Dr Ingo Greger

Ingo Greger

University position

Group leader

Dr Ingo Greger is pleased to consider applications from prospective PhD students.


Medical Research Council Laboratory of Molecular Biology



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Research Theme

Cellular and Molecular Neuroscience


Information transfer in the brain occurs at synapses where chemical transmitters are released from presynaptic terminals and are received by postsynaptic receptors. Glutamate is a major neurotransmitter and glutamate receptors are key to synaptic transmission and plasticity. Our research focuses on these receptors, in particular on the AMPA-type (AMPAR).

AMPARs are the first to respond to glutamate and initiate synaptic signaling by depolarizing the postsynaptic membrane. AMPARs are unique as their rapid kinetics permit faithful decoding of high-frequency nerve impulses. Moreover, AMPAR are mobile and their trafficking is a major determinant of synaptic plasticity.

Our ultimate aim is to understand how regulation of these receptors underlies learning and information storage at synapses. Towards this goal we are utilizing a variety of experimental approaches at different levels of complexity, ranging from the atomic structure of the receptor to its operation in neural networks.

Research Focus


AMPA receptor


RNA editing

synaptic plasticity

ligand design

Clinical conditions


Alzheimer's disease

Autoimmune diseases




cryo electron microscopy (cryo-EM)

Electrophysiological recording techniques

Field potential recording

Fluorescence microscopy

Molecular biology

Protein purification

superresolution microscopy

Whole cell patch clamp

X-ray crystallography



Ole Paulsen

United Kingdom

A. Radu Aricescu Web: https://www.strubi.ox.ac.uk/researc...

Stuart Cull-Candy Web: http://www.ucl.ac.uk/npp/res...

Jernej Ule Web: http://ulelab.info/


Ivet Bahar Web: http://www.ccbb.pitt.edu/Faculty...

Terunaga Nakagawa Web: http://www.mc.vanderbilt.edu/root/vu...

Associated News Items

Key publications

Herguedas B, Garcia-Nafria J, Cais O, Fernandez-Leiro R, Krieger J, Ho Ho, Greger IH. (2016), “Structure and organization of heteromeric AMPA-type glutamate receptors” Science doi: 10.1126/Science.aad3873



Buonarati OR, Hammes EA, Watson JF, Greger IH, Hell JW. (2019), “Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation.” Sci Signal. eaar6889

Herguedas B, Watson JF, Ho H, Cais O, García-Nafría J, Greger IH. (2019), “Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP ?8.” Science eaav9011

Lee JY, Krieger J, Herguedas B, García-Nafría J, Dutta A, Shaikh SA, Greger IH, Bahar I. (2019), “Druggability Simulations and X-Ray Crystallography Reveal a Ligand-Binding Site in the GluA3 AMPA Receptor N-Terminal Domain.” Structure 27


Davies B et al (2017), “A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.” Hum Mol Genet 26

Greger IH, Watson JF, Cull-Candy S (2017), “Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins” Neuron 94:713-730

Watson JF, Ho H, Greger IH (2017), “Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain” eLife


Dutta A, Krieger J, Lee JY, Garcia-Nafria J, Greger IH, Bahar I (2015), “Cooperative Dynamics of Intact AMPA and NMDA Glutamate Receptors: Similarities and Subfamily-Specific Differences” Structure

in press

Garcia-Nafria J, Hergueda B, Watson J, Greger IH (in press), “Structural dynamics of synaptic AMPA receptors” J. Physiol.


Krieger J, Bahar I, Greger IH (2015), “Structure, Dynamics, and Allosteric Potential of Ionotropic Glutamate Receptor N-Terminal Domains” Biophys. J


Cais O, Herguedas B, Krol K, Cull-Candy SG, Farrant M, Greger IH (2014), “Mapping the interaction sites between AMPA receptors and TARPs reveals a role for the receptor N-terminal domain in channel gating” Cell Reports 9, 728-40. PDF

Shanks NF, Cais O, Maruo T, Savas JN, Zaika EI, Azumaya CM, Yates JR 3rd, Greger I, Nakagawa T (2014), “Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3.” J Neurosci 34(36):12104-20 Details


Balik A, Penn AC, Nemoda Z, Greger IH (2013), “Activity-regulated RNA editing in select neuronal subfields in hippocampus.” Nucleic Acids Res 41(2):1124-34 Details

Herguedas B, Krieger J, Greger IH (2013), “Receptor heteromeric assembly-how it works and why it matters: the case of ionotropic glutamate receptors.” Prog Mol Biol Transl Sci 117:361-86 PDF Details

Penn AC, Balik A, Greger IH (2013), “Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system.” Front Neurosci 7:61 Details

Penn AC, Balik A, Greger IH (2013), “Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing.” Nucleic Acids Res 41(2):1113-23 Details


Dutta A, Shrivastava IH, Sukumaran M, Greger IH, Bahar I (2012), “Comparative dynamics of NMDA- and AMPA-glutamate receptor N-terminal domains.” Structure 20(11):1838-49 Details

Penn AC, Balik A, Wozny C, Cais O, Greger IH (2012), “Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain.” Neuron 76(3):503-10 Details

Shanks NF, Savas JN, Maruo T, Cais O, Hirao A, Oe S, Ghosh A, Noda Y, Greger IH, Yates JR 3rd, Nakagawa T (2012), “Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L.” Cell Rep 1(6):590-8 Details

Sukumaran M, Penn AC, Greger IH (2012), “AMPA receptor assembly: atomic determinants and built-in modulators.” Adv Exp Med Biol 970:241-64 PDF Details


Jensen MH, Sukumaran M, Johnson CM, Greger IH, Neuweiler H (2011), “Intrinsic motions in the N-terminal domain of an ionotropic glutamate receptor detected by fluorescence correlation spectroscopy.” J Mol Biol 414(1):96-105 Details

Rossmann M, Sukumaran M, Penn AC, Veprintsev DB, Babu MM, Greger IH (2011), “Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers.” EMBO J 30(5):959-71 Details

Sukumaran M, Rossmann M, Shrivastava I, Dutta A, Bahar I, Greger IH (2011), “Dynamics and allosteric potential of the AMPA receptor N-terminal domain.” EMBO J 30(5):972-82 Details


Penn AC, Greger IH (2009), “Sculpting AMPA receptor formation and function by alternative RNA processing.” RNA Biol 6(5):517-21 PDF Details


Penn AC, Williams SR, Greger IH (2008), “Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum.” EMBO J 27(22):3056-68 Details


Greger IH, Esteban JA (2007), “AMPA receptor biogenesis and trafficking.” Curr Opin Neurobiol 17(3):289-97 Details

Greger IH, Ziff EB, Penn AC (2007), “Molecular determinants of AMPA receptor subunit assembly.” Trends Neurosci 30(8):407-16 PDF Details


Greger IH, Akamine P, Khatri L, Ziff EB (2006), “Developmentally regulated, combinatorial RNA processing modulates AMPA receptor biogenesis.” Neuron 51(1):85-97 Details


Greger IH, Khatri L, Kong X, Ziff EB (2003), “AMPA receptor tetramerization is mediated by Q/R editing” Neuron 40:763-774

Greger IH, Khatri L, Kong X, Ziff EB (2003), “AMPA receptor tetramerization is mediated by Q/R editing.” Neuron 40(4):763-74 Details


Greger IH, Khatri L, Ziff EB (2002), “RNA editing at Arg607 controls AMPA receptor exit from the endoplasmic reticulum” Neuron 34:759-772