Professor Ian Goodyer FMedSci University positionProfessor Professor Ian Goodyer FMedSci is pleased to consider applications from prospective PhD students. DepartmentsInstitutesHome pagehttp://www.psychiatry.cam.ac.uk/dev/Pro... Research ThemesInterestsI am a Child and Adolescent Psychiatrist based at Cambridge University pursuing research into the connections between human development and psychopathology. My studies are centred on adolescents in the community as well as current patients. Our research programme uses experimental and neuroimaging approaches embedded in longitudinal designs to measure the effects of genes and the social environment, on cognition and brain structures. We use these methods in epidemiological cohort studies of adolescent development and randomised controlled trials of treatment for depression and conduct disorders. Research Focus
EquipmentBehavioural analysis Computational modelling Magnetic resonance imaging (MRI) Neuropsychological testing Randomised control trials Collaborators
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Key publicationsOwens M, Goodyer IM, Wilkinson P, Bhardwaj A, Abbott R, Croudace T, Dunn V, Jones PB, Walsh ND, Ban M, Sahakian BJ (2012), “5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence.” PLoS One 7(11):e48482 Details Walsh ND, Dalgleish T, Dunn VJ, Abbott R, St Clair MC, Owens M, Fairchild G, Kerslake WS, Hiscox LV, Passamonti L, Ewbank M, Ban M, Calder AJ, Goodyer IM (2012), “5-HTTLPR-environment interplay and its effects on neural reactivity in adolescents.” Neuroimage 63(3):1670-80 PDF Details Fairchild G, Passamonti L, Hurford G, Hagan CC, von dem Hagen EA, van Goozen SH, Goodyer IM, Calder AJ (2011), “Brain structure abnormalities in early-onset and adolescent-onset conduct disorder.” Am J Psychiatry 168(6):624-33 Details Goodyer IM, Croudace T, Dudbridge F, Ban M, Herbert J (2010), “Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.” Br J Psychiatry 197(5):365-71 Details Passamonti L, Fairchild G, Goodyer IM, Hurford G, Hagan CC, Rowe JB, Calder AJ (2010), “Neural abnormalities in early-onset and adolescence-onset conduct disorder.” Arch Gen Psychiatry 67(7):729-38 Details Goodyer I, Dubicka B, Wilkinson P, Kelvin R, Roberts C, Byford S, Breen S, Ford C, Barrett B, Leech A, Rothwell J, White L, Harrington R (2007), “Selective serotonin reuptake inhibitors (SSRIs) and routine specialist care with and without cognitive behaviour therapy in adolescents with major depression: randomised controlled trial.” BMJ 335(7611):142 Details Publications2015Barry TJ, Murray L, Fearon RM, Moutsiana C, Cooper P, Goodyer IM, Herbert J, Halligan SL (2015), “Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood.” Psychoneuroendocrinology 52:251-60 Details Hagan CC, Graham JM, Tait R, Widmer B, van Nieuwenhuizen AO, Ooi C, Whitaker KJ, Simas T, Bullmore ET, Lennox BR, Sahakian BJ, Goodyer IM, Suckling J (2015), “Adolescents with current major depressive disorder show dissimilar patterns of age-related differences in ACC and thalamus.” Neuroimage Clin 7:391-9 Details 2014Brodbeck J, Goodyer IM, Abbott RA, Dunn VJ, St Clair MC, Owens M, Jones PB, Croudace TJ (2014), “General distress, hopelessness-suicidal ideation and worrying in adolescence: concurrent and predictive validity of a symptom-level bifactor model for clinical diagnoses.” J Affect Disord 152-154:299-305 Details Collings PJ, Wijndaele K, Corder K, Westgate K, Ridgway CL, Dunn V, Goodyer I, Ekelund U, Brage S (2014), “Levels and patterns of objectively-measured physical activity volume and intensity distribution in UK adolescents: the ROOTS study.” Int J Behav Nutr Phys Act 11:23 Details Corder K, van Sluijs EM, Ridgway CL, Steele RM, Prynne CJ, Stephen AM, Bamber DJ, Dunn VJ, Goodyer IM, Ekelund U (2014), “Breakfast consumption and physical activity in adolescents: daily associations and hourly patterns.” Am J Clin Nutr 99(2):361-8 Details Fairchild G, Hagan CC, Passamonti L, Walsh ND, Goodyer IM, Calder AJ (2014), “Atypical neural responses during face processing in female adolescents with conduct disorder.” J Am Acad Child Adolesc Psychiatry 53(6):677-687.e5 Details Hay DF, Waters CS, Perra O, Swift N, Kairis V, Phillips R, Jones R, Goodyer I, Harold G, Thapar A, van Goozen S (2014), “Precursors to aggression are evident by 6 months of age.” Dev Sci 17(3):471-80 Details Moutsiana C, Fearon P, Murray L, Cooper P, Goodyer I, Johnstone T, Halligan S (2014), “Making an effort to feel positive: insecure attachment in infancy predicts the neural underpinnings of emotion regulation in adulthood.” J Child Psychol Psychiatry Details Moutsiana C, Johnstone T, Murray L, Fearon P, Cooper PJ, Pliatsikas C, Goodyer I, Halligan SL (2014), “Insecure attachment during infancy predicts greater amygdala volumes in early adulthood.” J Child Psychol Psychiatry Details Owens M, Herbert J, Jones PB, Sahakian BJ, Wilkinson PO, Dunn VJ, Croudace TJ, Goodyer IM (2014), “Elevated morning cortisol is a stratified population-level biomarker for major depression in boys only with high depressive symptoms.” Proc Natl Acad Sci U S A 111(9):3638-43 Details St Clair MC, Croudace T, Dunn VJ, Jones PB, Herbert J, Goodyer IM (2014), “Childhood adversity subtypes and depressive symptoms in early and late adolescence.” Dev Psychopathol :1-15 Details Stochl J, Khandaker GM, Lewis G, Perez J, Goodyer IM, Zammit S, Sullivan S, Croudace TJ, Jones PB (2014), “Mood, anxiety and psychotic phenomena measure a common psychopathological factor.” Psychol Med :1-11 Details Toseeb U, Brage S, Corder K, Dunn VJ, Jones PB, Owens M, St Clair MC, van Sluijs EM, Goodyer IM (2014), “Exercise and depressive symptoms in adolescents: a longitudinal cohort study.” JAMA Pediatr 168(12):1093-100 Details Walsh ND, Dalgleish T, Lombardo MV, Dunn VJ, Van Harmelen AL, Ban M, Goodyer IM (2014), “General and specific effects of early-life psychosocial adversities on adolescent grey matter volume.” Neuroimage Clin 4:308-18 Details 2013Fairchild G, van Goozen SH, Calder AJ, Goodyer IM (2013), “Research review: evaluating and reformulating the developmental taxonomic theory of antisocial behaviour.” J Child Psychol Psychiatry 54(9):924-40 Details Fonagy P, Butler S, Goodyer I, Cottrell D, Scott S, Pilling S, Eisler I, Fuggle P, Kraam A, Byford S, Wason J, Haley R (2013), “Evaluation of multisystemic therapy pilot services in the Systemic Therapy for At Risk Teens (START) trial: study protocol for a randomised controlled trial.” Trials 14:265 Details Graham J, Salimi-Khorshidi G, Hagan C, Walsh N, Goodyer I, Lennox B, Suckling J (2013), “Meta-analytic evidence for neuroimaging models of depression: state or trait?” J Affect Disord 151(2):423-31 Details Hagan CC, Graham JM, Widmer B, Holt RJ, Ooi C, van Nieuwenhuizen AO, Fonagy P, Reynolds S, Target M, Kelvin R, Wilkinson PO, Bullmore ET, Lennox BR, Sahakian BJ, Goodyer I, Suckling J (2013), “Magnetic resonance imaging of a randomized controlled trial investigating predictors of recovery following psychological treatment in adolescents with moderate to severe unipolar depression: study protocol for Magnetic Resonance-Improving Mood with Psychoanalytic and Cognitive Therapies (MR-IMPACT).” BMC Psychiatry 13:247 Details Ho V, Simmons RK, Ridgway CL, van Sluijs EM, Bamber DJ, Goodyer IM, Dunn VJ, Ekelund U, Corder K (2013), “Is wearing a pedometer associated with higher physical activity among adolescents?” Prev Med Details Spence R, Owens M, Goodyer I (2013), “The longitudinal psychometric properties of the EAS temperament survey in adolescence.” J Pers Assess 95(6):633-9 Details Waters CS, van Goozen S, Phillips R, Swift N, Hurst SL, Mundy L, Jones R, Jones I, Goodyer I, Hay DF (2013), “Infants at familial risk for depression show a distinct pattern of cortisol response to experimental challenge.” J Affect Disord 150(3):955-60 Details Wilkinson PO, Croudace TJ, Goodyer IM (2013), “Rumination, anxiety, depressive symptoms and subsequent depression in adolescents at risk for psychopathology: a longitudinal cohort study.” BMC Psychiatry 13:250 Details 2012Cole DA, Cho SJ, Martin NC, Youngstrom EA, March JS, Findling RL, Compas BE, Goodyer IM, Rohde P, Weissman M, Essex MJ, Hyde JS, Curry JF, Forehand R, Slattery MJ, Felton JW, Maxwell MA (2012), “Are increased weight and appetite useful indicators of depression in children and adolescents?” J Abnorm Psychol 121(4):838-51 Details Fairchild G, Hagan CC, Walsh ND, Passamonti L, Calder AJ, Goodyer IM (2012), “Brain structure abnormalities in adolescent girls with conduct disorder.” J Child Psychol Psychiatry Details Goodyer IM (2012), “Mathematical models as an aid for improving the validity of descriptive psychiatry.” Br J Psychiatry 201:335-6 Details Hinrichs S, Owens M, Dunn V, Goodyer I (2012), “General practitioner experience and perception of Child and Adolescent Mental Health Services (CAMHS) care pathways: a multimethod research study.” BMJ Open 2(6) Details Passamonti L, Fairchild G, Fornito A, Goodyer IM, Nimmo-Smith I, Hagan CC, Calder AJ (2012), “Abnormal Anatomical Connectivity between the Amygdala and Orbitofrontal Cortex in Conduct Disorder.” PLoS One 7(11):e48789 Details Spence R, Owens M, Goodyer I (2012), “Item response theory and validity of the NEO-FFI in adolescents.” Pers Individ Dif 53(6-4):801-807 Details Wilkinson PO, Harris C, Kelvin R, Dubicka B, Goodyer IM (2012), “Associations between adolescent depression and parental mental health, before and after treatment of adolescent depression.” Eur Child Adolesc Psychiatry Details 2011Brodbeck J, Abbott RA, Goodyer IM, Croudace TJ (2011), “General and specific components of depression and anxiety in an adolescent population.” BMC Psychiatry 11:191 Details Cole DA, Cai L, Martin NC, Findling RL, Youngstrom EA, Garber J, Curry JF, Hyde JS, Essex MJ, Compas BE, Goodyer IM, Rohde P, Stark KD, Slattery MJ, Forehand R (2011), “Structure and measurement of depression in youths: Applying item response theory to clinical data.” Psychol Assess Details Dunn VJ, Abbott RA, Croudace TJ, Wilkinson P, Jones PB, Herbert J, Goodyer IM (2011), “Profiles of family-focused adverse experiences through childhood and early adolescence: the ROOTS project a community investigation of adolescent mental health.” BMC Psychiatry 11:109 Details Goodyer IM, Tsancheva S, Byford S, Dubicka B, Hill J, Kelvin R, Reynolds S, Roberts C, Senior R, Suckling J, Wilkinson P, Target M, Fonagy P (2011), “Improving mood with psychoanalytic and cognitive therapies (IMPACT): a pragmatic effectiveness superiority trial to investigate whether specialised psychological treatment reduces the risk for relapse in adolescents with moderate to severe unipolar depression: study protocol for a randomised controlled trial.” Trials 12:175 Details Ha C, Sharp C, Goodyer I (2011), “The role of child and parental mentalizing for the development of conduct problems over time.” Eur Child Adolesc Psychiatry 20(6):291-300 Details Hay DF, Mundy L, Roberts S, Carta R, Waters CS, Perra O, Jones R, Jones I, Goodyer I, Harold G, Thapar A, van Goozen S (2011), “Known risk factors for violence predict 12-month-old infants' aggressiveness with peers.” Psychol Sci 22(9):1205-11 Details Murray L, Arteche A, Fearon P, Halligan S, Goodyer I, Cooper P (2011), “Maternal postnatal depression and the development of depression in offspring up to 16 years of age.” J Am Acad Child Adolesc Psychiatry 50(5):460-70 Details Prynne CJ, Handford C, Dunn V, Bamber D, Goodyer IM, Stephen AM (2011), “The quality of midday meals eaten at school by adolescents; school lunches compared with packed lunches and their contribution to total energy and nutrient intakes.” Public Health Nutr :1-8 Details Ridgway CL, Brage S, Sharp SJ, Corder K, Westgate KL, van Sluijs EM, Goodyer IM, Hallal PC, Anderssen SA, Sardinha LB, Andersen LB, Ekelund U (2011), “Does birth weight influence physical activity in youth? A combined analysis of four studies using objectively measured physical activity.” PLoS One 6(1):e16125 Details Russ SJ, Herbert J, Cooper P, Gunnar MR, Goodyer I, Croudace T, Murray L (2011), “Cortisol levels in response to starting school in children at increased risk for social phobia.” Psychoneuroendocrinology Details St Clair MC, Goodyer IM, Dunn V, Herbert J, Jones PB, Croudace T (2011), “Depressive symptoms during adolescence: comparison between epidemiological and high risk sampling.” Soc Psychiatry Psychiatr Epidemiol Details Wilkinson P, Goodyer I (2011), “Non-suicidal self-injury.” Eur Child Adolesc Psychiatry Details Wilkinson P, Kelvin R, Roberts C, Dubicka B, Goodyer I (2011), “Clinical and Psychosocial Predictors of Suicide Attempts and Nonsuicidal Self-Injury in the Adolescent Depression Antidepressants and Psychotherapy Trial (ADAPT).” Am J Psychiatry Details Wilkinson PO, Goodyer IM (2011), “Childhood adversity and allostatic overload of the hypothalamic-pituitary-adrenal axis: A vulnerability model for depressive disorders.” Dev Psychopathol 23(4):1017-37 Details 2010Akister J, Owens M, Goodyer IM (2010), “Leaving care and mental health: outcomes for children in out-of-home care during the transition to adulthood.” Health Res Policy Syst 8:10 Details Corder K, van Sluijs EM, Steele RM, Stephen AM, Dunn V, Bamber D, Goodyer I, Griffin SJ, Ekelund U (2010), “Breakfast consumption and physical activity in British adolescents.” Br J Nutr :1-6 Details Dubicka B, Elvins R, Roberts C, Chick G, Wilkinson P, Goodyer IM (2010), “Combined treatment with cognitive-behavioural therapy in adolescent depression: meta-analysis.” Br J Psychiatry 197:433-40 Details Fairchild G, Stobbe Y, van Goozen SH, Calder AJ, Goodyer IM (2010), “Facial expression recognition, fear conditioning, and startle modulation in female subjects with conduct disorder.” Biol Psychiatry 68(3):272-9 Details Goodyer IM, Wilkinson P, Dubicka B, Kelvin R (2010), “Forum: the use of selective serotonin reuptake inhibitors in depressed children and adolescents: commentary on the meta-analysis by Hetrick et al.” Curr Opin Psychiatry 23(1):58-61 Details Hay DF, Perra O, Hudson K, Waters CS, Mundy L, Phillips R, Goodyer I, Harold G, Thapar A, van Goozen S, the CCDS Team (2010), “Identifying early signs of aggression: psychometric properties of the cardiff infant contentiousness scale.” Aggress Behav Details 2009Fairchild G, Van Goozen SH, Calder AJ, Stollery SJ, Goodyer IM (2009), “Deficits in facial expression recognition in male adolescents with early-onset or adolescence-onset conduct disorder.” J Child Psychol Psychiatry 50(5):627-36 Details Fairchild G, van Goozen SH, Stollery SJ, Aitken MR, Savage J, Moore SC, Goodyer IM (2009), “Decision making and executive function in male adolescents with early-onset or adolescence-onset conduct disorder and control subjects.” Biol Psychiatry 66(2):162-8 Details Goodyer IM, Bacon A, Ban M, Croudace T, Herbert J (2009), “Serotonin transporter genotype, morning cortisol and subsequent depression in adolescents.” Br J Psychiatry 195(1):39-45 Details Goodyer IM, Croudace T, Dunn V, Herbert J, Jones PB (2009), “Cohort Profile: Risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.” Int J Epidemiol Details Murray L, Halligan SL, Goodyer I, Herbert J (2009), “Disturbances in early parenting of depressed mothers and cortisol secretion in offspring: A preliminary study.” J Affect Disord Details Newbury DF, Winchester L, Addis L, Paracchini S, Buckingham LL, Clark A, Cohen W, Cowie H, Dworzynski K, Everitt A, Goodyer IM, Hennessy E, Kindley AD, Miller LL, Nasir J, O'Hare A, Shaw D, Simkin Z, Simonoff E, Slonims V, Watson J, Ragoussis J, Fisher SE, Seckl JR, Helms PJ, Bolton PF, Pickles A, Conti-Ramsden G, Baird G, Bishop DV, Monaco AP (2009), “CMIP and ATP2C2 modulate phonological short-term memory in language impairment.” Am J Hum Genet 85(2):264-72 Details Wilkinson P, Dubicka B, Kelvin R, Roberts C, Goodyer I (2009), “Treated depression in adolescents: predictors of outcome at 28 weeks.” Br J Psychiatry 194(4):334-41 Details 2008Fairchild G, van Goozen SH, Stollery SJ, Brown J, Gardiner J, Herbert J, Goodyer IM (2008), “Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder.” Biol Psychiatry 64(7):599-606 Details Fairchild G, Van Goozen SH, Stollery SJ, Goodyer IM (2008), “Fear conditioning and affective modulation of the startle reflex in male adolescents with early-onset or adolescence-onset conduct disorder and healthy control subjects.” Biol Psychiatry 63(3):279-85 Details Falcaro M, Pickles A, Newbury DF, Addis L, Banfield E, Fisher SE, Monaco AP, Simkin Z, Conti-Ramsden G, SLI Consortium (2008), “Genetic and phenotypic effects of phonological short-term memory and grammatical morphology in specific language impairment.” Genes Brain Behav 7(4):393-402 Details Goodyer IM (2008), “Emanuel Miller Lecture: early onset depressions--meanings, mechanisms and processes.” J Child Psychol Psychiatry 49(12):1239-56 Details Goodyer IM, Dubicka B, Wilkinson P, Kelvin R, Roberts C, Byford S, Breen S, Ford C, Barrett B, Leech A, Rothwell J, White L, Harrington R (2008), “A randomised controlled trial of cognitive behaviour therapy in adolescents with major depression treated by selective serotonin reuptake inhibitors. The ADAPT trial.” Health Technol Assess 12(14):iii-iv, ix-60 Details Sharp C, Petersen N, Goodyer I (2008), “Emotional reactivity and the emergence of conduct problems and emotional symptoms in 7- to 11-year-olds: a 1-year follow-up study.” J Am Acad Child Adolesc Psychiatry 47(5):565-73 Details Wilkinson PO, Goodyer IM (2008), “The effects of cognitive-behavioural therapy on mood-related ruminative response style in depressed adolescents.” Child Adolesc Psychiatry Ment Health 2(1):3 Details 2007Byford S, Barrett B, Roberts C, Wilkinson P, Dubicka B, Kelvin RG, White L, Ford C, Breen S, Goodyer I (2007), “Cost-effectiveness of selective serotonin reuptake inhibitors and routine specialist care with and without cognitive behavioural therapy in adolescents with major depression.” Br J Psychiatry 191:521-7 Details Duffy A, Alda M, Trinneer A, Demidenko N, Grof P, Goodyer IM (2007), “Temperament, life events, and psychopathology among the offspring of bipolar parents.” Eur Child Adolesc Psychiatry 16(4):222-8 Details Halligan SL, Herbert J, Goodyer I, Murray L (2007), “Disturbances in morning cortisol secretion in association with maternal postnatal depression predict subsequent depressive symptomatology in adolescents.” Biol Psychiatry 62(1):40-6 Details 2006Dunn V, Goodyer IM (2006), “Longitudinal investigation into childhood- and adolescence-onset depression: psychiatric outcome in early adulthood.” Br J Psychiatry 188:216-22 Details Herbert J, Goodyer IM, Grossman AB, Hastings MH, de Kloet ER, Lightman SL, Lupien SJ, Roozendaal B, Seckl JR (2006), “Do corticosteroids damage the brain?” J Neuroendocrinol 18(6):393-411 Details Kyte ZA, Carlson GA, Goodyer IM (2006), “Clinical and neuropsychological characteristics of child and adolescent bipolar disorder.” Psychol Med 36(9):1197-211 Details Murray L, Halligan SL, Adams G, Patterson P, Goodyer IM (2006), “Socioemotional development in adolescents at risk for depression: the role of maternal depression and attachment style.” Dev Psychopathol 18(2):489-516 Details Sharp C, Goodyer IM, Croudace TJ (2006), “The Short Mood and Feelings Questionnaire (SMFQ): a unidimensional item response theory and categorical data factor analysis of self-report ratings from a community sample of 7-through 11-year-old children.” J Abnorm Child Psychol 34(3):379-91 Details Wilkinson PO, Goodyer IM (2006), “Attention difficulties and mood-related ruminative response style in adolescents with unipolar depression.” J Child Psychol Psychiatry 47(12):1284-91 Details |