Dr Gabriel Balmus

University position

Group Leader

Dr Gabriel Balmus is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

UK Dementia Research Institute at University of Cambridge

Home page

http://balmuslab.org (personal home page)

Research Themes

Cellular and Molecular Neuroscience

Developmental Neuroscience

Interests

My lab is interested in understanding the roles of DNA Damage Repair (DDR) in mature neurons and its links to neurodegenerative disorders (including Alzheimer's and related diseases) and ageing. We are using a variety of tools including CRISPR-Cas9 screens in mature neurons as well as mouse models of disease. While maintenance of genome stability is important for all cells and has been implicated in an array of pathologies, it is critical for the terminally differentiated neuron that has no other way of protecting its genetic material but through repair. As such, the bulk of DDR syndromes present neurological features and loss of DDR pathway regulation is one of the first events in the ageing brain. In my lab we are interested in understanding the mechanisms by which neurons deal with endogenous genotoxic stresses, their contribution to progression of neurodegeneration and ageing, and how to harness this knowledge to inform on key nodes that can be targeted to confer protection.

Research Focus

Keywords

neurodegeneration

DNA-damage

aging

CRISPR-Cas9

cell cycle

Clinical conditions

Aging

Alzheimer's disease

Cerebellar ataxias

Dementia

Genetic disorders

Huntington's disease

Parkinson's disease

Equipment

Using an array of equipment and techniques including CRISPR-Cas9

Collaborators

No collaborators listed

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