Dr Ian Wilkinson University positionSenior Lecturer Dr Ian Wilkinson is pleased to consider applications from prospective PhD students. DepartmentsInstitutesHome pagehttp://www-clinpharm.medschl.cam.ac.uk/ Research ThemesInterestsMy research is clinically orientated and centres on the physiology and pharmacology of the cardiovascular system, and particularly the large arteries and endothelial function. As a clinical pharmacologist, I combine detailed physiological measurement with pharmacological probes to investigate the mechanisms underlying the development of hypertension, arteriosclerosis and ultimately cardiovascular disease. My current research projects include investigating the effect of ageing on the cardiovascular system, and the link between arterial stiffening on cognitive function. I am involved in a number of large collaborative studies including CLEAREST Study and the Caerphilly Heart Study. Research Focus
EquipmentArterial sfiffness Calcium imaging Computerised tomography Endothelial function Haemodynamic monitoring Collaborators
Associated News ItemsKey publicationsHoran M, Newsway V, Yasmin, Lewis MD, Easter TE, Rees DA, Mahto A, Millar DS, Procter AM, Scanlon MF, Wilkinson IB, Hall IP, Wheatley A, Blakey J, Bath PM, Cockcroft JR, Krawczak M, Cooper DN (2006), “Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke” Hum Genet 119:527-540 Turner CL, Wilkinson IB, & Kirkpatrick PJ (2006), “Use of antihypertension agents for the suppression of arterial pulse pressure waveforms in patients with intracranial aneurysms” J Neurosurg 104:531-536 Details Wilkinson IB, Qasem A, McEniery CM, Webb DJ, Avolio AP, Cockcroft JR (2002), “Nitric oxide regulates local arterial distensibility in vivo” Circulation 105:213-217 Publications2014Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, Hwang SJ, Lakatta EG, Laurent S, Maldonado J, Mitchell GF, Najjar SS, Newman AB, Ohishi M, Pannier B, Pereira T, Vasan RS, Shokawa T, Sutton-Tyrell K, Verbeke F, Wang KL, Webb DJ, Willum Hansen T, Zoungas S, McEniery CM, Cockcroft JR, Wilkinson IB (2014), “Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects.” J Am Coll Cardiol 63(7):636-46 Details Everett TR, Wilkinson IB, Mahendru AA, McEniery CM, Garner SF, Goodall AH, Lees CC (2014), “S-nitrosoglutathione improves haemodynamics in early-onset pre-eclampsia.” Br J Clin Pharmacol Details Fisk M, Gajendragadkar PR, Mäki-Petäjä KM, Wilkinson IB, Cheriyan J (2014), “Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease.” Am J Cardiovasc Drugs 14(3):155-65 Details Gajendragadkar PR, Hubsch A, Mäki-Petäjä KM, Serg M, Wilkinson IB, Cheriyan J (2014), “Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial.” PLoS One 9(6):e99070 Details Johal T, Lees CC, Everett TR, Wilkinson IB (2014), “The nitric oxide pathway and possible therapeutic options in pre-eclampsia.” Br J Clin Pharmacol 78(2):244-57 Details Mahendru AA, Everett TR, Wilkinson IB, Lees CC, McEniery CM (2014), “A longitudinal study of maternal cardiovascular function from preconception to the postpartum period.” J Hypertens 32(4):849-56 Details McEniery CM, Cockcroft JR, Roman MJ, Franklin SS, Wilkinson IB (2014), “Central blood pressure: current evidence and clinical importance.” Eur Heart J 35(26):1719-1725 Details Mohan D, Gale NS, McEniery CM, Bolton CE, Cockcroft JR, MacNee W, Fuld J, Lomas DA, Calverley PM, Shale DJ, Miller BE, Wilkinson IB, Tal-Singer R, Polkey MI, on behalf of the ERICA Consortium (2014), “Evaluating the Role of Inflammation in Chronic Airways Disease: The ERICA Study.” COPD Details Moody WE, Tomlinson LA, Ferro CJ, Steeds RP, Mark PB, Zehnder D, Tomson CR, Cockcroft JR, Wilkinson IB, Townend JN (2014), “Effect of A Reduction in glomerular filtration rate after NEphrectomy on arterial STiffness and central hemodynamics: rationale and design of the EARNEST study.” Am Heart J 167(2):141-149.e2 Details Selvarajah V, Pasea L, Ojha S, Wilkinson IB, Tomlinson LA (2014), “Pre-dialysis systolic blood pressure-variability is independently associated with all-cause mortality in incident haemodialysis patients.” PLoS One 9(1):e86514 Details Taviani V, Hickson SS, Hardy CJ, Patterson AJ, Young VE, McEniery CM, Wilkinson IB, Gillard JH, Graves MJ (2014), “Estimation of aortic pulse pressure using fourier velocity encoded M-mode MR.” J Magn Reson Imaging 39(1):85-93 Details 2013Annamalai AK, Webb A, Kandasamy N, Elkhawad M, Moir S, Khan F, Maki-Petaja K, Gayton EL, Strey CH, O'Toole S, Ariyaratnam S, Halsall DJ, Chaudhry AN, Berman L, Scoffings DJ, Antoun NM, Dutka DP, Wilkinson IB, Shneerson JM, Pickard JD, Simpson HL, Gurnell M (2013), “A comprehensive study of clinical, biochemical, radiological, vascular, cardiac, and sleep parameters in an unselected cohort of patients with acromegaly undergoing presurgical somatostatin receptor ligand therapy.” J Clin Endocrinol Metab 98(3):1040-50 Details Butlin M, Qasem A, Battista F, Bozec E, McEniery CM, Millet-Amaury E, Pucci G, Wilkinson IB, Schillaci G, Boutouyrie P, Avolio AP (2013), “Carotid-femoral pulse wave velocity assessment using novel cuff-based techniques: comparison with tonometric measurement.” J Hypertens 31(11):2237-43; discussion 2243 Details Everett TR, Mahendru AA, McEniery CM, Wilkinson IB, Lees CC (2013), “Mid-trimester maternal heart rate is related to neonatal birth weight.” J Matern Fetal Neonatal Med 26(11):1082-5 Details Mahendru AA, Everett TR, McEniery CM, Wilkinson IB, Lees CC (2013), “The feasibility of prospectively studying maternal cardiovascular changes from before conception.” Hypertens Res 36(8):698-704 Details Mahendru AA, Everett TR, McEniery CM, Wilkinson IB, Lees CC (2013), “Cardiovascular function in women with recurrent miscarriage, pre-eclampsia and/or intrauterine growth restriction.” J Matern Fetal Neonatal Med 26(4):351-6 Details McDonnell BJ, Maki-Petaja KM, Munnery M, Yasmin, Wilkinson IB, Cockcroft JR, McEniery CM (2013), “Habitual exercise and blood pressure: age dependency and underlying mechanisms.” Am J Hypertens 26(3):334-41 Details McEniery CM, Franklin SS, Wilkinson IB, Cockcroft JR (2013), “Isolated systolic hypertension in the young: a need for clarity.” J Hypertens 31(9):1911-3 Details McEniery CM, Wilkinson IB (2013), “The pressures of aging.” Hypertension 62(5):823-4 Details Pucci G, Cheriyan J, Hubsch A, Hickson SS, Gajendragadkar PR, Watson T, O'Sullivan M, Woodcock-Smith J, Schillaci G, Wilkinson IB, McEniery CM (2013), “Evaluation of the Vicorder, a novel cuff-based device for the noninvasive estimation of central blood pressure.” J Hypertens 31(1):77-85 Details Shaw KC, McEniery CM, Wilkinson IB, Brown MJ (2013), “Unsafe health and safety: sphygmomanometer cuffs are not interchangeable.” J Hum Hypertens 27(7):434-6 Details Teoh WL, Price JF, Williamson RM, Payne RA, Van Look LA, Reynolds RM, Frier BM, Wilkinson IB, Webb DJ, Strachan MW, ET2DS Investigators (2013), “Metabolic parameters associated with arterial stiffness in older adults with Type 2 diabetes: the Edinburgh Type 2 diabetes study.” J Hypertens 31(5):1010-7 Details Tomlinson LA, Abel GA, Chaudhry AN, Tomson CR, Wilkinson IB, Roland MO, Payne RA (2013), “ACE inhibitor and angiotensin receptor-II antagonist prescribing and hospital admissions with acute kidney injury: a longitudinal ecological study.” PLoS One 8(11):e78465 Details Tomlinson LA, Riding AM, Payne RA, Abel GA, Tomson CR, Wilkinson IB, Roland MO, Chaudhry AN (2013), “The accuracy of diagnostic coding for acute kidney injury in England - a single centre study.” BMC Nephrol 14:58 Details 2012Bolton CE, Stocks J, Hennessy E, Cockcroft JR, Fawke J, Lum S, McEniery CM, Wilkinson IB, Marlow N (2012), “The EPICure study: association between hemodynamics and lung function at 11 years after extremely preterm birth.” J Pediatr 161(4):595-601.e2 Details Elkhawad M, Rudd JH, Sarov-Blat L, Cai G, Wells R, Davies LC, Collier DJ, Marber MS, Choudhury RP, Fayad ZA, Tawakol A, Gleeson FV, Lepore JJ, Davis B, Willette RN, Wilkinson IB, Sprecher DL, Cheriyan J (2012), “Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis.” JACC Cardiovasc Imaging 5(9):911-22 Details Everett TR, Mahendru AA, McEniery CM, Wilkinson IB, Lees CC (2012), “Raised uterine artery impedance is associated with increased maternal arterial stiffness in the late second trimester.” Placenta 33(7):572-7 Details Everett TR, Wilkinson IB, Lees CC (2012), “Drug development in preeclampsia: a 'no go' area?” J Matern Fetal Neonatal Med 25(1):50-2 Details Franklin SS, Wilkinson IB, McEniery CM (2012), “Unusual hypertensive phenotypes: what is their significance?” Hypertension 59(2):173-8 Details Johansen NB, Vistisen D, Brunner EJ, Tabák AG, Shipley MJ, Wilkinson IB, McEniery CM, Roden M, Herder C, Kivimäki M, Witte DR (2012), “Determinants of aortic stiffness: 16-year follow-up of the Whitehall II study.” PLoS One 7(5):e37165 Details Mahendru AA, Daemen A, Everett TR, Wilkinson IB, McEniery CM, Abdallah Y, Timmerman D, Bourne T, Lees CC (2012), “Impact of ovulation and implantation timing on first-trimester crown-rump length and gestational age.” Ultrasound Obstet Gynecol 40(6):630-5 Details Mahendru AA, Everett TR, Wilkinson IB, Lees CC, McEniery CM (2012), “Maternal cardiovascular changes from pre-pregnancy to very early pregnancy.” J Hypertens 30(11):2168-72 Details Mäki-Petäjä KM, Elkhawad M, Cheriyan J, Joshi FR, Ostör AJ, Hall FC, Rudd JH, Wilkinson IB (2012), “Anti-tumor necrosis factor-? therapy reduces aortic inflammation and stiffness in patients with rheumatoid arthritis.” Circulation 126(21):2473-80 Details Mitchell GF, Verwoert GC, Tarasov KV, Isaacs A, Smith AV, Yasmin, Rietzschel ER, Tanaka T, Liu Y, Parsa A, Najjar SS, O'Shaughnessy KM, Sigurdsson S, De Buyzere ML, Larson MG, Sie MP, Andrews JS, Post WS, Mattace-Raso FU, McEniery CM, Eiriksdottir G, Segers P, Vasan RS, van Rijn MJ, Howard TD, McArdle PF, Dehghan A, Jewell ES, Newhouse SJ, Bekaert S, Hamburg NM, Newman AB, Hofman A, Scuteri A, De Bacquer D, Ikram MA, Psaty BM, Fuchsberger C, Olden M, Wain LV, Elliott P, Smith NL, Felix JF, Erdmann J, Vita JA, Sutton-Tyrrell K, Sijbrands EJ, Sanna S, Launer LJ, De Meyer T, Johnson AD, Schut AF, Herrington DM, Rivadeneira F, Uda M, Wilkinson IB, Aspelund T, Gillebert TC, Van Bortel L, Benjamin EJ, Oostra BA, Ding J, Gibson Q, Uitterlinden AG, Abecasis GR, Cockcroft JR, Gudnason V, De Backer GG, Ferrucci L, Harris TB, Shuldiner AR, van Duijn CM, Levy D, Lakatta EG, Witteman JC (2012), “Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium.” Circ Cardiovasc Genet 5(1):81-90 Details Tomlinson LA, Wilkinson IB (2012), “Does it matter where we measure blood pressure?” Br J Clin Pharmacol 74(2):241-5 Details Wilkinson IB, McEniery CM (2012), “Arteriosclerosis: inevitable or self-inflicted?” Hypertension 60(1):3-5 Details 2011Brunner EJ, Shipley MJ, Witte DR, Singh-Manoux A, Britton AR, Tabak AG, McEniery CM, Wilkinson IB, Kivimaki M (2011), “Arterial stiffness, physical function, and functional limitation: the Whitehall II Study.” Hypertension 57(5):1003-9 Details Cheriyan J, Webb AJ, Sarov-Blat L, Elkhawad M, Wallace SM, Mäki-Petäjä KM, Collier DJ, Morgan J, Fang Z, Willette RN, Lepore JJ, Cockcroft JR, Sprecher DL, Wilkinson IB (2011), “Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia.” Circulation 123(5):515-23 Details Chirinos JA, Kips JG, Roman MJ, Medina-Lezama J, Li Y, Woodiwiss AJ, Norton GR, Yasmin, Van Bortel L, Wang JG, Cockcroft JR, Devereux RB, Wilkinson IB, Segers P, McEniery CM (2011), “Ethnic differences in arterial wave reflections and normative equations for augmentation index.” Hypertension 57(6):1108-16 Details Cockcroft JR, Wilkinson IB, Avolio AP, McEniery CM, Butlin M (2011), “Weight loss, blood pressure reduction, and aortic stiffness: an old dilemma revisited.” Obesity (Silver Spring) 19(3):468 Details Hickson SS, Miles KL, McDonnell BJ, Yasmin, Cockcroft JR, Wilkinson IB, McEniery CM, ENIGMA Study Investigators (2011), “Use of the oral contraceptive pill is associated with increased large artery stiffness in young women: the ENIGMA study.” J Hypertens 29(6):1155-9 Details McEniery CM, Bolton CE, Fawke J, Hennessy E, Stocks J, Wilkinson IB, Cockcroft JR, Marlow N (2011), “Cardiovascular consequences of extreme prematurity: the EPICure study.” J Hypertens 29(7):1367-73 Details Miles KL, McDonnell BJ, Maki-Petaja KM, Yasmin, Cockcroft JR, Wilkinson IB, McEniery CM, Enigma Study investigators (2011), “The impact of birth weight on blood pressure and arterial stiffness in later life: the Enigma Study.” J Hypertens 29(12):2324-31 Details Taviani V, Hickson SS, Hardy CJ, McEniery CM, Patterson AJ, Gillard JH, Wilkinson IB, Graves MJ (2011), “Age-related changes of regional pulse wave velocity in the descending aorta using Fourier velocity encoded M-mode.” Magn Reson Med 65(1):261-8 Details Tomlinson LA, Selvarajah V, Wilkinson IB (2011), “Rate-limiting step: can different effects of antihypertensives on central blood pressure be translated into outcomes?” Hypertension 57(6):1047-8 Details Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM, Henneman P, Smith AV, Ehret GB, Amin N, Larson MG, Mooser V, Hadley D, Dörr M, Bis JC, Aspelund T, Esko T, Janssens AC, Zhao JH, Heath S, Laan M, Fu J, Pistis G, Luan J, Arora P, Lucas G, Pirastu N, Pichler I, Jackson AU, Webster RJ, Zhang F, Peden JF, Schmidt H, Tanaka T, Campbell H, Igl W, Milaneschi Y, Hottenga JJ, Vitart V, Chasman DI, Trompet S, Bragg-Gresham JL, Alizadeh BZ, Chambers JC, Guo X, Lehtimäki T, Kühnel B, Lopez LM, Polašek O, Boban M, Nelson CP, Morrison AC, Pihur V, Ganesh SK, Hofman A, Kundu S, Mattace-Raso FU, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Hwang SJ, Vasan RS, Wang TJ, Bergmann S, Vollenweider P, Waeber G, Laitinen J, Pouta A, Zitting P, McArdle WL, Kroemer HK, Völker U, Völzke H, Glazer NL, Taylor KD, Harris TB, Alavere H, Haller T, Keis A, Tammesoo ML, Aulchenko Y, Barroso I, Khaw KT, Galan P, Hercberg S, Lathrop M, Eyheramendy S, Org E, Sõber S, Lu X, Nolte IM, Penninx BW, Corre T, Masci (2011), “Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.” Nat Genet 43(10):1005-11 Details 2010Cockcroft JR, McEniery CM, Wilkinson IB (2010), “Essential hypertension, hypertension in pregnancy, and subsequent blood pressure: another old dilemma revisited.” Hypertension 56(3):e32; author reply e33 Details Hickson SS, Butlin M, Graves M, Taviani V, Avolio AP, McEniery CM, Wilkinson IB (2010), “The relationship of age with regional aortic stiffness and diameter.” JACC Cardiovasc Imaging 3(12):1247-55 Details Kiotsekoglou A, Saha SK, Moggridge JC, Kapetanakis V, Bijnens BH, Mullen MJ, Camm J, Sutherland GR, Wilkinson IB, Child AH (2010), “Effect of aortic stiffness on left ventricular long-axis systolic function in adults with Marfan syndrome.” Hellenic J Cardiol 51(6):501-11 Details Li Y, Borlotti A, Hickson SS, McEniery CM, Wilkinson IB, Khir AW (2010), “Using magnetic resonance imaging measurements for the determination of local wave speed and arrival time of reflected waves in human ascending aorta.” Conf Proc IEEE Eng Med Biol Soc 2010:5153-6 Details Lunnon MW, Wallace SM, Palmer JE, Francis-Lang A, Laurijssens BE, Mistry P, Albala B, Nagafuji T, Wilkinson IB, Maltby K (2010), “Prolonged pharmacodynamic effects of S-0139, an intravenously administered endothelin A (ET) antagonist, in the human forearm blood flow model.” Br J Clin Pharmacol 69(3):252-61 Details McEniery CM, Spratt M, Munnery M, Yarnell J, Lowe GD, Rumley A, Gallacher J, Ben-Shlomo Y, Cockcroft JR, Wilkinson IB (2010), “An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study.” Hypertension 56(1):36-43 Details McEniery CM, Yasmin, Maki-Petaja KM, McDonnell BJ, Munnery M, Hickson SS, Franklin SS, Cockcroft JR, Wilkinson IB, Anglo-Cardiff Collaboration Trial Investigators (2010), “The impact of cardiovascular risk factors on aortic stiffness and wave reflections depends on age: the Anglo-Cardiff Collaborative Trial (ACCT III).” Hypertension 56(4):591-7 Details Payne RA, Wilkinson IB, Webb DJ (2010), “Arterial stiffness and hypertension: emerging concepts.” Hypertension 55(1):9-14 Details Wallace SM, Mäki-Petäjä KM, Cheriyan J, Davidson EH, Cherry L, McEniery CM, Sattar N, Wilkinson IB, Kharbanda RK (2010), “Simvastatin prevents inflammation-induced aortic stiffening and endothelial dysfunction.” Br J Clin Pharmacol 70(6):799-806 Details Wilkinson IB, McEniery CM, Cockcroft JR (2010), “Central blood pressure estimation for the masses moves a step closer.” J Hum Hypertens 24(8):495-7 Details 2009Bennett Britton TM, Wallace SM, Wilkinson IB, Mortimer PS, Peters AM, Purushotham AD (2009), “Sympathetic nerve damage as a potential cause of lymphoedema after axillary dissection for breast cancer.” Br J Surg 96(8):865-9 Details Bolton CE, Cockcroft JR, Sabit R, Munnery M, McEniery CM, Wilkinson IB, Ebrahim S, Gallacher JE, Shale DJ, Ben-Shlomo Y (2009), “Lung function in mid-life compared with later life is a stronger predictor of arterial stiffness in men: the Caerphilly Prospective Study.” Int J Epidemiol 38(3):867-76 Details Bowden DJ, Aitken SR, Wilkinson IB, Dixon AK (2009), “Interobserver variability in the measurement of abdominal aortic calcification using unenhanced CT.” Br J Radiol 82(973):69-72 Details Cheriyan J, Burton TJ, Bradley TJ, Wallace SM, Mäki-Petäjä KM, Mackenzie IS, McEniery CM, Brown J, Wilkinson IB (2009), “The effects of urotensin II and urantide on forearm blood flow and systemic haemodynamics in humans.” Br J Clin Pharmacol 68(4):518-23 Details Hickson SS, Butlin M, Broad J, Avolio AP, Wilkinson IB, McEniery CM (2009), “Validity and repeatability of the Vicorder apparatus: a comparison with the SphygmoCor device.” Hypertens Res 32(12):1079-85 Details Hickson SS, Butlin M, Mir FA, Graggaber J, Cheriyan J, Khan F, Grace AA, Yasmin, Cockcroft JR, Wilkinson IB, McEniery CM, Anglo-Cardiff Collaboration Trial Investigators (2009), “The accuracy of central SBP determined from the second systolic peak of the peripheral pressure waveform.” J Hypertens 27(9):1784-8 Details Mackenzie IS, McEniery CM, Dhakam Z, Brown MJ, Cockcroft JR, Wilkinson IB (2009), “Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension.” Hypertension 54(2):409-13 Details Mäki-Petäjä KM, Wilkinson IB (2009), “Anti-inflammatory drugs and statins for arterial stiffness reduction.” Curr Pharm Des 15(3):290-303 Details McEniery CM, McDonnell BJ, So A, Aitken S, Bolton CE, Munnery M, Hickson SS, Yasmin, Maki-Petaja KM, Cockcroft JR, Dixon AK, Wilkinson IB, Anglo-Cardiff Collaboration Trial Investigators (2009), “Aortic calcification is associated with aortic stiffness and isolated systolic hypertension in healthy individuals.” Hypertension 53(3):524-31 Details Schumacher W, Cockcroft J, Timpson NJ, McEniery CM, Gallacher J, Rumley A, Lowe G, Smith GD, Wilkinson IB, Ben-Shlomo Y (2009), “Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity.” Hypertension 53(2):150-7 Details Wilkinson IB, McEniery CM, Cockcroft JR (2009), “Arteriosclerosis and atherosclerosis: guilty by association.” Hypertension 54(6):1213-5 Details 2008Burton TJ, Wilkinson IB (2008), “The dangers of immediate-release nifedipine in the emergency treatment of hypertension.” J Hum Hypertens 22(4):301-2 Details Dhakam Z, Yasmin, McEniery CM, Burton T, Brown MJ, Wilkinson IB (2008), “A comparison of atenolol and nebivolol in isolated systolic hypertension.” J Hypertens 26(2):351-6 Details Kinra S, Rameshwar Sarma KV, Ghafoorunissa, Mendu VV, Ravikumar R, Mohan V, Wilkinson IB, Cockcroft JR, Davey Smith G, Ben-Shlomo Y (2008), “Effect of integration of supplemental nutrition with public health programmes in pregnancy and early childhood on cardiovascular risk in rural Indian adolescents: long term follow-up of Hyderabad nutrition trial.” BMJ 337:a605 Details Mäki-Petäjä KM, Cheriyan J, Booth AD, Hall FC, Brown J, Wallace SM, Ashby MJ, McEniery CM, Wilkinson IB (2008), “Inducible nitric oxide synthase activity is increased in patients with rheumatoid arthritis and contributes to endothelial dysfunction.” Int J Cardiol 129(3):399-405 Details McEniery CM, Yasmin, McDonnell B, Munnery M, Wallace SM, Rowe CV, Cockcroft JR, Wilkinson IB, Anglo-Cardiff Collaborative Trial Investigators (2008), “Central pressure: variability and impact of cardiovascular risk factors: the Anglo-Cardiff Collaborative Trial II.” Hypertension 51(6):1476-82 Details Mills NL, Miller JJ, Anand A, Robinson SD, Frazer GA, Anderson D, Breen L, Wilkinson IB, McEniery CM, Donaldson K, Newby DE, Macnee W (2008), “Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk.” Thorax 63(4):306-11 Details Nichols WW, Denardo SJ, Wilkinson IB, McEniery CM, Cockcroft J, O'Rourke MF (2008), “Effects of arterial stiffness, pulse wave velocity, and wave reflections on the central aortic pressure waveform.” J Clin Hypertens (Greenwich) 10(4):295-303 Details Sharman JE, McEniery CM, Campbell R, Pusalkar P, Wilkinson IB, Coombes JS, Cockcroft JR (2008), “Nitric oxide does not significantly contribute to changes in pulse pressure amplification during light aerobic exercise.” Hypertension 51(4):856-61 Details 2007Agabiti-Rosei E, Mancia G, O'Rourke MF, Roman MJ, Safar ME, Smulyan H, Wang JG, Wilkinson IB, Williams B, Vlachopoulos C (2007), “Central blood pressure measurements and antihypertensive therapy: a consensus document.” Hypertension 50(1):154-60 Details Cheriyan J, Wilkinson IB (2007), “Role of increased aortic stiffness in the pathogenesis of heart failure.” Curr Heart Fail Rep 4(3):121-6 Details Mäki-Petäjä KM, Booth AD, Hall FC, Wallace SM, Brown J, McEniery CM, Wilkinson IB (2007), “Ezetimibe and simvastatin reduce inflammation, disease activity, and aortic stiffness and improve endothelial function in rheumatoid arthritis.” J Am Coll Cardiol 50(9):852-8 Details McEniery CM, Wilkinson IB, Avolio AP (2007), “Age, hypertension and arterial function.” Clin Exp Pharmacol Physiol 34(7):665-71 Details Sabit R, Bolton CE, Edwards PH, Pettit RJ, Evans WD, McEniery CM, Wilkinson IB, Cockcroft JR, Shale DJ (2007), “Arterial stiffness and osteoporosis in chronic obstructive pulmonary disease.” Am J Respir Crit Care Med 175(12):1259-65 Details Sharman JE, McEniery CM, Dhakam ZR, Coombes JS, Wilkinson IB, Cockcroft JR (2007), “Pulse pressure amplification during exercise is significantly reduced with age and hypercholesterolemia.” J Hypertens 25(6):1249-54 Details Sommerfield AJ, Wilkinson IB, Webb DJ, Frier BM (2007), “Vessel wall stiffness in type 1 diabetes and the central hemodynamic effects of acute hypoglycemia.” Am J Physiol Endocrinol Metab 293(5):E1274-9 Details Wallace SM, Yasmin, McEniery CM, Mäki-Petäjä KM, Booth AD, Cockcroft JR, Wilkinson IB (2007), “Isolated systolic hypertension is characterized by increased aortic stiffness and endothelial dysfunction.” Hypertension 50(1):228-33 Details 2006Dhakam Z, McEniery CM, Yasmin, Cockcroft JR, Brown MJ, Wilkinson IB (2006), “Atenolol and eprosartan: differential effects on central blood pressure and aortic pulse wave velocity.” Am J Hypertens 19(2):214-9 Details Horan M, Newsway V, Yasmin, Lewis MD, Easter TE, Rees DA, Mahto A, Millar DS, Procter AM, Scanlon MF, Wilkinson IB, Hall IP, Wheatley A, Blakey J, Bath PM, Cockcroft JR, Krawczak M, Cooper DN (2006), “Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke.” Hum Genet 119(5):527-40 Details Mäki-Petäjä KM, Hall FC, Booth AD, Wallace SM, Yasmin, Bearcroft PW, Harish S, Furlong A, McEniery CM, Brown J, Wilkinson IB (2006), “Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti-tumor necrosis factor-alpha therapy.” Circulation 114(11):1185-92 Details McEniery CM, Wallace S, Mackenzie IS, McDonnell B, Yasmin, Newby DE, Cockcroft JR, Wilkinson IB (2006), “Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans.” Hypertension 48(4):602-8 Details McEniery CM, Wilkinson IB, Cockcroft JR (2006), “Systolic hypertension in young adults: spurious definition of a genuine condition.” J Hypertens 24(11):2316-7; author reply 2317-9 Details Sharman JE, Lim R, Qasem AM, Coombes JS, Burgess MI, Franco J, Garrahy P, Wilkinson IB, Marwick TH (2006), “Validation of a generalized transfer function to noninvasively derive central blood pressure during exercise.” Hypertension 47(6):1203-8 Details Wilkinson IB, McEniery CM, Cockcroft JR (2006), “Atenolol and cardiovascular risk: an issue close to the heart.” Lancet 367(9511):627-9 Details Yasmin, McEniery CM, O'Shaughnessy KM, Harnett P, Arshad A, Wallace S, Maki-Petaja K, McDonnell B, Ashby MJ, Brown J, Cockcroft JR, Wilkinson IB (2006), “Variation in the human matrix metalloproteinase-9 gene is associated with arterial stiffness in healthy individuals.” Arterioscler Thromb Vasc Biol 26(8):1799-805 Details Yasmin, O'Shaughnessy KM, McEniery CM, Cockcroft JR, Wilkinson IB (2006), “Genetic variation in fibrillin-1 gene is not associated with arterial stiffness in apparently healthy individuals.” J Hypertens 24(3):499-502 Details Yasmin, Wilkinson IB, O'Shaughnessy KM (2006), “Influence of fibrillin-1 genotype on aortic stiffness in men: a note of caution.” J Appl Physiol (1985) 100(4):1431; author reply 1431-2 Details 2005Cockcroft JR, Wilkinson IB, Evans M, McEwan P, Peters JR, Davies S, Scanlon MF, Currie CJ (2005), “Pulse pressure predicts cardiovascular risk in patients with type 2 diabetes mellitus.” Am J Hypertens 18(11):1463-7; discussion 1468-9 Details Mackenzie IS, Maki-Petaja KM, McEniery CM, Bao YP, Wallace SM, Cheriyan J, Monteith S, Brown MJ, Wilkinson IB (2005), “Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans.” Arterioscler Thromb Vasc Biol 25(9):1891-5 Details McEniery CM, Wilkinson IB (2005), “Large artery stiffness and inflammation.” J Hum Hypertens 19(7):507-9 Details McEniery CM, Yasmin, Hall IR, Qasem A, Wilkinson IB, Cockcroft JR, ACCT Investigators (2005), “Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT).” J Am Coll Cardiol 46(9):1753-60 Details McEniery CM, Yasmin, Wallace S, Maki-Petaja K, McDonnell B, Sharman JE, Retallick C, Franklin SS, Brown MJ, Lloyd RC, Cockcroft JR, Wilkinson IB, ENIGMA Study Investigators (2005), “Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults.” Hypertension 46(1):221-6 Details Neal DA, Brown MJ, Wilkinson IB, Alexander GJ (2005), “Mechanisms of hypertension after liver transplantation.” Transplantation 79(8):935-40 Details Schmitt M, Avolio A, Qasem A, McEniery CM, Butlin M, Wilkinson IB, Cockcroft JR (2005), “Basal NO locally modulates human iliac artery function in vivo.” Hypertension 46(1):227-31 Details Sharman JE, McEniery CM, Campbell RI, Coombes JS, Wilkinson IB, Cockcroft JR (2005), “The effect of exercise on large artery haemodynamics in healthy young men.” Eur J Clin Invest 35(12):738-44 Details Wilkinson IB, McEniery CM, Cockcroft JR (2005), “Pulse waveform analysis and arterial stiffness: realism can replace evangelism and scepticism.” J Hypertens 23(1):213; author reply 213-4 Details Yasmin, McEniery CM, Wallace S, Dakham Z, Pulsalkar P, Maki-Petaja K, Ashby MJ, Cockcroft JR, Wilkinson IB (2005), “Matrix metalloproteinase-9 (MMP-9), MMP-2, and serum elastase activity are associated with systolic hypertension and arterial stiffness.” Arterioscler Thromb Vasc Biol 25(2):372 Details 2004Booth AD, Jayne DR, Kharbanda RK, McEniery CM, Mackenzie IS, Brown J, Wilkinson IB (2004), “Infliximab improves endothelial dysfunction in systemic vasculitis: a model of vascular inflammation.” Circulation 109(14):1718-23 Details Booth AD, Wallace S, McEniery CM, Yasmin, Brown J, Jayne DR, Wilkinson IB (2004), “Inflammation and arterial stiffness in systemic vasculitis: a model of vascular inflammation.” Arthritis Rheum 50(2):581-8 Details McEniery CM, Schmitt M, Qasem A, Webb DJ, Avolio AP, Wilkinson IB, Cockcroft JR (2004), “Nebivolol increases arterial distensibility in vivo.” Hypertension 44(3):305-10 Details McLeod AL, Uren NG, Wilkinson IB, Webb DJ, Maxwell SR, Northridge DB, Newby DE (2004), “Non-invasive measures of pulse wave velocity correlate with coronary arterial plaque load in humans.” J Hypertens 22(2):363-8 Details Mir FA, Wilkinson IB (2004), “A rational approach to hypertension.” Practitioner 248(1656):176, 179, 182-9 passim Details Neal DA, Brown MJ, Wilkinson IB, Byrne CD, Alexander GJ (2004), “Hemodynamic effects of amlodipine, bisoprolol, and lisinopril in hypertensive patients after liver transplantation.” Transplantation 77(5):748-50 Details Schmitt M, Qasem A, McEniery C, Wilkinson IB, Tatarinoff V, Noble K, Klemes J, Payne N, Frenneaux MP, Cockcroft J, Avolio A (2004), “Role of natriuretic peptides in regulation of conduit artery distensibility.” Am J Physiol Heart Circ Physiol 287(3):H1167-71 Details Wilkinson IB, Cockcroft JR (2004), “Commentary: birthweight arterial stiffness and blood pressure: in search of a unifying hypothesis.” Int J Epidemiol 33(1):161-2 Details Wilkinson IB, Cockcroft JR (2004), “Estimation of central aortic pressure: shedding new light or clouding the issue?” Clin Sci (Lond) 106(4):433-4 Details Wilkinson IB, Franklin SS, Cockcroft JR (2004), “Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology.” Hypertension 44(2):112-6 Details Wilkinson IB, McEniery C (2004), “Use of arterial transfer functions for the derivation of central aortic waveform characteristics in subjects with type 2 diabetes and cardiovascular disease.” Diabetes Care 27(10):2564; author reply 2565-7 Details Wilkinson IB, McEniery CM (2004), “Arterial stiffness, endothelial function and novel pharmacological approaches.” Clin Exp Pharmacol Physiol 31(11):795-9 Details Yasmin, McEniery CM, Wallace S, Mackenzie IS, Cockcroft JR, Wilkinson IB (2004), “C-reactive protein is associated with arterial stiffness in apparently healthy individuals.” Arterioscler Thromb Vasc Biol 24(5):969-74 Details 2003Cockcroft JR, McEniery CM, Wilkinson IB (2003), “Pseudo hypertension of youth: too much of a good thing?” Am J Hypertens 16(3):262-4 Details Cockcroft JR, Wilkinson IB (2003), “Evaluation of methods to measure endothelium-dependent vasodilation.” Clin Sci (Lond) 104(4):367-8; author reply 368 Details McEniery CM, Qasem A, Schmitt M, Avolio AP, Cockcroft JR, Wilkinson IB (2003), “Endothelin-1 regulates arterial pulse wave velocity in vivo.” J Am Coll Cardiol 42(11):1975-81 Details |