Dr Hannah Clarke

University position

MRC Research Fellow

Dr Hannah Clarke is pleased to consider applications from prospective PhD students.


Department of Physiology, Development and Neuroscience


Behavioural and Clinical Neuroscience Institute

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Research Themes

Cognitive and Behavioural Neuroscience

Cellular and Molecular Neuroscience


Understanding the neural and neurochemical basis of behaviours mediated by the prefrontal cortex and their relevance to psychiatric disorders.

Dark-field photomicrograph of serotonergic fibres and teminals within the orbital sector of the PFC
Dark-field photomicrograph of serotonergic fibres and teminals within the orbital sector of the PFC
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Research Focus



prefrontal cortex



reversal learning

Clinical conditions

Anxiety disorders

Cognitive impairment

Depressive disorders

Obsessive compulsive disorder

Post-traumatic stress disorder




Behavioural analysis


Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)



Anne Ferguson-Smith

Trevor Robbins

Angela Roberts

Associated News Items

Key publications

Clarke HF, Horst NK, Roberts AC (2015), “Regional inactivations of primate ventral prefrontal cortex reveal two distinct mechanisms underlying negative bias in decision making” PNAS

Clarke HF, Walker SC, Robbins TW, Roberts AC (2007), “Cognitive Inflexibility after Prefrontal Serotonin Depletion is Behaviorally and Neurochemically Specific” Cerebral Cortex 7(1):18-27 Details

Clarke HF, Walker SC, Crofts HS, Dalley JW, Robbins TW, Roberts AC (2005), “Prefrontal serotonin depletion affects reversal learning but not attentional set shifting” Journal of Neuroscience 12:532-538 Details



Clarke HF, Cardinal RN, Rygula R, Hong YT, Fryer TD, Sawiak SJ, Ferrari V, Cockcroft G, Aigbirhio FI, Robbins TW, Roberts AC (2014), “Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.” J Neurosci 34(22):7663-76 Details

Rygula R, Clarke HF, Cardinal RN, Cockcroft GJ, Xia J, Dalley JW, Robbins TW, Roberts AC (2014), “Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.” Cereb Cortex Details


Agustín-Pavón C, Braesicke K, Shiba Y, Santangelo AM, Mikheenko Y, Cockroft G, Asma F, Clarke H, Man MS, Roberts AC (2012), “Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.” Biol Psychiatry 72(4):266-72 Details


Clarke HF, Hill GJ, Robbins TW, Roberts AC (2011), “Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus.” J Neurosci 31(11):4290-7 Details


Rygula R, Walker SC, Clarke HF, Robbins TW, Roberts AC (2010), “Differential contributions of the primate ventrolateral prefrontal and orbitofrontal cortex to serial reversal learning.” J Neurosci 30(43):14552-9 Details


Man MS, Clarke HF, Roberts AC (2009), “The role of the orbitofrontal cortex and medial striatum in the regulation of prepotent responses to food rewards.” Cereb Cortex 19(4):899-906 Details


Clarke HF, Robbins TW, Roberts AC (2008), “Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex.” J Neurosci 28(43):10972-82 Details


Clarke HF, Dalley JW, Crofts HS, Robbins TW, Roberts AC (2004), “Cognitive inflexibility after prefrontal serotonin depletion.” Science 304(5672):878-80 Details


Guscott MR, Clarke HF, Murray F, Grimwood S, Bristow LJ, Hutson PH (2003), “The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze.” Eur J Pharmacol 476(3):193-9 Details