Dr Hisham Ziauddeen MRCPsych PhD


I am a Senior Clinical Research Associate working with Prof. Paul Fletcher. I work on brain reward systems using pharmacological fMRI and behavioural measures, to study the role of environmental influences and opioid and dopaminergic systems in controlling food reward processing and eating behaviour. In collaboration with GSK, we have recently completed a proof of concept study of a novel mu-opioid antagonist. My current work involves the use of pharmacological fMRI to study the role of the dopaminergic system in food reward processing in healthy controls. This work has a particular focus on the effect of the atypical antipsychotics which cause significant weight gain with serious consequences for health. As a side interest, I have spent some time looking at the matter of food addiction both in the scientific literature and in stand up comedy (sets on YouTube)

I am also an honorary consultant psychiatrist working with the Cambridgeshire and Peterborough Foundation Trust (CPFT).

Research Focus






Clinical conditions




Behavioural analysis

Magnetic resonance imaging (MRI)



Ed Bullmore

Sadaf Farooqi

Paul Fletcher

Theresa Marteau

Nenad Medic

Naresh Subramaniam

Associated News Items

Key publications

Ziauddeen H, Fletcher PC (2013), “Is food addiction a valid and useful concept?” Obes Rev 14(1):19-28 Details

Cambridge VC, Ziauddeen H, Nathan PJ, Subramaniam N, Dodds C, Chamberlain SR, Koch A, Maltby K, Skeggs AL, Napolitano A, Sadaf Farooqi I, Bullmore ET, Fletcher PC (2012), “Neural and Behavioral Effects of a Novel Mu Opioid Receptor Antagonist in Binge-Eating Obese People.” Biol Psychiatry Details

Ziauddeen H, Chamberlain SR, Nathan PJ, Koch A, Maltby K, Bush M, Tao WX, Napolitano A, Skeggs AL, Brooke AC, Cheke L, Clayton NS, Sadaf Farooqi I, O'Rahilly S, Waterworth D, Song K, Hosking L, Richards DB, Fletcher PC, Bullmore ET (2012), “Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.” Mol Psychiatry Details

Ziauddeen H, Farooqi IS, Fletcher PC (2012), “Obesity and the brain: how convincing is the addiction model?” Nat Rev Neurosci 13(4):279-86 Details

Ziauddeen H, Subramaniam N, Gaillard R, Burke LK, Farooqi IS, Fletcher PC (2012), “Food images engage subliminal motivation to seek food.” Int J Obes (Lond) 36(9):1245-7 Details


in press

Medic N, Ziauddeen H, Ersche KD, Farooqi IS, Bullmore ET, Nathan PJ, Ronan L, Fletcher PC (in press), “Increased Body Mass Index is Associated with Specific Regional Alterations in Brain Structure” Int. J. Obesity

Medic N, Ziauddeen H, Forwood SE, Davies KM, Ahern AL, Jebb SA, Marteau TM, Fletcher PC (in press), “The presence of real food usurps hypothetical health value judgment in overweight people ” eNeuro


Arrondo G, Segarra N, Metastasio A, Ziauddeen H, Spencer J, Reinders NR, Dudas RB, Robbins TW, Fletcher PC, Murray GK. (2015), “Reduction in ventral striatal activity when anticipating a reward in depression and schizophrenia: a replicated cross-diagnostic finding.” Frontiers Psychol 26;6:1280

Segarra N, Metastasio A, Ziauddeen H, Spencer J, Reinders NR , Dudas RB , Arrondo G, Robbins TW, Clark L , Fletcher PC, Murray GK. (2015), “Abnormal frontostriatal activity during unexpected reward receipt in depression and schizophrenia: relationship to anhedonia” Neuropsychopharmcology Dec 28. doi: 10.1038/npp.2015.370.

Ziauddeen H, Alonso-Alonso M, Hill JO, Kelley M, Khan NA (2015), “Obesity and the Neurocognitive Basis of Food Reward and the Control of Intake.” Adv. Nutr. 15;6(4):474-86


Chuang JY, Murray GK, Metastasio A, Segarra N, Tait R, Spencer J, Ziauddeen H, Dudas RB, Fletcher PC, Suckling J (2014), “Brain structural signatures of negative symptoms in depression and schizophrenia.” Front Psychiatry 5:116 Details

Hill JO, Berridge K, Avena NM, Ziauddeen H, Alonso-Alonso M, Allison DB, Khan NA, Kelley M (2014), “Neurocognition: the food–brain connection.” Adv Nutr 5(5):544-6

Medic N, Ziauddeen H, Vestergaard MD, Henning E, Schultz W, Farooqi IS, Fletcher PC (2014), “Dopamine modulates the neural representation of subjective value of food in hungry subjects.” J Neurosci 34(50):16856-64 Details

Pearse LJ, Dibben C, Ziauddeen H, Denman C, McKenna PJ (2014), “A study of psychotic symptoms in borderline personality disorder.” J Nerv Ment Dis 202(5):368-71 Details

Ziauddeen H, Subramaniam N, Cambridge VC, Medic N, Farooqi IS, Fletcher PC (2014), “Studying food reward and motivation in humans.” J Vis Exp (85) Details


Ziauddeen H, Fletcher PC (2013), “Central nervous system biomarkers for antiobesity drug development.” Drug Discov Today 18(23-24):1282-91 Details

Ziauddeen H, Nathan PJ, Dodds C, Maltby K, Miller SR, Waterworth D, Song K, Warren L, Hosking L, Zucchetto M, Bush M, Johnson LV, Sarai B, Mogg K, Bradley BP, Richards DB, Fletcher PC, Bullmore ET (2013), “The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects.” J Clin Pharmacol 53(10):1078-90 Details


Ziauddeen H, Dibben C, Kipps C, Hodges JR, McKenna PJ (2011), “Negative schizophrenic symptoms and the frontal lobe syndrome: one and the same?” Eur Arch Psychiatry Clin Neurosci 261(1):59-67 Details


Ziauddeen H, Murray GK (2010), “The relevance of reward pathways for schizophrenia.” Curr Opin Psychiatry 23(2):91-6 Details