Professor John Aston

University position


Professor John Aston is pleased to consider applications from prospective PhD students.


Department of Pure Mathematics and Mathematical Statistics


Statistical Laboratory

Home page (personal home page)

Research Theme

Cognitive and Behavioural Neuroscience


Statistical Neuroimaging

Research Focus





Image Analysis

Clinical conditions

No direct clinical relevance


Computational modelling



United Kingdom

Federico Turkheimer Web:


Alexander Hammers Web:

Associated News Items

    Key publications

    Sorrentino A, Johansen AM, Aston JAD, Nichols TE, Kendall WS (2013), “Dynamic ltering of Static Dipoles in MagnetoEncephaloGraphy” Annals of Applied Statistics 7:955--988

    Aston JAD, Kirch C (2012), “Evaluating stationarity via change-point alternatives with applications to fMRI data” Annals of Applied Statistics 6 (4), 1906-1948

    Functional Phylogenies Group (2012), “Phylogenetic inference for function-valued traits: speech sound evolution.” Trends Ecol Evol 27(3):160-6 Details

    Nam CFH, Aston JAD, Johansen AM (2012), “Quantifying uncertainty in change points” Journal of Time Series Analysis 33:807--823

    Aston JAD, Chiou J-M, Evans JP . (2010), “Linguistic Pitch Analysis using Functional Principal Component Mixed E ffect Models.” Journal of the Royal Statistical Society, Series C (Applied Statistics) 59: 297-317

    Jiang CR, Aston JA, Wang JL (2009), “Smoothing dynamic positron emission tomography time courses using functional principal components.” Neuroimage 47(1):184-93 Details

    Aston JA, Gunn RN, Hinz R, Turkheimer FE (2005), “Wavelet variance components in image space for spatiotemporal neuroimaging data.” Neuroimage 25(1):159-68 Details

    Turkheimer FE, Aston JA, Banati RB, Riddell C, Cunningham VJ (2003), “A linear wavelet filter for parametric imaging with dynamic PET.” IEEE Trans Med Imaging 22(3):289-301 Details

    Worsley KJ, Liao CH, Aston J, Petre V, Duncan GH, Morales F, Evans AC (2002), “A general statistical analysis for fMRI data.” Neuroimage 15(1):1-15 Details

    Aston JA, Gunn RN, Worsley KJ, Ma Y, Evans AC, Dagher A (2000), “A statistical method for the analysis of positron emission tomography neuroreceptor ligand data.” Neuroimage 12(3):245-56 Details



    Caudron Q, Lyn-Adams C, Aston JAD, Frenguelli BG, Moffat KG (2014), “Quantitative Assessment of Ommatidial Distortion in Drosophila melanogaster” Drosophila Information Service 96:136--144

    Hall AJ, Chappell MJ, Aston JA, Ward SA (2014), “Reprint of "Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin"” Comput Methods Programs Biomed Details

    in press

    Minas G, Aston JAD, Stallard N (in press), “Adaptive Multivariate Global Testing” Journal of the American Statistical Association

    Nam CFH, Aston JAD, Eckley I, Killick R (in press), “The Uncertainty of Storm Season Changes: Quantifying the Uncertainty of Autocovariance Changepoints” Technometrics

    Pigoli D, Aston JAD, Dryden I Secchi P (in press), “Distances and Inference for Covariance Functions” Biometrika


    Hall AJ, Chappell MJ, Aston JA, Ward SA (2013), “Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin.” Comput Methods Programs Biomed 112(1):1-15 Details

    in press

    Nam CFH Aston JAD Johansen AM (in press), “Parallel Sequential Monte Carlo Samplers and Estimation of the Number of States in a Hidden Markov Model” Annals of the Institute of Statistical Mathematics


    Zhou Y, Aston JAD, Johansen AM (2013), “Bayesian Model Comparison for Compartmental Models with Applications in Positron Emission Tomography” Journal of Applied Statistics 40:993--1016


    Aston JAD, Kirch C (2012), “Detecting and estimating changes in dependent functional data” Journal of Multivariate Analysis 109:204-220

    Aston JAD, Peng JY, Martin DEK (2012), “Implied Distributions in Multiple Change Point Model” Statistics and Computing 22:981-993

    Hadjipantelis PZ, Aston JA, Evans JP (2012), “Characterizing fundamental frequency in Mandarin: a functional principal component approach utilizing mixed effect models.” J Acoust Soc Am 131(6):4651-64 Details

    Minas G, Rigat F, Nichols TE, Aston JA, Stallard N (2012), “A hybrid procedure for detecting global treatment effects in multivariate clinical trials: theory and applications to fMRI studies.” Stat Med 31(3):253-68 Details

    Vavoulis DV, Straub VA, Aston JA, Feng J (2012), “A self-organizing state-space-model approach for parameter estimation in hodgkin-huxley-type models of single neurons.” PLoS Comput Biol 8(3):e1002401 Details


    Chi W-C, Lee WHK, Lin CJ,Aston JAD, Liu CC (2011), “Inversion of Ground Motion Data from a Seismometer Array for Rotation using a Modi cation of Jeager's Method” Bulletin of the Seismological Society of America 101:3105-9

    Peng JY, Aston JAD (2011), “The State Space Models Toolbox for MATLAB” Journal of Statistical Software 41:6:1-26


    Cheng PE, Liou M, Aston JAD (2010), “Likelihood Ratio Tests in Three-Way Tables” Journal of the American Statistical Association 105:740-749

    Evans J, Chu MN, Aston JA, Su CY (2010), “Linguistic and human effects on F(0) in a tonal dialect of Qiang.” Phonetica 67(1-2):82-99 Details


    Lee JD, Su HR, Cheng PE, Liou M, Aston JA, Tsai AC, Chen CY (2009), “MR image segmentation using a power transformation approach.” IEEE Trans Med Imaging 28(6):894-905 Details

    Liou M, Su HR, Savostyanov AN, Lee JD, Aston JA, Chuang CH, Cheng PE (2009), “Beyond p-values: averaged and reproducible evidence in fMRI experiments.” Psychophysiology 46(2):367-78 Details


    Cheng PE, Liou M, Aston JAD, Tsai AC (2008), “Information Identities and Testing Hypotheses: Power Analysis for Contingency Tables” Statistica Sinica 18:535-558

    Peng JY, Aston JA, Gunn RN, Liou CY, Ashburner J (2008), “Dynamic positron emission tomography data-driven analysis using sparse Bayesian learning.” IEEE Trans Med Imaging 27(9):1356-69 Details


    Aston JAD, Martin DEK (2007), “Distributions associated with general runs and patterns in hidden Markov models” Annals of Applied Statistics 1:585-611.


    Aston JA, Turkheimer FE, Brett M (2006), “HBM functional imaging analysis contest data analysis in wavelet space.” Hum Brain Mapp 27(5):372-9 Details

    Liou M, Su HR, Lee JD, Aston JA, Tsai AC, Cheng PE (2006), “A method for generating reproducible evidence in fMRI studies.” Neuroimage 29(2):383-95 Details

    Turkheimer FE, Aston JA, Asselin MC, Hinz R (2006), “Multi-resolution Bayesian regression in PET dynamic studies using wavelets.” Neuroimage 32(1):111-21 Details


    Aston JAD, Gunn.RN, (2005), “Statistical Estimation with Kronecker Products in Positron Emission Tomography.” Linear Algebra and its Applications 398:25-36


    Turkheimer FE, Aston JA, Cunningham VJ (2004), “On the logic of hypothesis testing in functional imaging.” Eur J Nucl Med Mol Imaging 31(5):725-32 Details


    Turkheimer FE, Hinz R, Gunn RN, Aston JA, Gunn SR, Cunningham VJ (2003), “Rank-shaping regularization of exponential spectral analysis for application to functional parametric mapping.” Phys Med Biol 48(23):3819-41 Details


    Aston JA, Cunningham VJ, Asselin MC, Hammers A, Evans AC, Gunn RN (2002), “Positron emission tomography partial volume correction: estimation and algorithms.” J Cereb Blood Flow Metab 22(8):1019-34 Details

    Gunn RN, Gunn SR, Turkheimer FE, Aston JA, Cunningham VJ (2002), “Positron emission tomography compartmental models: a basis pursuit strategy for kinetic modeling.” J Cereb Blood Flow Metab 22(12):1425-39 Details

    Liao CH, Worsley KJ, Poline JB, Aston JA, Duncan GH, Evans AC (2002), “Estimating the delay of the fMRI response.” Neuroimage 16(3 Pt 1):593-606 Details


    Dagher A, Bleicher C, JAD Aston JAD, Gunn RN, Clarke PBS, Cumming P (2001), “Reduced dopamine D1 receptor binding in the ventral striatum of cigarette smokers” Synapse 42(1):48-53


    Turkheimer FE, Banati RB, Visvikis D, Aston JA, Gunn RN, Cunningham VJ (2000), “Modeling dynamic PET-SPECT studies in the wavelet domain.” J Cereb Blood Flow Metab 20(5):879-93 Details

    Turkheimer FE, Brett M, Aston JA, Leff AP, Sargent PA, Wise RJ, Grasby PM, Cunningham VJ (2000), “Statistical modeling of positron emission tomography images in wavelet space.” J Cereb Blood Flow Metab 20(11):1610-8 Details