Dr Hovy Wong University positionResearch Associate DepartmentsDepartment of Physiology, Development and Neuroscience Home pageResearch ThemesInterestsThe role of local translation in axonal branching and synaptogenesis in vivo Research Focus
EquipmentCell culture Confocal microscopy Immunohistochemistry Microscopy Recombinant protein expression CollaboratorsNo collaborators listed Associated News ItemsKey publicationsWong HH, Lin JQ, Ströhl F, Roque CG, Cioni JM, Cagnetta R, Turner-Bridger B, Laine RF, Harris WA, Kaminski CF, Holt CE (2017), “RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo” Neuron 95(4): 852-868.e8 Publications2019Cagnetta R, Wong HHW, Frese C, Mallucci GR, Krijgsveld J, Holt CE (2019), “Noncanonical modulation of eIF2 pathway controls increase in local translation during neural wiring” Molecular Cell 73(3) 2018Cioni JM, Wong HH, Bressan D, Kodama L, Harris WA, Holt CE (2018), “Axon-axon interactions regulate topographic optic tract sorting via CYFIP2-dependent WAVE complex function” Neuron 97(5): 1078–1093.e6 Leung KM*, Lu B*, Wong HH*, Lin JQ, Turner-Bridger B, Holt CE (2018), “Cue-polarized transport of β-actin mRNA depends on 3’UTR and microtubules in live growth cones” Front Cell Neurosci Turner-Bridger B, Jakobs M, Muresan L, Wong HH, Franze K, Harris WA, Holt CE (2018), “Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons” PNAS Wong HH, Holt CE (2018), “Targeted electroporation in the CNS in Xenopus embryos” Methods Mol Biol 2017Ströhl F, Lin JQ, Laine RF, Wong HH, Urbančič V, Cagnetta R, Holt CE, Kaminski CF (2017), “Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons” Sci Rep. 7(1):709 Ströhl F, Wong HH, Holt CE, Kaminski CF (2017), “Total internal reflection fluorescence anisotropy imaging microscopy: setup, calibration, and data processing for protein polymerization measurements in living cells” Methods Appl Fluoresc 2016Konopacki FA, Wong HH, Dwivedy A, Bellon A, Blower MD, Holt CE (2016), “ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis” Open Biol. 6 150218 Roque CG, Wong HH, Lin JQ, Holt CE (2016), “Tumor protein Tctp regulates axon development in the embryonic visual system” Development 143: 1134-1148 2013Fu AK, Hung KW, Wong HH, Fu WY, Ip NY (2013), “Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death.” Neurosignals 21(1-2):55-60 Details |