Dr Gwyneth ZaiUniversity positionPostdoctoral Fellow DepartmentsInstitutesBehavioural and Clinical Neuroscience Institute Research ThemesInterestsMy research area focuses on the genetics and pharmacogenetics of psychiatric disorders. Almost all psychiatric disorders are complex and heterogeneous in nature and my research aims to identify homogeneous phenotypes, specifically cognitive profiles, in psychiatric disorders, and to examine the genetics of these specific phenotypes. The main disorders that I am interested in include schizophrenia and obsessive-compulsive and related disorders. Through genetics and pharmacogenetics research, my clinical goals are to choose the best therapy for each patient using personalized medicine in order to avoid adverse drug reaction and to maximize drug efficacy. My scientific goals are to link genetic variations to variations in phenotypes, in order to determine mechanisms responsible for that link, and to translate the identified link into enhanced understanding, treatment, and prevention of psychiatry disorders. Research Focus
EquipmentBehavioural analysis Biostatistics Cross-sectional and cohort studies Molecular genetics Neuropsychological testing Collaborators
Associated News ItemsPublications2021Bousman CA, Bengesser SA, Aitchison KJ, Amare AT, Aschauer H, Baune BT, Asl BB, Bishop JR, Burmeister M, Chaumette B, Chen LS, Cordner ZA, Deckert J, Degenhardt F, DeLisi LE, Folkersen L, Kennedy JL, Klein TE, McClay JL, McMahon FJ, Musil R, Saccone NL, Sangkuhl K, Stowe RM, Tan EC, Tiwari AK, Zai CC, Zai G, Zhang J, Gaedigk A, Müller DJ (2021), “Review and consensus on pharmacogenomics testing in psychiatry” Pharmacopsychiatry 54(1):5-17 Burton CL, Lemire M, Xiao B, Corfield EC, Erdman L, Bralten J, Poelmans G, Yu D, Shaheen SM, Goodale T, Sinopoli VM; OCD Working Group of the Psychiatric Genomics Consortium, Soreni N, Hanna GL, Fitzgerald KD, Rosenberg D, Nestadt G, Paterson AD, Strug LJ, Schachar RJ, Corsbie J, Arnold PD (2021), “Genomic-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder” Transl Psychiatry 11(1):91 Zai G (2021), “Pharmacogenetics of obsessive-compulsive disorder: an evidence-update” Curr Top Behav Neurosci 49:385-398 Zai G, Arnold PD, Richter MA, Hanna GI, Rosenberg D, Kennedy JL (2021), “Genetic analyses showing an association of the myelin oligodendrocyte glycoprotein (MOG) gene with white matter volume in pediatric obsessive-compulsive disorder” Psychiatr Res: Neuroimaging 307:111231 2020Cappi C, Oliphant ME, Péter Z, Zai G, do Rosársio MC, Sullivan CAW, Gupta AR, Hoffman EJ, Virdee M, Olfson E, Abdallah SB, Willsey AJ, Shavitt RG, Miguel EC, Kennedy JL, Richter MA, Fernandez TV (2020), “De novo damaging DNA coding mutations are associated with obsessive-compulsive disorder and overlap with Tourette’s disorder and autism” Biol Psychiatry 87(12):1035-1044 Lisoway AJ, Zai CC, Tiwari AK, Nair A, Ebrahimi S, Zai G, Kaminsky ZA, Richter MA, Kennedy JL (2020), “Integrating genetic variation with DNA methylation at SKA2 rs7208505 in analyses of obsessive-compulsive disorder disease risk and symptom severity” Per Med Psychiatry 21-22:100058 Lu, JY, Tiwari AK, Freeman N, Zai GC, Luca V, Müller DJ, Tampakeras M, Herbert D, Emmerson H, Cheema SY, King N, Voineskos AN, Potkin SG, Lieberman JA, Meltzer HY, Remington G, Kennedy JL, Zai CC (2020), “Liver enzyme CYP2D6 gene and tardive dyskinesia” Pharmacogenomics 21(15):1065-1072 Tomasi J, Zai CC, Zai G, Herbert D, King N, Freeman N, Kennedy JL, Tiwari AK (2020), “The effect of polymorphisms in startle-related genes on anxiety symptom severity” J Psychiatr Res 125:144-151 Yilmaz Z, Halvorsen M, Bryois J, Yu D, Thornton LM, Zerwas S, Micali N, Moessner R, Burton CL, Zai G, Erdman L, Kas MJ, Arnold PD, Davis LK, Knowles JA, Breen G, Scharf JM, Nestadt G, Mathews CA, Bulik CM, Mattheisen M, Crowley JJ; Eating Disorders Working Group of the Psychiatric Genomics Consortium, Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium (2020), “Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder” Mol Psychiatry 25(9):2036-2046 2019Cross-Disorder Group of the Psychiatric Genomics Consortium (2019), “Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders” Cell 179(7):1469-1482.e11 Huang E, Hettige N, Zai G, Huang J, Zai CC, Tiwari AK, Müller DJ, Kennedy JL (2019), “Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and clinical response to antipsychotic treatment in schizophrenia and schizo-affective disorder patients: a meta-analysis” Pharmacogenomics 19(3):269-76 Hübel C, Gaspar HA, Coleman JRI, Finucane H, Purves KL, Hanscombe KB, Prokopenko I; MAGIC investigators, Graff M, Ngwa JS, Workalemahu T; Eating Disorders Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium, O’Reilly PF, Bulik CM, Breen G (2019), “Genomics of body fat percentage may contribute to sex bias in anorexia nervosa” Am J Med Genet B Neuropsychiatr Genet 180(6):428-438 Khramtsova EA, Heldman R, Derks EM, Yu D; Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium, Davis LK, Stranger BE (2019), “Sex differences in the genetic architecture of obsessive-compulsive disorder” Am J Med Genet B Neuropsychiatr Genet 180(6):351-364 McNiven V, Mamane S, Zai G, So J (2019), “The nose knows… or does it? Olfactory reference syndrome in patients presenting for assessment of unusual body odour” J Nerv Ment Dis 207(3):145-51 Nurnberger JI Jr, Austin J, Berrettini WH, Besterman AD, DeLisi LE, Grice DE, Kennedy JL, Moreno-De-Luca D, Potash JB, Ross DA, Schulze TG, Zai G (2019), “Dr Nurnberger and Colleagues Reply” J Clin Psychiatry 80(3):pii:19lr12741a Pettersson E, Lichtenstein P, Larsson H, Song J; Attention Deficit/Hyperactivity Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Autism Spectrum Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Bipolar Disorder Working Group of the PGC, Eating Disorder Working Group of the PGC, Major Depressive Disorder Working Group of the PGC, Obsessive Compulsive Disorders and Tourette Syndrome Working Group of the PGC, Schizophrenia CLOZUK, Substance Use Disorder Working Group of the PGC, Agrawal A, Børglum AD, Bulik CM, Daly MJ, Davis LK, Demontis D, Edenberg HJ, Grove J, Gelernter J, Neale BM, Pardiñas AF, Stahl E, Walters JTR, Walters R, Sullivan PF, Posthuma D, Polderman TJC (2019), “Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls” Psychol Med 49(7):1166-1173 Tomasi J, Lisoway AJ, Zai CC, Harripaul R, Müller DJ, Zai GCM, McCabe RE, Richter MA, Kennedy JL, Tiwari AK (2019), “Towards precision medicine in generalized anxiety disorder: review of genetics and pharmaco(epi)genetics” J Psychiatr Res 119:33-47 Zai CC, George J, Cheema SY, Zai GC, Fonseka TM, Danesi M, Shaikh SA, Irwin D, Tampakeras M, Freeman N, Rehm J, Wells S, Kennedy JL (2019), “An examination of genes, stress and suicidal behaviour in two first Nations communities: the role of the brain-derived neurotrophic factor gene” Psychiatry Res 275:247-52 Zai CC, Tiwari AK, Zai GC, Freeman N, Pouget JG, Greco J, Tampakeras M, Shaikh SA, Herbert D, Emmerson H, Cheema SY, Braganza N, Müller DJ, Voineskos AN, Remington G, Kennedy JL (2019), “Association Study of the Complement Component C4 Gene in Tardive Dyskinesia” Front Pharmacol 10:1339 Zai G, Barta C, Cath D, Eapen V, Geller D, Grunblatt E (2019), “New insights and perspectives on the genetics of obsessive-compulsive disorder” Psychiatr Genet 29(5):142-151 2018Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, ..., Zai G, et al. (2018), “Analysis of shared heritability in common disorders of the brain” Science 360(6395):pii:eaap8757 Inkster B, Simmons A, Cole J, Schoof E, Linding R, Nichols T, Muglia P, Holsboer F, Saemann P, McGuffin P, Fu C, Miskowiak K, Matthews PM, Zai G, Nicodemus K (2018), “Unravelling the GSK3?-related genotypic interaction network influencing hippocampal volume in recurrent major depressive disorder” Psychiatr Genet 28(5):77-84 International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS) (2018), “Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis” Mol Psychiatry 23(5):1181-8 Lu JY, Tiwari AK, Zai GC, Rastogi A, Shaikh SA, Müller DJ, Voineskos AN, Potkin SG, Lieberman JA, Meltzer HY, Remington G, Wong AHC, Kennedy JL, Zai CC (2018), “Association study of Disrupted-In-Schizophrenia-1 gene variants and Tardive dyskinesia” Neurosci Lett 686:17-22 Nurnberger Jr JI, Austin J, Berrettini WH, Besterman AD, DeLisi LE, Grice DE, Kennedy JL, Moreno-De-Luca D, Potash JB, Ross DA, Schulze TG, Zai G (2018), “What should a psychiatrist know about genetics? Review and recommendations from the Education Taskforce of the International Society of Psychiatric Genetics” J Clin Psychiatry 80(1):pii:17nr12046 Zai CC, Lee FH, Tiwari AK, Lu JY, de Luca V, Maes MS, Herbert D, Shahmirian A, Cheema SY, Zai GC, Atukuri A, Sherman M, Shaikh SA, Tampakeras M, Freeman N, King N, Müller DJ, Greenbaum L, Lerer B, Voineskos AN, Potkin SG, Lieberman JA, Meltzer HY, Remington G, Kennedy JL (2018), “Investigation of the HSPG2 gene in Tardive dyskinesia - new data and meta-analysis” Front Pharmacol 9:974 Zai CC, Maes MS, Tiwari AK, Zai G, Remington G, Kennedy JL (2018), “Genetics of Tardive dyskinesia: promising leads and ways forward” J Neurol Sci 389:28-34 Zai CC, Manchia M, Zai GC, Woo J, Tiwari AK, de Luca V, Kennedy JL (2018), “Association study of BDNF and DRD3 genes with alcohol use disorder in Schizophrenia” Neurosci Lett 671:1-6 Zai CC, Tiwari AK, Zai GC, de Luca V, Shaikh SA, King N, Strauss J, Kennedy JL, Vincent JB (2018), “Sequence analysis of drug target genes with suicidal behavior in bipolar disorder patients” Mol Neuropsychiatry 4(1):1-6 Zai CC, Tiwari AK, Zai GC, Maes MS, Kennedy JL (2018), “New findings in pharmacogenetics of schizophrenia” Curr Opin Psychiatry 31(3):200-12 Zai G, Inkster B, Lewis G, Miskowiak KW (2018), “GSK3-beta: a plausible mechanism of hippocampal changes induced by erythropoietin treatment in mood disorders” Transl Psychiatry 8(1):216 Zai G, Lisoway AJ, Tiwari AK, Zai CC, Wigg K, Goncalves V, Zhang D, Freeman N, Müller DJ, Kennedy JL, Richter MA (2018), “Pharmacogenetic evaluation of a DISP1 gene variant in antidepressant treatment of obsessive-compulsive disorder” Hum Psychopharmacol 33(4):e2659 2017Shavitt RG, Requena G, Alonso P, Zai G, Costa DLC, de Bragança Pereira CA, do Rosário MC, Morais I, Fontenelle L, Cappi C, Kennedy J, Menchon JM, Miguel E, Richter PMA (2017), “Quantifying dimensional severity of obsessive-compulsive disorder for neurobiological research” Prog Neuropsychopharmacol Biol Psychiatry 79(Pt B):206-12 Weidt S, Brühl AB, Delsignore A, Zai G, Kuenburg A, Klaghofer R, Rufer M (2017), “Trichotillomania: the impact of treatment history on the outcome of an internet-based intervention” Neuropsychiatr Dis Treat 13:1153-62 Zai G, Robbins TW, Sahakian BJ, Kennedy JL (2017), “A review of molecular genetic studies of neurocognitive deficits in schizophrenia” Neurosci Biobehav Rev 72:50-67 2016Bandelow B, Baldwin D, Abelli M, Altamura C, Dell'Osso B, Domschke K, Fineberg NA, Grünblatt E, Jarema M, Maron E, Nutt D, Pini S, Vaghi MM, Wichniak A, Zai G, Riederer P (2016), “Biological markers for anxiety disorders, OCD and PTSD - a consensus statement. Part I: Neuroimaging and genetics” World J Biol Psychiatry 17(5):321-65 Cappi C, Brentani H, Lima L, Sanders SJ, Zai G, Diniz BJ, Reis VN, Hounie AG, Conceição do Rosário M, Mariani D, Requena GL, Puga R, Souza-Duran FL, Shavitt RG, Pauls DL, Miguel EC, Fernandez TV (2016), “Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways” Transl Psychiatry 6:e764 Weidt S, Zai G, Drabe N, Delsignore A, Bruehl AB, Klaghofer R, Rufer M (2016), “Affective regulation in trichotillomania before and after self-help interventions” J Psychiatr Res 75:7-13 Zai G, Alberry B, Arloth J, Bánlaki Z, Bares C, Boot E, Camilo C, Chadha K, Chen Q, Cole CB, Cost KT, Crow M, Ekpor I, Fischer SB, Flatau L, Gagliano S, Kirli U, Kukshal P, Labrie V, Lang M, Lett TA, Maffioletti E, Maier R, Mihaljevic M, Mittal K, Monson ET, O'Brien NL, Østergaard SD, Ovenden E, Patel S, Peterson RE, Pouget JG, Rovaris DL, Seaman L, Shankarappa B, Tsetsos F, Vereczkei A, Wang C, Xulu K, Yuen RK, Zhao J, Zai CC, Kennedy JL (2016), “Rapporteur summaries of plenary, symposia, and oral sessions from the XXIIIrd World Congress of Psychiatric Genetics Meeting in Toronto, Canada, 16-20 October 2015” Psychiatr Genet 26(6):229-57 2015Phillips KA, Zai G, King NA, Menard W, Kennedy JL, Richter MA (2015), “A preliminary candidate gene study in body dysmorphic disorder” J Obsessive Compuls Relat Disord 6:72-6 Zai G, Zai CC, Arnold PD, Freeman N, Burroughs E, Kennedy JL, Richter MA (2015), “Meta-analysis and association of brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder.” Psychiatr Genet 25(2):95-6 Details 2014Lanktree MB, Zai G, Vanderbeek LE, Giuffra DE, Smithson DS, Kipp LB, Dalseg TR, Speechley M, Kennedy JL (2014), “Positive perception of pharmacogenetic testing for psychotropic medications.” Hum Psychopharmacol 29(3):287-91 Details Zai CC, Manchia M, Sønderby IE, Yilmaz Z, De Luca V, Tiwari AK, Squassina A, Zai GC, Shaikh SA, Strauss J, King N, Le Foll B, Kaplan AS, Finseth PI, Vaaler AE, Djurovic S, Andreassen OA, Vincent JB, Kennedy JL (2014), “Investigation of the genetic interaction between BDNF and DRD3 genes in suicidical behaviour in psychiatric disorders.” World J Biol Psychiatry :1-9 Details Zai CC, Zai GC, Tiwari AK, Manchia M, de Luca V, Shaikh SA, Strauss J, Kennedy JL (2014), “Association study of GABRG2 polymorphisms with suicidal behaviour in schizophrenia patients with alcohol use disorder.” Neuropsychobiology 69(3):154-8 Details Zai G, Brandl EJ, Müller DJ, Richter MA, Kennedy JL (2014), “Pharmacogenetics of antidepressant treatment in obsessive-compulsive disorder: an update and implications for clinicians.” Pharmacogenomics 15(8):1147-57 Details 2012Dai N, Foldager L, Gallego JA, Hack LM, Ji Y, Lett TA, Liu BC, Loken EK, Mandelli L, Mehta D, Power RA, Sprooten E, Stephens SH, Paska AV, Yan J, Zai CC, Zai G, Zhang-James Y, O'Shea A, Delisi LE (2012), “Summaries from the XIX World Congress of Psychiatric Genetics, Washington, DC, September 10-14, 2011.” Am J Med Genet B Neuropsychiatr Genet 159B(1):128-9 Details Zai CC, Manchia M, De Luca V, Tiwari AK, Chowdhury NI, Zai GC, Tong RP, Yilmaz Z, Shaikh SA, Strauss J, Kennedy JL (2012), “The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis.” Int J Neuropsychopharmacol 15(8):1037-42 Details Zai G, Sicard T, Burroughs E, Kennedy JL, Richter MA (2012), “An exploration of the oligodendrocyte lineage transcription factor 2 gene and obsessive-compulsive disorder.” Psychiatr Genet 22(3):149 Details Zai GC, Zai CC, Chowdhury NI, Tiwari AK, Souza RP, Lieberman JA, Meltzer HY, Potkin SG, Müller DJ, Kennedy JL (2012), “The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain.” Prog Neuropsychopharmacol Biol Psychiatry 39(1):96-101 Details 2011Zai G, Zai C, Tiwari A, King N, Braithwaite J, van Tol H, Kennedy JL (2011), “Weak association of the platelet-derived growth factor beta (PDGFB) and PDGF receptor beta (PDGFRB) genes with schizophrenia and schizoaffective disorder.” World J Biol Psychiatry 12(2):127-33 Details 2010Zai CC, Manchia M, De Luca V, Tiwari AK, Squassina A, Zai GC, Strauss J, Shaikh SA, Freeman N, Meltzer HY, Lieberman J, Le Foll B, Kennedy JL (2010), “Association study of BDNF and DRD3 genes in schizophrenia diagnosis using matched case-control and family based study designs.” Prog Neuropsychopharmacol Biol Psychiatry 34(8):1412-8 Details 2009Richter MA, Zai G, McBride JC, Mundo E, Swinson RP, Kennedy JL (2009), “The GABA(A)-receptor ?2 (GABRG2) gene in obsessive-compulsive disorder.” Rev Bras Psiquiatr 31(4):328-31 Details Zai CC, Tiwari AK, De Luca V, Müller DJ, Bulgin N, Hwang R, Zai GC, King N, Voineskos AN, Meltzer HY, Lieberman JA, Potkin SG, Remington G, Kennedy JL (2009), “Genetic study of BDNF, DRD3, and their interaction in tardive dyskinesia.” Eur Neuropsychopharmacol 19(5):317-28 Details 2008Voineskos AN, Lang DJ, Zai G, Bulgin N, Shaikh S, Su W, Kopala LC, MacEwan GW, Thornton AE, Smith GN, Austin JC, Honer WG, Kennedy JL (2008), “MAG gene variation and cortical gray matter volume in first episode schizophrenia” Brain Imaging Behav 2(2):117-22 Zai CC, Romano-Silva MA, Hwang R, Zai GC, Deluca V, Müller DJ, King N, Voineskos AN, Meltzer HY, Lieberman JA, Potkin SG, Remington G, Kennedy JL (2008), “Genetic study of eight AKT1 gene polymorphisms and their interaction with DRD2 gene polymorphisms in tardive dyskinesia.” Schizophr Res 106(2-3):248-52 Details 2007Shinkai T, De Luca V, Hwang R, Müller DJ, Lanktree M, Zai G, Shaikh S, Wong G, Sicard T, Potapova N, Trakalo J, King N, Matsumoto C, Hori H, Wong AH, Ohmori O, Macciardi F, Nakamura J, Kennedy JL (2007), “Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia.” Neuromolecular Med 9(2):169-77 Details Zai CC, Hwang RW, De Luca V, Müller DJ, King N, Zai GC, Remington G, Meltzer HY, Lieberman JA, Potkin SG, Kennedy JL (2007), “Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patients.” Int J Neuropsychopharmacol 10(5):639-51 Details Zai G, Mundo E, Strauss J, Wong GW, Kennedy JL (2007), “Brain-derived neurotrophic factor (BDNF) gene not associated with antidepressant-induced mania.” Bipolar Disord 9(5):521-5 Details 2006De Luca V, Zai G, Tharmalingam S, de Bartolomeis A, Wong G, Kennedy JL (2006), “Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia.” Eur Neuropsychopharmacol 16(4):268-71 Details Shinkai T, Müller DJ, De Luca V, Shaikh S, Matsumoto C, Hwang R, King N, Trakalo J, Potapova N, Zai G, Hori H, Ohmori O, Meltzer HY, Nakamura J, Kennedy JL (2006), “Genetic association analysis of the glutathione peroxidase (GPX1) gene polymorphism (Pro197Leu) with tardive dyskinesia.” Psychiatry Res 141(2):123-8 Details Zai G, Arnold PD, Burroughs E, Richter MA, Kennedy JL (2006), “Tumor necrosis factor-alpha gene is not associated with obsessive-compulsive disorder.” Psychiatr Genet 16(1):43-5 Details Zai G, Müller DJ, Volavka J, Czobor P, Lieberman JA, Meltzer HY, Kennedy JL (2006), “Family and case-control association study of the tumor necrosis factor-alpha (TNF-alpha) gene with schizophrenia and response to antipsychotic medication.” Psychopharmacology (Berl) 188(2):171-82 Details 2005Zai G, Arnold P, Burroughs E, Barr CL, Richter MA, Kennedy JL (2005), “Evidence for the gamma-amino-butyric acid type B receptor 1 (GABBR1) gene as a susceptibility factor in obsessive-compulsive disorder.” Am J Med Genet B Neuropsychiatr Genet 134B(1):25-9 Details Zai G, Arnold P, Strauss J, King N, Burroughs E, Richter MA, Kennedy JL (2005), “No association between brain-derived neurotrophic factor gene and obsessive-compulsive disorder.” Psychiatr Genet 15(4):235 Details Zai G, King N, Wigg K, Couto J, Wong GW, Honer WG, Barr CL, Kennedy JL (2005), “Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophrenia.” Genes Brain Behav 4(1):2-9 Details Zai G, King N, Wong GW, Barr CL, Kennedy JL (2005), “Possible association between the gamma-aminobutyric acid type B receptor 1 (GABBR1) gene and schizophrenia.” Eur Neuropsychopharmacol 15(3):347-52 Details 2004Arnold PD, Zai G, Richter MA (2004), “Genetics of anxiety disorders.” Curr Psychiatry Rep 6(4):243-54 Details Shinkai T, De Luca V, Zai G, Shaikh S, Matsumoto C, Arnold PD, Hwang R, King N, Trakalo J, Potapova N, Wong G, Hori H, Wong AH, Ohmori O, Nakamura J, Kennedy JL (2004), “No association between the Pro197Leu polymorphism in the glutathione peroxidase (GPX1) gene and schizophrenia.” Psychiatr Genet 14(3):177-80 Details Zai G, Bezchlibnyk YB, Richter MA, Arnold P, Burroughs E, Barr CL, Kennedy JL (2004), “Myelin oligodendrocyte glycoprotein (MOG) gene is associated with obsessive-compulsive disorder.” Am J Med Genet B Neuropsychiatr Genet 129B(1):64-8 Details 2002Mundo E, Richter MA, Zai G, Sam F, McBride J, Macciardi F, Kennedy JL (2002), “5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study.” Mol Psychiatry 7(7):805-9 Details Wigg K, Zai G, Schachar R, Tannock R, Roberts W, Malone M, Kennedy JL, Barr CL (2002), “Attention deficit hyperactivity disorder and the gene for dopamine Beta-hydroxylase.” Am J Psychiatry 159(6):1046-8 Details 2001Barr CL, Wigg K, Zai G, Roberts W, Malone M, Schachar R, Tannock R, Kennedy JL (2001), “Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C.” Mol Psychiatry 6(3):334-7 Details Barr CL, Xu C, Kroft J, Feng Y, Wigg K, Zai G, Tannock R, Schachar R, Malone M, Roberts W, Nöthen MM, Grünhage F, Vandenbergh DJ, Uhl G, Sunohara G, King N, Kennedy JL (2001), “Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder.” Biol Psychiatry 49(4):333-9 Details Mundo E, Zai G, Lee L, Parikh SV, Kennedy JL (2001), “The 5HT1Dbeta receptor gene in bipolar disorder: a family-based association study.” Neuropsychopharmacology 25(4):608-13 Details 2000Barr CL, Wigg KG, Feng Y, Zai G, Malone M, Roberts W, Schachar R, Tannock R, Kennedy JL (2000), “Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor.” Mol Psychiatry 5(5):548-51 Details |