Dr Iris Hardege

(she/her/hers)

University Position

Royal Society University Research Fellow

Dr Iris Hardege is pleased to consider applications from prospective PhD students.

Interests

The basics of neural communication is conserved across species, with neurotransmitters acting as messengers across synapses. My work focusses on the receptors for these neurotransmitters and understanding their diversity and function with the nervous system of the model organism C. elegans. The nematode C. elegans is a powerful model organism, having a small and completely mapped nervous system and genome, allowing us to probe the detailed mechanisms of these receptors within a whole organism. I am particularly interested in ion channel receptors and understanding the way in which their balance at the synapses effects circuits and learning.

Key Publications

A Novel and Functionally Diverse Class of Acetylcholine-gated Ion Channels

DOI: http://doi.org/10.1101/2021.10.06.463318
Journal:
E-pub date: 1 Aug 2021
Authors: I Hardege, J Morud, A Courtney, W Schafer

Neuronally Produced Betaine Acts via a Novel Ligand Gated Ion Channel to Control Behavioural States

DOI: http://doi.org/10.1101/2021.10.29.466399
Journal:
E-pub date: 1 Aug 2021
Authors: I Hardege, J Morud, J Yu, TS Wilson, FC Schroeder, WR Schafer

Deorphanisation of novel biogenic amine-gated ion channels identifies a new serotonin receptor for learning

DOI: http://doi.org/10.1101/2020.09.17.301382
Journal:
E-pub date: 1 Aug 2020
Authors: J Morud, I Hardege, H Liu, T Wu, S Basu, Y Zhang, W Schafer

Publications

Neuropeptide signalling shapes feeding and reproductive behaviours in male C. elegans

DOI: http://doi.org/10.1101/2021.11.29.470485
Journal:
E-pub date: 1 Aug 2021
Authors: M Gadenne, I Hardege, D Suleski, P Jaggers, I Beets, W Schafer, YL Chew

Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock

DOI: http://doi.org/10.1101/2021.11.15.468673
Journal:
E-pub date: 1 Aug 2021
Authors: E Kaulich, B Ackley, Y-Q Tang, I Hardege, W Schafer, D Walker

Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans.

DOI: http://doi.org/10.1016/j.devcel.2020.10.024
Journal: Dev Cell
E-pub date: 21 Dec 2020
Authors: NP Özbey, S Imanikia, C Krueger, I Hardege, J Morud, M Sheng, WR Schafer, MO Casanueva, RC Taylor

Functional characterization of common BCL11B gene desert variants suggests a lymphocyte-mediated association of BCL11B with aortic stiffness.

DOI: http://doi.org/10.1038/s41431-018-0226-z
Journal: Eur J Hum Genet
E-pub date: 1 Nov 2018
Authors: RA Maskari, I Hardege, S Cleary, N Figg, Y Li, K Siew, A Khir, Y Yu, P Liu, I Wilkinson, K O'Shaughnessy, Yasmin

Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels.

DOI: http://doi.org/10.1042/CS20171285
Journal: Clin Sci (Lond)
E-pub date: 16 Jan 2018
Authors: I Hardege, L Long, R Al Maskari, N Figg, KM O'Shaughnessy

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.

DOI: http://doi.org/10.15252/emmm.201505444
Journal: EMBO Mol Med
E-pub date: 1 Oct 2015
Authors: F-R Schumacher, K Siew, J Zhang, C Johnson, N Wood, SE Cleary, RS Al Maskari, JT Ferryman, I Hardege, Yasmin, NL Figg, R Enchev, A Knebel, KM O'Shaughnessy, T Kurz

Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells.

DOI: http://doi.org/10.1210/me.2015-1195
Journal: Mol Endocrinol
E-pub date: 1 Oct 2015
Authors: I Hardege, S Xu, RD Gordon, AJ Thompson, N Figg, M Stowasser, R Murrell-Lagnado, KM O'Shaughnessy

A conserved domain targets exported PHISTb family proteins to the periphery of Plasmodium infected erythrocytes.

DOI: http://doi.org/10.1016/j.molbiopara.2014.07.011
Journal: Mol Biochem Parasitol
E-pub date: 31 Aug 2014
Authors: SJ Tarr, RW Moon, I Hardege, AR Osborne