Ms Francesca van Tartwijk

University position

PhD student
Supervised by Professor Clemens Kaminski

Departments

Department of Chemical Engineering and Biotechnology

Research Themes

Cellular and Molecular Neuroscience

Developmental Neuroscience

Interests

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease, characterised by the death of motor neurons. Though the causes of ALS are unknown, mutations in several genes have been linked to ALS, including in that encoding the protein ‘Fused in sarcoma’ (FUS). FUS cycles between different phases, the balance between which is disturbed in disease through unknown mechanisms. Perturbation of FUS phase transition is known to influence global local protein synthesis (LPS) in axon termini. My aim is to characterise FUS phase transitions and correlate them with changes in local synthesis of specific proteins, and eventually in cellular phenotype. Novel imaging techniques and protocols will be developed and used for this purpose. Xenopus retinal ganglion cells will be used as a relevant neuronal model system of LPS that is suitable for high-resolution imaging.

Research Focus

Keywords

None specified

Clinical conditions

Amyotrophic lateral sclerosis

Equipment

Fluorescence microscopy

Collaborators

No collaborators listed

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