Mr Luke Pattison


University position

PhD student
Supervised by Ewan St. John Smith

Departments

Department of Pharmacology

Email

lap48@cam.ac.uk

Home page

https://www.phar.cam.ac.uk/researc...

Research Themes

Cellular and Molecular Neuroscience

Cognitive and Behavioural Neuroscience

Interests

My research focuses on the role of proton-sensing G protein-coupled receptors in inflammation.

Research Focus

Keywords

acid-sensing

GPCR

inflammation

pain

Clinical conditions

Inflammatory Conditions

Equipment

Behavioural analysis

Calcium imaging

Cell culture

Confocal microscopy

Electrophysiological recording techniques

Fluorescence microscopy

Immunohistochemistry

Intracellular recording

Microscopy

Whole cell patch clamp

Collaborators

No collaborators listed

Associated News Items


    Publications

    2019

    Lu VB, Rievaj J, O'Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F (2019), “Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.” Nat Commun. 10(1):1029

    Zhao P, Pattison LA, Jensen DD, Jiminez-Vargas N, Latorre R, Lieu T, Jaramillo JO, Lopez-Lopez C, Poole DP, Vanner SJ, Schmidt BL, Bunnett NW (2019), “Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2” J Biol Chem

    2018

    Chakrabarti S, Pattison LA, Singhal K, Hockley JRF, Callejo G, Smith ESJ (2018), “Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.” Neuropharmacology 143:49-62

    Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW (2018), “Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.” PNAS 115(31):E7438-E7447