Mr Luke PattisonUniversity positionPhD student DepartmentsHome pagehttps://www.phar.cam.ac.uk/researc... Research ThemesInterestsMy research focuses on the role of proton-sensing G protein-coupled receptors in inflammation. Research Focus
EquipmentBehavioural analysis Calcium imaging Cell culture Confocal microscopy Electrophysiological recording techniques Fluorescence microscopy Immunohistochemistry Intracellular recording Microscopy Whole cell patch clamp CollaboratorsNo collaborators listed Associated News ItemsPublications2021Pattison LA, Krock E, Svensson CI and Smith ES (2021), “Cell-cell interactions in joint pain: rheumatoid arthritis and osteoarthritis” Pain 162(3): 714-717 2020Callejo G, Pattison LA, Greenhalgh JC, Chakrabarti S, Andreopoulou E, Hockley JRF, Smith ES, Rahman T (2020), “In silicoscreening of GMQ-like compounds reveals guanabenz and sephin1 asnew allosteric modulators of acid-sensing ion channel 3” Biochem Pharmacol 174 Chakrabarti S, Hore Z, Pattison LA, Lalnunhlimi S, Bhebhe CN, Callejo G, Bulmer DC, Taams LS, Denk F, Smith ES (2020), “Sensitization of knee-innervating sensory neurons by tumor necrosis factor-?-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain” Pain Chakrabarti S, Pattison LA, Doleschall B, Rickman RH, Blake H, Callejo G, Heppenstall PA, Smith ES (2020), “Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice” Arthritis Rheumatol. Lee MC, Nahorski MS, Hockley JRF, Lu VB, Ison G, Pattison LA, Callejo G, Stouffer K, Fletcher E, Brown C, Drissi I, Wheeler D, Ernfors P, Menon D, Reimann F, Smith ES, Woods CG (2020), “Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel K V 6.4 Subunit” Cell Rep. 2019Lu VB, Rievaj J, O'Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F (2019), “Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.” Nat Commun. 10(1):1029 Pattison LA, Callejo G, Smith ES (2019), “Evolution of acid nociception: ion channels and receptors for detecting acid.” Philos T R Soc B Zhao P, Pattison LA, Jensen DD, Jiminez-Vargas N, Latorre R, Lieu T, Jaramillo JO, Lopez-Lopez C, Poole DP, Vanner SJ, Schmidt BL, Bunnett NW (2019), “Protein kinase D and G?? mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2” J Biol Chem 2018Chakrabarti S, Pattison LA, Singhal K, Hockley JRF, Callejo G, Smith ESJ (2018), “Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.” Neuropharmacology 143:49-62 Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW (2018), “Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.” PNAS 115(31):E7438-E7447 |