Dr Gonca Bayraktar University positionResearch Associate DepartmentsDepartment of Clinical Neurosciences InstitutesUK Dementia Research Institute at University of Cambridge Home pagehttps://ukdri.ac.uk/team/gi... Research ThemesInterestsMy research aims to understand how synaptic plasticity governs learning and memory function of the brain and how gradual loss of function or impairment leads to neurodegeneration. treatment of dementia like Alzheimer’s disease. My research focuses on the study of neurodegeneration from various aspects 1) at the level of transcription in relation to epigenetic mechanisms and chromatin biology (studies with ATAC-seq, Split-seq single-nucleotide transcriptomics) and 2) at the level of protein translation through elongation control. Protein translation and signalling mechanisms regulating different stages of protein translation are known to be implicated in diseases of synaptic degeneration. The key proteins controlling the translation elongation are eEF2 and its kinase eEF2K. We modulate the eEF2/eEF2K pathway, known to be impaired in neurodegeneration, in vitro and in vivo studies to find the basis for an early possible intervention in early neurodegeneration. Research Focus
EquipmentBehavioural analysis Cell culture Confocal microscopy Fluorescence microscopy gene expression assays, qPCR, protein immunoblotting, ex vivo tissue treatment Immunohistochemistry Microscopy Protein purification Recombinant protein expression Collaborators
Associated News ItemsKey publicationsGonca Bayraktar, PingAn Yuanxiang, Alessandro D. Confettura, Guilherme M. Gomes, Syed A. Raza, Oliver Stork, Shoji Tajima, Isao Suetake, Anna Karpova, Ferah Yildirim, Michael R. Kreutz (in press), “Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus” Neuropsychopharmacology Publications2018Bayraktar G, Kreutz MR (2018), “Neuronal DNA methyltransferases: epigenetic mediators between synaptic activity and gene expression?” The Neuroscientist 24(2): 171-185 Bayraktar G, Kreutz MR (2018), “The role of activity-dependent DNA demethylation in the adult brain and in neurological disorders” Frontiers in molecular neuroscience 11(169) 2016Spilker C, Nullmeier S, Grochowska KM, Schumacher A, Butnaru I, Macharadze T, Gomes GM, Yuanxiang P, Bayraktar G, Rodenstein C, Geiseler C, Kolodziej A, Lopez-Rojas J, Montag D, Angenstein F, Bär J, D'Hanis W, Roskoden T, Mikhaylova M, Budinger E, Ohl FW, Stork O, Zenclussen AC, Karpova A, Schwegler H, Kreutz MR (2016), “A Jacob/Nsmf gene knockout results in hippocampal dysplasia and impaired BDNF signaling in dendritogenesis” PLoS genetics 12(3) 2012Wegenast-Braun BM, Skodras A, Bayraktar G, Mahler J, Fritschi SK, Klingstedt T, Mason JJ, Hammarström P, Nilsson KPR, Liebig C, Jucker M (2012), “Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes” The American journal of pathology 181(6): 1953-1960 |