-31 Details Moustafa RR, Izquierdo-Garcia D, Fryer TD, Graves MJ, Rudd JH, Gillard JH, Weissberg PL, Baron JC, Warburton EA (2010), “Carotid plaque inflammation is associated with cerebral microembolism in patients with recent transient ischemic attack or stroke: a pilot study.” Circ Cardiovasc Imaging 3(5):536-41 Details Moustafa RR, Izquierdo-Garcia D, Jones PS, Graves MJ, Fryer TD, Gillard JH, Warburton EA, Baron JC (2010), “Watershed infarcts in transient ischemic attack/minor stroke with > or = 50% carotid stenosis: hemodynamic or embolic?” Stroke 41(7):1410-6 Details Villain N, Fouquet M, Baron JC, Mézenge F, Landeau B, de La Sayette V, Viader F, Eustache F, Desgranges B, Chételat G (2010), “Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer's disease.” Brain 133(11):3301-14 Details 2009Alawneh JA, Moustafa RR, Baron JC (2009), “Hemodynamic factors and perfusion abnormalities in early neurological deterioration.” Stroke 40(6):e443-50 Details Baron JC (2009), “[Stroke: update on therapy].” Med Sci (Paris) 25(10):771-2 Details Bousser MG, Amarenco P, Chamorro A, Fisher M, Ford I, Fox K, Hennerici MG, Mattle HP, Rothwell PM, PERFORM Study Investigators (2009), “Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study.” Cerebrovasc Dis 27(5):509-18 Details Chételat G, Villain N, Desgranges B, Eustache F, Baron JC (2009), “Posterior cingulate hypometabolism in early Alzheimer's disease: what is the contribution of local atrophy versus disconnection?” Brain 132(Pt 12):e133; author reply e134 Details Cho TH, Hermier M, Alawneh JA, Ritzenthaler T, Desestret V, Østergaard L, Derex L, Baron JC, Nighoghossian N (2009), “Total mismatch: negative diffusion-weighted imaging but extensive perfusion defect in acute stroke.” Stroke 40(10):3400-2 Details Clatworthy PL, Lewis SJ, Brichard L, Hong YT, Izquierdo D, Clark L, Cools R, Aigbirhio FI, Baron JC, Fryer TD, Robbins TW (2009), “Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory.” J Neurosci 29(15):4690-6 Details Cumberland Consensus Working Group, Cheeran B, Cohen L, Dobkin B, Ford G, Greenwood R, Howard D, Husain M, Macleod M, Nudo R, Rothwell J, Rudd A, Teo J, Ward N, Wolf S (2009), “The future of restorative neurosciences in stroke: driving the translational research pipeline from basic science to rehabilitation of people after stroke.” Neurorehabil Neural Repair 23(2):97-107 Details Dalley JW, Fryer TD, Aigbirhio FI, Brichard L, Richards HK, Hong YT, Baron JC, Everitt BJ, Robbins TW (2009), “Modelling human drug abuse and addiction with dedicated small animal positron emission tomography.” Neuropharmacology 56 Suppl 1:9-17 Details Donnan GA, Baron JC, Ma H, Davis SM (2009), “Penumbral selection of patients for trials of acute stroke therapy.” Lancet Neurol 8(3):261-9 Details Donswijk ML, Jones PS, Guadagno JV, Carpenter TA, Moustafa RR, Fryer TD, Aigbirhio FI, Warburton EA, Baron JC (2009), “T2*-weighted MRI versus oxygen extraction fraction PET in acute stroke.” Cerebrovasc Dis 28(3):306-13 Details Fouquet M, Desgranges B, Landeau B, Duchesnay E, Mézenge F, de la Sayette V, Viader F, Baron JC, Eustache F, Chételat G (2009), “Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease.” Brain 132(Pt 8):2058-67 Details Kalpouzos G, Chételat G, Baron JC, Landeau B, Mevel K, Godeau C, Barré L, Constans JM, Viader F, Eustache F, Desgranges B (2009), “Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging.” Neurobiol Aging 30(1):112-24 Details Moustafa RR, Allen CM, Baron JC (2009), “Call-Fleming syndrome associated with subarachnoid haemorrhage: three new cases.” BMJ Case Rep 2009 Details Moustafa RR, Izquierdo D, Weissberg PL, Baron JC, Warburton EA (2009), “Identifying aortic plaque inflammation as a potential cause of stroke.” BMJ Case Rep 2009:bcr2007123232 Details Pitel AL, Aupée AM, Chételat G, Mézenge F, Beaunieux H, de la Sayette V, Viader F, Baron JC, Eustache F, Desgranges B (2009), “Morphological and glucose metabolism abnormalities in alcoholic Korsakoff's syndrome: group comparisons and individual analyses.” PLoS One 4(11):e7748 Details Sharma N, Baron JC, Rowe JB (2009), “Motor imagery after stroke: relating outcome to motor network connectivity.” Ann Neurol 66(5):604-16 Details Sharma N, Simmons LH, Jones PS, Day DJ, Carpenter TA, Pomeroy VM, Warburton EA, Baron JC (2009), “Motor imagery after subcortical stroke: a functional magnetic resonance imaging study.” Stroke 40(4):1315-24 Details 2008Auriacombe S, Amarenco P, Baron JC, Ceccaldi M, Dartigues JF, Lehéricy S, Hénon H, Hinaut P, Orgogozo JM, Groupe de consensus Théma (2008), “[Update on vascular dementias].” Rev Neurol (Paris) 164(1):22-41 Details Chételat G, Desgranges B, Landeau B, Mézenge F, Poline JB, de la Sayette V, Viader F, Eustache F, Baron JC (2008), “Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease.” Brain 131(Pt 1):60-71 Details Chételat G, Fouquet M, Kalpouzos G, Denghien I, De la Sayette V, Viader F, Mézenge F, Landeau B, Baron JC, Eustache F, Desgranges B (2008), “Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry.” Neuropsychologia 46(6):1721-31 Details Giffard C, Landeau B, Kerrouche N, Young AR, Barré L, Baron JC (2008), “Decreased chronic-stage cortical 11C-flumazenil binding after focal ischemia-reperfusion in baboons: a marker of selective neuronal loss?” Stroke 39(3):991-9 Details Guadagno JV, Jones PS, Aigbirhio FI, Wang D, Fryer TD, Day DJ, Antoun N, Nimmo-Smith I, Warburton EA, Baron JC (2008), “Selective neuronal loss in rescued penumbra relates to initial hypoperfusion.” Brain 131(Pt 10):2666-78 Details Hamon M, Baron JC, Viader F, Hamon M (2008), “Periprocedural stroke and cardiac catheterization.” Circulation 118(6):678-83 Details Lees KR, Ford GA, Muir KW, Ahmed N, Dyker AG, Atula S, Kalra L, Warburton EA, Baron JC, Jenkinson DF, Wahlgren NG, Walters MR, SITS-UK Group (2008), “Thrombolytic therapy for acute stroke in the United Kingdom: experience from the safe implementation of thrombolysis in stroke (SITS) register.” QJM 101(11):863-9 Details Moustafa RR, Allen CM, Baron JC (2008), “Call-Fleming syndrome associated with subarachnoid haemorrhage: three new cases.” J Neurol Neurosurg Psychiatry 79(5):602-5 Details Moustafa RR, Baron JC (2008), “Pathophysiology of ischaemic stroke: insights from imaging, and implications for therapy and drug discovery.” Br J Pharmacol 153 Suppl 1:S44-54 Details Moustafa RR, Izquierdo D, Weissberg PL, Baron JC, Warburton EA (2008), “Neurological picture. Identifying aortic plaque inflammation as a potential cause of stroke.” J Neurol Neurosurg Psychiatry 79(2):236 Details Piolino P, Desgranges B, Hubert V, Bernard FA, Matuszewski V, Chételat G, Baron JC, Eustache F (2008), “Reliving lifelong episodic autobiographical memories via the hippocampus: a correlative resting PET study in healthy middle-aged subjects.” Hippocampus 18(5):445-59 Details SCOPE (Stroke Complications and Outcomes Prediction Engine) Collaborations, IST, Lewis SC, Sandercock PA, Dennis MS (2008), “Predicting outcome in hyper-acute stroke: validation of a prognostic model in the Third International Stroke Trial (IST3).” J Neurol Neurosurg Psychiatry 79(4):397-400 Details Sharma N, Jones PS, Carpenter TA, Baron JC (2008), “Mapping the involvement of BA 4a and 4p during Motor Imagery.” Neuroimage 41(1):92-9 Details Simmons L, Sharma N, Baron JC, Pomeroy VM (2008), “Motor imagery to enhance recovery after subcortical stroke: who might benefit, daily dose, and potential effects.” Neurorehabil Neural Repair 22(5):458-67 Details Takasawa M, Jones PS, Guadagno JV, Christensen S, Fryer TD, Harding S, Gillard JH, Williams GB, Aigbirhio FI, Warburton EA, Østergaard L, Baron JC (2008), “How reliable is perfusion MR in acute stroke? 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SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S (2008), “Acute stroke imaging research roadmap.” AJNR Am J Neuroradiol 29(5):e23-30 Details Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S (2008), “Acute stroke imaging research roadmap.” Stroke 39(5):1621-8 Details 2007Atack JR, Scott-Stevens P, Beech JS, Fryer TD, Hughes JL, Cleij MC, Baron JC, Clark JC, Hargreaves RJ, Aigbirhio FI (2007), “Comparison of lorazepam [7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one] occupancy of rat brain 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Desgranges B, Landeau B, Baron JC, Eustache F (2001), “Visual priming within and across symbolic format using a tachistoscopic picture identification task: a PET study.” J Cogn Neurosci 13(5):670-86 Details Meguro K, LeMestric C, Landeau B, Desgranges B, Eustache F, Baron JC (2001), “Relations between hypometabolism in the posterior association neocortex and hippocampal atrophy in Alzheimer's disease: a PET/MRI correlative study.” J Neurol Neurosurg Psychiatry 71(3):315-21 Details |