Mr Luke Pattison
My research focuses on the role of proton-sensing G protein-coupled receptors in inflammation.
Electrophysiological recording techniques
Whole cell patch clamp
No collaborators listed
Associated News Items
Callejo G, Pattison LA, Greenhalgh JC, Chakrabarti S, Andreopoulou E, Hockley JRF, Smith ES, Rahman T (2020), “In silicoscreening of GMQ-like compounds reveals guanabenz and sephin1 asnew allosteric modulators of acid-sensing ion channel 3” Biochem Pharmacol 174
Chakrabarti S, Hore Z, Pattison LA, Lalnunhlimi S, Bhebhe CN, Callejo G, Bulmer DC, Taams LS, Denk F, Smith ES (2020), “Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain” Pain
Chakrabarti S, Pattison LA, Doleschall B, Rickman RH, Blake H, Callejo G, Heppenstall PA, Smith ES (2020), “Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice” Arthritis Rheumatol.
Lee MC, Nahorski MS, Hockley JRF, Lu VB, Ison G, Pattison LA, Callejo G, Stouffer K, Fletcher E, Brown C, Drissi I, Wheeler D, Ernfors P, Menon D, Reimann F, Smith ES, Woods CG (2020), “Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel K V 6.4 Subunit” Cell Rep.
Lu VB, Rievaj J, O'Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F (2019), “Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.” Nat Commun. 10(1):1029
Pattison LA, Callejo G, Smith ES (2019), “Evolution of acid nociception: ion channels and receptors for detecting acid.” Philos T R Soc B
Zhao P, Pattison LA, Jensen DD, Jiminez-Vargas N, Latorre R, Lieu T, Jaramillo JO, Lopez-Lopez C, Poole DP, Vanner SJ, Schmidt BL, Bunnett NW (2019), “Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2” J Biol Chem
Chakrabarti S, Pattison LA, Singhal K, Hockley JRF, Callejo G, Smith ESJ (2018), “Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.” Neuropharmacology 143:49-62
Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW (2018), “Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.” PNAS 115(31):E7438-E7447