Dr Hovy Wong


The role of local translation in axonal branching and synaptogenesis in vivo

Research Focus


RNA localization

Local translation

Axon remodelling


Synaptic plasticity

Clinical conditions

No direct clinical relevance


Cell culture

Confocal microscopy



Recombinant protein expression


No collaborators listed

Associated News Items

    Key publications

    Wong HH, Lin JQ, Ströhl F, Roque CG, Cioni JM, Cagnetta R, Turner-Bridger B, Laine RF, Harris WA, Kaminski CF, Holt CE (2017), “RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo” Neuron 95(4): 852-868.e8



    Cagnetta R, Wong HHW, Frese C, Mallucci GR, Krijgsveld J, Holt CE (2019), “Noncanonical modulation of eIF2 pathway controls increase in local translation during neural wiring” Molecular Cell 73(3)


    Cioni JM, Wong HH, Bressan D, Kodama L, Harris WA, Holt CE (2018), “Axon-axon interactions regulate topographic optic tract sorting via CYFIP2-dependent WAVE complex function” Neuron 97(5): 1078–1093.e6

    Leung KM*, Lu B*, Wong HH*, Lin JQ, Turner-Bridger B, Holt CE (2018), “Cue-polarized transport of β-actin mRNA depends on 3’UTR and microtubules in live growth cones” Front Cell Neurosci

    Turner-Bridger B, Jakobs M, Muresan L, Wong HH, Franze K, Harris WA, Holt CE (2018), “Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons” PNAS

    Wong HH, Holt CE (2018), “Targeted electroporation in the CNS in Xenopus embryos” Methods Mol Biol


    Ströhl F, Lin JQ, Laine RF, Wong HH, Urbančič V, Cagnetta R, Holt CE, Kaminski CF (2017), “Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons” Sci Rep. 7(1):709

    Ströhl F, Wong HH, Holt CE, Kaminski CF (2017), “Total internal reflection fluorescence anisotropy imaging microscopy: setup, calibration, and data processing for protein polymerization measurements in living cells” Methods Appl Fluoresc


    Konopacki FA, Wong HH, Dwivedy A, Bellon A, Blower MD, Holt CE (2016), “ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis” Open Biol. 6 150218

    Roque CG, Wong HH, Lin JQ, Holt CE (2016), “Tumor protein Tctp regulates axon development in the embryonic visual system” Development 143: 1134-1148


    Fu AK, Hung KW, Wong HH, Fu WY, Ip NY (2013), “Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death.” Neurosignals 21(1-2):55-60 Details