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Research Focus

Keywords

  • Diffusion MRI
  • MRI
  • MRI Methods
  • fMRI Significance
  • Clinical Conditions

  • Alzheimer's disease
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Computational modelling
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    Professor Guy Williams

    University Position
    Professor
    Professor Guy Williams is pleased to consider applications from prospective PhD students.

    Interests

    Our group's research interests lie broadly in nuclear magnetic resonance (NMR). This phenomenon allows data to be collected noninvasively on both the structure and function of the human brain. We research novel acquisition methods to provide contrasts relevant for neuroscience. As a group embedded in the WBIC, the common theme is to translate basic physics research into relevant tools for a range of neuroscience investigations. For example, we are developing and optimising pulse sequences for inferring the diffusion characteristics in the brain. These provide a useful tool for assessing tissue following head trauma and for dementia projects. We also have interests in novel MR acquisitions applied to psychology research areas such as learning and behaviour. Of equal importance is the subsequent processing and analysis of the acquired datasets, including machine learning approaches.

    Key Publications

    Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1007/s00415-022-11061-7
    Journal: J Neurol
    E-pub date: 31 Aug 2022
    Authors: M-E Dounavi, C Newton, N Jenkins, E Mak, A Low, G Muniz-Terrera, GB Williams, B Lawlor, L Naci, P Malhotra, CE Mackay, I Koychev, K Ritchie, CW Ritchie, L Su, JT O'Brien

    Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation.

    DOI: http://doi.org/10.1073/pnas.2026289118
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 27 Jul 2021
    Authors: LRB Spindler, AI Luppi, RM Adapa, MM Craig, P Coppola, ARD Peattie, AE Manktelow, P Finoia, BJ Sahakian, GB Williams, J Allanson, JD Pickard, DK Menon, EA Stamatakis

    A protocol for ultra-high field laminar fMRI in the human brain.

    DOI: http://doi.org/10.1016/j.xpro.2021.100415
    Journal: STAR Protoc
    E-pub date: 18 Jun 2021
    Authors: K Jia, E Zamboni, C Rua, NR Goncalves, V Kemper, AKT Ng, CT Rodgers, G Williams, R Goebel, Z Kourtzi

    Neuroanatomical Substrates and Symptoms Associated With Magnetic Resonance Imaging of Patients With Mild Traumatic Brain Injury.

    DOI: http://doi.org/10.1001/jamanetworkopen.2021.0994
    Journal: JAMA Netw Open
    E-pub date: 1 Mar 2021
    Authors: S Richter, S Winzeck, EN Kornaropoulos, T Das, T Vande Vyvere, J Verheyden, GB Williams, MM Correia, DK Menon, VFJ Newcombe, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Magnetic Resonance Imaging (CENTER-TBI MRI) Substudy Participants and Investigators

    Recurrent Processing Drives Perceptual Plasticity.

    DOI: http://doi.org/10.1016/j.cub.2020.08.016
    Journal: Curr Biol
    E-pub date: 2 Nov 2020
    Authors: K Jia, E Zamboni, V Kemper, C Rua, NR Goncalves, AKT Ng, CT Rodgers, G Williams, R Goebel, Z Kourtzi

    Multi-centre, multi-vendor reproducibility of 7T QSM and R2* in the human brain: results from the UK7T study

    DOI: http://doi.org/10.1101/2020.04.22.055624
    Journal:
    E-pub date: 1 Aug 2020
    Authors: C Rua, W Clarke, I Driver, O Mougin, A Morgan, S Clare, S Francis, K Muir, R Wise, A Carpenter, G Williams, J Rowe, R Bowtell, C Rodgers

    Incidence and mechanisms of cerebral ischemia in early clinical head injury.

    DOI: http://doi.org/10.1097/01.WCB.0000103022.98348.24
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Feb 2004
    Authors: JP Coles, TD Fryer, P Smielewski, DA Chatfield, LA Steiner, AJ Johnston, SPMJ Downey, GB Williams, F Aigbirhio, PJ Hutchinson, K Rice, TA Carpenter, JC Clark, JD Pickard, DK Menon

    Publications

    A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition

    DOI: http://doi.org/10.7554/elife.88173.1
    Journal:
    E-pub date: 25 Jul 2023
    Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, RL Carhart-Harris, GB Williams, MM Craig, P Finoia, AM Owen, L Naci, DK Menon, D Bor, EA Stamatakis

    A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition

    DOI: http://doi.org/10.7554/elife.88173
    Journal:
    E-pub date: 25 Jul 2023
    Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, RL Carhart-Harris, GB Williams, MM Craig, P Finoia, AM Owen, L Naci, DK Menon, D Bor, EA Stamatakis

    Use of Support Vector Machines Approach via ComBat Harmonized Diffusion Tensor Imaging for the Diagnosis and Prognosis of Mild Traumatic Brain Injury: A CENTER-TBI Study.

    DOI: http://doi.org/10.1089/neu.2022.0365
    Journal: J Neurotrauma
    E-pub date: 1 Jul 2023
    Authors: M Siqueira Pinto, S Winzeck, EN Kornaropoulos, S Richter, R Paolella, MM Correia, B Glocker, G Williams, A Vik, JP Posti, A Haberg, J Stenberg, P-J Guns, AJ den Dekker, DK Menon, J Sijbers, P Van Dyck, VFJ Newcombe

    Do Regions of Increased Inflammation Progress to New White Matter Hyperintensities?: A Longitudinal Positron Emission Tomography-Magnetic Resonance Imaging Study.

    DOI: http://doi.org/10.1161/STROKEAHA.122.039517
    Journal: Stroke
    E-pub date: 1 Feb 2023
    Authors: DJ Tozer, RB Brown, J Walsh, YT Hong, GB Williams, JT O'Brien, FI Aigbirhio, TD Fryer, HS Markus

    Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

    DOI: http://doi.org/10.1038/s42003-023-04474-1
    Journal: Commun Biol
    E-pub date: 28 Jan 2023
    Authors: AI Luppi, J Vohryzek, ML Kringelbach, PAM Mediano, MM Craig, R Adapa, RL Carhart-Harris, L Roseman, I Pappas, ARD Peattie, AE Manktelow, BJ Sahakian, P Finoia, GB Williams, J Allanson, JD Pickard, DK Menon, S Atasoy, EA Stamatakis

    The complexity of the stream of consciousness.

    DOI: http://doi.org/10.1038/s42003-022-04109-x
    Journal: Commun Biol
    E-pub date: 3 Nov 2022
    Authors: P Coppola, J Allanson, L Naci, R Adapa, P Finoia, GB Williams, JD Pickard, AM Owen, DK Menon, EA Stamatakis

    Reduced emergent character of neural dynamics in patients with a disrupted connectome

    DOI: http://doi.org/10.1101/2022.06.16.496445
    Journal:
    E-pub date: 1 Aug 2022
    Authors: A Luppi, PAM Mediano, F Rosas, J Allanson, J Pickard, G Williams, M Craig, P Finoia, ARD Peattie, P Coppola, D Menon, D Bor, E Stamatakis

    Network dynamics scale with levels of awareness.

    DOI: http://doi.org/10.1016/j.neuroimage.2022.119128
    Journal: Neuroimage
    E-pub date: 1 Jul 2022
    Authors: P Coppola, LRB Spindler, AI Luppi, R Adapa, L Naci, J Allanson, P Finoia, GB Williams, JD Pickard, AM Owen, DK Menon, EA Stamatakis

    Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness.

    DOI: http://doi.org/10.1038/s42003-022-03330-y
    Journal: Commun Biol
    E-pub date: 20 Apr 2022
    Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, GB Williams, MM Craig, P Finoia, ARD Peattie, P Coppola, AM Owen, L Naci, DK Menon, D Bor, EA Stamatakis

    Paths to Oblivion: Common Neural Mechanisms of Anaesthesia and Disorders of Consciousness

    DOI: http://doi.org/10.1101/2021.02.14.431140
    Journal:
    E-pub date: 1 Aug 2021
    Authors: A Luppi, PAM Mediano, F Rosas, J Allanson, J Pickard, G Williams, M Craig, P Finoia, ARD Peattie, P Coppola, A Owen, L Naci, D Menon, D Bor, E Stamatakis

    Network dynamics scale with levels of awareness

    DOI: http://doi.org/10.1101/2021.04.12.439452
    Journal:
    E-pub date: 1 Aug 2021
    Authors: P Coppola, LRB Spindler, A Luppi, R Adapa, L Naci, J Allanson, P Finoia, G Williams, J Pickard, A Owen, D Menon, E Stamatakis

    Preserved fractal character of structural brain networks is associated with covert consciousness after severe brain injury.

    DOI: http://doi.org/10.1016/j.nicl.2021.102682
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2021
    Authors: AI Luppi, MM Craig, P Coppola, ARD Peattie, P Finoia, GB Williams, J Allanson, JD Pickard, DK Menon, EA Stamatakis

    Substantia nigra ferric overload and neuromelanin loss in Parkinson’s disease measured with 7T MRI

    DOI: http://doi.org/10.1101/2021.04.13.21255416
    Journal:
    E-pub date: 1 Aug 2021
    Authors: C Rua, C O’Callaghan, R Ye, F Hezemans, L Passamonti, S Jones, G Williams, C Rodgers, J Rowe

    Resting-state based prediction of task-related activation in patients with disorders of consciousness

    DOI: http://doi.org/10.1101/2021.03.27.436534
    Journal:
    E-pub date: 1 Aug 2021
    Authors: M Craig, I Pappas, J Allanson, P Finoia, G Williams, J Pickard, D Menon, E Stamatakis

    Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction.

    DOI: http://doi.org/10.1016/j.biopsych.2020.12.009
    Journal: Biol Psychiatry
    E-pub date: 15 May 2021
    Authors: KD Ersche, TV Lim, AG Murley, C Rua, MM Vaghi, TL White, GB Williams, TW Robbins

    In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2021.01.016
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Holland, PS Jones, G Savulich, A Low, M Malpetti, SS Kaalund, L Passamonti, T Rittman, R Romero-Garcia, R Manavaki, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study.

    DOI: http://doi.org/10.1016/j.neuroimage.2021.117749
    Journal: Neuroimage
    E-pub date: 1 Apr 2021
    Authors: E Mak, M-E Dounavi, A Low, SF Carter, E McKiernan, GB Williams, PS Jones, I Carriere, GT Muniz, K Ritchie, C Ritchie, L Su, JT O'Brien

    An in vivo probabilistic atlas of the human locus coeruleus at ultra-high field.

    DOI: http://doi.org/10.1016/j.neuroimage.2020.117487
    Journal: Neuroimage
    E-pub date: 15 Jan 2021
    Authors: R Ye, C Rua, C O'Callaghan, PS Jones, FH Hezemans, SS Kaalund, KA Tsvetanov, CT Rodgers, G Williams, L Passamonti, JB Rowe

    Gray matter changes related to microglial activation in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.06.010
    Journal: Neurobiol Aging
    E-pub date: 1 Oct 2020
    Authors: N Nicastro, M Malpetti, E Mak, GB Williams, WR Bevan-Jones, SF Carter, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

    Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

    DOI: http://doi.org/10.1101/2020.08.10.244459
    Journal:
    E-pub date: 1 Aug 2020
    Authors: A Luppi, J Vohryzek, M Kringelbach, PAM Mediano, M Craig, R Adapa, R Carhart-Harris, L Roseman, I Pappas, ARD Peattie, A Manktelow, B Sahakian, P Finoia, G Williams, J Allanson, J Pickard, D Menon, S Atasoy, E Stamatakis

    A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition

    DOI: http://doi.org/10.1101/2020.11.25.398081
    Journal:
    E-pub date: 1 Aug 2020
    Authors: A Luppi, PAM Mediano, F Rosas, J Allanson, J Pickard, R Carhart-Harris, G Williams, M Craig, P Finoia, A Owen, L Naci, D Menon, D Bor, E Stamatakis

    Recurrent processing drives experience-dependent plasticity for perceptual decisions

    DOI: http://doi.org/10.1101/2020.04.07.030510
    Journal:
    E-pub date: 1 Aug 2020
    Authors: K Jia, E Zamboni, V Kemper, C Rua, N Reis Goncalves, AKT Ng, C Rodgers, G Williams, R Goebel, Z Kourtzi

    Fractal dimension of cortical functional connectivity networks & severity of disorders of consciousness.

    DOI: http://doi.org/10.1371/journal.pone.0223812
    Journal: PLoS One
    E-pub date: 1 Aug 2020
    Authors: TF Varley, M Craig, R Adapa, P Finoia, G Williams, J Allanson, J Pickard, DK Menon, EA Stamatakis

    Brain networks underlying vulnerability and resilience to drug addiction.

    DOI: http://doi.org/10.1073/pnas.2002509117
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 30 Jun 2020
    Authors: KD Ersche, C Meng, H Ziauddeen, J Stochl, GB Williams, ET Bullmore, TW Robbins

    Consciousness-specific dynamic interactions of brain integration and functional diversity.

    DOI: http://doi.org/10.1038/s41467-019-12658-9
    Journal: Nat Commun
    E-pub date: 10 Oct 2019
    Authors: AI Luppi, MM Craig, I Pappas, P Finoia, GB Williams, J Allanson, JD Pickard, AM Owen, L Naci, DK Menon, EA Stamatakis

    Fractal Dimension of Cortical Functional Connectivity Networks Predicts Severity in Disorders of Consciousness

    DOI: http://doi.org/10.1101/789636
    Journal:
    E-pub date: 1 Aug 2019
    Authors: TF Varley, M Craig, R Adapa, P Finoia, G Williams, J Alanson, J Pickard, DK Menon, EA Stamatakis

    In vivo coupling of tau pathology and cortical thinning in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.dadm.2018.08.005
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Aug 2018
    Authors: E Mak, RAI Bethlehem, R Romero-Garcia, S Cervenka, T Rittman, S Gabel, A Surendranathan, RW Bevan-Jones, L Passamonti, P Vázquez Rodríguez, L Su, R Arnold, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    Disrupted iron regulation in the brain and periphery in cocaine addiction.

    DOI: http://doi.org/10.1038/tp.2016.271
    Journal: Transl Psychiatry
    E-pub date: 21 Feb 2017
    Authors: KD Ersche, J Acosta-Cabronero, PS Jones, H Ziauddeen, RPL van Swelm, CMM Laarakkers, R Raha-Chowdhury, GB Williams

    Carrots and sticks fail to change behavior in cocaine addiction.

    DOI: http://doi.org/10.1126/science.aaf3700
    Journal: Science
    E-pub date: 17 Jun 2016
    Authors: KD Ersche, CM Gillan, PS Jones, GB Williams, LHE Ward, M Luijten, S de Wit, BJ Sahakian, ET Bullmore, TW Robbins

    Dynamic Changes in White Matter Abnormalities Correlate With Late Improvement and Deterioration Following TBI: A Diffusion Tensor Imaging Study.

    DOI: http://doi.org/10.1177/1545968315584004
    Journal: Neurorehabil Neural Repair
    E-pub date: 1 Jan 2016
    Authors: VFJ Newcombe, MM Correia, C Ledig, MG Abate, JG Outtrim, D Chatfield, T Geeraerts, AE Manktelow, E Garyfallidis, JD Pickard, BJ Sahakian, PJA Hutchinson, D Rueckert, JP Coles, GB Williams, DK Menon

    Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study.

    DOI: http://doi.org/10.1227/NEU.0000000000000575
    Journal: Neurosurgery
    E-pub date: 1 Jan 2015
    Authors: AIR Maas, DK Menon, EW Steyerberg, G Citerio, F Lecky, GT Manley, S Hill, V Legrand, A Sorgner, CENTER-TBI Participants and Investigators

    Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging.

    DOI: http://doi.org/10.1038/jcbfm.2013.11
    Journal: Journal of Cerebral Blood Flow and Metabolism
    E-pub date: 1 Jun 2013
    Authors: VFJ Newcombe, GB Williams, JG Outtrim, D Chatfield, M Gulia Abate, T Geeraerts, A Manktelow, H Room, L Mariappen, PJ Hutchinson, JP Coles, DK Menon

    Abnormal brain structure implicated in stimulant drug addiction.

    DOI: http://doi.org/10.1126/science.1214463
    Journal: Science
    E-pub date: 3 Feb 2012
    Authors: KD Ersche, PS Jones, GB Williams, AJ Turton, TW Robbins, ET Bullmore

    White matter changes and word finding failures with increasing age.

    DOI: http://doi.org/10.1371/journal.pone.0014496
    Journal: PLoS One
    E-pub date: 7 Jan 2011
    Authors: EA Stamatakis, MA Shafto, G Williams, P Tam, LK Tyler