Dr Faye Begeti
Academic foundation doctor
Problems in cognition are a part of Huntington’s disease (HD) and have a significant impact on quality of life. My main research interest is to investigate the cognitive aspects of HD with the aim of translating animal research into the clinic in order to facilitate the development of future therapies.
Emerging evidence from HD animal models has suggested that the hippocampus, a key structure in learning and memory which if damaged can lead to amnesia, is affected in HD. I am currently using analogous tests to those which have been used in mice to test premanifest and manifest HD gene carriers as well as controls.
Concurrently, I am doing comparable experiments on mice focusing on the neuronal growth in the hippocampus, which is one of only two areas in the brain capable of neurogenesis, a process which plays a key role in learning and memory. This neuronal production is decreased in HD mice and I am investigating the cause and testing potential treatments to remedy this.
Cross-sectional and cohort studies
No collaborators listed
Associated News Items
Mason SL, Zhang J, Begeti F, Guzman NV, Lazar AS, Rowe JB, Barker RA, Hampshire A (2015), “The role of the amygdala during emotional processing in Huntington's disease: from pre-manifest to late stage disease.” Neuropsychologia 70:80-9 Details
Choi ML, Begeti F, Oh JH, Lee SY, O'Keeffe GC, Clelland CD, Tyers P, Cho ZH, Kim YB, Barker RA (2014), “Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease.” Neurobiol Dis 66:19-27 Details
Begeti F, Tan AY, Cummins GA, Collins LM, Guzman NV, Mason SL, Barker RA (2013), “The Addenbrooke's Cognitive Examination-Revised accurately detects cognitive decline in Huntington's disease.” J Neurol 260(11):2777-85 Details
Milton AL, Schramm MJ, Wawrzynski JR, Gore F, Oikonomou-Mpegeti F, Wang NQ, Samuel D, Economidou D, Everitt BJ (2012), “Antagonism at NMDA receptors, but not β-adrenergic receptors, disrupts the reconsolidation of pavlovian conditioned approach and instrumental transfer for ethanol-associated conditioned stimuli.” Psychopharmacology (Berl) 219(3):751-61 Details