Dr Hannah ClarkeUniversity positionMRC Research Fellow Dr Hannah Clarke is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Physiology, Development and Neuroscience InstitutesBehavioural and Clinical Neuroscience Institute Home pageResearch ThemesInterestsUnderstanding the neural and neurochemical basis of behaviours mediated by the prefrontal cortex and their relevance to psychiatric disorders.  Dark-field photomicrograph of serotonergic fibres and teminals within the orbital sector of the PFC View image full-size (1240x1567 pixels) Research Focus
EquipmentBehavioural analysis FPLC/HPLC Magnetic resonance imaging (MRI) Neuropsychological testing Positron Emission Tomography (PET) Collaborators
Associated News Items
Key publicationsClarke HF, Horst NK, Roberts AC (2015), “Regional inactivations of primate ventral prefrontal cortex reveal two distinct mechanisms underlying negative bias in decision making” PNAS Clarke HF, Walker SC, Robbins TW, Roberts AC (2007), “Cognitive Inflexibility after Prefrontal Serotonin Depletion is Behaviorally and Neurochemically Specific” Cerebral Cortex 7(1):18-27 Details Clarke HF, Walker SC, Crofts HS, Dalley JW, Robbins TW, Roberts AC (2005), “Prefrontal serotonin depletion affects reversal learning but not attentional set shifting” Journal of Neuroscience 12:532-538 Details Publications2014Clarke HF, Cardinal RN, Rygula R, Hong YT, Fryer TD, Sawiak SJ, Ferrari V, Cockcroft G, Aigbirhio FI, Robbins TW, Roberts AC (2014), “Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.” J Neurosci 34(22):7663-76 Details Rygula R, Clarke HF, Cardinal RN, Cockcroft GJ, Xia J, Dalley JW, Robbins TW, Roberts AC (2014), “Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.” Cereb Cortex Details 2012Agustín-Pavón C, Braesicke K, Shiba Y, Santangelo AM, Mikheenko Y, Cockroft G, Asma F, Clarke H, Man MS, Roberts AC (2012), “Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.” Biol Psychiatry 72(4):266-72 Details 2011Clarke HF, Hill GJ, Robbins TW, Roberts AC (2011), “Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus.” J Neurosci 31(11):4290-7 Details 2010Rygula R, Walker SC, Clarke HF, Robbins TW, Roberts AC (2010), “Differential contributions of the primate ventrolateral prefrontal and orbitofrontal cortex to serial reversal learning.” J Neurosci 30(43):14552-9 Details 2009Man MS, Clarke HF, Roberts AC (2009), “The role of the orbitofrontal cortex and medial striatum in the regulation of prepotent responses to food rewards.” Cereb Cortex 19(4):899-906 Details 2008Clarke HF, Robbins TW, Roberts AC (2008), “Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex.” J Neurosci 28(43):10972-82 Details 2004Clarke HF, Dalley JW, Crofts HS, Robbins TW, Roberts AC (2004), “Cognitive inflexibility after prefrontal serotonin depletion.” Science 304(5672):878-80 Details 2003Guscott MR, Clarke HF, Murray F, Grimwood S, Bristow LJ, Hutson PH (2003), “The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze.” Eur J Pharmacol 476(3):193-9 Details |
