Dr Geoffrey Cook University positionAffiliated Lecturer DepartmentsDepartment of Physiology, Development and Neuroscience Home pageResearch ThemesInterestsMy research concerns the mechanisms controlling axon growth. In the laboratory we are investigating two axon-repulsive systems, 1) the characterization of somite glycoproteins that repel axons, creating the segmented pattern of spinal nerves during development and 2) a repulsive glycoprotein in the grey matter of the adult brain that may contribute to CNS regenerative failure. Research Focus
EquipmentProtein purification and characterization Collaborators
Associated News ItemsKey publicationsManns RP, Cook GM, Holt CE, Keynes RJ (2012), “Differing semaphorin 3A concentrations trigger distinct signaling mechanisms in growth cone collapse.” J Neurosci 32(25):8554-9 Details Keynes R, Tannahill D, Morgenstern DA, Johnson AR, Cook GM, Pini A (1997), “Surround repulsion of spinal sensory axons in higher vertebrate embryos.” Neuron 18(6):889-97 Details Davies JA, Cook GM, Stern CD, Keynes RJ (1990), “Isolation from chick somites of a glycoprotein fraction that causes collapse of dorsal root ganglion growth cones.” Neuron 4(1):11-20 Details Publications2014Manns R, Schmandke A, Schmandke A, Jareonsettasin P, Cook G, Schwab ME, Holt C, Keynes R (2014), “Protein synthesis dependence of growth cone collapse induced by different nogo-a-domains.” PLoS One 9(1):e86820 Details 2006Cook,G Fawcett,J Keynes R Tessier-Laigne M (2006), “The Regenerating Brain” Phil Trans B 361 pp1459-1671 2004Kuan CY, Tannahill D, Cook GM, Keynes RJ (2004), “Somite polarity and segmental patterning of the peripheral nervous system.” Mech Dev 121(9):1055-68 Details 2000Tannahill D, Britto JM, Vermeren MM, Ohta K, Cook GM, Keynes RJ (2000), “Orienting axon growth: spinal nerve segmentation and surround-repulsion.” Int J Dev Biol 44(1):119-27 Details Vermeren MM, Cook GM, Johnson AR, Keynes RJ, Tannahill D (2000), “Spinal nerve segmentation in the chick embryo: analysis of distinct axon-repulsive systems.” Dev Biol 225(1):241-52 Details 1999Ohta K, Tannahill D, Yoshida K, Johnson AR, Cook GM, Keynes RJ (1999), “Embryonic lens repels retinal ganglion cell axons.” Dev Biol 211(1):124-32 Details 1998Tannahill D, Cook GMW, Keynes RJ (1998), “Axon guidance and somites” Cell Tissue Res 291(2):363 Details 1997Tannahill D, Cook GM, Keynes RJ (1997), “Axon guidance and somites.” Cell Tissue Res 290(2):275-83 Details 1996Keynes R, Cook GM (1996), “Axons turn as netrins find their receptor.” Neuron 17(6):1031-4 Details 1995Cook GM (1995), “Glycobiology of the cell surface: the emergence of sugars as an important feature of the cell periphery.” Glycobiology 5(5):449-58 Details Keynes R, Cook GM (1995), “Axon guidance molecules.” Cell 83(2):161-9 Details 1994Cook GM (1994), “Recognising the attraction of sugars at the cell surface.” Bioessays 16(4):287-95 Details 1992Keynes RJ, Cook GM (1992), “Contact inhibition of growth-cone motility during peripheral nerve segmentation.” Biochem Soc Trans 20(2):399-401 Details Keynes RJ, Cook GM (1992), “Repellent cues in axon guidance.” Curr Opin Neurobiol 2(1):55-9 Details McClure MO, Moore JP, Blanc DF, Scotting P, Cook GM, Keynes RJ, Weber JN, Davies D, Weiss RA (1992), “Investigations into the mechanism by which sulfated polysaccharides inhibit HIV infection in vitro.” AIDS Res Hum Retroviruses 8(1):19-26 Details 1991Davies JA, Cook GM (1991), “Growth cone inhibition--an important mechanism in neural development?” Bioessays 13(1):11-5 Details Keynes RJ, Jaques KF, Cook GM (1991), “Axon repulsion during peripheral nerve segmentation.” Development Suppl 2:131-9 Details Keynes RJ, Johnson AR, Picart CJ, Dunin-Borkowski OM, Cook GM (1991), “A growth cone collapsing activity in chicken gray matter.” Ann N Y Acad Sci 633:562 Details 1990Cook GM, Buckie JW (1990), “Lectin-mediated isolation of cell surface glycoproteins.” Methods Enzymol 184:304-14 Details Keynes R, Cook G (1990), “Cell-cell repulsion: clues from the growth cone?” Cell 62(4):609-10 Details Keynes R, Cook G, Davies J, Lumsden A, Norris W, Stern C (1990), “Segmentation and the development of the vertebrate nervous system.” J Physiol (Paris) 84(1):27-32 Details 1988Buckie JW, Cook GM (1988), “Use of biotinylated lectins and immobilized streptavidin for the specific isolation of surface glycoconjugates.” Prog Clin Biol Res 270:243-5 Details 1986Buckie JW, Cook GM (1986), “Specific isolation of surface glycoproteins from intact cells by biotinylated concanavalin A and immobilized streptavidin.” Anal Biochem 156(2):463-72 Details Cook GM (1986), “Cell surface carbohydrates: molecules in search of a function?” J Cell Sci Suppl 4:45-70 Details 1985Cook GM, Bellairs R, Rutherford NG, Stafford CA, Alderson T (1985), “Isolation, characterization and localization of a lectin within the vitelline membrane of the hen's egg.” J Embryol Exp Morphol 90:389-407 Details 1984Rutherford NG, Cook GM (1984), “Endogenous lectins of the developing chick embryo.” Prog Clin Biol Res 151:129-46 Details |